Issue #334: Normalization (#337)

* add normalization example to test notebook

* update notebook metadata

* a few simple behavior tests

* Add keys to ReferenceLengthExpression and LiteralSequenceExpression

* Make LiteralSequenceExpression not-identifiable

* remove unnecessary / unused code

* addresses #338 (comment)

* Fix ReferenceLengthExpression tests in test_allele_translator

* linewise diff for test_annotate_vcf_grch38_noattrs

* Update test_vcf_expected_output_no_vrs_attrs.vcf.gz ReferenceLengthExpression

* Fix test_annotate_vcf_grch38_attrs

* Fix test_annotate_vcf_grch38_attrs_altsonly

---------

Co-authored-by: Kyle Ferriter <[email protected]>

src/ga4gh/core/__init__.py

@@ -13,7 +13,7 @@
     parse_ga4gh_identifier, GA4GHComputeIdentifierWhen, use_ga4gh_compute_identifier_when
 )
 from ._internal.pydantic import (
-    is_pydantic_instance, is_curie_type, is_identifiable, is_literal, pydantic_copy
+    is_pydantic_instance, is_curie_type, is_ga4gh_identifiable, is_literal, pydantic_copy
 )
 from ._internal import models as core_models
 

src/ga4gh/core/_internal/enderef.py

@@ -15,7 +15,7 @@
     is_pydantic_instance,
     is_list,
     is_curie_type,
-    is_identifiable,
+    is_ga4gh_identifiable,
     get_pydantic_root,
     pydantic_copy)
 
@@ -60,7 +60,7 @@ def _enref(o):
 
     if not is_pydantic_instance(o):
         raise ValueError("Called ga4gh_enref() with non-pydantic instance")
-    if not is_identifiable(o):
+    if not is_ga4gh_identifiable(o):
         raise ValueError("Called ga4gh_enref() with non-identifiable object")
 
     # in-place replacement on object copy
@@ -101,7 +101,7 @@ def _deref(o):
 
     if not is_pydantic_instance(o):
         raise ValueError("Called ga4gh_deref() with non-non-pydantic instance")
-    if not is_identifiable(o):
+    if not is_ga4gh_identifiable(o):
         raise ValueError("Called ga4gh_deref() with non-identifiable object")
 
     # in-place replacement on object copy

src/ga4gh/core/_internal/identifiers.py

@@ -28,7 +28,7 @@
 from .pydantic import (
     is_pydantic_instance,
     is_curie_type,
-    is_identifiable,
+    is_ga4gh_identifiable,
     getattr_in,
     get_pydantic_root,
     is_pydantic_custom_type
@@ -143,7 +143,7 @@ def ga4gh_identify(vro):
     'ga4gh:VSL.u5fspwVbQ79QkX6GHLF8tXPCAXFJqRPx'
 
     """
-    if is_identifiable(vro):
+    if is_ga4gh_identifiable(vro):
         when_rule = ga4gh_compute_identifier_when.get(GA4GHComputeIdentifierWhen.ALWAYS)
         do_compute = False
         ir = None
@@ -281,7 +281,7 @@ def identify_all(
 
     if is_pydantic_custom_type(input_obj):
         val = export_pydantic_model(input_obj)
-        if isinstance(val, str) and is_curie_type(val) and is_ga4gh_identifier(val):
+        if isinstance(val, str) and is_ga4gh_identifier(val):
             val = parse_ga4gh_identifier(val)["digest"]
         output_obj = val
     elif is_pydantic_instance(input_obj):
@@ -307,7 +307,7 @@ def identify_all(
             # Assumes any obj with 'digest' should be collapsed.
             collapsed_output_obj = collapse_identifiable_values(output_obj)
             # Add a digest to the output if it is identifiable
-            if is_identifiable(input_obj):
+            if is_ga4gh_identifiable(input_obj):
                 # Compute digest for updated object, not re-running compaction
                 output_obj["digest"] = ga4gh_digest(collapsed_output_obj, do_compact=False)
     else:
@@ -317,22 +317,22 @@ def identify_all(
     return output_obj
 
