diff --git a/ro-base.json b/ro-base.json
index 57840400..517c1a57 100644
--- a/ro-base.json
+++ b/ro-base.json
@@ -13715,14 +13715,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002002",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002323"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002083",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002081"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0011013",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0011004"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002083",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002081"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0004007",
       "pred" : "subPropertyOf",
@@ -13751,14 +13751,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002009",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002292"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002110",
-      "pred" : "inverseOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002113"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002103",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002120"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002110",
+      "pred" : "inverseOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002113"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002567",
       "pred" : "subPropertyOf",
@@ -13859,14 +13859,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0004047",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002418"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002016",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002017"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0004005",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0004000"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002016",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002017"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002411",
       "pred" : "subPropertyOf",
@@ -14019,14 +14019,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0004028",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002410"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002381",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/BFO_0000050"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002488",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002490"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002381",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000050"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0001023",
       "pred" : "subPropertyOf",
@@ -14207,14 +14207,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002291",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002206"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002225",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002202"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002223",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002222"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002225",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002202"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002492",
       "pred" : "subPropertyOf",
@@ -14315,14 +14315,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0012006",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000022",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_HOM0000011"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002230",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/BFO_0000051"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000022",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_HOM0000011"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002590",
       "pred" : "subPropertyOf",
@@ -14359,14 +14359,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002339",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002344"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002012",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002418"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/BFO_0000015",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/BFO_0000003"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002012",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002418"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002209",
       "pred" : "subPropertyOf",
@@ -14527,6 +14527,10 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002315",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0040036"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002455",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002442"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002252",
       "pred" : "subPropertyOf",
@@ -14535,22 +14539,18 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002466",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002465"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002455",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002442"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002263",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002264"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000007",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_HOM0000001"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002310",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/BFO_0000015"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000007",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_HOM0000001"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0011014",
       "pred" : "subPropertyOf",
@@ -15247,14 +15247,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002245",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002206"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002231",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002479"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002180",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/BFO_0000051"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002231",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002479"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0013005",
       "pred" : "subPropertyOf",
@@ -15268,17 +15268,17 @@
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002091"
     }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002007",
+      "sub" : "http://purl.obolibrary.org/obo/RO_0004024",
       "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/BFO_0000050"
+      "obj" : "http://purl.obolibrary.org/obo/RO_0004023"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0004012",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0004010"
     }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0004024",
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002007",
       "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0004023"
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000050"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002525",
       "pred" : "subPropertyOf",
@@ -15311,10 +15311,6 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000062",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_HOM0000007"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002085",
-      "pred" : "inverseOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002092"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002084",
       "pred" : "inverseOf",
@@ -15323,6 +15319,10 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002087",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002090"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002085",
+      "pred" : "inverseOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002092"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0011004",
       "pred" : "subPropertyOf",
@@ -15575,14 +15575,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002203",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002286"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0004034",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002263"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002588",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002297"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0004034",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002263"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002219",
       "pred" : "inverseOf",
@@ -15799,14 +15799,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0000079",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0000085"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002159",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002320"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002090",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/BFO_0000063"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002159",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002320"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000045",
       "pred" : "subPropertyOf",
@@ -16131,14 +16131,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0013003",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0013001"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002286",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002384"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002026",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002323"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002286",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002384"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "pred" : "inverseOf",
@@ -16175,14 +16175,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002355",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0040036"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002256",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002258"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0004015",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0004010"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002256",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002258"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002254",
       "pred" : "inverseOf",
@@ -16519,10 +16519,6 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002462",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002461"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002297",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002295"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000065",
       "pred" : "subPropertyOf",
@@ -16531,6 +16527,10 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000060",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_HOM0000050"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002297",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002295"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002331",
       "pred" : "subPropertyOf",
@@ -16727,14 +16727,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002229",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002222"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0013002",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002110"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002020",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002313"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0013002",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002110"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002086",
       "pred" : "subPropertyOf",
@@ -16796,7 +16796,7 @@
         "pred" : "http://xmlns.com/foaf/0.1/homepage",
         "val" : " https://github.com/oborel/obo-relations/"
       } ],
-      "version" : "http://purl.obolibrary.org/obo/ro/releases/2022-07-19/ro-base.owl"
+      "version" : "http://purl.obolibrary.org/obo/ro/releases/2022-09-07/ro-base.owl"
     },
     "equivalentNodesSets" : [ ],
     "logicalDefinitionAxioms" : [ ],
@@ -16853,13 +16853,6 @@
       "predicateId" : "http://purl.obolibrary.org/obo/RO_0002332",
       "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000015" ],
       "rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ]
-    }, {
-      "predicateId" : "http://purl.obolibrary.org/obo/RO_0002179",
-      "allValuesFromEdges" : [ {
-        "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
-        "pred" : "http://purl.obolibrary.org/obo/RO_0002179",
-        "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
-      } ]
     }, {
       "predicateId" : "http://purl.obolibrary.org/obo/RO_0009004",
       "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ],
