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28 changes: 14 additions & 14 deletions 10-MultipleRegression-FactorialDesigns.html
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Expand Up @@ -700,15 +700,15 @@ <h2><span class="header-section-number">4.1</span> Verwijderen van

Linear Hypotheses:
Estimate Std. Error t value Pr(&gt;|t|)
poison: II - I == 0 0.04686 0.01744 2.688 0.07352 .
poison: II - I == 0 0.04686 0.01744 2.688 0.07355 .
poison: III - I == 0 0.19964 0.01744 11.451 &lt; 0.001 ***
poison: III - II == 0 0.15278 0.01744 8.763 &lt; 0.001 ***
treat: B - A == 0 -0.16574 0.02013 -8.233 &lt; 0.001 ***
treat: C - A == 0 -0.05721 0.02013 -2.842 0.05085 .
treat: C - A == 0 -0.05721 0.02013 -2.842 0.05088 .
treat: D - A == 0 -0.13583 0.02013 -6.747 &lt; 0.001 ***
treat: C - B == 0 0.10853 0.02013 5.391 &lt; 0.001 ***
treat: D - B == 0 0.02991 0.02013 1.485 0.61546
treat: D - C == 0 -0.07862 0.02013 -3.905 0.00282 **
treat: D - B == 0 0.02991 0.02013 1.485 0.61547
treat: D - C == 0 -0.07862 0.02013 -3.905 0.00274 **
---
Signif. codes: 0 &#39;***&#39; 0.001 &#39;**&#39; 0.01 &#39;*&#39; 0.05 &#39;.&#39; 0.1 &#39; &#39; 1
(Adjusted p values reported -- single-step method)</code></pre>
Expand All @@ -721,21 +721,21 @@ <h2><span class="header-section-number">4.1</span> Verwijderen van

Fit: lm(formula = 1/time ~ poison + treat, data = rats)

Quantile = 2.8497
Quantile = 2.8499
95% family-wise confidence level


Linear Hypotheses:
Estimate lwr upr
poison: II - I == 0 0.0468641 -0.0028208 0.0965491
poison: III - I == 0 0.1996425 0.1499575 0.2493274
poison: III - II == 0 0.1527784 0.1030934 0.2024633
treat: B - A == 0 -0.1657402 -0.2231115 -0.1083690
treat: C - A == 0 -0.0572135 -0.1145848 0.0001577
treat: D - A == 0 -0.1358338 -0.1932051 -0.0784626
treat: C - B == 0 0.1085267 0.0511554 0.1658979
treat: D - B == 0 0.0299064 -0.0274648 0.0872777
treat: D - C == 0 -0.0786203 -0.1359915 -0.0212490</code></pre>
poison: II - I == 0 0.0468641 -0.0028243 0.0965526
poison: III - I == 0 0.1996425 0.1499540 0.2493310
poison: III - II == 0 0.1527784 0.1030899 0.2024668
treat: B - A == 0 -0.1657402 -0.2231155 -0.1083649
treat: C - A == 0 -0.0572135 -0.1145888 0.0001618
treat: D - A == 0 -0.1358338 -0.1932091 -0.0784585
treat: C - B == 0 0.1085267 0.0511514 0.1659020
treat: D - B == 0 0.0299064 -0.0274689 0.0872817
treat: D - C == 0 -0.0786203 -0.1359956 -0.0212450</code></pre>
<div class="sourceCode" id="cb17"><pre class="sourceCode r"><code class="sourceCode r"><span id="cb17-1"><a href="#cb17-1" aria-hidden="true" tabindex="-1"></a><span class="fu">plot</span>(comparisons,<span class="at">yaxt=</span><span class="st">&quot;none&quot;</span>)</span>
<span id="cb17-2"><a href="#cb17-2" aria-hidden="true" tabindex="-1"></a>contrastNames <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">&quot;II-I&quot;</span>,<span class="st">&quot;III-I&quot;</span>,<span class="st">&quot;III-II&quot;</span>,<span class="st">&quot;B-A&quot;</span>,<span class="st">&quot;C-A&quot;</span>,<span class="st">&quot;D-A&quot;</span>,<span class="st">&quot;C-B&quot;</span>,<span class="st">&quot;D-B&quot;</span>,<span class="st">&quot;D-C&quot;</span>)</span>
<span id="cb17-3"><a href="#cb17-3" aria-hidden="true" tabindex="-1"></a><span class="fu">axis</span>(<span class="dv">2</span>,<span class="at">at=</span><span class="fu">c</span>(<span class="fu">length</span>(contrastNames)<span class="sc">:</span><span class="dv">1</span>), <span class="at">labels=</span>contrastNames,<span class="at">las=</span><span class="dv">2</span>)</span></code></pre></div>