 
-def scrape_model_metadata(obj, meta={}) -> dict:
-    """
-    For a Pydantic object obj, pull out .ga4gh.identifiable
-    and .ga4gh.keys and put them in meta keyed by the class name of obj
-    """
-    assert isinstance(obj, BaseModel)
-    name = type(obj).__name__
-    if is_pydantic_custom_str_type(obj):
-        meta[name] = {"identifiable": False, "keys": None}
-    else:
-        meta[name] = {}
-        identifiable = getattr_in(obj, ["ga4gh", "identifiable"])
-        if identifiable:
-            meta[name]["identifiable"] = identifiable
-        keys = getattr_in(obj, ["ga4gh", "keys"])
-        if keys and len(keys) > 0:
-            meta[name]["keys"] = keys
-        # TODO recurse into fields
-    return meta
+# def scrape_model_metadata(obj, meta={}) -> dict:
+#     """
+#     For a Pydantic object obj, pull out .ga4gh.identifiable
+#     and .ga4gh.keys and put them in meta keyed by the class name of obj
+#     """
+#     assert isinstance(obj, BaseModel)
+#     name = type(obj).__name__
+#     if is_pydantic_custom_str_type(obj):
+#         meta[name] = {"identifiable": False, "keys": None}
+#     else:
+#         meta[name] = {}
+#         identifiable = getattr_in(obj, ["ga4gh", "identifiable"])
+#         if identifiable:
+#             meta[name]["identifiable"] = identifiable
+#         keys = getattr_in(obj, ["ga4gh", "keys"])
+#         if keys and len(keys) > 0:
+#             meta[name]["keys"] = keys
+#         # TODO recurse into fields
+#     return meta

src/ga4gh/core/_internal/pydantic.py

@@ -21,15 +21,15 @@ def getattr_in(obj, names) -> Any:
     return v
 
 
-def is_identifiable(o: Any) -> bool:
+def is_ga4gh_identifiable(o: Any) -> bool:
     """
-    Determine if object is identifiable. An object is considered identifiable if
-    contains a `ga4gh_digest` attribute
+    Determine if object is GA4GH identifiable. An object is considered
+    GA4GH identifiable if it contains a `ga4gh_prefix` attribute
 
     :param o: Object
-    :return: `True` if `o` has `ga4gh_digest` attribute. `False` otherwise.
+    :return: `True` if `o` has `ga4gh_prefix` attribute. `False` otherwise.
     """
-    return getattr_in(o, ['ga4gh', 'identifiable'])
+    return bool(getattr_in(o, ['ga4gh', 'prefix']))
 
 
 def is_literal(o: Any) -> bool:

src/ga4gh/vrs/_internal/models.py

@@ -26,7 +26,7 @@
 from pydantic import BaseModel, ConfigDict, Field, RootModel, constr
 
 from ga4gh.core._internal.pydantic import (
-    is_identifiable,
+    is_ga4gh_identifiable,
     getattr_in
 )
 from ga4gh.core._internal.models import IRI, _Entity
@@ -91,7 +91,7 @@ def pydantic_class_refatt_map():
     # Types directly reffable
     reffable_classes = list(filter(
         lambda c: ('id' in c.model_fields
-                   and is_identifiable(c)),
+                   and is_ga4gh_identifiable(c)),
         model_classes
     ))
     # Types reffable because they are a union of reffable types
@@ -172,16 +172,17 @@ class _ValueObject(_Entity):
         description='A sha512t24u digest created using the VRS Computed Identifier algorithm.',
     )
 
+    class ga4gh:
+        keys: List[str]
+
 
 class _Ga4ghIdentifiableObject(_ValueObject):
     """A contextual value object for which a GA4GH computed identifier can be created."""
 
     type: str
 
-    class ga4gh:
-        identifiable = True
+    class ga4gh(_ValueObject.ga4gh):
         prefix: str
-        keys: List[str]
 
 
 class Expression(BaseModel):
@@ -239,7 +240,7 @@ class SequenceReference(_ValueObject):
     )
     residueAlphabet: Optional[ResidueAlphabet] = None
 
-    class ga4gh:
+    class ga4gh(_ValueObject.ga4gh):
         assigned: bool = Field(
             True,
             description='This special property indicates that the `digest` field follows an alternate convention and is expected to have the value assigned following that convention. For SequenceReference, it is expected the digest will be the refget accession value without the `SQ.` prefix.'
@@ -262,6 +263,13 @@ class ReferenceLengthExpression(_ValueObject):
         None, description='The number of residues in the repeat subunit.'
     )
 