@@ -16898,17 +16891,9 @@
     }, {
       "predicateId" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "allValuesFromEdges" : [ {
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-        "obj" : "http://purl.obolibrary.org/obo/BFO_0000031"
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-        "obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
-      }, {
-        "sub" : "http://purl.obolibrary.org/obo/BFO_0000017",
+        "sub" : "http://purl.obolibrary.org/obo/BFO_0000003",
         "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "obj" : "http://purl.obolibrary.org/obo/BFO_0000017"
+        "obj" : "http://purl.obolibrary.org/obo/BFO_0000003"
       }, {
         "sub" : "http://purl.obolibrary.org/obo/BFO_0000019",
         "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
@@ -16918,13 +16903,21 @@
         "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
         "obj" : "http://purl.obolibrary.org/obo/BFO_0000020"
       }, {
-        "sub" : "http://purl.obolibrary.org/obo/BFO_0000003",
+        "sub" : "http://purl.obolibrary.org/obo/BFO_0000004",
         "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "obj" : "http://purl.obolibrary.org/obo/BFO_0000003"
+        "obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
       }, {
         "sub" : "http://purl.obolibrary.org/obo/BFO_0000002",
         "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
         "obj" : "http://purl.obolibrary.org/obo/BFO_0000002"
+      }, {
+        "sub" : "http://purl.obolibrary.org/obo/BFO_0000017",
+        "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
+        "obj" : "http://purl.obolibrary.org/obo/BFO_0000017"
+      }, {
+        "sub" : "http://purl.obolibrary.org/obo/BFO_0000031",
+        "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
+        "obj" : "http://purl.obolibrary.org/obo/BFO_0000031"
       } ]
     }, {
       "predicateId" : "http://purl.obolibrary.org/obo/RO_0002202",
@@ -17067,13 +17060,13 @@
     }, {
       "predicateId" : "http://purl.obolibrary.org/obo/RO_HOM0000000",
       "allValuesFromEdges" : [ {
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-        "pred" : "http://purl.obolibrary.org/obo/RO_HOM0000000",
-        "obj" : "http://purl.obolibrary.org/obo/BFO_0000002"
-      }, {
         "sub" : "http://purl.obolibrary.org/obo/BFO_0000003",
         "pred" : "http://purl.obolibrary.org/obo/RO_HOM0000000",
         "obj" : "http://purl.obolibrary.org/obo/BFO_0000003"
+      }, {
+        "sub" : "http://purl.obolibrary.org/obo/BFO_0000002",
+        "pred" : "http://purl.obolibrary.org/obo/RO_HOM0000000",
+        "obj" : "http://purl.obolibrary.org/obo/BFO_0000002"
       } ]
     }, {
       "predicateId" : "http://purl.obolibrary.org/obo/RO_0002414",
@@ -17403,13 +17396,13 @@
     }, {
       "predicateId" : "http://purl.obolibrary.org/obo/RO_0002214",
       "allValuesFromEdges" : [ {
-        "sub" : "http://purl.obolibrary.org/obo/BFO_0000015",
-        "pred" : "http://purl.obolibrary.org/obo/RO_0002214",
-        "obj" : "http://purl.obolibrary.org/obo/BFO_0000015"
-      }, {
         "sub" : "http://purl.obolibrary.org/obo/BFO_0000002",
         "pred" : "http://purl.obolibrary.org/obo/RO_0002214",
         "obj" : "http://purl.obolibrary.org/obo/BFO_0000002"
+      }, {
+        "sub" : "http://purl.obolibrary.org/obo/BFO_0000015",
+        "pred" : "http://purl.obolibrary.org/obo/RO_0002214",
+        "obj" : "http://purl.obolibrary.org/obo/BFO_0000015"
       } ]
     }, {
       "predicateId" : "http://purl.obolibrary.org/obo/RO_0002215",
diff --git a/ro-base.obo b/ro-base.obo
index d0dd25bb..96d3c1ce 100644
--- a/ro-base.obo
+++ b/ro-base.obo
@@ -1,5 +1,5 @@
 format-version: 1.2
-data-version: ro/releases/2022-07-19/ro-base.owl
+data-version: ro/releases/2022-09-07/ro-base.owl
 subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension ""
 subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term ""
 subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology ""
@@ -117,10 +117,6 @@ id: BFO:0000141
 name: immaterial entity
 is_a: BFO:0000004 ! independent continuant
 
-[Term]
-id: CARO:0000006
-relationship: RO:0002179 CARO:0000003 ! drains
-
 [Term]
 id: CHEBI:50906
 is_a: PATO:0000001
diff --git a/ro-base.owl b/ro-base.owl
index 47c9729a..21494b43 100644
--- a/ro-base.owl
+++ b/ro-base.owl
@@ -18,7 +18,7 @@
      xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#"
      xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#">
     <owl:Ontology rdf:about="http://purl.obolibrary.org/obo/ro/ro-base.owl">
-        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/ro/releases/2022-07-19/ro-base.owl"/>
+        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/ro/releases/2022-09-07/ro-base.owl"/>
         <dc:description xml:lang="en">The OBO Relations Ontology (RO) is a collection of OWL relations (ObjectProperties) intended for use across a wide variety of biological ontologies.</dc:description>
         <dc:title xml:lang="en">OBO Relations Ontology</dc:title>
         <terms:license rdf:resource="https://creativecommons.org/publicdomain/zero/1.0/"/>
@@ -12189,14 +12189,7 @@ For example, protein A (transcription factor) indirectly increases by expression
 
     <!-- http://purl.obolibrary.org/obo/CARO_0000006 -->
 
-    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0000006">
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002179"/>
-                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CARO_0000003"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
-    </owl:Class>
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0000006"/>
     
 
 
diff --git a/ro.json b/ro.json
index eb78d7b1..5e5d05bb 100644
--- a/ro.json
+++ b/ro.json
@@ -14178,14 +14178,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002505",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0000057"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002578",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002211"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002555",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002574"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002578",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002211"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002375",
       "pred" : "subPropertyOf",
@@ -14198,22 +14198,22 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002436",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002434"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002614",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002616"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002615",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0003301"
     }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0016301",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0016772"
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002614",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002616"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0015001",
       "pred" : "subPropertyOf",
       "obj" : "http://www.w3.org/2002/07/owl#topObjectProperty"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0016301",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_0016772"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0008504",
       "pred" : "subPropertyOf",
@@ -14230,14 +14230,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002002",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002323"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002083",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002081"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0011013",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0011004"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002083",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002081"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0004007",
       "pred" : "subPropertyOf",
@@ -14266,14 +14266,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002009",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002292"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002110",
-      "pred" : "inverseOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002113"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002103",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002120"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002110",
+      "pred" : "inverseOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002113"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002567",
       "pred" : "subPropertyOf",
@@ -14338,14 +14338,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002572",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002571"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002521",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002514"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002520",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002524"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002521",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002514"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002571",
       "pred" : "subPropertyOf",
@@ -14378,14 +14378,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0004047",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002418"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002411",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002418"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0004005",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0004000"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002411",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002418"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002016",
       "pred" : "subPropertyOf",
@@ -14550,14 +14550,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0004028",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002410"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002488",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002490"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002381",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/BFO_0000050"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002488",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002490"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0001023",
       "pred" : "subPropertyOf",
@@ -14582,14 +14582,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0004020",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0004019"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0016004",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002244"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002507",
       "pred" : "inverseOf",
@@ -14878,14 +14878,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0012006",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002230",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/BFO_0000051"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000022",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_HOM0000011"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002230",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000051"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002590",
       "pred" : "subPropertyOf",
@@ -14930,14 +14930,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002339",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002344"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/BFO_0000015",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/BFO_0000003"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002012",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002418"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/BFO_0000015",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000003"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002209",
       "pred" : "subPropertyOf",
@@ -15071,17 +15071,17 @@
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002131"
     }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0030425",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/GO_0043005"
+      "sub" : "http://purl.obolibrary.org/obo/RO_0008502",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002440"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/PATO_0001199",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/PATO_0000052"
     }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0008502",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002440"