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4 changes: 2 additions & 2 deletions 10-Recap-AlgemeenLineairModel-OverigeConcepten.html
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Expand Up @@ -905,14 +905,14 @@ <h3><span class="header-section-number">4.1.2</span> Besluitvorming</h3>
##
## Fit: lm(formula = BPSysAve ~ Age * Gender, data = bpData, weights = 1/mSd$fitted^2)
##
## Quantile = 2.3167
## Quantile = 2.317
## 95% family-wise confidence level
##
##
## Linear Hypotheses:
## Estimate lwr upr
## Age == 0 0.4400 0.4050 0.4750
## Age + Age:Gendermale == 0 0.2484 0.2049 0.2919
## Age + Age:Gendermale == 0 0.2484 0.2048 0.2919
## Age:Gendermale == 0 -0.1916 -0.2475 -0.1357</code></pre>
</div>
<div id="conclusie" class="section level3" number="4.1.3">
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10 changes: 5 additions & 5 deletions Examenvoorbeeld_oefening_1.html
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Expand Up @@ -743,7 +743,7 @@ <h1><span class="header-section-number">3</span> Hypotheses testen</h1>
## Estimate Std. Error t value Pr(&gt;|t|)
## bacon == 0 -1.19081 0.13182 -9.034 &lt;0.001 ***
## bacon + bacon:sexmale == 0 -0.87572 0.06286 -13.930 &lt;0.001 ***
## bacon:sexmale == 0 0.31509 0.14603 2.158 0.0734 .
## bacon:sexmale == 0 0.31509 0.14603 2.158 0.0736 .
## ---
## Signif. codes: 0 &#39;***&#39; 0.001 &#39;**&#39; 0.01 &#39;*&#39; 0.05 &#39;.&#39; 0.1 &#39; &#39; 1
## (Adjusted p values reported -- single-step method)</code></pre>
Expand All @@ -754,15 +754,15 @@ <h1><span class="header-section-number">3</span> Hypotheses testen</h1>
##
## Fit: lm(formula = permeat ~ bacon + length + sex + bacon:sex, data = pigs)
##
## Quantile = 2.3172
## Quantile = 2.3178
## 95% family-wise confidence level
##
##
## Linear Hypotheses:
## Estimate lwr upr
## bacon == 0 -1.19081 -1.49627 -0.88535
## bacon + bacon:sexmale == 0 -0.87572 -1.02139 -0.73005
## bacon:sexmale == 0 0.31509 -0.02329 0.65347</code></pre>
## bacon == 0 -1.19081 -1.49634 -0.88528
## bacon + bacon:sexmale == 0 -0.87572 -1.02142 -0.73001
## bacon:sexmale == 0 0.31509 -0.02337 0.65355</code></pre>
</div>
<div id="conclusie" class="section level1" number="4">
<h1><span class="header-section-number">4</span> Conclusie</h1>
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22 changes: 11 additions & 11 deletions Examenvoorbeeld_oefening_2.html
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Expand Up @@ -692,7 +692,7 @@ <h1><span class="header-section-number">3</span> Hypotheses testen</h1>
## Estimate Std. Error t value Pr(&gt;|t|)
## tissueV == 0 7.9680 0.4532 17.580 &lt;0.001 ***
## tissueV + locationR:tissueV == 0 5.5038 0.4532 12.143 &lt;0.001 ***
## locationR:tissueV == 0 -2.4641 0.6410 -3.844 0.0193 *
## locationR:tissueV == 0 -2.4641 0.6410 -3.844 0.0195 *
## ---
## Signif. codes: 0 &#39;***&#39; 0.001 &#39;**&#39; 0.01 &#39;*&#39; 0.05 &#39;.&#39; 0.1 &#39; &#39; 1
## (Adjusted p values reported -- single-step method)</code></pre>
Expand All @@ -703,24 +703,24 @@ <h1><span class="header-section-number">3</span> Hypotheses testen</h1>
