diff --git a/.test/three_prime/config/config.yaml b/.test/three_prime/config/config.yaml
index 6e983190..dc5416b4 100644
--- a/.test/three_prime/config/config.yaml
+++ b/.test/three_prime/config/config.yaml
@@ -98,6 +98,23 @@ enrichment:
     # the species specified by resources -> ref -> species above
     pathway_database: "panther"
 
+meta_comparisons:
+  # comparison is only run if set to `true`
+  activate: false
+  # Define here the coparisons under interest
+  comparisons:
+    # Define any name for comparison
+    model_X_vs_model_Y:
+      items:
+        # Define the two underlying models for the comparison. The models must be defined in the diffexp/models in the config
+        - label: X # Arbitrary label
+          model: model_X # Must match a diffexp model from config
+        - label: Y # Arbitrary label
+          model: model_Y # Must match a diffexp model from config
+      desc: |
+        Comparison between model_X and model_Y effect.
+      label: model_X vs. model_Y effect
+
 bootstrap_plots:
   # desired false discovery rate for bootstrap plots, i.e. a lower FDR will result in fewer boxplots generated
   FDR: 0.01