Compartmental modeling

EN.580.439 Models of the Neuron

Model details

• Humpback whale cerebellar stellate cell
• Morphometry data: http://neuromorpho.org/neuron_info.jsp?neuron_name=202-2-23nj

Topics explored

• Temporal response at the soma to transient inputs applied at different locations within the dendritic tree
• Effectiveness of on-path vs off-path shunting inhibition
• Low pass filtering abilities of the dendritic tree

Conclusions

• As input distance from the soma increases, the voltage response of the soma to that input decreases and slows
• On-path inhibition is much stronger than off-path, but that effect is blunted by distance between the inhibition and excitation
• Inhibition that comes just after excitation has the strongest inhibitory effect
• Dendrites can act as a low pass filter
• Dendritic filtering effects increases as function of distance