## Fit: lm(formula = intensity %&gt;% log2 ~ location * tissue + patient,
## data = hart)
##
## Quantile = 3.0262
## Quantile = 3.0167
## 95% family-wise confidence level
##
##
## Linear Hypotheses:
## Estimate lwr upr
## tissueV == 0 7.9680 6.5963 9.3396
## tissueV + locationR:tissueV == 0 5.5038 4.1322 6.8755
## locationR:tissueV == 0 -2.4641 -4.4039 -0.5244</code></pre>
## tissueV == 0 7.9680 6.6006 9.3353
## tissueV + locationR:tissueV == 0 5.5038 4.1365 6.8711
## locationR:tissueV == 0 -2.4641 -4.3978 -0.5304</code></pre>
<div class="sourceCode" id="cb29"><pre class="sourceCode r"><code class="sourceCode r"><span id="cb29-1"><a href="#cb29-1" aria-hidden="true" tabindex="-1"></a><span class="dv">2</span><span class="sc">^</span><span class="fu">confint</span>(mcp)<span class="sc">$</span>confint</span></code></pre></div>
<pre><code>## Estimate lwr upr
## tissueV 250.3757829 96.85309171 647.2486482
## tissueV + locationR:tissueV 45.3753769 17.55259829 117.3002876
## locationR:tissueV 0.1812291 0.04730366 0.6943223
## tissueV 250.3757829 96.81778511 647.4846807
## tissueV + locationR:tissueV 45.3753769 17.54619970 117.3430636
## locationR:tissueV 0.1812291 0.04727928 0.6946804
## attr(,&quot;conf.level&quot;)
## [1] 0.95
## attr(,&quot;calpha&quot;)
## [1] 3.023148</code></pre>
## [1] 3.024308</code></pre>
</div>
<div id="conclusie" class="section level1" number="4">
<h1><span class="header-section-number">4</span> Conclusie:</h1>
Expand All @@ -729,10 +729,10 @@ <h1><span class="header-section-number">4</span> Conclusie:</h1>
0.001).</p>
<p>Het geometrisch gemiddelde van de expressie van Myosin3L is een
factor 250 hoger in het linkerventrikel dan in het linkeratrium (p &lt;
0.001, 95% BI [96.5, 649.4]).</p>
0.001, 95% BI [96.8, 647.9]).</p>
<p>Het geometrisch gemiddelde van de expressie van Myosin3L is een
factor 45 hoger in het rechterventrikel dan in het rechteratrium (p &lt;
0.001, 95% BI [17.6, 117.2]).</p>
0.001, 95% BI [17.5, 117.4]).</p>
<p>De opregulatie van Myosin3L in ventrikel vs het atrium is gemiddeld
een factor 6 hoger in de linker- dan in de rechterzijde (p = 0.018, 95%
BI [1.4, 21.1] ).</p>
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6 changes: 3 additions & 3 deletions Exp_design_fast_1_sol.html
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Expand Up @@ -677,9 +677,9 @@ <h2><span class="header-section-number">4.2</span> Simulation</h2>
<span id="cb15-4"><a href="#cb15-4" aria-hidden="true" tabindex="-1"></a>alpha <span class="ot">&lt;-</span> <span class="fl">0.05</span> </span>
<span id="cb15-5"><a href="#cb15-5" aria-hidden="true" tabindex="-1"></a>power <span class="ot">&lt;-</span> <span class="fu">simFast</span>(form, rodents, betas, sd, <span class="at">contrasts =</span> contrast, <span class="at">alpha =</span> alpha, <span class="at">nSim =</span> nSim)</span>
<span id="cb15-6"><a href="#cb15-6" aria-hidden="true" tabindex="-1"></a>power</span></code></pre></div>
<pre><code>## [1] 0.2137</code></pre>
<pre><code>## [1] 0.2239</code></pre>
<p>We observe that the experiment is severly underpowered. We only have
a power of 21.4% to pick up the treatment effect.</p>
a power of 22.4% to pick up the treatment effect.</p>
</div>
</div>
<div id="power-for-a-balanced-design" class="section level1" number="5">
Expand All @@ -696,7 +696,7 @@ <h1><span class="header-section-number">5</span> Power for a balanced