+      "sub" : "http://purl.obolibrary.org/obo/GO_0030425",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_0043005"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002478",
       "pred" : "subPropertyOf",
@@ -15110,14 +15110,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002599",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002597"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/GO_0044456",
-      "pred" : "is_a",
-      "obj" : "http://www.w3.org/2002/07/owl#Thing"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002130",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002131"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/GO_0044456",
+      "pred" : "is_a",
+      "obj" : "http://www.w3.org/2002/07/owl#Thing"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002333",
       "pred" : "subPropertyOf",
@@ -15131,29 +15131,29 @@
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0040036"
     }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002455",
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002252",
       "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002442"
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002375"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002466",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002465"
     }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002252",
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002455",
       "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002375"
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002442"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002263",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002264"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002310",
-      "pred" : "is_a",
-      "obj" : "http://purl.obolibrary.org/obo/BFO_0000015"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000007",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_HOM0000001"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002310",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000015"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0011014",
       "pred" : "subPropertyOf",
@@ -15314,10 +15314,6 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002430",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002428"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002379",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002131"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002113",
       "pred" : "subPropertyOf",
@@ -15326,6 +15322,10 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002114",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002120"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002379",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002131"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002329",
       "pred" : "subPropertyOf",
@@ -15378,14 +15378,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002006",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002131"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000062",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_HOM0000065"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002618",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002619"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000062",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_HOM0000065"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002600",
       "pred" : "subPropertyOf",
@@ -15466,14 +15466,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002533",
       "pred" : "is_a",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002532"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002022",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002334"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002260",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0000087"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002022",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002334"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000012",
       "pred" : "subPropertyOf",
@@ -15614,14 +15614,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002386",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002384"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002305",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0004046"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002258",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002286"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002305",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0004046"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/PATO_0000402",
       "pred" : "is_a",
@@ -15734,14 +15734,14 @@
       "sub" : "http://purl.obolibrary.org/obo/BFO_0000062",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002086"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002372",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002567"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0004001",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0004011"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002372",
+      "pred" : "subPropertyOf",
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     }, {
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@@ -15770,14 +15770,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002229",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/BFO_0000050"
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       "sub" : "http://purl.obolibrary.org/obo/RO_0004002",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0004012"
+    }, {
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+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/GO_0044456"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002384",
       "pred" : "subPropertyOf",
@@ -15886,34 +15886,34 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002526",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002514"
-    }, {
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-      "pred" : "is_a",
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       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002162"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/PATO_0002009",
+      "pred" : "is_a",
+      "obj" : "http://purl.obolibrary.org/obo/PATO_0000052"
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     }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002180",
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002245",
       "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/BFO_0000051"
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002206"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002231",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002479"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002180",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000051"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0013005",
       "pred" : "subPropertyOf",
@@ -15926,6 +15926,10 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002088",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002091"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002007",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000050"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0004012",
       "pred" : "subPropertyOf",
@@ -15934,10 +15938,6 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0004024",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0004023"
-    }, {
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-      "obj" : "http://purl.obolibrary.org/obo/BFO_0000050"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002525",
       "pred" : "subPropertyOf",
@@ -16002,26 +16002,26 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002004",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0001018"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002458",
-      "pred" : "subPropertyOf",
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     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002476",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002258"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002458",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002438"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002233",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0000057"
-    }, {
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-      "pred" : "inverseOf",
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     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002006",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002130"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0001020",
+      "pred" : "inverseOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0001022"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002622",
       "pred" : "inverseOf",
@@ -16050,14 +16050,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002000",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002002"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002216",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002500"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002495",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002494"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002216",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002500"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000044",
       "pred" : "subPropertyOf",
@@ -16086,14 +16086,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0004009",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0004007"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002473",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/BFO_0000051"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002624",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002625"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002473",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000051"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002340",
       "pred" : "subPropertyOf",
@@ -16178,14 +16178,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0004023",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0040035"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0000080",
-      "pred" : "inverseOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0000086"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0008501",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0008502"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0000080",
+      "pred" : "inverseOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0000086"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0013008",
       "pred" : "inverseOf",
@@ -16390,14 +16390,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002445",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002443"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002309",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002244"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002529",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002529"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002309",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002244"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002360",
       "pred" : "subPropertyOf",
@@ -16410,14 +16410,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002444",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002454"
-    }, {
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-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002206"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002461",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0000056"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002246",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002206"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002232",
       "pred" : "subPropertyOf",
@@ -16482,6 +16482,10 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002624",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002618"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0000079",
+      "pred" : "inverseOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0000085"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002159",
       "pred" : "subPropertyOf",
@@ -16490,10 +16494,6 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002090",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/BFO_0000063"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0000079",