+    class ga4gh(_ValueObject.ga4gh):
+        keys = [
+            'length',
+            'repeatSubunitLength',
+            'type'
+        ]
+
 
 class LiteralSequenceExpression(_ValueObject):
     """An explicit expression of a Sequence."""
@@ -271,6 +279,12 @@ class LiteralSequenceExpression(_ValueObject):
     )
     sequence: SequenceString = Field(..., description='the literal sequence')
 
+    class ga4gh(_ValueObject.ga4gh):
+        keys = [
+            'sequence',
+            'type'
+        ]
+
 
 class SequenceLocation(_Ga4ghIdentifiableObject):
     """A `Location` defined by an interval on a referenced `Sequence`."""
@@ -407,7 +421,6 @@ class GenotypeMember(_ValueObject):
     )
 
     class ga4gh(_Ga4ghIdentifiableObject.ga4gh):
-        identifiable = False
         keys = [
             'type',
             'count',

tests/extras/test_allele_translator.py

@@ -111,7 +111,7 @@ def tlr(rest_dataproxy):
 insertion_output = {
     "location": {
         "end": 20003010,
-        "start":20003010,
+        "start": 20003010,
         "sequenceReference": {
             "refgetAccession": "SQ._0wi-qoDrvram155UmcSC-zA5ZK4fpLT",
             "type": "SequenceReference"
@@ -265,6 +265,7 @@ def test_to_spdi(tlr):
     assert 1 == len(to_spdi)
     assert spdiexpr == to_spdi[0]
 
+
 hgvs_tests = (
     ("NC_000013.11:g.32936732=", {
         "id": "ga4gh:VA.GuDPEe-WojSx4b4DxupN3si1poaR61qL",
@@ -303,7 +304,7 @@ def test_to_spdi(tlr):
         "type": "Allele"
     }),
     ("NC_000007.14:g.55181220del", {
-        "id": "ga4gh:VA.BNV6SfAuqDYKTTRknLcS-QuTryF5rSBi",
+        "id": "ga4gh:VA.wlYnlMsWc0ZTPZb-nQv2dXHbFcXa6J9u",
         "location": {
             "id": "ga4gh:SL.hnIOG_kul0Lf3mO1ddTRFb0GbQhtQ19t",
             "end": 55181220,
@@ -341,7 +342,7 @@ def test_to_spdi(tlr):
         "type": "Allele"
     }),
     ("NC_000013.11:g.32331093_32331094dup", {
-        "id": "ga4gh:VA.g-q4OzcyYFC5eVQFSrbXwgJScSREvrY-",
+        "id": "ga4gh:VA.x5iNzjjXbb1-wWTBLMBcicYlCMwYoedq",
         "location": {
             "id": "ga4gh:SL.PJ8lHWhAMNRSrxHvkarfDjRWxF-GwaJ_",
             "end": 32331094,
@@ -361,7 +362,7 @@ def test_to_spdi(tlr):
         "type": "Allele"
     }),
     ("NC_000013.11:g.32316467dup", {
-        "id": "ga4gh:VA._KlbF6GZCbuLxbL9z4hZE3oZSLzBHstS",
+        "id": "ga4gh:VA.ZAyA7Mmd7ERWN6CEd6muxn2mk_gTvEvF",
         "location": {
             "id": "ga4gh:SL.LURTeRdwh5bQf_QqPBoaA--MECYmrY5U",
             "end": 32316467,
@@ -434,7 +435,7 @@ def test_hgvs(tlr, hgvsexpr, expected):
 
 def test_to_hgvs_invalid(tlr):
     # IRI is passed
-    iri_vo =  models.Allele(
+    iri_vo = models.Allele(
         **{
             "location": {
                 "end": 1263,

tests/extras/test_vcf_annotation.py

@@ -8,10 +8,12 @@
 
 TEST_DATA_DIR = "tests/extras/data"
 
+
 @pytest.fixture
 def vcf_annotator():
     return VCFAnnotator("rest")
 