<span id="cb19-2"><a href="#cb19-2" aria-hidden="true" tabindex="-1"></a>predictorData <span class="ot">&lt;-</span> <span class="fu">data.frame</span>(<span class="at">group =</span> <span class="fu">rep</span>(<span class="fu">c</span>(<span class="st">&quot;ctrl&quot;</span>,<span class="st">&quot;treat&quot;</span>),<span class="fu">c</span>(n1,n2)) <span class="sc">%&gt;%</span> as.factor)</span>
<span id="cb19-3"><a href="#cb19-3" aria-hidden="true" tabindex="-1"></a>powerBalanced <span class="ot">&lt;-</span> <span class="fu">simFast</span>(form, predictorData, betas, sd, <span class="at">contrasts =</span> contrast, <span class="at">alpha =</span> alpha, <span class="at">nSim =</span> nSim)</span>
<span id="cb19-4"><a href="#cb19-4" aria-hidden="true" tabindex="-1"></a>powerBalanced</span></code></pre></div>
<pre><code>## [1] 0.2462</code></pre>
<pre><code>## [1] 0.2596</code></pre>
<p>We observe that the power is larger for the balanced design. We could
also have known this from formula of the standard error from the
two-sample t-test.</p>
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6 changes: 3 additions & 3 deletions Exp_design_fast_2_sol.html
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Expand Up @@ -606,10 +606,10 @@ <h2><span class="header-section-number">1.3</span> Power for <span
<span id="cb7-10"><a href="#cb7-10" aria-hidden="true" tabindex="-1"></a></span>
<span id="cb7-11"><a href="#cb7-11" aria-hidden="true" tabindex="-1"></a>power <span class="ot">&lt;-</span> <span class="fu">simFast</span>(form, Puromycin, betas, sd, <span class="at">contrasts =</span> contrast, <span class="at">alpha =</span> alpha, <span class="at">nSim =</span> nSim)</span>
<span id="cb7-12"><a href="#cb7-12" aria-hidden="true" tabindex="-1"></a>power</span></code></pre></div>
<pre><code>[1] 0.4223</code></pre>
<pre><code>[1] 0.4285</code></pre>
<p>The power to pick up a slope of <span
class="math inline">\(\beta_1=10\)</span> for this experiment is only
42.2%.</p>
42.9%.</p>
</div>
<div
id="calculate-the-number-of-repeats-needed-per-concentration-to-obtain-a-power-of-90-to-pick-up-an-effect-of-beta_110."
Expand Down Expand Up @@ -672,7 +672,7 @@ <h1><span class="header-section-number">2</span> Optimal design with 12
</div>
<div class="sourceCode" id="cb11"><pre class="sourceCode r"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1" aria-hidden="true" tabindex="-1"></a>powerOpt <span class="ot">&lt;-</span> <span class="fu">simFast</span>(form, simData, betas, sd, <span class="at">contrasts =</span> contrast, <span class="at">alpha =</span> alpha, <span class="at">nSim =</span> nSim)</span>
<span id="cb11-2"><a href="#cb11-2" aria-hidden="true" tabindex="-1"></a>powerOpt</span></code></pre></div>
<pre><code>[1] 0.6081</code></pre>
<pre><code>[1] 0.6047</code></pre>
<p>Note that the power for a design where we repeat each concentration 1
time and the minimum and maximum concentration 4 times is considerably
higher than that for the designs where we repeat all data points.</p>
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28 changes: 14 additions & 14 deletions Exp_design_fast_3_sol.html
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Expand Up @@ -683,9 +683,9 @@ <h2><span class="header-section-number">2.1</span> Import KPNA2 data in