-      "pred" : "inverseOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0000085"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000045",
       "pred" : "subPropertyOf",
@@ -16706,26 +16706,26 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002459",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002574"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0003305",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0003304"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002177",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002323"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0003305",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0003304"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002551",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002576"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002381",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002375"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/BFO_0000054",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/BFO_0000055"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002381",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002375"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0008505",
       "pred" : "subPropertyOf",
@@ -16818,14 +16818,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002380",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002569"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002331",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002431"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002256",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002257"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002331",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002431"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0013003",
       "pred" : "subPropertyOf",
@@ -17002,14 +17002,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002607",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002610"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0004022",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002200"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002559",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002566"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0004022",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002200"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002204",
       "pred" : "subPropertyOf",
@@ -17246,14 +17246,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002297",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002295"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000060",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_HOM0000050"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000065",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_HOM0000000"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_HOM0000060",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_HOM0000050"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002331",
       "pred" : "subPropertyOf",
@@ -17278,14 +17278,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002641",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002635"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002326",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002329"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002091",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002222"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002326",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002329"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002512",
       "pred" : "inverseOf",
@@ -17342,14 +17342,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0004002",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0004000"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002223",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/BFO_0000050"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0004009",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002233"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002223",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/BFO_0000050"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002252",
       "pred" : "subPropertyOf",
@@ -17434,14 +17434,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002205",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002330"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0004000",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002410"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002204",
       "pred" : "inverseOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002205"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0004000",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002410"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002569",
       "pred" : "subPropertyOf",
@@ -17466,14 +17466,14 @@
       "sub" : "http://purl.obolibrary.org/obo/RO_0002229",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002222"
-    }, {
-      "sub" : "http://purl.obolibrary.org/obo/RO_0002020",
-      "pred" : "subPropertyOf",
-      "obj" : "http://purl.obolibrary.org/obo/RO_0002313"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0013002",
       "pred" : "subPropertyOf",
       "obj" : "http://purl.obolibrary.org/obo/RO_0002110"
+    }, {
+      "sub" : "http://purl.obolibrary.org/obo/RO_0002020",
+      "pred" : "subPropertyOf",
+      "obj" : "http://purl.obolibrary.org/obo/RO_0002313"
     }, {
       "sub" : "http://purl.obolibrary.org/obo/RO_0002086",
       "pred" : "subPropertyOf",
@@ -17551,12 +17551,12 @@
         "val" : "Includes Ontology(OntologyID(OntologyIRI(<http://purl.obolibrary.org/obo/ro/temporal-intervals.owl>) VersionIRI(<null>))) [Axioms: 146 Logical Axioms: 45]"
       }, {
         "pred" : "http://www.w3.org/2002/07/owl#versionInfo",
-        "val" : "2022-07-19"
+        "val" : "2022-09-07"
       }, {
         "pred" : "http://xmlns.com/foaf/0.1/homepage",
         "val" : " https://github.com/oborel/obo-relations/"
       } ],
-      "version" : "http://purl.obolibrary.org/obo/ro/releases/2022-07-19/ro.owl"
+      "version" : "http://purl.obolibrary.org/obo/ro/releases/2022-09-07/ro.owl"
     },
     "equivalentNodesSets" : [ ],
     "logicalDefinitionAxioms" : [ ],
@@ -17613,13 +17613,6 @@
       "predicateId" : "http://purl.obolibrary.org/obo/RO_0002332",
       "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000015" ],
       "rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ]
-    }, {
-      "predicateId" : "http://purl.obolibrary.org/obo/RO_0002179",
-      "allValuesFromEdges" : [ {
-        "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
-        "pred" : "http://purl.obolibrary.org/obo/RO_0002179",
-        "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
-      } ]
     }, {
       "predicateId" : "http://purl.obolibrary.org/obo/RO_0009004",
       "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ],
@@ -17669,33 +17662,33 @@
     }, {
       "predicateId" : "http://purl.obolibrary.org/obo/BFO_0000050",
       "allValuesFromEdges" : [ {
-        "sub" : "http://purl.obolibrary.org/obo/BFO_0000003",
+        "sub" : "http://purl.obolibrary.org/obo/BFO_0000020",
         "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "obj" : "http://purl.obolibrary.org/obo/BFO_0000003"
+        "obj" : "http://purl.obolibrary.org/obo/BFO_0000020"
       }, {
-        "sub" : "http://purl.obolibrary.org/obo/BFO_0000019",
+        "sub" : "http://purl.obolibrary.org/obo/BFO_0000031",
         "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "obj" : "http://purl.obolibrary.org/obo/BFO_0000019"
+        "obj" : "http://purl.obolibrary.org/obo/BFO_0000031"
       }, {
-        "sub" : "http://purl.obolibrary.org/obo/BFO_0000017",
+        "sub" : "http://purl.obolibrary.org/obo/BFO_0000002",
         "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "obj" : "http://purl.obolibrary.org/obo/BFO_0000017"
+        "obj" : "http://purl.obolibrary.org/obo/BFO_0000002"
       }, {
         "sub" : "http://purl.obolibrary.org/obo/BFO_0000004",
         "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
         "obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
       }, {
-        "sub" : "http://purl.obolibrary.org/obo/BFO_0000020",
+        "sub" : "http://purl.obolibrary.org/obo/BFO_0000017",
         "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "obj" : "http://purl.obolibrary.org/obo/BFO_0000020"
+        "obj" : "http://purl.obolibrary.org/obo/BFO_0000017"
       }, {
-        "sub" : "http://purl.obolibrary.org/obo/BFO_0000002",
+        "sub" : "http://purl.obolibrary.org/obo/BFO_0000003",
         "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "obj" : "http://purl.obolibrary.org/obo/BFO_0000002"
+        "obj" : "http://purl.obolibrary.org/obo/BFO_0000003"
       }, {
-        "sub" : "http://purl.obolibrary.org/obo/BFO_0000031",
+        "sub" : "http://purl.obolibrary.org/obo/BFO_0000019",
         "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
-        "obj" : "http://purl.obolibrary.org/obo/BFO_0000031"
+        "obj" : "http://purl.obolibrary.org/obo/BFO_0000019"
       } ]
     }, {
       "predicateId" : "http://purl.obolibrary.org/obo/RO_0002202",
@@ -17838,13 +17831,13 @@
     }, {
       "predicateId" : "http://purl.obolibrary.org/obo/RO_HOM0000000",
       "allValuesFromEdges" : [ {
-        "sub" : "http://purl.obolibrary.org/obo/BFO_0000003",
-        "pred" : "http://purl.obolibrary.org/obo/RO_HOM0000000",
-        "obj" : "http://purl.obolibrary.org/obo/BFO_0000003"
-      }, {
         "sub" : "http://purl.obolibrary.org/obo/BFO_0000002",
         "pred" : "http://purl.obolibrary.org/obo/RO_HOM0000000",
         "obj" : "http://purl.obolibrary.org/obo/BFO_0000002"
+      }, {
+        "sub" : "http://purl.obolibrary.org/obo/BFO_0000003",
+        "pred" : "http://purl.obolibrary.org/obo/RO_HOM0000000",
+        "obj" : "http://purl.obolibrary.org/obo/BFO_0000003"
       } ]
     }, {
       "predicateId" : "http://purl.obolibrary.org/obo/RO_0002414",
diff --git a/ro.obo b/ro.obo
index 51d5ef8e..2a084f4c 100644
--- a/ro.obo
+++ b/ro.obo
@@ -1,5 +1,5 @@
 format-version: 1.2
-data-version: releases/2022-07-19
+data-version: releases/2022-09-07
 subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension ""
 subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term ""
 subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology ""
@@ -26,7 +26,7 @@ property_value: http://purl.org/dc/elements/1.1/description "The OBO Relations O
 property_value: http://purl.org/dc/elements/1.1/title "OBO Relations Ontology" xsd:string
 property_value: http://purl.org/dc/terms/license https://creativecommons.org/publicdomain/zero/1.0/
 property_value: http://xmlns.com/foaf/0.1/homepage " https://github.com/oborel/obo-relations/" xsd:anyURI
-property_value: owl:versionInfo "2022-07-19" xsd:string
+property_value: owl:versionInfo "2022-09-07" xsd:string
