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<!DOCTYPE HTML><!-- Editorial by HTML5 UP html5up.net | @ajlkn Free for personal and commercial use under the CCA 3.0 license (html5up.net/license)--><html><head> <!-- Global site tag (gtag.js) - Google Analytics --> <script async src="https://www.googletagmanager.com/gtag/js?id=G-XYKQVV10GS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-XYKQVV10GS'); </script> <title>Ottavia Dipasquale | Home</title> <meta charset="utf-8" /> <meta name="viewport" content="width=device-width, initial-scale=1, user-scalable=no" /> <link rel="stylesheet" href="assets/css/main.css" /> <link rel="apple-touch-icon" sizes="180x180" href="assets/favicon/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="assets/favicon/favicon-32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="assets/favicon/favicon-16x16.png"> <link rel="manifest" href="assets/favicon/site.webmanifest"> <link rel="mask-icon" href="assets/favicon/safari-pinned-tab.svg" color="#0d58ff"> <link rel="shortcut icon" href="assets/favicon/favicon.ico"> <meta name="msapplication-TileColor" content="#da532c"> <meta name="msapplication-config" content="assets/favicon/browserconfig.xml"> <meta name="theme-color" content="#ffffff"></script><meta name="google-site-verification" content="Tce1sXjWQUvyNGyGBKN5p5WmiplxtT4Dhdq0UVp9kCY" /></head><body class="is-preload"> <!-- Wrapper --> <div id="wrapper"> <!-- Main --> <div id="main"> <div class="inner"> <!-- Header --> <header id="header"> <a href="index.html" class="logo">Ottavia Dipasquale</a> <ul class="icons"> <li><a href="mailto:[email protected]" class="icon fa-envelope"><span class="label"></span></a></li> <li><a href="https://twitter.com/otta_dps" target="_blank" class="icon brands fa-twitter"><span class="label">Twitter</span></a></li> <li><a href="www.linkedin.com/in/ottaviadipasquale" target="_blank" class="icon brands fa-linkedin"><span class="label">LinkedIn</span></a></li> </ul> </header> <!-- Banner --> <section id="banner"> <div class="content"> <header> <h1>Hi, I’m <br /> Ottavia Dipasquale</h1> <p>Senior imaging scientist at King's College London</p> </header> <p> The key goal of my research is to <strong>develop neuroimaging biomarkers</strong> for pharmacological and clinical studies using novel multimodal techniques. <br /> These biomarkers are of key importance: <ul style="margin-top:-25px;"> <li><u>In drug challenges</u>, to explore the <strong>effects of pharmacological manipulation </strong> of brain networks from a molecular perspective.</li> <li><u>In clinical studies</u>, to provide insights into the neurochemical mechanisms underlying functional alterations in brain disorders, fundamental condition for moving towards <strong>precision/personalised medicine</strong>.</li> </ul></p> <ul class="actions"> <li><a href="bio.html" class="button big">More</a></li> <li><a href="https://scholar.google.com/citations?user=b2U6encAAAAJ" target="_blank" class="button big">Scholar</a></li> <li><a href="contact_me.html" class="button big">Contact Me</a></li> </ul> </div> <span class="image object"> <img src="images/mypic.jpg" alt="" /> </span> </section> <!-- Section --> <section> <header class="major"> <h2>Research interests and activity</h2> </header> <div class="row"> <div class="col-6 col-12-small"> <span class="fas fa-brain fa-4x fa-pull-left " style="color:#f56a6a"></span> <div class="content"> <h4>STUDYING BRAIN FUNCTION AND CONNECTIVITY</h4> <p>Sequence development and testing, acquisition and analysis of resting state BOLD fMRI, ASL and CMRO2 data.</p> </div> </div> <div class="col-6 col-12-small"> <span class="fas fa-capsules fa-4x fa-pull-left" style="color:#f56a6a"></span> <div class="content"> <h4>PHARMACOLOGICAL STUDIES</h4> <p>Development of <strong><a href="https://doi.org/10.1016/j.neuroimage.2019.04.007" target="_blank">REACT</a></strong>, a multimodal method that uses <strong>PET atlases to enrich resting state fMRI analysis</strong>. Application in healthy populations and clinical cohorts to tackle different limitations of drug fMRI studies.</p> </div> </div> </div> <div class="row"> <div class="col-6 col-12-small"> <span class="fas fa-university fa-4x fa-pull-left" style="color:#f56a6a"></span> <div class="content"> <h4>TEACHING </h4> <p>I give lectures in the MSc Neuroscience programme on “Analysis of Resting state fMRI data”. I also organise workshops on resting state fMRI analysis for PhD students and post-docs.</p> </div> </div> <div class="col-6 col-12-small"> <span class="fas fa-users fa-4x fa-pull-left" style="color:#f56a6a"></span> <div class="content"> <h4>STUDENT SUPERVISION</h4> <p>I'm involved in <a href="https://kclpure.kcl.ac.uk/portal/en/persons/ottavia-dipasquale(b4144d58-9aa2-41f3-9e96-4aa122ab6ff2)/supervision.html" target="_blank">postgraduate supervision</a>. <br />Please get in touch if you have a background in engineering, neuroscience or a related field and would like to discuss possible MSc and PhD projects.</p> </div> </div> </div> <!