## Estimate Std. Error t value Pr(&gt;|t|)
## grade3 == 0 1.6675 0.1827 9.127 &lt; 0.001 ***
## grade3 + grade3:node1 == 0 0.8928 0.1827 4.886 &lt; 0.001 ***
## node1 == 0 0.6577 0.1827 3.600 0.00712 **
## node1 + grade3:node1 == 0 -0.1170 0.1827 -0.640 0.89823
## grade3:node1 == 0 -0.7748 0.2584 -2.998 0.02653 *
## node1 == 0 0.6577 0.1827 3.600 0.00728 **
## node1 + grade3:node1 == 0 -0.1170 0.1827 -0.640 0.89822
## grade3:node1 == 0 -0.7748 0.2584 -2.998 0.02662 *
## ---
## Signif. codes: 0 &#39;***&#39; 0.001 &#39;**&#39; 0.01 &#39;*&#39; 0.05 &#39;.&#39; 0.1 &#39; &#39; 1
## (Adjusted p values reported -- single-step method)</code></pre>
Expand Down Expand Up @@ -744,7 +744,7 @@ <h2><span class="header-section-number">3.2</span> power of current
<span id="cb32-13"><a href="#cb32-13" aria-hidden="true" tabindex="-1"></a>power1 <span class="ot">&lt;-</span> <span class="fu">simFastMultipleContrasts</span>(form, kpna2, betas, sd, contrasts, <span class="at">nSim =</span> nSim)</span>
<span id="cb32-14"><a href="#cb32-14" aria-hidden="true" tabindex="-1"></a>power1</span></code></pre></div>
<pre><code>## graden0 graden1 nodeg1 nodeg3 interaction
## 1.00000 0.97115 0.77105 0.02580 0.57105</code></pre>
## 1.00000 0.97210 0.77340 0.02430 0.57225</code></pre>
<p>We observe large powers for all contrasts, except for contrast
nodeg3, which has a small effect size.</p>
</div>
Expand Down Expand Up @@ -780,15 +780,15 @@ <h2><span class="header-section-number">3.3</span> Power for increasing
<span id="cb34-26"><a href="#cb34-26" aria-hidden="true" tabindex="-1"></a>}</span>
<span id="cb34-27"><a href="#cb34-27" aria-hidden="true" tabindex="-1"></a>powers</span></code></pre></div>
<pre><code>## n graden0 graden1 nodeg1 nodeg3 interaction
## [1,] 2 0.70525 0.21170 0.11090 0.01155 0.07710
## [2,] 3 0.99170 0.56765 0.29185 0.01600 0.19135
## [3,] 4 0.99995 0.80185 0.47860 0.01945 0.31810
## [4,] 5 1.00000 0.92250 0.64605 0.02170 0.45465
## [5,] 6 1.00000 0.96890 0.76020 0.02395 0.56840
## [6,] 7 1.00000 0.98930 0.85155 0.02610 0.66720
## [7,] 8 1.00000 0.99650 0.90705 0.03195 0.74735
## [8,] 9 1.00000 0.99895 0.94380 0.03340 0.81375
## [9,] 10 1.00000 0.99940 0.96920 0.03760 0.86985</code></pre>
## [1,] 2 0.70425 0.21590 0.10945 0.01315 0.07565
## [2,] 3 0.99330 0.56650 0.29390 0.01475 0.19335
## [3,] 4 0.99985 0.80505 0.48135 0.01875 0.31890
## [4,] 5 1.00000 0.91870 0.63915 0.02080 0.44875
## [5,] 6 1.00000 0.97270 0.76385 0.02415 0.57265
## [6,] 7 1.00000 0.98935 0.85140 0.02930 0.67180
## [7,] 8 1.00000 0.99680 0.90725 0.03055 0.75520
## [8,] 9 1.00000 0.99900 0.94380 0.03385 0.81975
## [9,] 10 1.00000 0.99960 0.96910 0.03955 0.86520</code></pre>
<div class="sourceCode" id="cb36"><pre class="sourceCode r"><code class="sourceCode r"><span id="cb36-1"><a href="#cb36-1" aria-hidden="true" tabindex="-1"></a>powers <span class="sc">%&gt;%</span> </span>
<span id="cb36-2"><a href="#cb36-2" aria-hidden="true" tabindex="-1"></a> as.data.frame <span class="sc">%&gt;%</span> </span>
<span id="cb36-3"><a href="#cb36-3" aria-hidden="true" tabindex="-1"></a> <span class="fu">gather</span>(contrast, power, <span class="sc">-</span>n) <span class="sc">%&gt;%</span> </span>
Expand Down Expand Up @@ -818,7 +818,7 @@ <h2><span class="header-section-number">3.4</span> Power when FC for
<span id="cb37-14"><a href="#cb37-14" aria-hidden="true" tabindex="-1"></a>power3 <span class="ot">&lt;-</span> <span class="fu">simFastMultipleContrasts</span>(form, kpna2, betas2, sd, contrasts,<span class="at">nSim =</span> nSim)</span>
<span id="cb37-15"><a href="#cb37-15" aria-hidden="true" tabindex="-1"></a>power3</span></code></pre></div>