 owl-axioms: Prefix(owl:=<http://www.w3.org/2002/07/owl#>)\nPrefix(rdf:=<http://www.w3.org/1999/02/22-rdf-syntax-ns#>)\nPrefix(xml:=<http://www.w3.org/XML/1998/namespace>)\nPrefix(xsd:=<http://www.w3.org/2001/XMLSchema#>)\nPrefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)\n\n\nOntology(\nDeclaration(Class(<http://purl.obolibrary.org/obo/BFO_0000002>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/BFO_0000003>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/BFO_0000004>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/BFO_0000006>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/BFO_0000015>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/BFO_0000016>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/BFO_0000019>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/BFO_0000023>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/BFO_0000031>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/BFO_0000034>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/BFO_0000040>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/BFO_0000141>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/CARO_0000006>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/CARO_0000007>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/CARO_0010000>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/CL_0000000>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/CL_0000101>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/CL_0000540>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/GO_0003674>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/GO_0004842>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/GO_0004872>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/GO_0005634>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/GO_0008150>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/GO_0016301>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/GO_0019107>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/GO_0042995>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/GO_0044456>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/OGMS_0000031>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/PATO_0000402>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/PATO_0001199>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/RO_0002532>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/RO_0002577>))\nDeclaration(Class(<http://purl.obolibrary.org/obo/UPHENO_0001001>))\nDeclaration(Class(<http://xmlns.com/foaf/0.1/image>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000050>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000051>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000055>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000062>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000063>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/BFO_0000066>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0000052>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0000053>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0000056>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0000057>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0000085>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0000086>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0000087>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0000091>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0001025>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002008>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002013>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002014>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002015>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002018>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002025>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002103>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002131>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002132>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002170>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002176>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002180>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002204>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002207>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002211>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002212>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002213>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002215>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002233>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002234>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002263>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002264>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002327>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002331>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002333>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002351>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002352>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002376>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002378>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002379>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002380>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002400>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002404>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002411>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002418>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002425>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002440>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002441>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002442>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002443>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002444>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002447>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002448>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002449>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002450>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002461>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002462>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002463>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002465>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002466>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002467>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002468>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002480>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002481>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002482>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002496>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002497>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002510>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002512>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002513>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002551>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002566>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002578>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002583>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002593>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002629>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0002630>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0003000>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0003301>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0004000>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0004022>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0004026>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0004027>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0004029>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0009001>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0009002>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0009003>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0009005>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0018001>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0018002>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0019001>))\nDeclaration(ObjectProperty(<http://purl.obolibrary.org/obo/RO_0019002>))\nDeclaration(DataProperty(<http://purl.obolibrary.org/obo/RO_0002029>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/IAO_0000426>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0001900>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002161>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002171>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002172>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002173>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002174>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002175>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002416>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002419>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002420>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002421>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002422>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002423>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002474>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002475>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002483>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002484>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002504>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002535>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002536>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002537>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002538>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002539>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002540>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002541>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002542>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002543>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002544>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002545>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002546>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002547>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002548>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002549>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002550>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002560>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002561>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002562>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002575>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002579>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002580>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002581>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002582>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002594>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002601>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002602>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002603>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002604>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002605>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002611>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002612>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002613>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0002617>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0004036>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0004048>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0004049>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0004050>))\nDeclaration(AnnotationProperty(<http://purl.obolibrary.org/obo/RO_0040042>))\nDeclaration(AnnotationProperty(<http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled>))\n############################\n#   Annotation Properties\n############################\n\n# Annotation Property: <http://purl.obolibrary.org/obo/IAO_0000426> (first order logic expression)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/IAO_0000426> <http://purl.obolibrary.org/obo/RO_0002422>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0001900> (temporal interpretation)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0001900> <http://purl.obolibrary.org/obo/RO_0002422>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002161> (never in taxon)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002161> <http://purl.obolibrary.org/obo/RO_0002172>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002171> (mutually spatially disjoint with)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002171> <http://purl.obolibrary.org/obo/RO_0002420>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002172> (taxonomic class assertion)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002172> <http://purl.obolibrary.org/obo/RO_0002420>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002173> (ambiguous for taxon)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002173> <http://purl.obolibrary.org/obo/RO_0002172>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002174> (dubious for taxon)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002174> <http://purl.obolibrary.org/obo/RO_0002172>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002175> (present in taxon)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002175> <http://purl.obolibrary.org/obo/RO_0002172>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002419> (annotation property cardinality)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002419> <http://purl.obolibrary.org/obo/RO_0002423>)\nAnnotationPropertyRange(<http://purl.obolibrary.org/obo/RO_0002419> xsd:nonNegativeInteger)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002420> (logical