diff --git a/setuptools/config/pyprojecttoml.py b/setuptools/config/pyprojecttoml.py
index 15b0baa18e..fb277f5b7a 100644
--- a/setuptools/config/pyprojecttoml.py
+++ b/setuptools/config/pyprojecttoml.py
@@ -41,6 +41,19 @@ def load_file(filepath: StrPath) -> dict:
 
 
 def validate(config: dict, filepath: StrPath) -> bool:
+    skip = os.getenv("SETUPTOOLS_DANGEROUSLY_SKIP_PYPROJECT_VALIDATION", "false")
+    if skip.lower() == "true":  # https://github.com/pypa/setuptools/issues/4459
+        SetuptoolsWarning.emit(
+            "Skipping the validation of `pyproject.toml`.",
+            """
+            Please note that some setuptools functionalities rely on the validation of
+            `pyproject.toml` against misconfiguration to ensure proper operation.
+            By skipping the automatic checks, you taking responsibility for making sure
+            the file is valid. Otherwise unexpected behaviours may occur.
+            """,
+        )
+        return True
+
     from . import _validate_pyproject as validator
 
     trove_classifier = validator.FORMAT_FUNCTIONS.get("trove-classifier")
diff --git a/setuptools/tests/config/test_pyprojecttoml.py b/setuptools/tests/config/test_pyprojecttoml.py
index db40fcd23d..df27487d51 100644
--- a/setuptools/tests/config/test_pyprojecttoml.py
+++ b/setuptools/tests/config/test_pyprojecttoml.py
@@ -17,6 +17,7 @@
 )
 from setuptools.dist import Distribution
 from setuptools.errors import OptionError
+from setuptools.warnings import SetuptoolsWarning
 
 import distutils.core
 
@@ -394,3 +395,9 @@ def test_warn_tools_typo(tmp_path):
 
     with pytest.warns(_ToolsTypoInMetadata):
         read_configuration(pyproject)
+
+
+def test_warn_skipping_validation(monkeypatch):
+    monkeypatch.setenv("SETUPTOOLS_DANGEROUSLY_SKIP_PYPROJECT_VALIDATION", "true")
+    with pytest.warns(SetuptoolsWarning, match="Skipping the validation"):
+        assert validate({"completely-wrong": "data"}, "pyproject.toml") is True