+
 @pytest.mark.vcr
 def test_annotate_vcf_grch38_noattrs(vcf_annotator, vcr_cassette):
     vcr_cassette.allow_playback_repeats = False
@@ -26,12 +28,14 @@ def test_annotate_vcf_grch38_noattrs(vcf_annotator, vcr_cassette):
         out_vcf_lines = out_vcf.readlines()
     with gzip.open(expected_vcf_no_vrs_attrs, "rt") as expected_output:
         expected_output_lines = expected_output.readlines()
-    assert out_vcf_lines == expected_output_lines
+    for actual_line, expected_line in zip(out_vcf_lines, expected_output_lines):
+        assert actual_line == expected_line
     assert os.path.exists(output_vrs_pkl)
     assert vcr_cassette.all_played
     os.remove(output_vcf)
     os.remove(output_vrs_pkl)
 
+
 @pytest.mark.vcr
 def test_annotate_vcf_grch38_attrs(vcf_annotator, vcr_cassette):
     vcr_cassette.allow_playback_repeats = False
@@ -46,12 +50,14 @@ def test_annotate_vcf_grch38_attrs(vcf_annotator, vcr_cassette):
         out_vcf_lines = out_vcf.readlines()
     with gzip.open(expected_vcf, "rt") as expected_output:
         expected_output_lines = expected_output.readlines()
-    assert out_vcf_lines == expected_output_lines
+    for actual_line, expected_line in zip(out_vcf_lines, expected_output_lines):
+        assert actual_line == expected_line
     assert os.path.exists(output_vrs_pkl)
     assert vcr_cassette.all_played
     os.remove(output_vcf)
     os.remove(output_vrs_pkl)
 
+
 @pytest.mark.vcr
 def test_annotate_vcf_grch38_attrs_altsonly(vcf_annotator, vcr_cassette):
     vcr_cassette.allow_playback_repeats = False
@@ -66,12 +72,14 @@ def test_annotate_vcf_grch38_attrs_altsonly(vcf_annotator, vcr_cassette):
         out_vcf_lines = out_vcf.readlines()
     with gzip.open(expected_altsonly_vcf, "rt") as expected_output:
         expected_output_lines = expected_output.readlines()
-    assert out_vcf_lines == expected_output_lines
+    for actual_line, expected_line in zip(out_vcf_lines, expected_output_lines):
+        assert actual_line == expected_line
     assert os.path.exists(output_vrs_pkl)
     assert vcr_cassette.all_played
     os.remove(output_vcf)
     os.remove(output_vrs_pkl)
 
+
 @pytest.mark.vcr
 def test_annotate_vcf_grch37_attrs(vcf_annotator, vcr_cassette):
     vcr_cassette.allow_playback_repeats = False
@@ -92,6 +100,7 @@ def test_annotate_vcf_grch37_attrs(vcf_annotator, vcr_cassette):
     os.remove(output_vcf)
     os.remove(output_vrs_pkl)
 
+
 @pytest.mark.vcr
 def test_annotate_vcf_pickle_only(vcf_annotator, vcr_cassette):
     vcr_cassette.allow_playback_repeats = False
@@ -106,6 +115,7 @@ def test_annotate_vcf_pickle_only(vcf_annotator, vcr_cassette):
     assert vcr_cassette.all_played
     os.remove(output_vrs_pkl)
 
+
 @pytest.mark.vcr
 def test_annotate_vcf_vcf_only(vcf_annotator, vcr_cassette):
     vcr_cassette.allow_playback_repeats = False
@@ -125,13 +135,15 @@ def test_annotate_vcf_vcf_only(vcf_annotator, vcr_cassette):
     assert not os.path.exists(output_vrs_pkl)
     os.remove(output_vcf)
 
+
 def test_annotate_vcf_input_validation(vcf_annotator):
     input_vcf = f"{TEST_DATA_DIR}/test_vcf_input.vcf"
 
     with pytest.raises(VCFAnnotatorException) as e:
         vcf_annotator.annotate(input_vcf)
     assert str(e.value) == "Must provide one of: `vcf_out` or `vrs_pickle_out`"
 
+
 @pytest.mark.vcr
 def test_get_vrs_object_invalid_input(vcf_annotator, caplog):
     """Test that _get_vrs_object method works as expected with invalid input"""