macro assertion on a class)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002420> <http://purl.obolibrary.org/obo/RO_0002416>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002421> (logical macro assertion on a property)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002421> <http://purl.obolibrary.org/obo/RO_0002416>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002422> (logical macro assertion on an object property)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002422> <http://purl.obolibrary.org/obo/RO_0002421>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002423> (logical macro assertion on an annotation property)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002423> <http://purl.obolibrary.org/obo/RO_0002421>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002474> (dispositional interpretation)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002474> <http://purl.obolibrary.org/obo/RO_0002422>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002475> (has no connections with)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002475> <http://purl.obolibrary.org/obo/RO_0002420>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002484> (curator guidance link)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002484> <http://purl.obolibrary.org/obo/RO_0002483>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002504> (always present in taxon)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002504> <http://purl.obolibrary.org/obo/RO_0002175>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002535> (temporal logical macro assertion on a class)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002535> <http://purl.obolibrary.org/obo/RO_0002420>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002536> (measurement property has unit)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002536> <http://purl.obolibrary.org/obo/RO_0002423>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002537> (has start time value)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002537> <http://purl.obolibrary.org/obo/RO_0002535>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002538> (has end time value)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002538> <http://purl.obolibrary.org/obo/RO_0002535>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002539> (start, days post fertilization)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002539> <http://purl.obolibrary.org/obo/RO_0002537>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002540> (end, days post fertilization)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002540> <http://purl.obolibrary.org/obo/RO_0002538>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002541> (start, years post birth)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002541> <http://purl.obolibrary.org/obo/RO_0002537>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002542> (end, years post birth)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002542> <http://purl.obolibrary.org/obo/RO_0002538>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002543> (start, months post birth)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002543> <http://purl.obolibrary.org/obo/RO_0002537>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002544> (end, months post birth)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002544> <http://purl.obolibrary.org/obo/RO_0002538>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002545> (month of gestation)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002545> <http://purl.obolibrary.org/obo/RO_0002535>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002546> (has developmental stage marker)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002546> <http://purl.obolibrary.org/obo/RO_0002535>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002547> (start, days post coitum)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002547> <http://purl.obolibrary.org/obo/RO_0002537>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002548> (end, days post coitum)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002548> <http://purl.obolibrary.org/obo/RO_0002538>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002549> (start, weeks post birth)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002549> <http://purl.obolibrary.org/obo/RO_0002537>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002550> (end, weeks post birth)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002550> <http://purl.obolibrary.org/obo/RO_0002538>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002560> (is asymmetric relational form of process class)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002560> <http://purl.obolibrary.org/obo/RO_0002562>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002561> (is symmetric relational form of process class)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002561> <http://purl.obolibrary.org/obo/RO_0002562>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002562> (is relational form of process class)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002562> <http://purl.obolibrary.org/obo/RO_0002594>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002575> (is direct form of)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002575> <http://purl.obolibrary.org/obo/RO_0002422>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002579> (is indirect form of)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002579> <http://purl.obolibrary.org/obo/RO_0002422>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002580> (logical macro assertion on an axiom)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002580> <http://purl.obolibrary.org/obo/RO_0002416>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002581> (is a defining property chain axiom)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002581> <http://purl.obolibrary.org/obo/RO_0002580>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002582> (is a defining property chain axiom where second argument is reflexive)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002582> <http://purl.obolibrary.org/obo/RO_0002581>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002594> (is relational form of a class)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002594> <http://purl.obolibrary.org/obo/RO_0002422>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002601> (logical macro assertion involving identity)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002601> <http://purl.obolibrary.org/obo/RO_0002416>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002602> (in approximate one to one relationship with)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002602> <http://purl.obolibrary.org/obo/RO_0002601>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002603> (is approximately equivalent to)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002603> <http://purl.obolibrary.org/obo/RO_0002602>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002604> (is opposite of)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002604> <http://purl.obolibrary.org/obo/RO_0002602>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002605> (is indistinguishable from)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002605> <http://purl.obolibrary.org/obo/RO_0002603>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002611> (evidential logical macro assertion on an axiom)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002611> <http://purl.obolibrary.org/obo/RO_0002580>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002612> (axiom has evidence)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002612> <http://purl.obolibrary.org/obo/RO_0002611>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002613> (axiom contradicted by evidence)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002613> <http://purl.obolibrary.org/obo/RO_0002611>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0002617> (is representative IRI for equivalence set)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0002617> <http://purl.obolibrary.org/obo/RO_0002601>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0004036> (nominally disjoint with)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0004036> <http://purl.obolibrary.org/obo/RO_0002422>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0004048> (is directional form of)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0004048> <http://purl.obolibrary.org/obo/RO_0002422>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0004049> (is positive form of)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0004049> <http://purl.obolibrary.org/obo/RO_0004048>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0004050> (is negative form of)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0004050> <http://purl.obolibrary.org/obo/RO_0004048>)\n\n# Annotation Property: <http://purl.obolibrary.org/obo/RO_0040042> (is homeomorphic for)\n\nSubAnnotationPropertyOf(<http://purl.obolibrary.org/obo/RO_0040042> <http://purl.obolibrary.org/obo/RO_0002422>)\n\n\n############################\n#   Object Properties\n############################\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0001025> (located in)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0001025> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/BFO_0000004> ObjectComplementOf(<http://purl.obolibrary.org/obo/BFO_0000006>)))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002008> (coincident with)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002008> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/BFO_0000002> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000053> <http://purl.obolibrary.org/obo/PATO_0001199>)))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002103> (synapsed by)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002103> ObjectUnionOf(<http://purl.obolibrary.org/obo/CL_0000540> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/CL_0000540>)))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002132> (has fasciculating neuron projection)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002132> ObjectUnionOf(<http://purl.obolibrary.org/obo/CL_0000540> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/CL_0000540>)))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002170> (connected to)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002170> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/RO_0002577>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002176> (connects)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002176> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/RO_0002577>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002204> (gene product of)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002204> ObjectUnionOf(<http://purl.obolibrary.org/obo/BFO_0000031> <http://purl.obolibrary.org/obo/BFO_0000040>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002207> (directly develops from)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002207> ObjectUnionOf(<http://purl.obolibrary.org/obo/CARO_0010000> <http://purl.obolibrary.org/obo/CL_0000000>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002351> (has member)\n\nIrreflexiveObjectProperty(<http://purl.obolibrary.org/obo/RO_0002351>)\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002378> (anabranch of)\n\nSubObjectPropertyOf(<http://purl.obolibrary.org/obo/RO_0002378> ObjectInverseOf(<http://purl.obolibrary.org/obo/RO_0002376>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002380> (branching part of)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002380> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000053> <http://purl.obolibrary.org/obo/PATO_0000402>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002425> (differs in attribute of)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002425> ObjectUnionOf(<http://purl.obolibrary.org/obo/BFO_0000004> <http://purl.obolibrary.org/obo/BFO_0000015>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002510> (transcribed from)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002510> ObjectUnionOf(<http://purl.obolibrary.org/obo/BFO_0000031> <http://purl.obolibrary.org/obo/BFO_0000040>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002512> (ribosomal