diff --git a/dts/arm/nordic/nrf5340_cpuapp.dtsi b/dts/arm/nordic/nrf5340_cpuapp.dtsi
index 4d0fadd419f8726..fa3ca57934c5ab7 100644
--- a/dts/arm/nordic/nrf5340_cpuapp.dtsi
+++ b/dts/arm/nordic/nrf5340_cpuapp.dtsi
@@ -74,7 +74,12 @@
 			status = "okay";
 		};
 
-		gpiote: gpiote0: gpiote@5000d000 {
+		/*
+		 * GPIOTE0 is always accessible as a secure peripheral,
+		 * so we give it the 'gpiote' label for use when building
+		 * code for this target.
+		 */
+		 gpiote: gpiote0: gpiote@5000d000 {
 			compatible = "nordic,nrf-gpiote";
 			reg = <0x5000d000 0x1000>;
 			interrupts = <13 5>;
@@ -82,6 +87,15 @@
 			instance = <0>;
 		};
 
+		/* Additional Non-Secure GPIOTE instance */
+		gpiote1: gpiote@4002f000 {
+			compatible = "nordic,nrf-gpiote";
+			reg = <0x4002f000 0x1000>;
+			interrupts = <47 5>;
+			status = "disabled";
+			instance = <1>;
+		};
+
 		cryptocell: crypto@50844000 {
 			compatible = "nordic,cryptocell", "arm,cryptocell-312";
 			reg = <0x50844000 0x1000>, <0x50845000 0x1000>;
diff --git a/dts/arm/nordic/nrf5340_cpuappns.dtsi b/dts/arm/nordic/nrf5340_cpuappns.dtsi
index 2ba35cfa69e1735..311f3ef47afb4f6 100644
--- a/dts/arm/nordic/nrf5340_cpuappns.dtsi
+++ b/dts/arm/nordic/nrf5340_cpuappns.dtsi
@@ -49,7 +49,11 @@
 			#include "nrf5340_cpuapp_peripherals.dtsi"
 		};
 
-		/* Additional Non-Secure peripherals */
+		/*
+ 		 * GPIOTE1 is always accessible as a non-secure peripheral,
+		 * so we give it the 'gpiote' label for use when building
+		 * code for this target.
+		 */
 		gpiote: gpiote1: gpiote@4002f000 {
 			compatible = "nordic,nrf-gpiote";
 			reg = <0x4002f000 0x1000>;
diff --git a/dts/arm/nordic/nrf91.dtsi b/dts/arm/nordic/nrf91.dtsi
index e874c49d56b3f51..a9f067a7e5ae5d1 100644
--- a/dts/arm/nordic/nrf91.dtsi
+++ b/dts/arm/nordic/nrf91.dtsi
@@ -60,7 +60,12 @@
 			status = "okay";
 		};
 
-		gpiote: gpiote0: gpiote@5000d000 {
+		/*
+		 * GPIOTE0 is always accessible as a secure peripheral,
+		 * so we give it the 'gpiote' label for use when building
+		 * code for this target.
+		 */
+		 gpiote: gpiote0: gpiote@5000d000 {
 			compatible = "nordic,nrf-gpiote";
 			reg = <0x5000d000 0x1000>;
 			interrupts = <13 5>;
@@ -68,6 +73,15 @@
 			instance = <0>;
 		};
 
+		/* Additional Non-Secure GPIOTE instance */
+		gpiote1: gpiote@40031000 {
+			compatible = "nordic,nrf-gpiote";
+			reg = <0x40031000 0x1000>;
+			interrupts = <49 5>;
+			status = "disabled";
+			instance = <1>;
+		};
+
 		spu: spu@50003000 {
 			compatible = "nordic,nrf-spu";
 			reg = <0x50003000 0x1000>;
diff --git a/dts/arm/nordic/nrf91ns.dtsi b/dts/arm/nordic/nrf91ns.dtsi
index bcf3c8cb5c0dd76..b5f6ff7f0517b77 100644
--- a/dts/arm/nordic/nrf91ns.dtsi
+++ b/dts/arm/nordic/nrf91ns.dtsi
@@ -46,7 +46,11 @@
 			#include "nrf91_peripherals.dtsi"
 		};
 
-		/* Additional Non-Secure peripherals */
+		/*
+ 		 * GPIOTE1 is always accessible as a non-secure peripheral,
+		 * so we give it the 'gpiote' label for use when building
+		 * code for this target.
+		 */
 		gpiote: gpiote1: gpiote@40031000 {
 			compatible = "nordic,nrf-gpiote";
 			reg = <0x40031000 0x1000>;