diff --git a/modules/hal_nordic/nrfx/nrfx_config.h b/modules/hal_nordic/nrfx/nrfx_config.h
index a0f2f481bc37ef..d1f9314954ae53 100644
--- a/modules/hal_nordic/nrfx/nrfx_config.h
+++ b/modules/hal_nordic/nrfx/nrfx_config.h
@@ -32,7 +32,7 @@
 #endif
 
 #ifdef CONFIG_CLOCK_CONTROL_NRF_K32SRC_RC
-#if defined(CONFIG_SOC_SERIES_NRF91X) || defined(CONFIG_SOC_SERIES_NRF53X)
+#if defined(CONFIG_SOC_SERIES_NRF91X) || defined(CONFIG_SOC_COMPATIBLE_NRF53X)
 #define NRFX_CLOCK_CONFIG_LF_SRC 1
 #else
 #define NRFX_CLOCK_CONFIG_LF_SRC 0
@@ -40,7 +40,7 @@
 #endif // CONFIG_CLOCK_CONTROL_NRF_K32SRC_RC
 
 #ifdef CONFIG_CLOCK_CONTROL_NRF_K32SRC_XTAL
-#if defined(CONFIG_SOC_SERIES_NRF91X) || defined(CONFIG_SOC_SERIES_NRF53X)
+#if defined(CONFIG_SOC_SERIES_NRF91X) || defined(CONFIG_SOC_COMPATIBLE_NRF53X)
 #define NRFX_CLOCK_CONFIG_LF_SRC 2
 #else
 #define NRFX_CLOCK_CONFIG_LF_SRC 1
@@ -48,7 +48,7 @@
 #endif // CONFIG_CLOCK_CONTROL_NRF_K32SRC_XTAL
 
 #ifdef CONFIG_CLOCK_CONTROL_NRF_K32SRC_SYNTH
-#ifdef CONFIG_SOC_SERIES_NRF53X
+#ifdef CONFIG_SOC_COMPATIBLE_NRF53X
 #define NRFX_CLOCK_CONFIG_LF_SRC 3
 #else
 #define NRFX_CLOCK_CONFIG_LF_SRC 2