translation of)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002512> ObjectUnionOf(<http://purl.obolibrary.org/obo/BFO_0000031> <http://purl.obolibrary.org/obo/BFO_0000040>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002513> (ribosomally translates to)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0002513> ObjectUnionOf(<http://purl.obolibrary.org/obo/BFO_0000031> <http://purl.obolibrary.org/obo/BFO_0000040>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0002551> (has skeleton)\n\nIrreflexiveObjectProperty(<http://purl.obolibrary.org/obo/RO_0002551>)\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0003301> (has role in modeling)\n\nIrreflexiveObjectProperty(<http://purl.obolibrary.org/obo/RO_0003301>)\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0004000> (condition has genetic basis in)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0004000> ObjectUnionOf(<http://purl.obolibrary.org/obo/BFO_0000015> <http://purl.obolibrary.org/obo/BFO_0000019> <http://purl.obolibrary.org/obo/BFO_0000040>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0004022> (disease has basis in feature)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0004022> ObjectUnionOf(<http://purl.obolibrary.org/obo/OGMS_0000031> <http://purl.obolibrary.org/obo/UPHENO_0001001>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0004026> (disease has location)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0004026> ObjectUnionOf(<http://purl.obolibrary.org/obo/CARO_0000006> <http://purl.obolibrary.org/obo/CARO_0000007>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0004027> (disease has inflammation site)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0004027> ObjectUnionOf(<http://purl.obolibrary.org/obo/CARO_0000006> <http://purl.obolibrary.org/obo/CARO_0000007>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0004029> (disease has feature)\n\nObjectPropertyRange(<http://purl.obolibrary.org/obo/RO_0004029> ObjectUnionOf(<http://purl.obolibrary.org/obo/OGMS_0000031> <http://purl.obolibrary.org/obo/UPHENO_0001001>))\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0009001> (has substance added)\n\nIrreflexiveObjectProperty(<http://purl.obolibrary.org/obo/RO_0009001>)\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0009002> (has substance removed)\n\nIrreflexiveObjectProperty(<http://purl.obolibrary.org/obo/RO_0009002>)\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0009003> (immersed in)\n\nIrreflexiveObjectProperty(<http://purl.obolibrary.org/obo/RO_0009003>)\n\n# Object Property: <http://purl.obolibrary.org/obo/RO_0009005> (has primary substance added)\n\nIrreflexiveObjectProperty(<http://purl.obolibrary.org/obo/RO_0009005>)\n\n\n############################\n#   Data Properties\n############################\n\n# Data Property: <http://purl.obolibrary.org/obo/RO_0002029> (has increased age-specific mortality rate)\n\nDataPropertyRange(<http://purl.obolibrary.org/obo/RO_0002029> DatatypeRestriction(xsd:short xsd:minInclusive \"0\"^^xsd:short xsd:maxInclusive \"100\"^^xsd:short))\n\n\n\n############################\n#   Classes\n############################\n\n# Class: <http://purl.obolibrary.org/obo/BFO_0000002> (continuant)\n\nSubClassOf(<http://purl.obolibrary.org/obo/BFO_0000002> owl:Thing)\nDisjointClasses(<http://purl.obolibrary.org/obo/BFO_0000002> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/BFO_0000003>))\n\n# Class: <http://purl.obolibrary.org/obo/BFO_0000003> (occurrent)\n\nSubClassOf(<http://purl.obolibrary.org/obo/BFO_0000003> owl:Thing)\nDisjointClasses(<http://purl.obolibrary.org/obo/BFO_0000003> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/BFO_0000002>))\n\n# Class: <http://purl.obolibrary.org/obo/BFO_0000040> (material entity)\n\nDisjointClasses(<http://purl.obolibrary.org/obo/BFO_0000040> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/BFO_0000141>))\n\n# Class: <http://purl.obolibrary.org/obo/BFO_0000141> (immaterial entity)\n\nDisjointClasses(<http://purl.obolibrary.org/obo/BFO_0000141> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/BFO_0000040>))\n\n# Class: <http://purl.obolibrary.org/obo/CL_0000101> (<http://purl.obolibrary.org/obo/CL_0000101>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/CL_0000101> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/GO_0004842> (ubiquitin-protein ligase activity)\n\nSubClassOf(<http://purl.obolibrary.org/obo/GO_0004842> ObjectHasSelf(<http://purl.obolibrary.org/obo/RO_0002482>))\n\n# Class: <http://purl.obolibrary.org/obo/GO_0004872> (<http://purl.obolibrary.org/obo/GO_0004872>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/GO_0004872> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/GO_0005634> (nucleus)\n\nSubClassOf(<http://purl.obolibrary.org/obo/GO_0005634> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/GO_0016301> (kinase activity)\n\nSubClassOf(<http://purl.obolibrary.org/obo/GO_0016301> ObjectHasSelf(<http://purl.obolibrary.org/obo/RO_0002481>))\n\n# Class: <http://purl.obolibrary.org/obo/GO_0019107> (<http://purl.obolibrary.org/obo/GO_0019107>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/GO_0019107> owl:Thing)\nSubClassOf(<http://purl.obolibrary.org/obo/GO_0019107> ObjectHasSelf(<http://purl.obolibrary.org/obo/RO_0018001>))\n\n# Class: <http://purl.obolibrary.org/obo/GO_0042995> (cell projection)\n\nSubClassOf(<http://purl.obolibrary.org/obo/GO_0042995> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/GO_0044456> (synapse part)\n\nSubClassOf(<http://purl.obolibrary.org/obo/GO_0044456> owl:Thing)\n\n# Class: <http://purl.obolibrary.org/obo/RO_0002532> (sequentially ordered entity)\n\nSubClassOf(<http://purl.obolibrary.org/obo/RO_0002532> owl:Thing)\n\n# Class: owl:Nothing (owl:Nothing)\n\nSubClassOf(owl:Nothing owl:Nothing)\n\n# Class: <http://xmlns.com/foaf/0.1/image> (<http://xmlns.com/foaf/0.1/image>)\n\nSubClassOf(<http://xmlns.com/foaf/0.1/image> owl:Thing)\n\n\nSubClassOf(ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002566> <http://purl.obolibrary.org/obo/BFO_0000040>) ObjectUnionOf(ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000056> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002418> <http://purl.obolibrary.org/obo/BFO_0000015>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002215> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000056> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002418> <http://purl.obolibrary.org/obo/BFO_0000015>)))))\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/BFO_0000055> <http://purl.obolibrary.org/obo/RO_0000052>) <http://purl.obolibrary.org/obo/RO_0000057>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0001025> ObjectInverseOf(<http://purl.obolibrary.org/obo/RO_0001025>)) <http://purl.obolibrary.org/obo/RO_0002379>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002215> <http://purl.obolibrary.org/obo/RO_0002481> <http://purl.obolibrary.org/obo/RO_0002400>) <http://purl.obolibrary.org/obo/RO_0002447>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002215> <http://purl.obolibrary.org/obo/RO_0002482> <http://purl.obolibrary.org/obo/RO_0002400>) <http://purl.obolibrary.org/obo/RO_0002480>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002215> <http://purl.obolibrary.org/obo/RO_0018001> <http://purl.obolibrary.org/obo/RO_0002400>) <http://purl.obolibrary.org/obo/RO_0018002>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002327> <http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/RO_0002333>) <http://purl.obolibrary.org/obo/RO_0002448>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002327> <http://purl.obolibrary.org/obo/RO_0002411> <http://purl.obolibrary.org/obo/RO_0002233>) <http://purl.obolibrary.org/obo/RO_0002566>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002327> <http://purl.obolibrary.org/obo/RO_0002411> <http://purl.obolibrary.org/obo/RO_0002333>) <http://purl.obolibrary.org/obo/RO_0002566>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002327> <http://purl.obolibrary.org/obo/RO_0002629> <http://purl.obolibrary.org/obo/RO_0002333>) <http://purl.obolibrary.org/obo/RO_0002450>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002327> <http://purl.obolibrary.org/obo/RO_0002630> <http://purl.obolibrary.org/obo/RO_0002333>) <http://purl.obolibrary.org/obo/RO_0002449>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002461> <http://purl.obolibrary.org/obo/RO_0002465> ObjectInverseOf(<http://purl.obolibrary.org/obo/RO_0002461>)) <http://purl.obolibrary.org/obo/RO_0002440>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002461> <http://purl.obolibrary.org/obo/RO_0002466> ObjectInverseOf(<http://purl.obolibrary.org/obo/RO_0002461>)) <http://purl.obolibrary.org/obo/RO_0002441>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002461> <http://purl.obolibrary.org/obo/RO_0002467> ObjectInverseOf(<http://purl.obolibrary.org/obo/RO_0002461>)) <http://purl.obolibrary.org/obo/RO_0002442>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002461> <http://purl.obolibrary.org/obo/RO_0002468> ObjectInverseOf(<http://purl.obolibrary.org/obo/RO_0002461>)) <http://purl.obolibrary.org/obo/RO_0002443>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002462> <http://purl.obolibrary.org/obo/RO_0002468> ObjectInverseOf(<http://purl.obolibrary.org/obo/RO_0002463>)) <http://purl.obolibrary.org/obo/RO_0002444>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002583> <http://purl.obolibrary.org/obo/BFO_0000062> ObjectInverseOf(<http://purl.obolibrary.org/obo/RO_0002583>)) <http://purl.obolibrary.org/obo/RO_0002496>)\nSubObjectPropertyOf(ObjectPropertyChain(<http://purl.obolibrary.org/obo/RO_0002593> <http://purl.obolibrary.org/obo/BFO_0000063> ObjectInverseOf(<http://purl.obolibrary.org/obo/RO_0002593>)) <http://purl.obolibrary.org/obo/RO_0002497>)\nSubObjectPropertyOf(ObjectPropertyChain(ObjectInverseOf(<http://purl.obolibrary.org/obo/BFO_0000066>) <http://purl.obolibrary.org/obo/RO_0002234>) <http://purl.obolibrary.org/obo/RO_0003000>)\nSubObjectPropertyOf(ObjectPropertyChain(ObjectInverseOf(<http://purl.obolibrary.org/obo/RO_0002176>) <http://purl.obolibrary.org/obo/RO_0002176>) <http://purl.obolibrary.org/obo/RO_0002170>)\nDLSafeRule(Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002180> Variable(<urn:swrl#w>) Variable(<urn:swrl#p>)) ClassAtom(<http://purl.obolibrary.org/obo/BFO_0000015> Variable(<urn:swrl#w>)) ClassAtom(<http://purl.obolibrary.org/obo/BFO_0000015> Variable(<urn:swrl#p>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002018> Variable(<urn:swrl#w>) Variable(<urn:swrl#p>))))\nDLSafeRule(Body(ClassAtom(<http://purl.obolibrary.org/obo/BFO_0000016> Variable(<urn:swrl#d>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0000053> Variable(<urn:swrl#e>) Variable(<urn:swrl#d>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0000091> Variable(<urn:swrl#e>) Variable(<urn:swrl#d>))))\nDLSafeRule(Body(ClassAtom(<http://purl.obolibrary.org/obo/BFO_0000019> Variable(<urn:swrl#d>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0000053> Variable(<urn:swrl#e>) Variable(<urn:swrl#d>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0000086> Variable(<urn:swrl#e>) Variable(<urn:swrl#d>))))\nDLSafeRule(Body(ClassAtom(<http://purl.obolibrary.org/obo/BFO_0000023> Variable(<urn:swrl#d>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0000053> Variable(<urn:swrl#e>) Variable(<urn:swrl#d>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0000087> Variable(<urn:swrl#e>) Variable(<urn:swrl#d>))))\nDLSafeRule(Body(ClassAtom(<http://purl.obolibrary.org/obo/BFO_0000034> Variable(<urn:swrl#d>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0000053> Variable(<urn:swrl#e>) Variable(<urn:swrl#d>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0000085> Variable(<urn:swrl#e>) Variable(<urn:swrl#d>))))\nDLSafeRule(Annotation(<http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled> \"true\"^^xsd:boolean) Annotation(rdfs:comment \"MF(X)-directly_regulates->MF(Y)-enabled_by->GP(Z) => MF(Y)-has_input->GP(Y) e.g. if 'protein kinase activity'(X) directly_regulates 'protein binding activity (Y)and this is enabled by GP(Z) then X has_input Z\"^^xsd:string) Annotation(rdfs:label \"infer input from direct