<pre><code>## graden0 graden1 nodeg1 nodeg3 interaction
## 0.63860 0.05100 0.76620 0.02570 0.56395</code></pre>
## 0.63630 0.05205 0.76120 0.02380 0.56895</code></pre>
<p>It is clear that only the power of the contrasts containing <span
class="math inline">\(\beta_g\)</span> change when the effect size of
<span class="math inline">\(\beta_g\)</span> changes.</p>
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14 changes: 7 additions & 7 deletions Practicum_1_oplossing_anova.html
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Expand Up @@ -769,9 +769,9 @@ <h2><span class="header-section-number">3.4</span> Post-hoc analyse</h2>
##
## Linear Hypotheses:
## Estimate Std. Error t value Pr(&gt;|t|)
## linseed - casein == 0 -104.83 23.28 -4.504 0.000201 ***
## soybean - casein == 0 -77.15 22.43 -3.440 0.004220 **
## soybean - linseed == 0 27.68 22.43 1.234 0.441428
## linseed - casein == 0 -104.83 23.28 -4.504 &lt; 0.001 ***
## soybean - casein == 0 -77.15 22.43 -3.440 0.00432 **
## soybean - linseed == 0 27.68 22.43 1.234 0.44141
## ---
## Signif. codes: 0 &#39;***&#39; 0.001 &#39;**&#39; 0.01 &#39;*&#39; 0.05 &#39;.&#39; 0.1 &#39; &#39; 1
## (Adjusted p values reported -- single-step method)</code></pre>
Expand Down Expand Up @@ -805,15 +805,15 @@ <h2><span class="header-section-number">3.4</span> Post-hoc analyse</h2>
##
## Fit: lm(formula = weight ~ feed, data = chickwts)
##
## Quantile = 2.4459
## Quantile = 2.4472
## 95% family-wise confidence level
##
##
## Linear Hypotheses:
## Estimate lwr upr
## linseed - casein == 0 -104.8333 -161.7640 -47.9026
## soybean - casein == 0 -77.1548 -132.0146 -22.2950
## soybean - linseed == 0 27.6786 -27.1812 82.5384</code></pre>
## linseed - casein == 0 -104.8333 -161.7946 -47.8720
## soybean - casein == 0 -77.1548 -132.0440 -22.2655
## soybean - linseed == 0 27.6786 -27.2107 82.5678</code></pre>
<div class="sourceCode" id="cb18"><pre class="sourceCode r"><code class="sourceCode r"><span id="cb18-1"><a href="#cb18-1" aria-hidden="true" tabindex="-1"></a><span class="fu">plot</span>(mcp)</span></code></pre></div>
<p><img src="Practicum_1_oplossing_anova_files/figure-html/unnamed-chunk-13-1.png" width="672" /></p>
</div>
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8 changes: 4 additions & 4 deletions fishtank_sol.html
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Expand Up @@ -668,13 +668,13 @@ <h2><span class="header-section-number">6.4</span> Post-hoc
<div class="sourceCode" id="cb12"><pre class="sourceCode r"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1" aria-hidden="true" tabindex="-1"></a>confDiet <span class="ot">&lt;-</span> <span class="fu">confint</span>(multComp)</span>
<span id="cb12-2"><a href="#cb12-2" aria-hidden="true" tabindex="-1"></a>confDiet<span class="sc">$</span>confint</span></code></pre></div>
<pre><code>## Estimate lwr upr
## 2 - 1 20.33333 12.79575 27.87091
## 3 - 1 44.00000 36.46242 51.53758
## 3 - 2 23.66667 16.12909 31.20425
## 2 - 1 20.33333 12.79917 27.86750
## 3 - 1 44.00000 36.46584 51.53416
## 3 - 2 23.66667 16.13250 31.20083
## attr(,&quot;conf.level&quot;)
## [1] 0.95
## attr(,&quot;calpha&quot;)
## [1] 2.793755</code></pre>
## [1] 2.792487</code></pre>
</div>
<div id="conclusion" class="section level2" number="6.5">
<h2><span class="header-section-number">6.5</span> Conclusion</h2>
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