-- <article> <span class="fas fa-fingerprint fa-4x fa-pull-left" style="color:#f56a6a"></span> <div class="content"> <h3>PRECISION MEDICINE</h3> <p>Aenean ornare velit lacus, ac varius enim lorem ullamcorper dolore. Proin aliquam facilisis ante interdum. Sed nulla amet lorem feugiat tempus aliquam.</p> </div> </article> --> </section> <!-- Section --> <section> <header class="major"> <h2>Selected publications</h2> </header> <div class="posts"> <article> <!--<a href="https://doi.org/10.1016/j.neuroimage.2019.04.007" target="_blank" class="image"><img src="images/REACT.jpg" alt="" /></a>--> <iframe width="100%" height="60%" src="https://www.youtube.com/embed/UmSK9KjKYvw" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" class="video" allowfullscreen></iframe> <h4>REACT</h4> <p>Receptor-Enriched Analysis of functional connectivity by targets (REACT): A novel, multimodal analytical approach informed by PET to study the pharmacodynamic response of the brain under MDMA.<br /> <i><a href="https://doi.org/10.1016/j.neuroimage.2019.04.007" target="_blank">Dipasquale et al, NeuroImage 2019</a></i></p> <ul class="actions"> </ul> </article> <article> <a href="https://doi.org/10.1101/2021.02.17.431572" target="_blank" class="image"><img src="images/OAreact.tiff" alt="" /></a> <h4>PAIN: DETECTING FUNCTIONAL ALTERATIONS AND PREDICTING ANALGESIC RESPONSE</h4> <p>A candidate neuroimaging biomarker for detection of neurotransmission-related functional alterations and prediction of pharmacological analgesic response in chronic pain.<br /> <i><a href="https://doi.org/10.1093/braincomms/fcab302" target="_blank">Martins et al, Brain Communications 2021</a></i></p> <ul class="actions"> </ul> </article> <article> <a href="https://doi.org/10.1101/2021.02.17.431572" target="_blank" class="image"><img src="images/imagetranscript.png" alt="" /></a> <h4>IMAGING TRANSCRIPTOMICS</h4> <p> Imaging Transcriptomics: Convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brain.<br /> <i><a href="https://doi.org/10.1016/j.celrep.2021.110173" target="_blank">Martins et al, Cell Reports 2021</a></i></p> <ul class="actions"> </ul> </article> <article> <!--<iframe width="560" height="315" src="https://www.youtube.com/embed/NO3DtF-SUBI" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe> --> <iframe width="100%" height="60%" src="https://www.youtube.com/embed/3dKpgCG6ylA" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" class="video" allowfullscreen></iframe> <!-- <a href="https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcab023/6159609" target="_blank" class="image"><img src="images/fatigue.jpg" alt="" /></a> --> <h4>MONOAMINE FUNCTIONAL CIRCUITS IMPAIRED IN COGNITIVE FATIGUE</h4> <p>Cognitive fatigue in Multiple Sclerosis is associated with alterations in the functional connectivity of monoamine circuits.<br /> <i><a href="https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcab023/6159609" target="_blank">Cercignani et al, Brain Communications 2021</a></i></p> <ul class="actions"> </ul> </article> <article> <a href="https://doi.org/10.1177/1073858421994784" target="_blank" class="image"><img src="images/complex.jpg" alt="" /></a> <h4>BRAIN COMPLEXITY</h4> <p>A Complex systems perspective on neuroimaging studies of behavior and its disorders.<br /> <i><a href="https://doi.org/10.1177/1073858421994784" target="_blank">Turkheimer et al, The Neuroscientist 2021</a></i></p> <ul class="actions"> </ul> </article> <article> <a href="https://doi.org/10.1038/s41386-020-0724-x" target="_blank" class="image"><img src="images/mph.jpg" height="200" alt="" /></a> <h4>DISENTANGLING MULTIPLE AFFINITIES OF METHYLPHENIDATE</h4> <p>Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits.<br /> <i><a href="https://doi.org/10.1038/s41386-020-0724-x" target="_blank">Dipasquale et al, Neuropsychopharmacology 2020</a></i></p> <ul class="actions"> </ul> </article> </div> </section> </div> </div> <!-- Sidebar --> <div id="sidebar"> <div class="inner"> <!-- Search --> <section id="search" class="alt"> <form method="post" action="#"> <input type="text" name="query" id="query" placeholder="Search" /> </form> </section> <!-- Menu --> <nav id="menu"> <header class="major"> <h2>Menu</h2> </header> <ul> <li><a href="index.html">About</a></li> <li><a href="bio.html">Bio</a></li> <li><a href="projects.html">Projects</a></li> <li><a href="publications.html">Publications</a></li> <li><a href="contact_me.html">Contact me</a></li> <!--<li> <span class="opener">Submenu</span> <ul> <li><a href="#">Lorem Dolor</a></li> <li><a href="#">Ipsum Adipiscing</a></li> <li><a href="#">Tempus Magna</a></li> <li><a href="#">Feugiat Veroeros</a></li> </ul> </li> --> </ul> </nav> <!-- Section --> <section> <header class="major"> <h2>Get in touch</h2> </header> <!--<p></p> --> <ul class="contact"> <li class="icon solid fa-envelope"><a href="mailto:[email protected]">[email protected]</a></li> <li class="icon solid fa-phone">+44 (0) 20 3288 3042</li> <li class="icon solid fa-home">Department of Neuroimaging<br /> Institute of Psychiatry, Psychology & Neuroscience<br /> King's College London<br /> De Crespigny Park<br /> SE5 8AF London (UK) </li> </ul> </section> <!-- Footer --> <footer id="footer"> <p class="copyright">© Ottavia Dipasquale. 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