reg\"^^xsd:string) Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002327> Variable(<http://purl.obolibrary.org/obo/ro.owl#z>) Variable(<http://purl.obolibrary.org/obo/ro.owl#y>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002578> Variable(<http://purl.obolibrary.org/obo/ro.owl#x>) Variable(<http://purl.obolibrary.org/obo/ro.owl#y>)) ClassAtom(<http://purl.obolibrary.org/obo/GO_0003674> Variable(<http://purl.obolibrary.org/obo/ro.owl#x>)) ClassAtom(<http://purl.obolibrary.org/obo/GO_0003674> Variable(<http://purl.obolibrary.org/obo/ro.owl#y>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002233> Variable(<http://purl.obolibrary.org/obo/ro.owl#x>) Variable(<http://purl.obolibrary.org/obo/ro.owl#z>))))\nDLSafeRule(Annotation(rdfs:comment \"GP(X)-enables->MF(Y)-has_part->MF(Z) => GP(X) enables MF(Z),\ne.g.  if GP X enables ATPase coupled transporter activity' and 'ATPase coupled transporter activity' has_part 'ATPase activity' then GP(X) enables 'ATPase activity'\") Annotation(rdfs:label \"enabling an MF enables its parts\") Body(ClassAtom(<http://purl.obolibrary.org/obo/GO_0003674> Variable(<urn:swrl#y>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002327> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/BFO_0000051> Variable(<urn:swrl#y>) Variable(<urn:swrl#z>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002327> Variable(<urn:swrl#x>) Variable(<urn:swrl#z>))))\nDLSafeRule(Annotation(<http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled> \"true\"^^xsd:boolean) Annotation(rdfs:comment \"GP(X)-enables->MF(Y)-part_of->BP(Z) => GP(X) involved_in BP(Z) e.g. if X enables 'protein kinase activity' and Y 'part of' 'signal tranduction' then X involved in 'signal transduction'\"^^xsd:string) Annotation(rdfs:label \"involved in BP\"^^xsd:string) Body(ClassAtom(<http://purl.obolibrary.org/obo/GO_0008150> Variable(<urn:swrl#z>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/BFO_0000050> Variable(<urn:swrl#y>) Variable(<urn:swrl#z>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002327> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002331> Variable(<urn:swrl#x>) Variable(<urn:swrl#z>))))\nDLSafeRule(Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002578> Variable(<urn:swrl#a1>) Variable(<urn:swrl#a2>)) ClassAtom(<http://purl.obolibrary.org/obo/GO_0016301> Variable(<urn:swrl#a1>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002333> Variable(<urn:swrl#a1>) Variable(<urn:swrl#g1>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002333> Variable(<urn:swrl#a2>) Variable(<urn:swrl#g2>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002447> Variable(<urn:swrl#g1>) Variable(<urn:swrl#g2>))))\nDLSafeRule(Annotation(rdfs:comment \"If a molecular function (X) has a regulatory subfunction, then any gene product which is an input to that subfunction has an activity that directly_regulates X.  Note:  this is intended for cases where the regaultory subfunction is protein binding, so it could be tightened with an additional clause to specify this.\") Annotation(rdfs:label \"inferring direct reg edge from input to regulatory subfunction\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002352> Variable(<urn:swrl#B>) Variable(<urn:swrl#C>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002333> Variable(<urn:swrl#A>) Variable(<urn:swrl#B>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002013> Variable(<urn:swrl#D>) Variable(<urn:swrl#C>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002578> Variable(<urn:swrl#A>) Variable(<urn:swrl#D>))))\nDLSafeRule(Annotation(rdfs:label \"inferring direct neg reg edge from input to regulatory subfunction\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002352> Variable(<urn:swrl#B>) Variable(<urn:swrl#C>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002333> Variable(<urn:swrl#A>) Variable(<urn:swrl#B>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002014> Variable(<urn:swrl#D>) Variable(<urn:swrl#C>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002630> Variable(<urn:swrl#A>) Variable(<urn:swrl#D>))))\nDLSafeRule(Annotation(rdfs:label \"inferring direct positive reg edge from input to regulatory subfunction\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002352> Variable(<urn:swrl#B>) Variable(<urn:swrl#C>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002333> Variable(<urn:swrl#A>) Variable(<urn:swrl#B>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002015> Variable(<urn:swrl#D>) Variable(<urn:swrl#C>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002629> Variable(<urn:swrl#A>) Variable(<urn:swrl#D>))))\nDLSafeRule(Annotation(rdfs:label \"effector input is compound function input\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002233> Variable(<urn:swrl#eff>) Variable(<urn:swrl#in>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002025> Variable(<urn:swrl#mf>) Variable(<urn:swrl#eff>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002233> Variable(<urn:swrl#mf>) Variable(<urn:swrl#in>))))\nDLSafeRule(Annotation(rdfs:label \"Input of effector is input of its parent MF\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002233> Variable(<urn:swrl#mf>) Variable(<urn:swrl#in>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002025> Variable(<urn:swrl#mf>) Variable(<urn:swrl#eff>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002233> Variable(<urn:swrl#eff>) Variable(<urn:swrl#in>))))\nDLSafeRule(Annotation(rdfs:comment \"if effector directly regulates X,  its parent MF directly regulates X\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002025> Variable(<urn:swrl#mf>) Variable(<urn:swrl#eff>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002578> Variable(<urn:swrl#mf>) Variable(<urn:swrl#mf2>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002578> Variable(<urn:swrl#eff>) Variable(<urn:swrl#mf2>))))\nDLSafeRule(Annotation(rdfs:comment \"if effector directly positively regulates X,  its parent MF directly positively regulates X\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002629> Variable(<urn:swrl#mf>) Variable(<urn:swrl#mf2>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002025> Variable(<urn:swrl#mf>) Variable(<urn:swrl#eff>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002629> Variable(<urn:swrl#eff>) Variable(<urn:swrl#mf2>))))\nDLSafeRule(Annotation(rdfs:label \"if effector directly negatively regulates X,  its parent MF directly negatively regulates X\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002025> Variable(<urn:swrl#mf>) Variable(<urn:swrl#eff>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002630> Variable(<urn:swrl#mf>) Variable(<urn:swrl#mf2>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002630> Variable(<urn:swrl#eff>) Variable(<urn:swrl#mf2>))))\nDLSafeRule(Annotation(rdfs:label \"'causally downstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties).\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002404> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002131> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)))Head(ClassAtom(owl:Nothing Variable(<urn:swrl#x>)) ClassAtom(owl:Nothing Variable(<urn:swrl#y>))))\nDLSafeRule(Annotation(rdfs:label \"'causally upstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties).\") Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002411> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002131> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)))Head(ClassAtom(owl:Nothing Variable(<urn:swrl#x>)) ClassAtom(owl:Nothing Variable(<urn:swrl#y>))))\nDLSafeRule(Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002213> Variable(<urn:swrl#y>) Variable(<urn:swrl#z>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002212> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002212> Variable(<urn:swrl#x>) Variable(<urn:swrl#z>))))\nDLSafeRule(Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002213> Variable(<urn:swrl#x>) Variable(<urn:swrl#y>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002212> Variable(<urn:swrl#y>) Variable(<urn:swrl#z>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002212> Variable(<urn:swrl#x>) Variable(<urn:swrl#z>))))\nDLSafeRule(Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0019002> Variable(<urn:swrl:var#y>) Variable(<urn:swrl:var#z>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002212> Variable(<urn:swrl:var#x>) Variable(<urn:swrl:var#y>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0019001> Variable(<urn:swrl:var#x>) Variable(<urn:swrl:var#z>))))\nDLSafeRule(Body(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002264> Variable(<urn:swrl:var#x>) Variable(<urn:swrl:var#y>)) ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002411> Variable(<urn:swrl:var#y>) Variable(<urn:swrl:var#z>)))Head(ObjectPropertyAtom(<http://purl.obolibrary.org/obo/RO_0002263> Variable(<urn:swrl:var#x>) Variable(<urn:swrl:var#z>))))\nAnnotationAssertion(rdfs:comment <http://purl.obolibrary.org/obo/RO_0002432> \"\")\n)
 
 [Term]
@@ -141,7 +141,6 @@ id: CARO:0000006
 name: material anatomical entity
 is_a: BFO:0000040 ! material entity
 is_a: CARO:0000000 ! anatomical entity
-relationship: RO:0002179 CARO:0000003 ! drains connected anatomical structure
 property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl
 
 [Term]
diff --git a/ro.owl b/ro.owl
index b60de390..a3db7bcc 100644
--- a/ro.owl
+++ b/ro.owl
@@ -18,7 +18,7 @@
      xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#"
      xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#">
     <owl:Ontology rdf:about="http://purl.obolibrary.org/obo/ro.owl">
-        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/ro/releases/2022-07-19/ro.owl"/>
+        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/ro/releases/2022-09-07/ro.owl"/>
         <owl:imports rdf:resource="http://purl.obolibrary.org/obo/ro/annotations.owl"/>
         <owl:imports rdf:resource="http://purl.obolibrary.org/obo/ro/chemical.owl"/>
         <owl:imports rdf:resource="http://purl.obolibrary.org/obo/ro/core.owl"/>
@@ -35,7 +35,7 @@
         <dc:description xml:lang="en">The OBO Relations Ontology (RO) is a collection of OWL relations (ObjectProperties) intended for use across a wide variety of biological ontologies.</dc:description>
         <dc:title xml:lang="en">OBO Relations Ontology</dc:title>
         <terms:license rdf:resource="https://creativecommons.org/publicdomain/zero/1.0/"/>
-        <owl:versionInfo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2022-07-19</owl:versionInfo>
+        <owl:versionInfo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2022-09-07</owl:versionInfo>
         <foaf:homepage rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI"> https://github.com/oborel/obo-relations/</foaf:homepage>
     </owl:Ontology>
     
@@ -9701,12 +9701,6 @@ For example, protein A (transcription factor) indirectly increases by expression
     <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CARO_0000006">
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
         <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CARO_0000000"/>
-        <rdfs:subClassOf>
-            <owl:Restriction>
-                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002179"/>
-                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CARO_0000003"/>
-            </owl:Restriction>
-        </rdfs:subClassOf>
     </rdf:Description>
     
 
diff --git a/src/ontology/subsets/ro-chado.obo b/src/ontology/subsets/ro-chado.obo
index e57923c9..2f7ad1fc 100644
--- a/src/ontology/subsets/ro-chado.obo
+++ b/src/ontology/subsets/ro-chado.obo
@@ -26,7 +26,7 @@ property_value: http://purl.org/dc/elements/1.1/description "The OBO Relations O
 property_value: http://purl.org/dc/elements/1.1/title "OBO Relations Ontology" xsd:string
 property_value: http://purl.org/dc/terms/license https://creativecommons.org/publicdomain/zero/1.0/
 property_value: http://xmlns.com/foaf/0.1/homepage " https://github.com/oborel/obo-relations/" xsd:anyURI
-property_value: owl:versionInfo "2022-07-19" xsd:string
+property_value: owl:versionInfo "2022-09-07" xsd:string
 
 [Typedef]
 id: BFO:0000050
diff --git a/subsets/ro-chado.obo b/subsets/ro-chado.obo
index e57923c9..2f7ad1fc 100644
--- a/subsets/ro-chado.obo
+++ b/subsets/ro-chado.obo
@@ -26,7 +26,7 @@ property_value: http://purl.org/dc/elements/1.1/description "The OBO Relations O
 property_value: http://purl.org/dc/elements/1.1/title "OBO Relations Ontology" xsd:string
 property_value: http://purl.org/dc/terms/license https://creativecommons.org/publicdomain/zero/1.0/
 property_value: http://xmlns.com/foaf/0.1/homepage " https://github.com/oborel/obo-relations/" xsd:anyURI
-property_value: owl:versionInfo "2022-07-19" xsd:string
+property_value: owl:versionInfo "2022-09-07" xsd:string
 
 [Typedef]
 id: BFO:0000050