diff --git a/src/ontology/components/hra_subset.owl b/src/ontology/components/hra_subset.owl index 608056bf91..46e6bb6583 100644 --- a/src/ontology/components/hra_subset.owl +++ b/src/ontology/components/hra_subset.owl @@ -8749,6 +8749,15 @@ + + + + + + + + + diff --git a/src/ontology/imports/go_import.owl b/src/ontology/imports/go_import.owl index 59e94886c2..6810876b2f 100644 --- a/src/ontology/imports/go_import.owl +++ b/src/ontology/imports/go_import.owl @@ -1,6 +1,9 @@ - + + + 2022-08-19 @@ -24,15 +29,351 @@ + + + + definition + + + + + + + + + + + + + + + + + + + + + + + + + + term replaced by + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + subset_property + + + + + + + + synonym_type_property + + + + + + + + consider + + + + + + + + + + + + + + + + + + + + + + + + + + has_alternative_id + + + + + + + + has_broad_synonym + + + + - + + database_cross_reference + + + + + + + + has_exact_synonym + + + + + + + + has_narrow_synonym + + + + + + + + has_obo_format_version + + + + + + + + has_obo_namespace + + + + + + + + has_related_synonym + + + + + + + + has_scope + + + + + + + + has_synonym_type + + + + + + + + + + + + + + in_subset + + + + + + + + + + + + + - + + shorthand + + + + + + + + + + + + + + + + + + + + + + + + + @@ -50,8 +391,11 @@ + BFO:0000050 + external + part_of part_of part of @@ -63,6 +407,8 @@ BFO:0000051 + external + has_part has_part has part @@ -74,6 +420,8 @@ RO:0002211 + external + regulates regulates regulates @@ -85,6 +433,8 @@ RO:0002212 + external + negatively_regulates negatively_regulates negatively regulates @@ -95,7 +445,13 @@ + + + + RO:0002213 + external + positively_regulates positively_regulates positively regulates @@ -117,8 +473,30 @@ + + The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. + GO:0019952 + GO:0050876 + Wikipedia:Reproduction + reproductive physiological process + biological_process + GO:0000003 + + + + + reproduction + + + + The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. + GOC:go_curators + GOC:isa_complete + GOC:jl + ISBN:0198506732 + @@ -128,8 +506,23 @@ + The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + glycan biosynthesis + glycan biosynthetic process + polysaccharide anabolism + polysaccharide biosynthesis + polysaccharide formation + polysaccharide synthesis + biological_process + GO:0000271 polysaccharide biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + GOC:go_curators + @@ -139,8 +532,22 @@ + The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + GO:0044244 + polysaccharide breakdown + polysaccharide catabolism + polysaccharide degradation + multicellular organismal polysaccharide catabolic process + biological_process + GO:0000272 polysaccharide catabolic process + + + + The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + PMID:33139480 + @@ -148,8 +555,19 @@ + The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. + biological_process + karyokinesis + GO:0000280 + nuclear division + + + + The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. + GOC:mah + @@ -174,8 +592,18 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. + regulation of glutamine family amino acid metabolism + biological_process + GO:0000820 regulation of glutamine family amino acid metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. + GOC:go_curators + @@ -183,8 +611,23 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. + response to acid + biological_process + response to acid anion + response to oxoanion + GO:0001101 + + This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead. response to acid chemical + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. + GOC:go_curators + GOC:rn + @@ -192,8 +635,20 @@ + The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). + skeletal development + biological_process + GO:0001501 skeletal system development + + + + The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). + GOC:dph + GOC:jid + GOC:tb + @@ -201,8 +656,23 @@ + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + Wikipedia:Ossification + bone biosynthesis + bone formation + osteogenesis + biological_process + GO:0001503 + Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. ossification + + + + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:mtg_mpo + PMID:17572649 + @@ -216,8 +686,25 @@ + Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. + Wikipedia:Angiogenesis + blood vessel formation from pre-existing blood vessels + biological_process + GO:0001525 angiogenesis + + + + Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. + ISBN:0878932453 + + + + + blood vessel formation from pre-existing blood vessels + + @@ -225,8 +712,23 @@ + Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. + ciliary/flagellar motility + biological_process + ciliary or bacterial-type flagellar motility + GO:0001539 + + Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC. cilium or flagellum-dependent cell motility + + + + Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. + GOC:cilia + GOC:hjd + GOC:krc + @@ -240,8 +742,20 @@ + The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation. + Wikipedia:Luteal_phase + Wikipedia:Luteinization + biological_process + luteal phase + GO:0001553 luteinization + + + + The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation. + https://www.ncbi.nlm.nih.gov/books/NBK279054/ + @@ -267,8 +781,17 @@ + Any process that modulates the frequency, rate, extent or direction of cell growth. + biological_process + GO:0001558 regulation of cell growth + + + + Any process that modulates the frequency, rate, extent or direction of cell growth. + GOC:go_curators + @@ -282,8 +805,18 @@ + The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. + biological_process + GO:0001568 blood vessel development + + + + The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. + GOC:hjd + UBERON:0001981 + @@ -308,8 +841,24 @@ + The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. + patterning of blood vessels + biological_process + GO:0001569 branching involved in blood vessel morphogenesis + + + + The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. + GOC:dph + + + + + patterning of blood vessels + GOC:dph + @@ -317,8 +866,26 @@ + A homeostatic process in which an organism modulates its internal body temperature. + Wikipedia:Thermoregulation + thermoregulation + biological_process + GO:0001659 temperature homeostasis + + + + A homeostatic process in which an organism modulates its internal body temperature. + GOC:jl + + + + + thermoregulation + GOC:dph + GOC:tb + @@ -327,8 +894,22 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. + response to hypoxic stress + response to lowered oxygen tension + response to intermittent hypoxia + response to sustained hypoxia + biological_process + GO:0001666 + Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. response to hypoxia + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. + GOC:hjd + @@ -336,8 +917,21 @@ + Cell migration that is accomplished by extension and retraction of a pseudopodium. + ameboid cell migration + amoeboid cell migration + amoeboidal cell migration + biological_process + GO:0001667 + Note that this term refers to a mode of migration rather than to any particular cell type. ameboidal-type cell migration + + + + Cell migration that is accomplished by extension and retraction of a pseudopodium. + GOC:dph + @@ -345,8 +939,20 @@ + The nucleus of the female germ cell, a reproductive cell in females. + GO:0043080 + female germ-cell nucleus + cellular_component + GO:0001674 female germ cell nucleus + + + + The nucleus of the female germ cell, a reproductive cell in females. + CL:0000021 + GOC:hjd + @@ -356,8 +962,19 @@ + The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. + histamine metabolism + biological_process + GO:0001692 histamine metabolic process + + + + The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. + GOC:jl + ISBN:0395825172 + @@ -366,8 +983,18 @@ + The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + hydrochloric acid secretion + biological_process + GO:0001696 gastric acid secretion + + + + The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:hjd + @@ -375,8 +1002,18 @@ + The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. + biological_process + GO:0001701 in utero embryonic development + + + + The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. + GOC:go_curators + GOC:mtg_sensu + @@ -390,8 +1027,17 @@ + The formation of the ectoderm, mesoderm and endoderm during gastrulation. + biological_process + GO:0001704 formation of primary germ layer + + + + The formation of the ectoderm, mesoderm and endoderm during gastrulation. + GOC:go_curators + @@ -405,8 +1051,17 @@ + The formation of ectoderm during gastrulation. + biological_process + GO:0001705 ectoderm formation + + + + The formation of ectoderm during gastrulation. + GOC:go_curators + @@ -420,8 +1075,26 @@ + The formation of the endoderm during gastrulation. + endoblast formation + biological_process + GO:0001706 endoderm formation + + + + The formation of the endoderm during gastrulation. + GOC:go_curators + + + + + endoblast formation + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -435,8 +1108,17 @@ + The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + biological_process + GO:0001707 mesoderm formation + + + + The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + GOC:go_curators + @@ -450,8 +1132,23 @@ + The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. + cellular_component + GO:0001750 photoreceptor outer segment + + + + The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. + GOC:cilia + GOC:krc + GOC:pde + ISBN:0824072820 + PMID:19501669 + PMID:26574505 + PMID:6771304 + @@ -460,8 +1157,24 @@ + The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. + branching morphogenesis + biological_process + GO:0001763 morphogenesis of a branching structure + + + + The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. + ISBN:0721662544 + + + + + branching morphogenesis + GOC:dph + @@ -469,8 +1182,18 @@ + A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. + biological_process + GO:0001775 + cell activation + + + + A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. + GOC:mgi_curators + @@ -479,8 +1202,28 @@ + The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. + 5-HT secretion + 5-hydroxytryptamine secretion + biological_process + serotonin release + GO:0001820 serotonin secretion + + + + The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. + GOC:ef + ISBN:0198506732 + ISBN:0781735149 + + + + + serotonin release + GOC:tb + @@ -494,8 +1237,18 @@ + The morphogenesis of an embryonic epithelium into a tube-shaped structure. + biological_process + GO:0001838 embryonic epithelial tube formation + + + + The morphogenesis of an embryonic epithelium into a tube-shaped structure. + GOC:dph + ISBN:0824072820 + @@ -509,8 +1262,28 @@ + The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + GO:0001679 + Wikipedia:Neurulation + neural tube morphogenesis + neurulation + biological_process + GO:0001841 neural tube formation + + + + The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + GOC:dph + ISBN:0878932437 + + + + + neural tube morphogenesis + GOC:dph + @@ -524,8 +1297,18 @@ + The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. + biological_process + GO:0001843 neural tube closure + + + + The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. + GOC:dph + ISBN:0878932437 + @@ -533,8 +1316,19 @@ + The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. + cellular_component + GO:0001917 + photoreceptor inner segment + + + + The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. + GOC:add + PMID:12019563 + @@ -548,8 +1342,19 @@ + The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. + biological_process + vascular system development + GO:0001944 vasculature development + + + + The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. + GOC:dph + UBERON:0002409 + @@ -557,8 +1362,33 @@ + Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. + Wikipedia:Intramembranous_ossification + dermal ossification + biological_process + intramembranous bone ossification + GO:0001957 + An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. intramembranous ossification + + + + Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. + ISBN:0878932437 + + + + + dermal ossification + GO_REF:0000034 + + + + + intramembranous bone ossification + GOC:cjm + @@ -572,8 +1402,19 @@ + Replacement ossification wherein bone tissue replaces cartilage. + Wikipedia:Endochondral_ossification + biological_process + GO:0001958 endochondral ossification + + + + Replacement ossification wherein bone tissue replaces cartilage. + GO_REF:0000034 + ISBN:0878932437 + @@ -598,8 +1439,29 @@ + The regulation of blood pressure mediated by detection of stimuli and a neurological response. + blood pressure regulation by neurological process + neurological process involved in regulation of systemic arterial blood pressure + neurological system process involved in regulation of systemic arterial blood pressure + biological_process + fast control of arterial pressure + GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure + + + + The regulation of blood pressure mediated by detection of stimuli and a neurological response. + GOC:mtg_cardio + ISBN:0721643949 + + + + + neurological process involved in regulation of systemic arterial blood pressure + GOC:dph + GOC:tb + @@ -613,8 +1475,28 @@ + A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. + biological_process + renal blood volume control of blood pressure + renal regulation of blood volume + GO:0001977 renal system process involved in regulation of blood volume + + + + A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. + GOC:dph + GOC:tb + ISBN:0721643949 + + + + + renal regulation of blood volume + GOC:dph + GOC:tb + @@ -628,8 +1510,35 @@ + The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control. + carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure + biological_process + baroreceptor feedback control of blood pressure + baroreceptor pressure buffer system + GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback + + + + The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control. + GOC:dph + GOC:tb + ISBN:0721643949 + + + + + carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure + GOC:dph + GOC:tb + + + + + baroreceptor pressure buffer system + ISBN:068340007X + @@ -637,8 +1546,35 @@ + The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. + chemoreceptor regulation of systemic arterial blood pressure + regulation of systemic arterial blood pressure by chemoreceptor signalling + biological_process + chemoreceptor control of blood pressure + GO:0001979 regulation of systemic arterial blood pressure by chemoreceptor signaling + + + + The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. + GOC:dph + GOC:tb + ISBN:0721643949 + + + + + chemoreceptor regulation of systemic arterial blood pressure + GOC:dph + GOC:tb + + + + + regulation of systemic arterial blood pressure by chemoreceptor signalling + GOC:mah + @@ -647,8 +1583,21 @@ + The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. + blood pressure regulation by hormone + hormonal regulation of blood pressure + biological_process + hormonal control of blood pressure + GO:0001990 regulation of systemic arterial blood pressure by hormone + + + + The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. + GOC:mtg_cardio + ISBN:0721643949 + @@ -656,8 +1605,20 @@ + The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport. + blood pressure regulation by vasopressin + biological_process + vasopressin control of blood pressure + GO:0001992 regulation of systemic arterial blood pressure by vasopressin + + + + The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport. + GOC:mtg_cardio + ISBN:0721643949 + @@ -683,8 +1644,24 @@ + The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. + detection of hypoxic conditions in blood by chemoreceptor signalling + biological_process + GO:0002007 detection of hypoxic conditions in blood by chemoreceptor signaling + + + + The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. + GOC:dph + + + + + detection of hypoxic conditions in blood by chemoreceptor signalling + GOC:mah + @@ -698,8 +1675,21 @@ + The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. + epithelium morphogenesis + biological_process + GO:0002009 morphogenesis of an epithelium + + + + The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. + GOC:dph + GOC:jl + GOC:tb + ISBN:0198506732 + @@ -707,8 +1697,29 @@ + The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood. + renin-angiotensin regulation of blood volume + biological_process + renin-angiotensin control of body fluid levels + GO:0002016 regulation of blood volume by renin-angiotensin + + + + The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood. + GOC:dph + GOC:mtg_cardio + GOC:tb + ISBN:0721643949 + + + + + renin-angiotensin regulation of blood volume + GOC:dph + GOC:tb + @@ -738,8 +1749,18 @@ + The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone. + biological_process + renin-angiotensin control of aldosterone production + GO:0002018 renin-angiotensin regulation of aldosterone production + + + + The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone. + ISBN:0721643949 + @@ -748,8 +1769,29 @@ + Any process that modulates the frequency or rate of heart contraction. + cardiac chronotropy + regulation of heart contraction rate + regulation of rate of heart contraction + biological_process + GO:0002027 regulation of heart rate + + + + Any process that modulates the frequency or rate of heart contraction. + GOC:dph + GOC:tb + PMID:10358008 + + + + + cardiac chronotropy + GOC:dph + GOC:tb + @@ -775,8 +1817,22 @@ + The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. + up regulation of mesenchymal cell proliferation + up-regulation of mesenchymal cell proliferation + upregulation of mesenchymal cell proliferation + activation of mesenchymal cell proliferation + stimulation of mesenchymal cell proliferation + biological_process + GO:0002053 positive regulation of mesenchymal cell proliferation + + + + The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. + GOC:dph + @@ -790,8 +1846,17 @@ + The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. + biological_process + GO:0002062 chondrocyte differentiation + + + + The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. + GOC:dph + @@ -805,8 +1870,17 @@ + The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. + biological_process + GO:0002063 chondrocyte development + + + + The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. + GOC:dph + @@ -826,8 +1900,28 @@ + A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. + neurological control of breathing + regulation of respiratory gaseous exchange by neurological system process + biological_process + GO:0002087 regulation of respiratory gaseous exchange by nervous system process + + + + A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. + GOC:dph + GOC:tb + PMID:12458206 + + + + + neurological control of breathing + GOC:dph + GOC:tb + @@ -835,8 +1929,18 @@ + The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form. + biological_process + GO:0002117 amphibian larval development + + + + The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form. + GOC:bf + PMID:27143402 + @@ -844,8 +1948,18 @@ + The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + biological_process + GO:0002119 nematode larval development + + + + The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + GOC:ems + GOC:kmv + @@ -854,8 +1968,18 @@ + The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters. + biological_process + GO:0002164 larval development + + + + The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters. + GOC:jid + ISBN:0877795088 + @@ -864,8 +1988,18 @@ + The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster. + biological_process + GO:0002165 instar larval or pupal development + + + + The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster. + GOC:jid + GOC:mtg_sensu + @@ -874,8 +2008,18 @@ + The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster. + biological_process + GO:0002168 instar larval development + + + + The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster. + GOC:bf + GOC:mtg_sensu + @@ -900,8 +2044,32 @@ + The series of events that restore integrity to damaged tissue that contribute to an inflammatory response. + biological_process + healing during inflammatory response + inflammatory response wound healing + GO:0002246 wound healing involved in inflammatory response + + + + The series of events that restore integrity to damaged tissue that contribute to an inflammatory response. + GOC:jal + ISBN:0721601871 + + + + + healing during inflammatory response + GOC:dph + + + + + inflammatory response wound healing + GOC:dph + @@ -909,8 +2077,19 @@ + An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. + immune response in organ or tissue + biological_process + GO:0002251 organ or tissue specific immune response + + + + An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. + GOC:jal + GO_REF:0000022 + @@ -918,8 +2097,20 @@ + Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. + https://github.com/geneontology/go-ontology/issues/18737 + biological_process + GO:0002252 immune effector process + + + + Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -945,8 +2136,26 @@ + A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. + biological_process + cell activation during immune response + GO:0002263 cell activation involved in immune response + + + + A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + + + + + cell activation during immune response + GOC:tb + @@ -971,8 +2180,26 @@ + A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response. + biological_process + immune cell activation during inflammatory response + leukocyte activation during inflammatory response + GO:0002269 leukocyte activation involved in inflammatory response + + + + A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response. + GOC:add + ISBN:0781735149 + + + + + leukocyte activation during inflammatory response + GOC:tb + @@ -992,8 +2219,25 @@ + A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + biological_process + lymphocyte activation during immune response + GO:0002285 lymphocyte activation involved in immune response + + + + A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + + + + + lymphocyte activation during immune response + GOC:tb + @@ -1013,8 +2257,28 @@ + The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. + biological_process + T cell activation during immune response + T lymphocyte activation during immune response + T-cell activation during immune response + T-lymphocyte activation during immune response + GO:0002286 T cell activation involved in immune response + + + + The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + + + + + T cell activation during immune response + GOC:tb + @@ -1034,8 +2298,36 @@ + The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. + biological_process + T cell development involved in immune response + T cell differentiation during immune response + T lymphocyte differentiation during immune response + T-cell differentiation during immune response + T-lymphocyte differentiation during immune response + GO:0002292 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. T cell differentiation involved in immune response + + + + The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. + GOC:add + ISBN:0781735149 + + + + + T cell development involved in immune response + GOC:add + + + + + T cell differentiation during immune response + GOC:tb + @@ -1055,8 +2347,27 @@ + The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. + biological_process + B cell activation during immune response + B lymphocyte activation during immune response + B-cell activation during immune response + B-lymphocyte activation during immune response + GO:0002312 B cell activation involved in immune response + + + + The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. + GOC:jal + + + + + B cell activation during immune response + GOC:tb + @@ -1076,8 +2387,35 @@ + The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response. + biological_process + mature B cell development involved in immune response + mature B cell differentiation during immune response + mature B lymphocyte differentiation during immune response + mature B-cell differentiation during immune response + mature B-lymphocyte differentiation during immune response + GO:0002313 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. mature B cell differentiation involved in immune response + + + + The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response. + GOC:jal + + + + + mature B cell development involved in immune response + GOC:add + + + + + mature B cell differentiation during immune response + GOC:tb + @@ -1085,8 +2423,25 @@ + The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody. + biological_process + plasma cell development + GO:0002317 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. plasma cell differentiation + + + + The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody. + GOC:jal + + + + + plasma cell development + GOC:add + @@ -1095,8 +2450,29 @@ + The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody. + memory B lymphocyte differentiation + memory B-cell differentiation + memory B-lymphocyte differentiation + biological_process + memory B cell development + GO:0002319 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. memory B cell differentiation + + + + The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody. + GOC:jal + ISBN:0781735149 + + + + + memory B cell development + GOC:add + @@ -1116,8 +2492,27 @@ + The expansion of a B cell population by cell division following B cell activation during an immune response. + biological_process + B cell proliferation during immune response + B lymphocyte proliferation during immune response + B-cell proliferation during immune response + B-lymphocyte proliferation during immune response + GO:0002322 B cell proliferation involved in immune response + + + + The expansion of a B cell population by cell division following B cell activation during an immune response. + GOC:jal + + + + + B cell proliferation during immune response + GOC:tb + @@ -1125,8 +2520,29 @@ + The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen. + mature B lymphocyte differentiation + mature B-cell differentiation + mature B-lymphocyte differentiation + biological_process + mature cell development + GO:0002335 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. mature B cell differentiation + + + + The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen. + GOC:jal + ISBN:0781735149 + + + + + mature cell development + GOC:add + @@ -1134,8 +2550,20 @@ + The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. + serotonin production involved in acute inflammatory response + biological_process + GO:0002351 serotonin production involved in inflammatory response + + + + The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. + GOC:add + ISBN:0781735149 + PMID:16730260 + @@ -1155,8 +2583,27 @@ + A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + biological_process + immune cell activation during immune response + leucocyte activation during immune response + leukocyte activation during immune response + GO:0002366 leukocyte activation involved in immune response + + + + A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + + + + + leukocyte activation during immune response + GOC:tb + @@ -1164,8 +2611,28 @@ + + Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. + + Wikipedia:Immune_system + biological_process + GO:0002376 + + + + + + + Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). immune system process + + + + Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. + GOC:add + GO_REF:0000022 + @@ -1173,8 +2640,25 @@ + The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + GO:0002378 + GO:0048305 + antibody production + immunoglobulin biosynthetic process + immunoglobulin secretion + biological_process + GO:0002377 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. immunoglobulin production + + + + The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:add + ISBN:0781735149 + @@ -1182,8 +2666,19 @@ + An immune response taking place in the liver. + biological_process + GO:0002384 hepatic immune response + + + + An immune response taking place in the liver. + GOC:jal + GO_REF:0000022 + ISBN:0781735149 + @@ -1192,8 +2687,22 @@ + The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. + biological_process + production of cellular mediator of immune response + GO:0002440 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. production of molecular mediator of immune response + + + + The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -1218,8 +2727,26 @@ + The regulated release of serotonin by a cell as part of an inflammatory response. + serotonin secretion involved in acute inflammatory response + biological_process + serotonin release involved in inflammatory response + GO:0002442 serotonin secretion involved in inflammatory response + + + + The regulated release of serotonin by a cell as part of an inflammatory response. + GOC:add + ISBN:0781735149 + + + + + serotonin release involved in inflammatory response + GOC:tb + @@ -1228,8 +2755,19 @@ + The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. + biological_process + GO:0002520 + immune system development + + + + The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. + GOC:add + GOC:dph + @@ -1243,8 +2781,21 @@ + The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. + immune cell differentiation + leucocyte differentiation + biological_process + GO:0002521 leukocyte differentiation + + + + The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. + CL:0000738 + GOC:add + PMID:16551264 + @@ -1258,8 +2809,22 @@ + The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. + production of molecular mediator involved in acute inflammatory response + biological_process + production of cellular mediator of acute inflammation + GO:0002532 production of molecular mediator involved in inflammatory response + + + + The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:add + GOC:dph + GOC:tb + ISBN:0781735149 + @@ -1284,8 +2849,22 @@ + Any process that modulates the frequency, rate, or extent of immunoglobulin production. + GO:0002640 + GO:0051023 + regulation of antibody production + regulation of immunoglobulin biosynthetic process + regulation of immunoglobulin secretion + biological_process + GO:0002637 regulation of immunoglobulin production + + + + Any process that modulates the frequency, rate, or extent of immunoglobulin production. + GOC:add + @@ -1311,8 +2890,25 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production. + GO:0002641 + GO:0051025 + down regulation of immunoglobulin production + down-regulation of immunoglobulin production + downregulation of immunoglobulin production + inhibition of immunoglobulin production + negative regulation of immunoglobulin biosynthetic process + negative regulation of immunoglobulin secretion + biological_process + GO:0002638 negative regulation of immunoglobulin production + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production. + GOC:add + @@ -1338,8 +2934,26 @@ + Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. + GO:0002642 + GO:0051024 + up regulation of immunoglobulin production + up-regulation of immunoglobulin production + upregulation of immunoglobulin production + activation of immunoglobulin production + positive regulation of immunoglobulin biosynthetic process + positive regulation of immunoglobulin secretion + stimulation of immunoglobulin production + biological_process + GO:0002639 positive regulation of immunoglobulin production + + + + Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. + GOC:add + @@ -1364,8 +2978,17 @@ + Any process that modulates the frequency, rate, or extent of an immune system process. + biological_process + GO:0002682 regulation of immune system process + + + + Any process that modulates the frequency, rate, or extent of an immune system process. + GOC:add + @@ -1391,8 +3014,21 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. + down regulation of immune system process + down-regulation of immune system process + downregulation of immune system process + inhibition of immune system process + biological_process + GO:0002683 negative regulation of immune system process + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. + GOC:add + @@ -1418,8 +3054,22 @@ + Any process that activates or increases the frequency, rate, or extent of an immune system process. + up regulation of immune system process + up-regulation of immune system process + upregulation of immune system process + activation of immune system process + stimulation of immune system process + biological_process + GO:0002684 positive regulation of immune system process + + + + Any process that activates or increases the frequency, rate, or extent of an immune system process. + GOC:add + @@ -1445,8 +3095,19 @@ + Any process that modulates the frequency, rate, or extent of leukocyte activation. + regulation of immune cell activation + regulation of leucocyte activation + biological_process + GO:0002694 regulation of leukocyte activation + + + + Any process that modulates the frequency, rate, or extent of leukocyte activation. + GOC:add + @@ -1473,8 +3134,23 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation. + down regulation of leukocyte activation + down-regulation of leukocyte activation + downregulation of leukocyte activation + negative regulation of immune cell activation + negative regulation of leucocyte activation + inhibition of leukocyte activation + biological_process + GO:0002695 negative regulation of leukocyte activation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation. + GOC:add + @@ -1501,8 +3177,24 @@ + Any process that activates or increases the frequency, rate, or extent of leukocyte activation. + positive regulation of immune cell activation + positive regulation of leucocyte activation + up regulation of leukocyte activation + up-regulation of leukocyte activation + upregulation of leukocyte activation + activation of leukocyte activation + stimulation of leukocyte activation + biological_process + GO:0002696 positive regulation of leukocyte activation + + + + Any process that activates or increases the frequency, rate, or extent of leukocyte activation. + GOC:add + @@ -1527,8 +3219,17 @@ + Any process that modulates the frequency, rate, or extent of an immune effector process. + biological_process + GO:0002697 regulation of immune effector process + + + + Any process that modulates the frequency, rate, or extent of an immune effector process. + GOC:add + @@ -1554,8 +3255,21 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. + down regulation of immune effector process + down-regulation of immune effector process + downregulation of immune effector process + inhibition of immune effector process + biological_process + GO:0002698 negative regulation of immune effector process + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. + GOC:add + @@ -1581,8 +3295,22 @@ + Any process that activates or increases the frequency, rate, or extent of an immune effector process. + up regulation of immune effector process + up-regulation of immune effector process + upregulation of immune effector process + activation of immune effector process + stimulation of immune effector process + biological_process + GO:0002699 positive regulation of immune effector process + + + + Any process that activates or increases the frequency, rate, or extent of an immune effector process. + GOC:add + @@ -1608,8 +3336,17 @@ + Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. + biological_process + GO:0002700 regulation of production of molecular mediator of immune response + + + + Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. + GOC:add + @@ -1636,8 +3373,21 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. + down regulation of production of molecular mediator of immune response + down-regulation of production of molecular mediator of immune response + downregulation of production of molecular mediator of immune response + inhibition of production of molecular mediator of immune response + biological_process + GO:0002701 negative regulation of production of molecular mediator of immune response + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. + GOC:add + @@ -1664,8 +3414,22 @@ + Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. + up regulation of production of molecular mediator of immune response + up-regulation of production of molecular mediator of immune response + upregulation of production of molecular mediator of immune response + activation of production of molecular mediator of immune response + stimulation of production of molecular mediator of immune response + biological_process + GO:0002702 positive regulation of production of molecular mediator of immune response + + + + Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. + GOC:add + @@ -1674,8 +3438,17 @@ + The controlled release of a peptide from a cell or a tissue. + biological_process + GO:0002790 peptide secretion + + + + The controlled release of a peptide from a cell or a tissue. + GOC:add + @@ -1701,8 +3474,17 @@ + Any process that modulates the frequency, rate, or extent of peptide secretion. + biological_process + GO:0002791 regulation of peptide secretion + + + + Any process that modulates the frequency, rate, or extent of peptide secretion. + GOC:add + @@ -1728,8 +3510,21 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. + down regulation of peptide secretion + down-regulation of peptide secretion + downregulation of peptide secretion + inhibition of peptide secretion + biological_process + GO:0002792 negative regulation of peptide secretion + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. + GOC:add + @@ -1755,8 +3550,22 @@ + Any process that activates or increases the frequency, rate, or extent of peptide secretion. + up regulation of peptide secretion + up-regulation of peptide secretion + upregulation of peptide secretion + activation of peptide secretion + stimulation of peptide secretion + biological_process + GO:0002793 positive regulation of peptide secretion + + + + Any process that activates or increases the frequency, rate, or extent of peptide secretion. + GOC:add + @@ -1776,8 +3585,33 @@ + A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. + puberty + biological_process + reproductive developmental process + GO:0003006 developmental process involved in reproduction + + + + A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. + GOC:dph + GOC:isa_complete + + + + + puberty + GOC:dph + + + + + reproductive developmental process + GOC:dph + GOC:tb + @@ -1785,8 +3619,18 @@ + A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. + organ system process + biological_process + GO:0003008 system process + + + + A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. + GOC:mtg_cardio + @@ -1794,8 +3638,20 @@ + A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. + biological_process + muscle physiological process + GO:0003012 + + muscle system process + + + + A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. + GOC:mtg_cardio + @@ -1803,8 +3659,20 @@ + A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. + Wikipedia:Circulatory_system + biological_process + GO:0003013 + + circulatory system process + + + + A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. + GOC:mtg_cardio + @@ -1812,8 +3680,22 @@ + A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). + excretory system process + biological_process + kidney system process + GO:0003014 + renal system process + + + + A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). + GOC:cjm + GOC:mtg_cardio + GOC:mtg_kidney_jan10 + @@ -1821,8 +3703,18 @@ + A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. + biological_process + cardiac process + GO:0003015 heart process + + + + A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. + GOC:mtg_cardio + @@ -1836,8 +3728,22 @@ + A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. + GO:0010802 + respiratory gaseous exchange + biological_process + GO:0003016 + respiratory system process + + + + A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. + GOC:dph + GOC:mtg_cardio + GOC:tb + @@ -1845,8 +3751,17 @@ + The flow of lymph through the body of an animal. + biological_process + GO:0003017 lymph circulation + + + + The flow of lymph through the body of an animal. + GOC:mtg_cardio + @@ -1860,8 +3775,18 @@ + The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris. + biological_process + GO:0003019 central nervous system control of baroreceptor feedback + + + + The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris. + GOC:mtg_cardio + ISBN:0323031951 + @@ -1875,8 +3800,25 @@ + The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. + detection of reduced oxygen by chemoreceptor signalling + biological_process + GO:0003020 detection of reduced oxygen by chemoreceptor signaling + + + + The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. + GOC:mtg_cardio + ISBN:0323031951 + + + + + detection of reduced oxygen by chemoreceptor signalling + GOC:mah + @@ -1884,8 +3826,25 @@ + The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors. + detection of pH by chemoreceptor signalling + biological_process + GO:0003022 detection of pH by chemoreceptor signaling + + + + The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors. + GOC:mtg_cardio + ISBN:0323031951 + + + + + detection of pH by chemoreceptor signalling + GOC:mah + @@ -1893,8 +3852,27 @@ + The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control. + baroreceptor regulation of systemic arterial blood pressure + biological_process + GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback + + + + The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control. + GOC:dph + GOC:mtg_cardio + GOC:tb + + + + + baroreceptor regulation of systemic arterial blood pressure + GOC:dph + GOC:tb + @@ -1902,8 +3880,42 @@ + The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. + vagal reflex + carotid body chemoreceptor regulation of systemic arterial blood pressure + carotid body chemoreceptor response to lowering of systemic arterial blood pressure + regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling + biological_process + GO:0003027 regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling + + + + The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. + GOC:dph + GOC:mtg_cardio + GOC:tb + + + + + carotid body chemoreceptor regulation of systemic arterial blood pressure + GOC:dph + GOC:tb + + + + + carotid body chemoreceptor response to lowering of systemic arterial blood pressure + GOC:dph + + + + + regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling + GOC:mah + @@ -1917,8 +3929,24 @@ + The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies. + detection of hypoxic conditions in blood by carotid body chemoreceptor signalling + biological_process + GO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling + + + + The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies. + GOC:mtg_cardio + + + + + detection of hypoxic conditions in blood by carotid body chemoreceptor signalling + GOC:mah + @@ -1926,8 +3954,17 @@ + The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal. + biological_process + GO:0003030 detection of hydrogen ion + + + + The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal. + GOC:mtg_cardio + @@ -1936,8 +3973,17 @@ + The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal. + biological_process + GO:0003032 detection of oxygen + + + + The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal. + GOC:mtg_cardio + @@ -1951,8 +3997,24 @@ + The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body. + detection of reduced oxygen by carotid body chemoreceptor signalling + biological_process + GO:0003039 detection of reduced oxygen by carotid body chemoreceptor signaling + + + + The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body. + GOC:mtg_cardio + + + + + detection of reduced oxygen by carotid body chemoreceptor signalling + GOC:mah + @@ -1960,8 +4022,18 @@ + The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine. + blood pressure regulation mediated by a chemical signal + biological_process + GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal + + + + The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine. + GOC:mtg_cardio + @@ -1986,8 +4058,28 @@ + Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. + renal control of blood pressure + renal regulation of systemic arterial blood pressure + biological_process + GO:0003071 renal system process involved in regulation of systemic arterial blood pressure + + + + Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. + GOC:dph + GOC:mtg_cardio + GOC:tb + + + + + renal regulation of systemic arterial blood pressure + GOC:dph + GOC:tb + @@ -1995,8 +4087,17 @@ + The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. + biological_process + GO:0003073 regulation of systemic arterial blood pressure + + + + The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. + GOC:mtg_cardio + @@ -2004,8 +4105,18 @@ + The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system. + blood pressure regulation by renin-angiotensin + biological_process + GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin + + + + The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system. + GOC:mtg_cardio + @@ -2014,8 +4125,18 @@ + Renal process involved in the maintenance of an internal steady state of water in the body. + water homeostasis by the renal system + biological_process + GO:0003091 renal water homeostasis + + + + Renal process involved in the maintenance of an internal steady state of water in the body. + GOC:mtg_cardio + @@ -2041,8 +4162,17 @@ + Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule. + biological_process + GO:0003093 regulation of glomerular filtration + + + + Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule. + GOC:mtg_cardio + @@ -2050,8 +4180,19 @@ + The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein. + biological_process + GO:0003094 glomerular filtration + + + + The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein. + GOC:mtg_cardio + GOC:sart + ISBN:0721643949 + @@ -2066,8 +4207,17 @@ + The directed movement of water (H2O) by the renal system. + biological_process + GO:0003097 renal water transport + + + + The directed movement of water (H2O) by the renal system. + GOC:mtg_cardio + @@ -2093,8 +4243,17 @@ + Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. + biological_process + GO:0003104 positive regulation of glomerular filtration + + + + Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. + GOC:mtg_cardio + @@ -2120,8 +4279,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. + biological_process + GO:0003105 negative regulation of glomerular filtration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. + GOC:mtg_cardio + @@ -2147,8 +4315,20 @@ + Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. + dph + 2009-11-02T02:07:40Z + biological_process + GO:0003330 regulation of extracellular matrix constituent secretion + + + + Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. + GOC:dph + GOC:tb + @@ -2175,8 +4355,20 @@ + Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. + dph + 2009-11-02T02:11:22Z + biological_process + GO:0003331 positive regulation of extracellular matrix constituent secretion + + + + Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. + GOC:dph + GOC:tb + @@ -2203,8 +4395,20 @@ + Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. + dph + 2009-11-02T02:13:49Z + biological_process + GO:0003332 negative regulation of extracellular matrix constituent secretion + + + + Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. + GOC:dph + GOC:tb + @@ -2212,8 +4416,49 @@ + The directed, self-propelled movement of a cilium. + https://github.com/geneontology/go-ontology/issues/19809 + + + + + + + dph + 2009-11-24T09:56:26Z + GO:0036142 + microtubule-based flagellum movement + flagellar movement + flagellum movement + biological_process + ciliary motility + cilium beating + flagellar motility + GO:0003341 + Note that we deem cilium and microtubule-based flagellum to be equivalent. cilium movement + + + + The directed, self-propelled movement of a cilium. + GOC:dph + GOC:jl + + + + + flagellar movement + GOC:bf + + + + + cilium beating + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -2238,8 +4483,30 @@ + Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + dph + 2009-12-03T10:12:00Z + GO:1900172 + regulation of microtubule-based flagellum movement + biological_process + regulation of flagellar movement + regulation of flagellum movement + GO:0003352 + Note that we deem cilium and microtubule-based flagellum to be equivalent. regulation of cilium movement + + + + Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + GOC:dph + + + + + regulation of flagellar movement + GOC:TermGenie + @@ -2258,15 +4525,37 @@ - + + Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + dph + 2009-12-03T10:16:10Z + GO:1900174 + positive regulation of microtubule-based flagellum movement + biological_process + positive regulation of flagellar movement + positive regulation of flagellum movement + GO:0003353 + Note that we deem cilium and microtubule-based flagellum to be equivalent. positive regulation of cilium movement + + + + Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + GOC:dph + + + + + positive regulation of flagellar movement + GOC:TermGenie + @@ -2285,15 +4574,30 @@ - + + Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + dph + 2009-12-03T10:17:47Z + GO:1900173 + negative regulation of microtubule-based flagellum movement + biological_process + negative regulation of flagellum movement + GO:0003354 + Note that we deem cilium and microtubule-based flagellum to be equivalent. negative regulation of cilium movement + + + + Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + GOC:dph + @@ -2318,8 +4622,21 @@ + The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. + dph + 2009-12-22T08:39:58Z + biological_process + GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis + + + + The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -2333,8 +4650,21 @@ + The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time. + dph + 2009-12-22T08:48:44Z + biological_process + GO:0003415 chondrocyte hypertrophy + + + + The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -2359,16 +4689,47 @@ + The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. + dph + 2009-12-22T12:42:44Z + biological_process + GO:0003433 chondrocyte development involved in endochondral bone morphogenesis + + + + The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. + GOC:ascb_2009 + GOC:dph + GOC:tb + + A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process. + GO:0005554 + molecular function + molecular_function + GO:0003674 + + + + + + + Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. molecular_function + + + + A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process. + GOC:pdt + @@ -2376,16 +4737,79 @@ + Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. + GO:0004926 + GO:0099600 + transmembrane receptor activity + Reactome:R-HSA-193672 + transmembrane signalling receptor activity + molecular_function + GO:0004888 + This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores. transmembrane signaling receptor activity + + + + Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. + GOC:go_curators + Wikipedia:Transmembrane_receptor + + + + + transmembrane receptor activity + GOC:bf + GOC:signaling + + + + + Reactome:R-HSA-193672 + Sphingomyelinase is activated by the NGF:p75NTR complex + + + + + transmembrane signalling receptor activity + GOC:mah + + A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). + GO:0008372 + NIF_Subcellular:sao1337158144 + cell or subcellular entity + cellular component + cellular_component + subcellular entity + GO:0005575 + + + + + + + Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. cellular_component + + + + A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). + GOC:pdt + NIF_Subcellular:sao1337158144 + + + + + subcellular entity + NIF_Subcellular:nlx_subcell_100315 + @@ -2393,8 +4817,31 @@ + The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. + Wikipedia:Extracellular + extracellular + cellular_component + GO:0005576 + + + + + + + + + + + + Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. extracellular region + + + + The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. + GOC:go_curators + @@ -2408,8 +4855,21 @@ + A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. + fibrinogen + fibrinogen alpha chain + fibrinogen beta chain + fibrinogen gamma chain + cellular_component + GO:0005577 fibrinogen complex + + + + A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. + ISBN:0198547684 + @@ -2417,8 +4877,22 @@ + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. + Wikipedia:Collagen + cellular_component + GO:0005581 collagen trimer + + + + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. + GOC:dos + GOC:mah + ISBN:0721639976 + PMID:19693541 + PMID:21421911 + @@ -2443,8 +4917,19 @@ + Any triple helical collagen trimer that forms fibrils. + cellular_component + GO:0005583 fibrillar collagen trimer + + + + Any triple helical collagen trimer that forms fibrils. + GOC:mah + ISBN:0721639976 + PMID:21421911 + @@ -2452,8 +4937,20 @@ + A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils. + Wikipedia:Collagen_type_I + cellular_component + GO:0005584 collagen type I trimer + + + + A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils. + GOC:mah + GOC:sl + ISBN:0721639976 + @@ -2461,8 +4958,18 @@ + A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils. + Wikipedia:Collagen_type_II + cellular_component + GO:0005585 collagen type II trimer + + + + A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils. + ISBN:0721639976 + @@ -2470,8 +4977,17 @@ + A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils. + cellular_component + GO:0005586 collagen type III trimer + + + + A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils. + ISBN:0721639976 + @@ -2480,8 +4996,20 @@ + A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. + Wikipedia:Collagen_type_IV + cellular_component + GO:0005587 collagen type IV trimer + + + + A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. + ISBN:0721639976 + PMID:19693541 + PMID:21421911 + @@ -2489,8 +5017,25 @@ + A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. + GO:0005605 + GO:0008003 + Wikipedia:Basement_membrane + cellular_component + basal lamina + basement lamina + lamina densa + GO:0005604 + Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. basement membrane + + + + A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. + ISBN:0198547684 + PMID:22505934 + @@ -2504,8 +5049,24 @@ + That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. + NIF_Subcellular:sao1425028079 + cellular_component + intercellular space + GO:0005615 + + + + + Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. extracellular space + + + + That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. + ISBN:0198547684 + @@ -2513,8 +5074,40 @@ + A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. + https://github.com/geneontology/go-ontology/issues/17776 + Wikipedia:Intracellular + internal to cell + intracellular + protoplasm + cellular_component + nucleocytoplasm + protoplast + GO:0005622 + + + + intracellular anatomical structure + + + + A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. + ISBN:0198506732 + + + + + nucleocytoplasm + GOC:mah + + + + + protoplast + GOC:mah + @@ -2522,8 +5115,41 @@ + A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. + NIF_Subcellular:sao1702920020 + Wikipedia:Cell_nucleus + cell nucleus + horsetail nucleus + cellular_component + GO:0005634 + + + + + + + + + + + nucleus + + + + A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. + GOC:go_curators + + + + + horsetail nucleus + GOC:al + GOC:mah + GOC:vw + PMID:15030757 + @@ -2543,8 +5169,22 @@ + The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). + GO:0005636 + Wikipedia:Nuclear_envelope + cellular_component + GO:0005635 + + + nuclear envelope + + + + The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). + ISBN:0198547684 + @@ -2558,8 +5198,26 @@ + The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. + https://github.com/geneontology/go-ontology/issues/23023 + Wikipedia:Cytoplasm + cellular_component + GO:0005737 + + + + + + + cytoplasm + + + + The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. + ISBN:0198547684 + @@ -2573,8 +5231,30 @@ + A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. + Wikipedia:Vacuole + cellular_component + vacuolar carboxypeptidase Y + GO:0005773 + + + + + + + + + + vacuole + + + + A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. + GOC:mtg_sensu + ISBN:0198506732 + @@ -2582,8 +5262,31 @@ + A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. + Wikipedia:Cytoskeleton + cellular_component + GO:0005856 + + + + + + + + + + + cytoskeleton + + + + A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. + GOC:mah + PMID:16959967 + PMID:27419875 + @@ -2597,8 +5300,24 @@ + A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. + FMA:63851 + NIF_Subcellular:sao952483289 + Wikipedia:Intermediate_filament + cellular_component + intermediate filament associated protein + type I intermediate filament associated protein + type II intermediate filament associated protein + GO:0005882 intermediate filament + + + + A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. + ISBN:0198506732 + http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm + @@ -2612,8 +5331,23 @@ + A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. + FMA:63850 + NIF_Subcellular:sao1588493326 + Wikipedia:Actin + microfilament + cellular_component + GO:0005884 actin filament + + + + A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. + GOC:mah + ISBN:0198506732 + PMID:10666339 + @@ -2627,8 +5361,50 @@ + The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. + GO:0005904 + juxtamembrane + NIF_Subcellular:sao1663586795 + Wikipedia:Cell_membrane + cell membrane + cellular membrane + cytoplasmic membrane + plasmalemma + bacterial inner membrane + inner endospore membrane + plasma membrane lipid bilayer + cellular_component + GO:0005886 + + + + + + + + + + plasma membrane + + + + The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. + ISBN:0716731363 + + + + + cellular membrane + NIF_Subcellular:sao6433132645 + + + + + plasma membrane lipid bilayer + GOC:mah + @@ -2642,8 +5418,29 @@ + Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. + + NIF_Subcellular:sao671419673 + Wikipedia:Microvillus + cellular_component + microvilli + GO:0005902 + + Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. microvillus + + + + Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. + ISBN:0815316194 + + + + + microvilli + NIF_Subcellular:sao671419673 + @@ -2651,8 +5448,34 @@ + A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. + https://github.com/geneontology/go-ontology/issues/22122 + cell-cell contact region + cell-cell contact zone + NIF_Subcellular:sao1922892319 + intercellular junction + cellular_component + GO:0005911 cell-cell junction + + + + A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. + GOC:aruk + GOC:bc + GOC:dgh + GOC:hb + GOC:mah + PMID:21422226 + PMID:28096264 + + + + + intercellular junction + NIF_Subcellular:sao1395777368 + @@ -2666,8 +5489,21 @@ + An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. + NIF_Subcellular:sao1939999134 + Wikipedia:Tight_junction + zonula occludens + cellular_component + GO:0005923 bicellular tight junction + + + + An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. + GOC:mah + ISBN:0815332181 + @@ -2682,8 +5518,43 @@ + A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. + + + + + + + GO:0072372 + FMA:67181 + NIF_Subcellular:sao787716553 + Wikipedia:Cilium + eukaryotic flagellum + microtubule-based flagellum + primary cilium + cellular_component + flagellum + GO:0005929 + + + + + Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. cilium + + + + A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. + GOC:cilia + GOC:curators + GOC:kmv + GOC:vw + ISBN:0198547684 + PMID:16824949 + PMID:17009929 + PMID:20144998 + @@ -2708,8 +5579,23 @@ + The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. + Wikipedia:Cell_cortex + cellular_component + cell periphery + peripheral cytoplasm + GO:0005938 + + cell cortex + + + + The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. + GOC:mah + ISBN:0815316194 + @@ -2718,8 +5604,36 @@ + The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + https://github.com/geneontology/go-ontology/issues/22880 + jl + 2012-10-23T15:40:34Z + GO:0044261 + GO:0044723 + Wikipedia:Carbohydrate_metabolism + carbohydrate metabolism + biological_process + GO:0005975 + + + + + + + + + + + carbohydrate metabolic process + + + + The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + GOC:mah + ISBN:0198506732 + @@ -2728,8 +5642,23 @@ + The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + GO:0044263 + polysaccharide metabolism + glycan metabolic process + glycan metabolism + multicellular organismal polysaccharide metabolic process + biological_process + GO:0005976 + polysaccharide metabolic process + + + + The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + ISBN:0198547684 + @@ -2738,8 +5667,18 @@ + The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. + glycogen metabolism + biological_process + GO:0005977 glycogen metabolic process + + + + The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. + ISBN:0198506732 + @@ -2748,8 +5687,22 @@ + The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + MetaCyc:GLYCOGENSYNTH-PWY + glycogen anabolism + glycogen biosynthesis + glycogen formation + glycogen synthesis + biological_process + GO:0005978 glycogen biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + ISBN:0198506732 + @@ -2775,8 +5728,21 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + regulation of glycogen anabolism + regulation of glycogen biosynthesis + regulation of glycogen formation + regulation of glycogen synthesis + biological_process + GO:0005979 regulation of glycogen biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + GOC:go_curators + @@ -2786,8 +5752,28 @@ + The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + MetaCyc:GLYCOCAT-PWY + glycogen breakdown + glycogen catabolism + glycogen degradation + glycogenolysis + biological_process + GO:0005980 glycogen catabolic process + + + + The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + ISBN:0198506732 + + + + + glycogenolysis + GOC:sl + @@ -2813,8 +5799,27 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + regulation of glycogen breakdown + regulation of glycogen catabolism + regulation of glycogen degradation + regulation of glycogenolysis + biological_process + GO:0005981 regulation of glycogen catabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + GOC:go_curators + + + + + regulation of glycogenolysis + GOC:sl + @@ -2823,8 +5828,18 @@ + The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. + monosaccharide metabolism + biological_process + GO:0005996 monosaccharide metabolic process + + + + The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. + ISBN:0198506732 + @@ -2832,8 +5847,25 @@ + The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. + cellular glucose metabolic process + glucose metabolism + biological_process + GO:0006006 glucose metabolic process + + + + The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. + ISBN:0198506732 + + + + + cellular glucose metabolic process + GOC:vw + @@ -2843,8 +5875,19 @@ + The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. + aminoglycan metabolism + biological_process + GO:0006022 aminoglycan metabolic process + + + + The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. + GOC:ai + ISBN:0198506732 + @@ -2855,8 +5898,22 @@ + The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. + aminoglycan anabolism + aminoglycan biosynthesis + aminoglycan formation + aminoglycan synthesis + biological_process + GO:0006023 aminoglycan biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. + GOC:ai + ISBN:0198506732 + @@ -2865,8 +5922,21 @@ + The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. + glycosaminoglycan anabolism + glycosaminoglycan biosynthesis + glycosaminoglycan formation + glycosaminoglycan synthesis + biological_process + GO:0006024 glycosaminoglycan biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. + ISBN:0192800981 + @@ -2875,8 +5945,20 @@ + The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. + alcohol metabolism + biological_process + GO:0006066 + + alcohol metabolic process + + + + The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. + ISBN:0198506732 + @@ -2885,8 +5967,18 @@ + The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, occurring at the level of an individual cell. + cellular glucan metabolism + biological_process + GO:0006073 cellular glucan metabolic process + + + + The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, occurring at the level of an individual cell. + ISBN:0198547684 + @@ -2895,8 +5987,22 @@ + The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. + aldehyde metabolism + alkanal metabolic process + alkanal metabolism + biological_process + GO:0006081 + cellular aldehyde metabolic process + + + + The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. + GOC:go_curators + ISBN:0198506732 + @@ -2906,8 +6012,19 @@ + The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. + organic acid metabolism + biological_process + GO:0006082 + organic acid metabolic process + + + + The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. + ISBN:0198506732 + @@ -2915,8 +6032,36 @@ + The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. + energy pathways + biological_process + intermediary metabolism + metabolic energy generation + GO:0006091 + + + + + + + + + + generation of precursor metabolites and energy + + + + The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. + GOC:jl + + + + + intermediary metabolism + GOC:mah + @@ -2941,8 +6086,18 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. + regulation of carbohydrate metabolism + biological_process + GO:0006109 regulation of carbohydrate metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. + GOC:go_curators + @@ -2950,8 +6105,19 @@ + The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. + energy reserve metabolism + biological_process + GO:0006112 + energy reserve metabolic process + + + + The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. + GOC:mah + @@ -2961,8 +6127,29 @@ + The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. + GO:0006519 + amino acid and derivative metabolism + amino acid metabolic process + cellular amino acid and derivative metabolic process + cellular amino acid metabolism + biological_process + GO:0006520 + + + + + + + cellular amino acid metabolic process + + + + The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. + ISBN:0198506732 + @@ -2989,8 +6176,18 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. + regulation of amino acid metabolism + biological_process + GO:0006521 regulation of cellular amino acid metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. + GOC:go_curators + @@ -2999,8 +6196,21 @@ + The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. + Wikipedia:Glutamic_acid + glutamate metabolism + glutamic acid metabolic process + glutamic acid metabolism + biological_process + GO:0006536 glutamate metabolic process + + + + The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. + GOC:go_curators + @@ -3009,8 +6219,44 @@ + The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. + amino acid derivative metabolic process + cellular amino acid derivative metabolic process + cellular amino acid derivative metabolism + cellular modified amino acid metabolism + modified amino acid metabolic process + modified amino acid metabolism + biological_process + GO:0006575 + + + cellular modified amino acid metabolic process + + + + The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. + GOC:ai + + + + + cellular modified amino acid metabolism + GOC:mah + + + + + modified amino acid metabolic process + GOC:mah + + + + + modified amino acid metabolism + GOC:mah + @@ -3018,8 +6264,19 @@ + The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. + biogenic amine metabolism + biological_process + GO:0006576 cellular biogenic amine metabolic process + + + + The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. + GOC:jl + ISBN:0395825172 + @@ -3028,8 +6285,19 @@ + The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + catecholamine metabolism + biological_process + GO:0006584 catecholamine metabolic process + + + + The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:jl + ISBN:0198506732 + @@ -3037,8 +6305,19 @@ + The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. + biological_process + GO:0006590 + Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis. thyroid hormone generation + + + + The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. + GOC:jl + ISBN:0716720094 + @@ -3047,8 +6326,31 @@ + The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. + Wikipedia:Lipid_metabolism + lipid metabolism + biological_process + GO:0006629 + + + + + + + + + + + + lipid metabolic process + + + + The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. + GOC:ma + @@ -3058,8 +6360,23 @@ + The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. + Wikipedia:Steroid_metabolisms#Steroid_biosynthesis + steroid anabolism + steroid biosynthesis + steroid formation + steroid synthesis + steroidogenesis + biological_process + GO:0006694 steroid biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. + GOC:go_curators + @@ -3070,8 +6387,21 @@ + The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. + bile acid anabolism + bile acid biosynthesis + bile acid formation + bile acid synthesis + biological_process + GO:0006699 bile acid biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. + GOC:go_curators + @@ -3081,8 +6411,21 @@ + The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. + C21-steroid hormone anabolism + C21-steroid hormone biosynthesis + C21-steroid hormone formation + C21-steroid hormone synthesis + biological_process + GO:0006700 C21-steroid hormone biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. + GOC:ai + @@ -3091,8 +6434,21 @@ + The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. + glucocorticoid anabolism + glucocorticoid biosynthesis + glucocorticoid formation + glucocorticoid synthesis + biological_process + GO:0006704 glucocorticoid biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. + ISBN:0198506732 + @@ -3101,8 +6457,21 @@ + The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. + mineralocorticoid anabolism + mineralocorticoid biosynthesis + mineralocorticoid formation + mineralocorticoid synthesis + biological_process + GO:0006705 mineralocorticoid biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. + ISBN:0198506732 + @@ -3110,8 +6479,22 @@ + The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. + aromatic compound metabolism + aromatic hydrocarbon metabolic process + aromatic hydrocarbon metabolism + biological_process + GO:0006725 + cellular aromatic compound metabolic process + + + + The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. + GOC:ai + ISBN:0198506732 + @@ -3119,8 +6502,21 @@ + The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. + nitrogen compound metabolism + biological_process + GO:0006807 + + nitrogen compound metabolic process + + + + The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. + GOC:jl + ISBN:0198506732 + @@ -3128,8 +6524,35 @@ + The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. + https://github.com/geneontology/go-ontology/issues/20292 + jl + 2012-12-13T16:25:32Z + GO:0015457 + GO:0015460 + GO:0044765 + biological_process + single-organism transport + GO:0006810 + + + + + + + + Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. transport + + + + The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. + GOC:dos + GOC:dph + GOC:jl + GOC:mah + @@ -3137,8 +6560,20 @@ + The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0006811 + + + ion transport + + + + The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -3146,8 +6581,28 @@ + The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GO:0006819 + GO:0015674 + GO:0072512 + di-, tri-valent inorganic cation transport + trivalent inorganic cation transport + biological_process + GO:0006812 cation transport + + + + The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + + + + + di-, tri-valent inorganic cation transport + GOC:mah + @@ -3155,8 +6610,18 @@ + The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GO:0006822 + biological_process + GO:0006820 anion transport + + + + The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -3164,8 +6629,17 @@ + The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0006833 water transport + + + + The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -3175,8 +6649,17 @@ + The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. + biological_process + GO:0006837 serotonin transport + + + + The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. + GOC:ai + @@ -3190,8 +6673,20 @@ + The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + biological_process + GO:0006869 + + + lipid transport + + + + The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + ISBN:0198506732 + @@ -3199,8 +6694,27 @@ + Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. + hydrogen ion homeostasis + biological_process + GO:0006885 regulation of pH + + + + Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. + GOC:dph + GOC:go_curators + GOC:tb + + + + + hydrogen ion homeostasis + GOC:dph + GOC:tb + @@ -3215,8 +6729,25 @@ + A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. + GO:0016194 + GO:0016195 + Wikipedia:Exocytosis + vesicle exocytosis + biological_process + nonselective vesicle exocytosis + GO:0006887 + exocytosis + + + + A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. + GOC:mah + ISBN:0716731363 + PMID:22323285 + @@ -3231,17 +6762,17 @@ + Fusion of the membrane of a transport vesicle with its target membrane. + biological_process + GO:0006906 vesicle fusion - - - - - - - - movement of cell or subcellular component - + + + + Fusion of the membrane of a transport vesicle with its target membrane. + GOC:jid + @@ -3249,8 +6780,21 @@ + A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. + Wikipedia:Muscle_contraction + biological_process + GO:0006936 + muscle contraction + + + + A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. + GOC:ef + GOC:mtg_muscle + ISBN:0198506732 + @@ -3275,8 +6819,17 @@ + Any process that modulates the frequency, rate or extent of muscle contraction. + biological_process + GO:0006937 regulation of muscle contraction + + + + Any process that modulates the frequency, rate or extent of muscle contraction. + GOC:go_curators + @@ -3284,8 +6837,21 @@ + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. + visceral muscle contraction + biological_process + GO:0006939 smooth muscle contraction + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. + GOC:ef + GOC:jl + GOC:mtg_muscle + ISBN:0198506732 + @@ -3310,8 +6876,17 @@ + Any process that modulates the frequency, rate or extent of smooth muscle contraction. + biological_process + GO:0006940 regulation of smooth muscle contraction + + + + Any process that modulates the frequency, rate or extent of smooth muscle contraction. + GOC:go_curators + @@ -3319,8 +6894,20 @@ + A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. + sarcomeric muscle contraction + biological_process + GO:0006941 striated muscle contraction + + + + A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. + GOC:jl + GOC:mtg_muscle + ISBN:0198506732 + @@ -3345,8 +6932,17 @@ + Any process that modulates the frequency, rate or extent of striated muscle contraction. + biological_process + GO:0006942 regulation of striated muscle contraction + + + + Any process that modulates the frequency, rate or extent of striated muscle contraction. + GOC:go_curators + @@ -3354,8 +6950,26 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). + biological_process + response to abiotic stress + response to biotic stress + GO:0006950 + + + + + + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to stress + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). + GOC:mah + @@ -3363,8 +6977,23 @@ + Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. + GO:0002217 + GO:0042829 + defence response + physiological defense response + biological_process + antimicrobial peptide activity + defense/immunity protein activity + GO:0006952 defense response + + + + Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. + GOC:go_curators + @@ -3372,8 +7001,21 @@ + The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. + inflammation + Wikipedia:Inflammation + biological_process + GO:0006954 + inflammatory response + + + + The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. + GO_REF:0000022 + ISBN:0198506732 + @@ -3382,8 +7024,19 @@ + Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. + biological_process + GO:0006955 + immune response + + + + Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. + GOC:add + GO_REF:0000022 + @@ -3391,8 +7044,40 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + jl + 2013-12-19T15:25:51Z + GO:1902589 + organelle organisation + single organism organelle organization + biological_process + organelle organization and biogenesis + single-organism organelle organization + GO:0006996 + + organelle organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + GOC:mah + + + + + single organism organelle organization + GOC:TermGenie + + + + + organelle organization and biogenesis + GOC:dph + GOC:jl + GOC:mah + @@ -3400,18 +7085,40 @@ + Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. + https://github.com/geneontology/go-ontology/issues/19809 + biological_process + GO:0007017 + microtubule-based process + + + + Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. + GOC:mah + - + A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. + biological_process + GO:0007018 + + microtubule-based movement + + + + A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. + GOC:cjm + ISBN:0815316194 + @@ -3419,8 +7126,27 @@ + The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. + Wikipedia:Cell_cycle + cell-division cycle + biological_process + GO:0007049 + + + + + + + cell cycle + + + + The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. + GOC:go_curators + GOC:mtg_cell_cycle + @@ -3450,8 +7176,22 @@ + A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. + + male nuclear division + biological_process + male meiosis + GO:0007140 male meiotic nuclear division + + + + A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. + GOC:dph + GOC:mah + GOC:vw + @@ -3481,8 +7221,24 @@ + A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. + + female meiosis + female meiotic division + biological_process + GO:0007143 + Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'. female meiotic nuclear division + + + + A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. + GOC:dph + GOC:ems + GOC:mah + GOC:vw + @@ -3490,8 +7246,20 @@ + Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + Wikipedia:Cell_signaling + biological_process + GO:0007154 + + cell communication + + + + Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:mah + @@ -3499,9 +7267,32 @@ - + The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. + dos + 2014-04-15T15:59:10Z + GO:0098602 + Wikipedia:Cell_adhesion + biological_process + cell adhesion molecule activity + single organism cell adhesion + GO:0007155 + + + + + + + + cell adhesion + + + + The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. + GOC:hb + GOC:pf + @@ -3509,8 +7300,21 @@ + The attachment of a leukocyte to another cell via adhesion molecules. + + + leukocyte adhesion + leukocyte cell adhesion + biological_process + GO:0007159 leukocyte cell-cell adhesion + + + + The attachment of a leukocyte to another cell via adhesion molecules. + GOC:go_curators + @@ -3536,8 +7340,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. + down regulation of cell adhesion + down-regulation of cell adhesion + downregulation of cell adhesion + inhibition of cell adhesion + biological_process + cell adhesion receptor inhibitor activity + GO:0007162 negative regulation of cell adhesion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. + GOC:go_curators + @@ -3564,8 +7382,43 @@ + The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. + GO:0023014 + GO:0023015 + GO:0023016 + GO:0023033 + GO:0023045 + Wikipedia:Signal_transduction + signal transduction by cis-phosphorylation + signal transduction by conformational transition + signal transduction by protein phosphorylation + signal transduction by trans-phosphorylation + signaling cascade + signalling cascade + biological_process + signaling pathway + signalling pathway + GO:0007165 + + + + + Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. signal transduction + + + + The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. + GOC:go_curators + GOC:mtg_signaling_feb11 + + + + + signalling pathway + GOC:mah + @@ -3574,8 +7427,21 @@ + Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. + cell-cell signalling + biological_process + GO:0007267 + + cell-cell signaling + + + + Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. + GOC:dos + GOC:mah + @@ -3584,8 +7450,25 @@ + The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + https://github.com/geneontology/go-ontology/issues/21234 + biological_process + GO:0007275 + + + + Note that this term was 'developmental process'. multicellular organism development + + + + The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:dph + GOC:ems + GOC:isa_complete + GOC:tb + @@ -3599,8 +7482,21 @@ + The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. + + GO:0009552 + biological_process + gametogenesis + GO:0007276 gamete generation + + + + The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. + GOC:ems + GOC:mtg_sensu + @@ -3616,8 +7512,19 @@ + The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. + germ-cell development + primordial germ cell development + biological_process + GO:0007281 germ cell development + + + + The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. + GOC:go_curators + @@ -3626,8 +7533,28 @@ + The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. + Wikipedia:Spermatogenesis + generation of spermatozoa + biological_process + GO:0007283 spermatogenesis + + + + The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. + GOC:jid + ISBN:9780878933846 + PMID:28073824 + PMID:30990821 + + + + + generation of spermatozoa + + @@ -3641,8 +7568,21 @@ + The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. + Wikipedia:Spermiogenesis + spermatid cell development + spermiogenesis + biological_process + GO:0007286 spermatid development + + + + The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. + GOC:dph + GOC:go_curators + @@ -3650,8 +7590,18 @@ + Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. + biological_process + GO:0007292 female gamete generation + + + + Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. + GOC:dph + ISBN:0198506732 + @@ -3667,8 +7617,18 @@ + The introduction of semen or sperm into the genital tract of a female. + Wikipedia:Insemination + biological_process + GO:0007320 insemination + + + + The introduction of semen or sperm into the genital tract of a female. + ISBN:0582227089 + @@ -3694,8 +7654,20 @@ + A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + Wikipedia:Gastrulation + biological_process + GO:0007369 + gastrulation + + + + A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + GOC:curators + ISBN:9780878933846 + @@ -3703,8 +7675,18 @@ + The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. + biological_process + GO:0007398 ectoderm development + + + + The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. + GOC:dph + GOC:tb + @@ -3712,8 +7694,19 @@ + The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. + biological_process + pan-neural process + GO:0007399 + nervous system development + + + + The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. + GOC:dgh + @@ -3721,8 +7714,18 @@ + The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. + biological_process + GO:0007492 endoderm development + + + + The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. + GOC:dph + GOC:tb + @@ -3730,8 +7733,19 @@ + The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. + biological_process + GO:0007498 + mesoderm development + + + + The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. + GOC:dph + GOC:tb + @@ -3739,8 +7753,18 @@ + The establishment of the sex of an organism by physical differentiation. + Wikipedia:Sexual_differentiation + biological_process + GO:0007548 sex differentiation + + + + The establishment of the sex of an organism by physical differentiation. + GOC:ai + @@ -3767,8 +7791,17 @@ + Any process that modulates the frequency, rate or extent of juvenile hormone secretion. + biological_process + GO:0007558 regulation of juvenile hormone secretion + + + + Any process that modulates the frequency, rate or extent of juvenile hormone secretion. + GOC:go_curators + @@ -3777,8 +7810,21 @@ + The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. + Wikipedia:Gestation + gestation + biological_process + carrying of young + GO:0007565 + female pregnancy + + + + The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. + ISBN:0192800825 + @@ -3786,8 +7832,20 @@ + The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. + breathing + respiration + biological_process + GO:0007585 + respiratory gaseous exchange by respiratory system + + + + The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. + ISBN:0198506732 + @@ -3795,8 +7853,21 @@ + The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + Wikipedia:Digestion + biological_process + GO:0007586 + + digestion + + + + The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:isa_complete + ISBN:0198506732 + @@ -3804,8 +7875,21 @@ + The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. + https://github.com/geneontology/go-ontology/issues/22368 + Wikipedia:Excretion + biological_process + GO:0007588 + + excretion + + + + The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. + ISBN:0192801023 + @@ -3814,8 +7898,20 @@ + The controlled release of a fluid by a cell or tissue in an animal. + biological_process + GO:0007589 body fluid secretion + + + + The controlled release of a fluid by a cell or tissue in an animal. + GOC:ai + GOC:dph + GOC:mah + GOC:tb + @@ -3835,8 +7931,25 @@ + The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. + Wikipedia:Lactation + milk secretion + biological_process + GO:0007595 lactation + + + + The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. + ISBN:0198506732 + + + + + milk secretion + GOC:pr + @@ -3851,8 +7964,20 @@ + The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. + Wikipedia:Coagulation + blood clotting + biological_process + GO:0007596 blood coagulation + + + + The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. + ISBN:0198506732 + http://www.graylab.ac.uk/omd/ + @@ -3860,8 +7985,18 @@ + The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. + Wikipedia:Hemostasis + biological_process + GO:0007599 hemostasis + + + + The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. + ISBN:0198506732 + @@ -3869,8 +8004,20 @@ + The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + Wikipedia:Perception + biological_process + GO:0007600 + sensory perception + + + + The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + GOC:dph + @@ -3878,8 +8025,21 @@ + The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. + Wikipedia:Visual_perception + sense of sight + sensory visual perception + vision + biological_process + GO:0007601 visual perception + + + + The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. + GOC:ai + @@ -3887,8 +8047,20 @@ + The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. + Wikipedia:Hearing_(sense) + hearing + perception of sound + biological_process + GO:0007605 sensory perception of sound + + + + The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. + GOC:ai + @@ -3896,8 +8068,18 @@ + The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + chemosensory perception + biological_process + GO:0007606 sensory perception of chemical stimulus + + + + The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + @@ -3905,17 +8087,59 @@ + The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process. + Wikipedia:Olfaction + olfaction + scent perception + sense of smell + smell perception + biological_process + GO:0007608 sensory perception of smell + + + + The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process. + GOC:ai + - + + + The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. + jl + 2012-09-20T14:06:08Z + GO:0023032 + GO:0044708 + GO:0044709 + Wikipedia:Behavior + behavioral response to stimulus + behaviour + behavioural response to stimulus + biological_process + single-organism behavior + GO:0007610 + + + + 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. +2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). behavior + + + + The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. + GOC:ems + GOC:jl + ISBN:0395448956 + PMID:20160973 + @@ -3924,8 +8148,18 @@ + The acquisition and processing of information and/or the storage and retrieval of this information over time. + biological_process + GO:0007611 learning or memory + + + + The acquisition and processing of information and/or the storage and retrieval of this information over time. + GOC:jid + PMID:8938125 + @@ -3933,8 +8167,19 @@ + Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. + Wikipedia:Learning + biological_process + GO:0007612 learning + + + + Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. + ISBN:0582227089 + ISBN:0721662544 + @@ -3942,58 +8187,58 @@ + The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). + Wikipedia:Memory + biological_process + GO:0007613 memory + + + + The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). + GOC:curators + ISBN:0582227089 + - - - - - - - - - - - - - - - - - + The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. + Wikipedia:Mating_behaviour + mating behaviour + biological_process + GO:0007617 mating behavior - - - - - - - - - - - - - - mating - + + + + The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. + GOC:ai + GOC:dph + - + + The act of sexual union between male and female, involving the transfer of sperm. + biological_process + GO:0007620 copulation + + + + The act of sexual union between male and female, involving the transfer of sperm. + ISBN:0721662544 + @@ -4001,9 +8246,21 @@ - + The specific behavior of an organism that recur with measured regularity. + rhythmic behavioral response to stimulus + rhythmic behaviour + rhythmic behavioural response to stimulus + biological_process + GO:0007622 rhythmic behavior + + + + The specific behavior of an organism that recur with measured regularity. + GOC:jl + GOC:pr + @@ -4011,8 +8268,25 @@ + Any biological process in an organism that recurs with a regularity of approximately 24 hours. + GO:0050895 + Wikipedia:Circadian_rhythm + circadian process + biological_process + circadian response + response to circadian rhythm + GO:0007623 + + circadian rhythm + + + + Any biological process in an organism that recurs with a regularity of approximately 24 hours. + GOC:bf + GOC:go_curators + @@ -4020,8 +8294,19 @@ + The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. + grooming behaviour + biological_process + GO:0007625 grooming behavior + + + + The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. + GOC:jl + GOC:pr + @@ -4029,8 +8314,23 @@ + The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. + behavior via locomotion + locomotion in response to stimulus + locomotory behavioral response to stimulus + locomotory behaviour + locomotory behavioural response to stimulus + biological_process + GO:0007626 + locomotory behavior + + + + The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. + GOC:dph + @@ -4038,8 +8338,44 @@ + Behavior associated with the intake of food. + https://github.com/geneontology/go-ontology/issues/18547 + jl + 2011-10-27T03:53:33Z + GO:0044366 + GO:0044367 + GO:0044368 + GO:0044369 + GO:0044370 + GO:0044371 + GO:0044372 + Wikipedia:List_of_feeding_behaviours + behavioral response to food + behavioural response to food + feeding behaviour + eating + feeding from phloem of other organism + feeding from plant phloem + feeding from tissue of other organism + feeding from vascular tissue of another organism + feeding from xylem of other organism + feeding on blood of other organism + feeding on or from other organism + feeding on plant sap + hematophagy + injection of substance into other organism during feeding on blood of other organism + taking of blood meal + biological_process + GO:0007631 + See also the biological process term 'behavior ; GO:0007610'. feeding behavior + + + + Behavior associated with the intake of food. + GOC:mah + @@ -4053,8 +8389,20 @@ + Behavior that is dependent upon the sensation of chemicals. + behavioral response to chemical stimulus + behavioural response to chemical stimulus + chemosensory behaviour + biological_process + GO:0007635 chemosensory behavior + + + + Behavior that is dependent upon the sensation of chemicals. + GOC:go_curators + @@ -4062,8 +8410,21 @@ + The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. + GO:0070261 + biological_process + hemolymph circulation + GO:0008015 + blood circulation + + + + The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. + GOC:mtg_heart + ISBN:0192800825 + @@ -4088,25 +8449,110 @@ + Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. + regulation of cardiac contraction + biological_process + GO:0008016 regulation of heart contraction + + + + Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. + GOC:dph + GOC:go_curators + GOC:tb + - + + Any process in which a protein is transported to, or maintained in, a specific location. + https://github.com/geneontology/go-ontology/issues/23112 + GO:0008105 + GO:0016249 + GO:0034613 + cellular protein localisation + cellular protein localization + protein localisation + channel localizer activity + biological_process + asymmetric protein localisation + asymmetric protein localization + establishment and maintenance of asymmetric protein localization + establishment and maintenance of protein localization + GO:0008104 + protein localization + + + + Any process in which a protein is transported to, or maintained in, a specific location. + GOC:ai + + + + + cellular protein localisation + GOC:mah + + + + + protein localisation + GOC:mah + + + + + channel localizer activity + GOC:mah + + + + + asymmetric protein localisation + GOC:mah + + A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. + jl + 2012-09-19T15:05:24Z + GO:0000004 + GO:0007582 + GO:0044699 + Wikipedia:Biological_process + biological process + physiological process + biological_process + single organism process + single-organism process + GO:0008150 + + + + + + + + Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. biological_process + + + + A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. + GOC:pdt + @@ -4114,8 +8560,36 @@ + + + The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. + jl + 2012-10-17T15:46:40Z + GO:0044236 + GO:0044710 + Wikipedia:Metabolism + metabolism + metabolic process resulting in cell growth + metabolism resulting in cell growth + multicellular organism metabolic process + biological_process + single-organism metabolic process + GO:0008152 + + + + + + Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. metabolic process + + + + The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. + GOC:go_curators + ISBN:0198547684 + @@ -4124,8 +8598,19 @@ + The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + Wikipedia:Steroid_metabolism + steroid metabolism + biological_process + GO:0008202 steroid metabolic process + + + + The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + ISBN:0198547684 + @@ -4135,8 +8620,18 @@ + The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + bile acid metabolism + biological_process + GO:0008206 bile acid metabolic process + + + + The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + GOC:go_curators + @@ -4145,8 +8640,18 @@ + The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. + C21-steroid hormone metabolism + biological_process + GO:0008207 C21-steroid hormone metabolic process + + + + The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. + GOC:ai + @@ -4154,8 +8659,20 @@ + The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. + glucocorticoid metabolism + glucocorticosteroid metabolic process + glucocorticosteroid metabolism + biological_process + GO:0008211 glucocorticoid metabolic process + + + + The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. + ISBN:0198506732 + @@ -4164,8 +8681,18 @@ + The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance. + mineralocorticoid metabolism + biological_process + GO:0008212 mineralocorticoid metabolic process + + + + The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance. + ISBN:0198506732 + @@ -4179,8 +8706,23 @@ + Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. + Wikipedia:Blood_pressure#Regulation + blood pressure regulation + biological_process + blood pressure homeostasis + control of blood pressure + GO:0008217 regulation of blood pressure + + + + Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. + GOC:dph + GOC:mtg_cardio + ISBN:0721643949 + @@ -4188,8 +8730,27 @@ + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + + biological_process + cell proliferation + GO:0008283 + + + + + + + This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. cell population proliferation + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + GOC:mah + GOC:mb + @@ -4215,8 +8776,24 @@ + Any process that activates or increases the rate or extent of cell proliferation. + + up regulation of cell proliferation + up-regulation of cell proliferation + upregulation of cell proliferation + activation of cell proliferation + stimulation of cell proliferation + biological_process + positive regulation of cell proliferation + GO:0008284 positive regulation of cell population proliferation + + + + Any process that activates or increases the rate or extent of cell proliferation. + GOC:go_curators + @@ -4242,8 +8819,23 @@ + Any process that stops, prevents or reduces the rate or extent of cell proliferation. + + down regulation of cell proliferation + down-regulation of cell proliferation + downregulation of cell proliferation + inhibition of cell proliferation + biological_process + negative regulation of cell proliferation + GO:0008285 negative regulation of cell population proliferation + + + + Any process that stops, prevents or reduces the rate or extent of cell proliferation. + GOC:go_curators + @@ -4251,8 +8843,22 @@ + Learning by associating a stimulus (the cause) with a particular outcome (the effect). + Wikipedia:Learning#Associative_learning + Pavlovian conditioning + classical conditioning + conditional learning + conditional response + biological_process + GO:0008306 associative learning + + + + Learning by associating a stimulus (the cause) with a particular outcome (the effect). + ISBN:0582227089 + @@ -4261,8 +8867,17 @@ + Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue. + biological_process + GO:0008355 olfactory learning + + + + Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue. + ISBN:0582227089 + @@ -4277,8 +8892,25 @@ + The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. + gonadogenesis + biological_process + GO:0008406 gonad development + + + + The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. + GOC:ems + ISBN:0198506732 + + + + + gonadogenesis + GOC:cjm + @@ -4292,8 +8924,18 @@ + Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. + gustatory receptor + molecular_function + GO:0008527 taste receptor activity + + + + Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. + GOC:dph + @@ -4301,8 +8943,27 @@ + The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. + + biological_process + hypodermis development + GO:0008544 epidermis development + + + + The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. + GOC:go_curators + UBERON:0001003 + + + + + hypodermis development + GOC:kmv + GOC:rk + @@ -4316,8 +8977,35 @@ + The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. + + GO:0061039 + biological_process + ovarian development + ovary development + GO:0008585 female gonad development + + + + The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. + GOC:dph + GOC:jid + GOC:tb + + + + + ovarian development + GOC:sl + + + + + ovary development + GOC:sl + @@ -4326,8 +9014,28 @@ + The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + lipid anabolism + lipid biosynthesis + lipid formation + lipid synthesis + lipogenesis + biological_process + GO:0008610 lipid biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + GOC:go_curators + + + + + lipogenesis + GOC:sl + @@ -4335,8 +9043,30 @@ + The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. + jl + 2012-10-17T15:52:35Z + GO:0044243 + GO:0044712 + Wikipedia:Catabolism + breakdown + catabolism + degradation + multicellular organismal catabolic process + biological_process + single-organism catabolic process + GO:0009056 + + + catabolic process + + + + The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. + ISBN:0198547684 + @@ -4345,8 +9075,31 @@ + The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GO:0043285 + GO:0044266 + biopolymer catabolic process + macromolecule breakdown + macromolecule catabolism + macromolecule degradation + multicellular organismal macromolecule catabolic process + biological_process + GO:0009057 + macromolecule catabolic process + + + + The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah + + + + + biopolymer catabolic process + GOC:mtg_chebi_dec09 + @@ -4354,8 +9107,32 @@ + The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. + jl + 2012-10-17T15:52:18Z + GO:0044274 + GO:0044711 + formation + Wikipedia:Anabolism + anabolism + biosynthesis + synthesis + multicellular organismal biosynthetic process + biological_process + single-organism biosynthetic process + GO:0009058 + + + biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. + GOC:curators + ISBN:0198547684 + @@ -4364,8 +9141,30 @@ + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GO:0043284 + biopolymer biosynthetic process + macromolecule anabolism + macromolecule biosynthesis + macromolecule formation + macromolecule synthesis + biological_process + GO:0009059 + macromolecule biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah + + + + + biopolymer biosynthetic process + GOC:mtg_chebi_dec09 + @@ -4373,8 +9172,18 @@ + The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. + glutamine family amino acid metabolism + biological_process + GO:0009064 glutamine family amino acid metabolic process + + + + The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. + GOC:ai + @@ -4383,8 +9192,21 @@ + The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + glucan anabolism + glucan biosynthesis + glucan formation + glucan synthesis + biological_process + GO:0009250 glucan biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + GOC:go_curators + @@ -4393,8 +9215,20 @@ + The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. + glucan breakdown + glucan catabolism + glucan degradation + biological_process + GO:0009251 glucan catabolic process + + + + The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. + GOC:go_curators + @@ -4402,8 +9236,18 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. + response to thermal stimulus + biological_process + GO:0009266 response to temperature stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. + GOC:hb + @@ -4413,8 +9257,22 @@ + The controlled release of proteins from a cell. + GO:0045166 + GO:0045731 + glycoprotein secretion + protein secretion during cell fate commitment + protein secretion resulting in cell fate commitment + biological_process + GO:0009306 protein secretion + + + + The controlled release of proteins from a cell. + GOC:ai + @@ -4422,8 +9280,21 @@ + The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. + amine metabolism + biological_process + GO:0009308 + + amine metabolic process + + + + The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. + GOC:jl + ISBN:0198506732 + @@ -4431,8 +9302,21 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. + response to electromagnetic radiation stimulus + response to radiation stimulus + biological_process + GO:0009314 + Note that 'radiation' refers to electromagnetic radiation of any wavelength. response to radiation + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. + GOC:jl + Wikipedia:Electromagnetic_radiation + @@ -4441,8 +9325,21 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. + response to dehydration + response to drought + response to thirst + biological_process + drought tolerance + GO:0009414 response to water deprivation + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. + GOC:lr + @@ -4453,8 +9350,24 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. + response to water stimulus + biological_process + GO:0009415 response to water + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. + GOC:jl + + + + + response to water stimulus + GOC:dos + @@ -4462,8 +9375,19 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. + biological_process + GO:0009416 + response to light stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. + GOC:go_curators + ISBN:0582227089 + @@ -4472,8 +9396,25 @@ + The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. + 4-aminobutanoate metabolic process + 4-aminobutanoate metabolism + 4-aminobutyrate metabolic process + 4-aminobutyrate metabolism + GABA metabolic process + GABA metabolism + gamma-aminobutyric acid metabolism + biological_process + GO:0009448 + See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'. gamma-aminobutyric acid metabolic process + + + + The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. + ISBN:0198506732 + @@ -4482,8 +9423,18 @@ + The series of events in which an external stimulus is received by a cell and converted into a molecular signal. + biological_process + perception of external stimulus + GO:0009581 detection of external stimulus + + + + The series of events in which an external stimulus is received by a cell and converted into a molecular signal. + GOC:hb + @@ -4492,8 +9443,18 @@ + The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. + biological_process + perception of abiotic stimulus + GO:0009582 detection of abiotic stimulus + + + + The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. + GOC:hb + @@ -4503,8 +9464,19 @@ + The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. + detection of light + biological_process + perception of light + GO:0009583 detection of light stimulus + + + + The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. + GOC:go_curators + @@ -4512,8 +9484,19 @@ + The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. + biological_process + perception of visible light + GO:0009584 detection of visible light + + + + The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. + GOC:go_curators + ISBN:0198506732 + @@ -4523,8 +9506,19 @@ + The series of events in which a gravitational stimulus is received and converted into a molecular signal. + biological_process + perception of gravity + GO:0009590 detection of gravity + + + + The series of events in which a gravitational stimulus is received and converted into a molecular signal. + GOC:dos + GOC:hb + @@ -4538,8 +9532,22 @@ + The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. + chemoperception + detection of chemical substance + biological_process + chemoreception + perception of chemical stimulus + perception of chemical substance + GO:0009593 detection of chemical stimulus + + + + The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. + GOC:jl + @@ -4547,8 +9555,22 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. + response to environmental stimulus + biological_process + GO:0009605 + + + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to external stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. + GOC:hb + @@ -4556,8 +9578,19 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. + GO:0002245 + physiological response to wounding + biological_process + GO:0009611 response to wounding + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. + GOC:go_curators + @@ -4566,8 +9599,19 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. + mechanical stimulus response + biological_process + chemi-mechanical coupling + GO:0009612 response to mechanical stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. + GOC:hb + @@ -4575,8 +9619,23 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. + https://github.com/geneontology/go-ontology/issues/16572 + response to abiotic stress + biological_process + GO:0009628 + + + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to abiotic stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. + GOC:hb + @@ -4584,8 +9643,18 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. + response to gravitational stimulus + biological_process + GO:0009629 response to gravity + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. + GOC:hb + @@ -4599,8 +9668,22 @@ + The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. + embryogenesis and morphogenesis + Wikipedia:Morphogenesis + anatomical structure organization + morphogenesis + biological_process + GO:0009653 anatomical structure morphogenesis + + + + The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. + GOC:go_curators + ISBN:0521436125 + @@ -4608,8 +9691,20 @@ + The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. + biological_process + catechol metabolic process + catechol metabolism + GO:0009712 catechol-containing compound metabolic process + + + + The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. + GOC:sm + ISBN:0198547684 + @@ -4617,8 +9712,27 @@ + The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + GO:0009795 + embryogenesis and morphogenesis + Wikipedia:Embryogenesis + embryogenesis + embryonal development + biological_process + GO:0009790 + + + embryo development + + + + The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + GOC:go_curators + GOC:isa_complete + GOC:mtg_sensu + @@ -4632,8 +9746,18 @@ + The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. + biological_process + GO:0009791 + post-embryonic development + + + + The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. + GOC:go_curators + @@ -4641,8 +9765,20 @@ + The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. + embryogenesis + biological_process + GO:0009792 embryo development ending in birth or egg hatching + + + + The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. + GOC:go_curators + GOC:isa_complete + GOC:mtg_sensu + @@ -4656,8 +9792,21 @@ + Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + histogenesis and organogenesis + biological_process + GO:0009887 animal organ morphogenesis + + + + Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GOC:dgh + GOC:go_curators + ISBN:0471245208 + ISBN:0721662544 + @@ -4665,8 +9814,25 @@ + The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. + + + + + + histogenesis and organogenesis + Wikipedia:Histogenesis + histogenesis + biological_process + GO:0009888 tissue development + + + + The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. + ISBN:0471245208 + @@ -4691,8 +9857,21 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. + regulation of anabolism + regulation of biosynthesis + regulation of formation + regulation of synthesis + biological_process + GO:0009889 regulation of biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. + GOC:go_curators + @@ -4718,8 +9897,25 @@ + Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. + down regulation of biosynthetic process + down-regulation of biosynthetic process + downregulation of biosynthetic process + negative regulation of anabolism + negative regulation of biosynthesis + negative regulation of formation + negative regulation of synthesis + inhibition of biosynthetic process + biological_process + GO:0009890 negative regulation of biosynthetic process + + + + Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. + GOC:go_curators + @@ -4745,8 +9941,26 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. + positive regulation of anabolism + positive regulation of biosynthesis + positive regulation of formation + positive regulation of synthesis + up regulation of biosynthetic process + up-regulation of biosynthetic process + upregulation of biosynthetic process + activation of biosynthetic process + stimulation of biosynthetic process + biological_process + GO:0009891 positive regulation of biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. + GOC:go_curators + @@ -4772,8 +9986,26 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GO:0044252 + down regulation of metabolic process + down-regulation of metabolic process + downregulation of metabolic process + negative regulation of metabolism + negative regulation of organismal metabolism + inhibition of metabolic process + inhibition of organismal metabolic process + negative regulation of multicellular organismal metabolic process + biological_process + GO:0009892 negative regulation of metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GOC:go_curators + @@ -4799,8 +10031,28 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GO:0044253 + positive regulation of metabolism + up regulation of metabolic process + up-regulation of metabolic process + upregulation of metabolic process + activation of metabolic process + positive regulation of multicellular organismal metabolic process + positive regulation of organismal metabolism + stimulation of metabolic process + stimulation of organismal metabolic process + up-regulation of organismal metabolic process + biological_process + GO:0009893 positive regulation of metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GOC:go_curators + @@ -4825,8 +10077,20 @@ + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. + regulation of breakdown + regulation of catabolism + regulation of degradation + biological_process + GO:0009894 regulation of catabolic process + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. + GOC:go_curators + @@ -4852,8 +10116,24 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + down regulation of catabolic process + down-regulation of catabolic process + downregulation of catabolic process + negative regulation of breakdown + negative regulation of catabolism + negative regulation of degradation + inhibition of catabolic process + biological_process + GO:0009895 negative regulation of catabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + GOC:go_curators + @@ -4879,8 +10159,25 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + positive regulation of breakdown + positive regulation of catabolism + positive regulation of degradation + up regulation of catabolic process + up-regulation of catabolic process + upregulation of catabolic process + activation of catabolic process + stimulation of catabolic process + biological_process + GO:0009896 positive regulation of catabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + GOC:go_curators + @@ -4894,8 +10191,30 @@ + The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. + GO:0043355 + biological_process + hypodermal cell differentiation + GO:0009913 epidermal cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. + GOC:dph + GOC:go_curators + GOC:mtg_sensu + GOC:sdb_2009 + GOC:tb + + + + + hypodermal cell differentiation + GOC:kmv + GOC:rk + @@ -4904,8 +10223,18 @@ + The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0009914 + hormone transport + + + + The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:tb + @@ -4932,8 +10261,26 @@ + Any process that modulates the frequency, rate or extent of signal transduction. + GO:0035466 + biological_process + regulation of signaling pathway + regulation of signalling pathway + GO:0009966 regulation of signal transduction + + + + Any process that modulates the frequency, rate or extent of signal transduction. + GOC:sm + + + + + regulation of signalling pathway + GOC:mah + @@ -4961,8 +10308,31 @@ + Any process that activates or increases the frequency, rate or extent of signal transduction. + GO:0035468 + up regulation of signal transduction + up-regulation of signal transduction + upregulation of signal transduction + activation of signal transduction + stimulation of signal transduction + biological_process + positive regulation of signaling pathway + positive regulation of signalling pathway + GO:0009967 positive regulation of signal transduction + + + + Any process that activates or increases the frequency, rate or extent of signal transduction. + GOC:sm + + + + + positive regulation of signalling pathway + GOC:mah + @@ -4990,8 +10360,30 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. + GO:0035467 + down regulation of signal transduction + down-regulation of signal transduction + downregulation of signal transduction + inhibition of signal transduction + biological_process + negative regulation of signaling pathway + negative regulation of signalling pathway + GO:0009968 negative regulation of signal transduction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. + GOC:sm + + + + + negative regulation of signalling pathway + GOC:mah + @@ -4999,8 +10391,30 @@ + + Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + jl + 2012-12-11T16:56:55Z + GO:0008151 + GO:0044763 + GO:0050875 + cell physiology + cellular physiological process + cell growth and/or maintenance + biological_process + single-organism cellular process + GO:0009987 + + cellular process + + + + Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:go_curators + GOC:isa_complete + @@ -5008,8 +10422,20 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. + GO:1990367 + process resulting in tolerance to organic substance + biological_process + GO:0010033 response to organic substance + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. + GOC:sm + PMID:23356676 + @@ -5017,8 +10443,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. + biological_process + GO:0010035 response to inorganic substance + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. + GOC:sm + @@ -5026,8 +10461,18 @@ + The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + biological_process + GO:0010463 mesenchymal cell proliferation + + + + The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:dph + GOC:tb + @@ -5052,8 +10497,18 @@ + Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + biological_process + GO:0010464 regulation of mesenchymal cell proliferation + + + + Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:dph + GOC:tb + @@ -5061,8 +10516,22 @@ + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + https://github.com/geneontology/go-ontology/issues/22557 + Wikipedia:Gene_expression + biological_process + GO:0010467 + gene expression + + + + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + GOC:txnOH-2018 + PMID:25934543 + PMID:31580950 + @@ -5087,8 +10556,29 @@ + Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + https://github.com/geneontology/go-ontology/issues/22557 + Wikipedia:Regulation_of_gene_expression + regulation of protein expression + biological_process + gene regulation + regulation of gene product expression + GO:0010468 + This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. regulation of gene expression + + + + Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + GOC:txnOH-2018 + + + + + gene regulation + GOC:cjm + @@ -5114,8 +10604,20 @@ + Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. + regulation of receptor activity + regulation of signalling receptor activity + biological_process + GO:0010469 regulation of signaling receptor activity + + + + Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. + GOC:dph + GOC:tb + @@ -5141,8 +10643,18 @@ + Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. + biological_process + GO:0010470 regulation of gastrulation + + + + Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. + GOC:dph + GOC:tb + @@ -5168,8 +10680,18 @@ + Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + biological_process + GO:0010556 regulation of macromolecule biosynthetic process + + + + Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -5196,8 +10718,18 @@ + Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + biological_process + GO:0010557 positive regulation of macromolecule biosynthetic process + + + + Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -5224,8 +10756,18 @@ + Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + biological_process + GO:0010558 negative regulation of macromolecule biosynthetic process + + + + Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -5250,8 +10792,18 @@ + Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. + biological_process + GO:0010564 regulation of cell cycle process + + + + Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. + GOC:dph + GOC:tb + @@ -5277,8 +10829,18 @@ + Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + biological_process + GO:0010565 regulation of cellular ketone metabolic process + + + + Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + GOC:dph + GOC:tb + @@ -5304,8 +10866,18 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. + biological_process + GO:0010566 regulation of ketone biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. + GOC:dph + GOC:tb + @@ -5331,8 +10903,18 @@ + Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + biological_process + GO:0010604 positive regulation of macromolecule metabolic process + + + + Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -5358,8 +10940,18 @@ + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + biological_process + GO:0010605 negative regulation of macromolecule metabolic process + + + + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -5385,8 +10977,18 @@ + Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + https://github.com/geneontology/go-ontology/issues/22557 + biological_process + GO:0010628 positive regulation of gene expression + + + + Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + GOC:txnOH-2018 + @@ -5412,8 +11014,20 @@ + Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + https://github.com/geneontology/go-ontology/issues/22557 + biological_process + gene silencing + GO:0010629 + This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. negative regulation of gene expression + + + + Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + GOC:txnOH-2018 + @@ -5439,8 +11053,32 @@ + Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. + positive regulation of organelle organisation + biological_process + positive regulation of organelle organization and biogenesis + GO:0010638 positive regulation of organelle organization + + + + Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. + GOC:dph + GOC:tb + + + + + positive regulation of organelle organisation + GOC:mah + + + + + positive regulation of organelle organization and biogenesis + GOC:mah + @@ -5466,8 +11104,32 @@ + Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. + negative regulation of organelle organisation + biological_process + negative regulation of organelle organization and biogenesis + GO:0010639 negative regulation of organelle organization + + + + Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. + GOC:dph + GOC:tb + + + + + negative regulation of organelle organisation + GOC:mah + + + + + negative regulation of organelle organization and biogenesis + GOC:mah + @@ -5492,8 +11154,18 @@ + Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + biological_process + GO:0010646 regulation of cell communication + + + + Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:dph + GOC:tb + @@ -5519,8 +11191,18 @@ + Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + biological_process + GO:0010647 positive regulation of cell communication + + + + Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:dph + GOC:tb + @@ -5546,8 +11228,18 @@ + Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + biological_process + GO:0010648 negative regulation of cell communication + + + + Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:dph + GOC:tb + @@ -5573,8 +11265,18 @@ + Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + biological_process + GO:0010675 regulation of cellular carbohydrate metabolic process + + + + Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + GOC:dph + GOC:tb + @@ -5601,8 +11303,18 @@ + Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + biological_process + GO:0010676 positive regulation of cellular carbohydrate metabolic process + + + + Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + GOC:dph + GOC:tb + @@ -5629,8 +11341,18 @@ + Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + biological_process + GO:0010677 negative regulation of cellular carbohydrate metabolic process + + + + Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + GOC:dph + GOC:tb + @@ -5650,14 +11372,25 @@ + + Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. + biological_process + GO:0010700 negative regulation of norepinephrine secretion + + + + Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. + GOC:dph + GOC:tb + @@ -5677,14 +11410,25 @@ + + Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. + biological_process + GO:0010701 positive regulation of norepinephrine secretion + + + + Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. + GOC:dph + GOC:tb + @@ -5710,8 +11454,19 @@ + Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + biological_process + GO:0010720 positive regulation of cell development + + + + Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + GOC:BHF + GOC:dph + GOC:tb + @@ -5737,8 +11492,19 @@ + Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + biological_process + GO:0010721 negative regulation of cell development + + + + Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + GOC:BHF + GOC:dph + GOC:tb + @@ -5746,8 +11512,19 @@ + Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. + biological_process + GO:0010817 regulation of hormone levels + + + + Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. + GOC:BHF + GOC:dph + GOC:tb + @@ -5772,8 +11549,18 @@ + Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. + biological_process + GO:0010837 regulation of keratinocyte proliferation + + + + Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. + GOC:dph + GOC:tb + @@ -5799,8 +11586,18 @@ + Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. + biological_process + GO:0010838 positive regulation of keratinocyte proliferation + + + + Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. + GOC:dph + GOC:tb + @@ -5826,8 +11623,18 @@ + Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. + biological_process + GO:0010839 negative regulation of keratinocyte proliferation + + + + Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. + GOC:dph + GOC:tb + @@ -5835,8 +11642,26 @@ + Any process in which a lipid is transported to, or maintained in, a specific location. + lipid localisation + biological_process + GO:0010876 lipid localization + + + + Any process in which a lipid is transported to, or maintained in, a specific location. + GOC:BHF + GOC:dph + GOC:tb + + + + + lipid localisation + GOC:mah + @@ -5863,8 +11688,17 @@ + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + biological_process + GO:0010893 positive regulation of steroid biosynthetic process + + + + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:tb + @@ -5891,8 +11725,18 @@ + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + biological_process + GO:0010894 negative regulation of steroid biosynthetic process + + + + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:BHF + GOC:tb + @@ -5918,8 +11762,25 @@ + Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + regulation of glucose metabolism + biological_process + GO:0010906 regulation of glucose metabolic process + + + + Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + GOC:BHF + GOC:tb + + + + + regulation of glucose metabolism + GOC:tb + @@ -5946,8 +11807,25 @@ + Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + positive regulation of glucose metabolism + biological_process + GO:0010907 positive regulation of glucose metabolic process + + + + Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + GOC:BHF + GOC:tb + + + + + positive regulation of glucose metabolism + GOC:tb + @@ -5973,8 +11851,20 @@ + Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. + tb + 2009-04-27T09:53:22Z + biological_process + GO:0010948 negative regulation of cell cycle process + + + + Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. + GOC:dph + GOC:tb + @@ -6001,8 +11891,20 @@ + Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + tb + 2009-05-11T12:17:53Z + biological_process + GO:0010962 regulation of glucan biosynthetic process + + + + Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + GOC:dph + GOC:tb + @@ -6022,8 +11924,21 @@ + A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. + Wikipedia:Endomembrane_system + cellular_component + GO:0012505 + + + endomembrane system + + + + A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. + GOC:lh + @@ -6048,8 +11963,19 @@ + The lipid bilayer surrounding any membrane-bounded vesicle in the cell. + NIF_Subcellular:sao1153182838 + cellular_component + GO:0012506 vesicle membrane + + + + The lipid bilayer surrounding any membrane-bounded vesicle in the cell. + GOC:mah + GOC:vesicle + @@ -6063,8 +11989,29 @@ + The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. + GO:0014024 + primary neural tube morphogenesis + primary neurulation + biological_process + neural rod cavitation + GO:0014020 primary neural tube formation + + + + The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. + GOC:ef + ISBN:0878932585 + PMID:15327780 + + + + + primary neural tube morphogenesis + GOC:dph + @@ -6082,6 +12029,7 @@ + @@ -6089,8 +12037,18 @@ + Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. + regulation of noradrenaline secretion + biological_process + GO:0014061 regulation of norepinephrine secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. + GOC:ef + @@ -6116,8 +12074,24 @@ + Any process that modulates the frequency, rate or extent of the regulated release of serotonin. + biological_process + regulation of serotonin release + GO:0014062 regulation of serotonin secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of serotonin. + GOC:ef + + + + + regulation of serotonin release + GOC:tb + @@ -6144,8 +12118,28 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. + down regulation of serotonin secretion + down-regulation of serotonin secretion + downregulation of serotonin secretion + inhibition of serotonin secretion + biological_process + positive regulation of serotonin release + GO:0014063 negative regulation of serotonin secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. + GOC:ef + + + + + positive regulation of serotonin release + GOC:tb + @@ -6172,8 +12166,29 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. + up regulation of serotonin secretion + up-regulation of serotonin secretion + upregulation of serotonin secretion + activation of serotonin secretion + stimulation of serotonin secretion + biological_process + positive regulation of serotonin release + GO:0014064 positive regulation of serotonin secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. + GOC:ef + + + + + positive regulation of serotonin release + GOC:tb + @@ -6181,8 +12196,17 @@ + A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. + biological_process + GO:0014821 phasic smooth muscle contraction + + + + A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. + GOC:mtg_muscle + @@ -6190,8 +12214,22 @@ + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract. + + biological_process + GO:0014832 urinary bladder smooth muscle contraction + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract. + GOC:mr + GOC:mtg_muscle + PMID:11768524 + PMID:18276178 + PMID:538956 + @@ -6199,8 +12237,20 @@ + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra. + biological_process + GO:0014848 urinary tract smooth muscle contraction + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra. + GOC:ef + GOC:mtg_muscle + MA:0000325 + MSH:D014551 + @@ -6210,8 +12260,22 @@ + The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GO:0015831 + enzyme transport + biological_process + GO:0015031 + + + protein transport + + + + The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -6219,8 +12283,38 @@ + The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. + cellular_component + GO:0015629 actin cytoskeleton + + + + The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. + GOC:jl + ISBN:0395825172 + ISBN:0815316194 + + + + + + + + + + The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. + biological_process + GO:0015695 + organic cation transport + + + + + The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. + GOC:ai + @@ -6229,8 +12323,18 @@ + The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. + biological_process + GO:0015711 organic anion transport + + + + The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. + GOC:ai + GOC:krc + @@ -6238,8 +12342,17 @@ + The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0015718 monocarboxylic acid transport + + + + The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:krc + @@ -6250,8 +12363,22 @@ + The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + bile acid transport + bile salt transport + biological_process + GO:0015721 bile acid and bile salt transport + + + + The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:dph + GOC:krc + PMID:12663868 + PMID:14699511 + @@ -6260,8 +12387,18 @@ + The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0015833 + peptide transport + + + + The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -6270,8 +12407,20 @@ + The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + amine/polyamine transport + GO:0015837 + amine transport + + + + The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + ISBN:0198506732 + @@ -6280,8 +12429,18 @@ + The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GO:0015873 + biological_process + GO:0015844 monoamine transport + + + + The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -6289,8 +12448,18 @@ + The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0015849 + organic acid transport + + + + The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + ISBN:0198506732 + @@ -6298,17 +12467,40 @@ + The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. + organic alcohol transport + biological_process + GO:0015850 organic hydroxy compound transport + + + + The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. + GOC:ai + + + The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. + levarterenol transport + noradrenaline transport + biological_process + GO:0015874 norepinephrine transport + + + + The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. + GOC:ai + ISBN:0198506732 + @@ -6316,8 +12508,18 @@ + The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. + chemoorganotrophy + biological_process + GO:0015980 energy derivation by oxidation of organic compounds + + + + The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. + GOC:mah + @@ -6325,8 +12527,33 @@ + A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. + 2014-03-06T11:37:54Z + GO:0098589 + GO:0098805 + Wikipedia:Biological_membrane + membrane region + region of membrane + whole membrane + cellular_component + GO:0016020 + + + + + + + membrane + + + + A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. + GOC:dos + GOC:mah + ISBN:0815316194 + @@ -6334,8 +12561,49 @@ + A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. + GO:0044235 + GO:0071842 + cell organisation + cellular component organisation at cellular level + cellular component organisation in other organism + cellular component organization at cellular level + cellular component organization in other organism + biological_process + cell organization and biogenesis + GO:0016043 + + + + cellular component organization + + + + A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. + GOC:ai + GOC:jl + GOC:mah + + + + + cellular component organisation at cellular level + GOC:mah + + + + + cellular component organisation in other organism + GOC:mah + + + + + cell organization and biogenesis + GOC:mah + @@ -6345,8 +12613,20 @@ + The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. + detection of temperature + detection of thermal stimulus + biological_process + perception of temperature + GO:0016048 detection of temperature stimulus + + + + The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. + GOC:hb + @@ -6355,8 +12635,41 @@ + The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. + GO:0048591 + cellular growth + growth of cell + biological_process + cell expansion + metabolic process resulting in cell growth + metabolism resulting in cell growth + non-developmental cell growth + non-developmental growth of a unicellular organism + GO:0016049 + + + + cell growth + + + + The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. + GOC:ai + + + + + non-developmental cell growth + GOC:mah + + + + + non-developmental growth of a unicellular organism + GOC:mah + @@ -6364,8 +12677,27 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. + vesicle organisation + biological_process + vesicle organization and biogenesis + GO:0016050 + + vesicle organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. + GOC:mah + + + + + vesicle organization and biogenesis + GOC:mah + @@ -6374,8 +12706,24 @@ + The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + GO:0006093 + anabolic carbohydrate metabolic process + anabolic carbohydrate metabolism + carbohydrate anabolism + carbohydrate biosynthesis + carbohydrate formation + carbohydrate synthesis + biological_process + GO:0016051 carbohydrate biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + ISBN:0198506732 + @@ -6384,8 +12732,29 @@ + The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + jl + 2012-10-23T16:34:39Z + GO:0006095 + GO:0044276 + GO:0044724 + carbohydrate breakdown + carbohydrate catabolism + carbohydrate degradation + catabolic carbohydrate metabolic process + catabolic carbohydrate metabolism + multicellular organismal carbohydrate catabolic process + biological_process + single-organism carbohydrate catabolic process + GO:0016052 carbohydrate catabolic process + + + + The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + ISBN:0198506732 + @@ -6396,8 +12765,21 @@ + The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. + organic acid anabolism + organic acid biosynthesis + organic acid formation + organic acid synthesis + biological_process + GO:0016053 organic acid biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. + ISBN:0198506732 + @@ -6405,9 +12787,37 @@ - + A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. + GO:0006899 + vesicle transport + vesicular transport + nonselective vesicle transport + biological_process + protein sorting along secretory pathway + vesicle trafficking + GO:0016192 + + + + + + vesicle-mediated transport + + + + A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. + GOC:ai + GOC:mah + ISBN:08789310662000 + + + + + vesicular transport + GOC:mah + @@ -6416,8 +12826,17 @@ + The process in which the anatomical structures of embryonic epithelia are generated and organized. + biological_process + GO:0016331 morphogenesis of embryonic epithelium + + + + The process in which the anatomical structures of embryonic epithelia are generated and organized. + GOC:jl + @@ -6425,8 +12844,22 @@ + The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. + Wikipedia:Cell_migration + biological_process + GO:0016477 cell migration + + + + The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. + GOC:cjm + GOC:dph + GOC:ems + GOC:pf + Wikipedia:Cell_migration + @@ -6452,8 +12885,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. + down regulation of angiogenesis + down-regulation of angiogenesis + downregulation of angiogenesis + inhibition of angiogenesis + biological_process + GO:0016525 negative regulation of angiogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. + GOC:go_curators + @@ -6461,8 +12907,19 @@ + The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. + stem cell renewal + biological_process + GO:0017145 stem cell division + + + + The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. + GOC:jid + ISBN:0582227089 + @@ -6488,8 +12945,17 @@ + Any process that modulates the frequency, rate or extent of exocytosis. + biological_process + GO:0017157 regulation of exocytosis + + + + Any process that modulates the frequency, rate or extent of exocytosis. + GOC:go_curators + @@ -6498,8 +12964,21 @@ + The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). + heterocycle anabolism + heterocycle biosynthesis + heterocycle formation + heterocycle synthesis + biological_process + GO:0018130 heterocycle biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). + ISBN:0198547684 + @@ -6509,8 +12988,24 @@ + The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. + UM-BBD_pathwayID:phe + carbolic acid metabolic process + carbolic acid metabolism + hydroxybenzene metabolic process + hydroxybenzene metabolism + phenol-containing compound metabolism + biological_process + GO:0018958 + Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. phenol-containing compound metabolic process + + + + The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. + ISBN:0198506732 + @@ -6523,15 +13018,42 @@ - + - + + + + + + + + The specific behavior of an organism that is associated with reproduction. + https://github.com/geneontology/go-ontology/issues/23491 + jl + 2012-09-19T16:01:37Z + GO:0033057 + GO:0044704 + GO:0044705 + reproductive behavior in a multicellular organism + reproductive behaviour + multi-organism reproductive behavior + multicellular organism reproductive behavior + biological_process + single-organism reproductive behavior + GO:0019098 reproductive behavior + + + + The specific behavior of an organism that is associated with reproduction. + GOC:jl + GOC:pr + @@ -6556,8 +13078,18 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. + regulation of lipid metabolism + biological_process + GO:0019216 regulation of lipid metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. + GOC:go_curators + @@ -6582,8 +13114,18 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. + regulation of steroid metabolism + biological_process + GO:0019218 regulation of steroid metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. + GOC:go_curators + @@ -6608,8 +13150,28 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GO:0044246 + regulation of metabolism + regulation of multicellular organismal metabolic process + regulation of organismal metabolic process + biological_process + GO:0019222 + regulation of metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GOC:go_curators + + + + + regulation of organismal metabolic process + GOC:tb + @@ -6623,8 +13185,18 @@ + The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors. + Wikipedia:Proprioception + biological_process + GO:0019230 proprioception + + + + The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors. + ISBN:072168677X + @@ -6632,8 +13204,20 @@ + The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. + Wikipedia:Nociception + nociception + perception of physiological pain + biological_process + GO:0019233 sensory perception of pain + + + + The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. + GOC:curators + @@ -6641,8 +13225,18 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus. + pheromone response + biological_process + GO:0019236 response to pheromone + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus. + GOC:jl + @@ -6650,8 +13244,18 @@ + The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + hexose metabolism + biological_process + GO:0019318 hexose metabolic process + + + + The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + ISBN:0198506732 + @@ -6660,8 +13264,23 @@ + The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring. + aromatic compound anabolism + aromatic compound biosynthesis + aromatic compound formation + aromatic compound synthesis + aromatic hydrocarbon biosynthesis + aromatic hydrocarbon biosynthetic process + biological_process + GO:0019438 aromatic compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring. + GOC:ai + @@ -6670,8 +13289,19 @@ + The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. + choline metabolism + biological_process + GO:0019695 choline metabolic process + + + + The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. + GOC:jl + ISBN:0192801023 + @@ -6679,8 +13309,18 @@ + The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). + carboxylic acid metabolism + biological_process + GO:0019752 carboxylic acid metabolic process + + + + The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). + ISBN:0198506732 + @@ -6688,9 +13328,20 @@ - + A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). + https://github.com/geneontology/go-ontology/issues/22929 + Wikipedia:Sexual_reproduction + biological_process + GO:0019953 + Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. sexual reproduction + + + + A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). + Wikipedia:Sexual_reproduction + @@ -6704,8 +13355,21 @@ + The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete. + biological_process + GO:0021506 anterior neuropore closure + + + + The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -6713,8 +13377,22 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. + biological_process + GO:0021700 + developmental maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -6735,8 +13413,21 @@ + The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. + biological_process + GO:0021915 neural tube development + + + + The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -6750,8 +13441,21 @@ + The process of joining together the neural folds at either end of the neural tube. + biological_process + GO:0021995 neuropore closure + + + + The process of joining together the neural folds at either end of the neural tube. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -6765,8 +13469,38 @@ + Generation of cells within the nervous system. + Wikipedia:Neurogenesis + nervous system cell generation + biological_process + neural cell differentiation + GO:0022008 neurogenesis + + + + Generation of cells within the nervous system. + GOC:cls + GOC:curators + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + + + + + nervous system cell generation + + + + + + neural cell differentiation + GOC:BHF + GOC:dph + @@ -6791,8 +13525,19 @@ + The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. + biological_process + GO:0022402 + cell cycle process + + + + The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. + GOC:isa_complete + GOC:mtg_cell_cycle + @@ -6817,8 +13562,17 @@ + Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. + biological_process + GO:0022407 regulation of cell-cell adhesion + + + + Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. + GOC:isa_complete + @@ -6844,8 +13598,21 @@ + Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. + down regulation of cell-cell adhesion + down-regulation of cell-cell adhesion + downregulation of cell-cell adhesion + inhibition of cell-cell adhesion + biological_process + GO:0022408 negative regulation of cell-cell adhesion + + + + Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. + GOC:isa_complete + @@ -6871,8 +13638,22 @@ + Any process that activates or increases the rate or extent of cell adhesion to another cell. + up regulation of cell-cell adhesion + up-regulation of cell-cell adhesion + upregulation of cell-cell adhesion + activation of cell-cell adhesion + stimulation of cell-cell adhesion + biological_process + GO:0022409 positive regulation of cell-cell adhesion + + + + Any process that activates or increases the rate or extent of cell adhesion to another cell. + GOC:isa_complete + @@ -6886,8 +13667,17 @@ + A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. + biological_process + GO:0022410 circadian sleep/wake cycle process + + + + A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. + GOC:isa_complete + @@ -6913,8 +13703,18 @@ + A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. + reproductive cellular process in multicellular organism + biological_process + GO:0022412 cellular process involved in reproduction in multicellular organism + + + + A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. + GOC:isa_complete + @@ -6939,8 +13739,24 @@ + + A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. + jl + 2012-09-19T15:56:06Z + GO:0044702 + biological_process + single organism reproductive process + GO:0022414 + reproductive process + + + + A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. + GOC:dph + GOC:isa_complete + @@ -6965,8 +13781,20 @@ + A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + biological_process + GO:0022600 + digestive system process + + + + A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:isa_complete + GOC:jid + GOC:mtg_cardio + @@ -6992,8 +13820,19 @@ + A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. + biological_process + estrous cycle process + menstrual cycle process + GO:0022602 ovulation cycle process + + + + A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. + GOC:isa_complete + @@ -7018,17 +13857,18 @@ + Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. + regulation of morphogenesis + biological_process + GO:0022603 regulation of anatomical structure morphogenesis - - - - - - - - biological adhesion - + + + + Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. + GOC:mah + @@ -7053,8 +13893,25 @@ + Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. + 2010-02-16T09:30:50Z + biological_process + regulation of gene expression as a consequence of signal transmission + GO:0023019 signal transduction involved in regulation of gene expression + + + + Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. + GOC:mtg_signal + + + + + regulation of gene expression as a consequence of signal transmission + GOC:bf + @@ -7079,8 +13936,32 @@ + Any process that modulates the frequency, rate or extent of a signaling process. + 2010-02-16T09:30:50Z + biological_process + regulation of signaling process + regulation of signalling process + GO:0023051 regulation of signaling + + + + Any process that modulates the frequency, rate or extent of a signaling process. + GOC:mtg_signal + + + + + regulation of signaling process + GOC:bf + + + + + regulation of signalling process + GOC:mah + @@ -7088,8 +13969,43 @@ + + The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. + jl + 2010-02-16T09:30:50Z + GO:0023046 + GO:0044700 + biological signaling + signaling process + signalling + biological_process + signalling process + single organism signaling + GO:0023052 + + + + + + + + Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. signaling + + + + The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. + GOC:mtg_signal + GOC:mtg_signaling_feb11 + GOC:signaling + + + + + signalling process + GOC:mah + @@ -7115,8 +14031,32 @@ + Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. + 2010-02-16T09:30:50Z + positive regulation of signalling process + biological_process + positive regulation of signaling process + GO:0023056 positive regulation of signaling + + + + Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. + GOC:mtg_signal + + + + + positive regulation of signalling process + GOC:mah + + + + + positive regulation of signaling process + GOC:bf + @@ -7142,8 +14082,32 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. + 2010-02-16T09:30:50Z + biological_process + negative regulation of signaling process + negative regulation of signalling process + GO:0023057 negative regulation of signaling + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. + GOC:mtg_signal + + + + + negative regulation of signaling process + GOC:bf + + + + + negative regulation of signalling process + GOC:mah + @@ -7168,8 +14132,25 @@ + The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. + 2010-02-16T09:30:50Z + signal secretion + biological_process + GO:0023061 signal release + + + + The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. + GOC:mtg_signal + + + + + signal secretion + GOC:bf + @@ -7177,8 +14158,18 @@ + The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. + Wikipedia:Myofibril + cellular_component + GO:0030016 myofibril + + + + The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. + ISBN:0815316194 + @@ -7186,8 +14177,28 @@ + A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. + + Wikipedia:Cell_junction + cellular_component + GO:0030054 + + + cell junction + + + + A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. + GOC:aruk + GOC:bc + GOC:mah + ISBN:0198506732 + PMID:26820516 + PMID:28096264 + http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html + @@ -7196,8 +14207,17 @@ + The regulated release of a peptide hormone from a cell. + biological_process + GO:0030072 peptide hormone secretion + + + + The regulated release of a peptide hormone from a cell. + GOC:mah + @@ -7206,8 +14226,19 @@ + The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. + https://github.com/geneontology/go-ontology/issues/11255#issuecomment-426191045 + biological_process + GO:0030073 insulin secretion + + + + The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. + GOC:mah + ISBN:0198506732 + @@ -7215,8 +14246,23 @@ + The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. + Wikipedia:Haematopoiesis + blood cell biosynthesis + blood cell formation + haemopoiesis + hematopoiesis + biological_process + GO:0030097 hemopoiesis + + + + The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. + GOC:dgh + ISBN:0198506732 + @@ -7225,8 +14271,29 @@ + The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + GO:0046650 + lymphocyte cell differentiation + lymphocytic blood cell differentiation + biological_process + lymphocyte development + GO:0030098 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. lymphocyte differentiation + + + + The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + CL:0000542 + GOC:go_curators + + + + + lymphocyte development + GOC:add + @@ -7234,8 +14301,17 @@ + The regulated release of vasopressin from secretory granules into the blood. + biological_process + GO:0030103 vasopressin secretion + + + + The regulated release of vasopressin from secretory granules into the blood. + GOC:mah + @@ -7243,8 +14319,23 @@ + Any process involved in the maintenance of an internal steady state of water within an organism or cell. + GO:0018987 + Wikipedia:Osmoregulation + regulation of osmotic pressure + biological_process + osmoregulation + GO:0030104 water homeostasis + + + + Any process involved in the maintenance of an internal steady state of water within an organism or cell. + GOC:dph + GOC:mah + GOC:tb + @@ -7252,8 +14343,24 @@ + The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. + Wikipedia:Cellular_differentiation + biological_process + GO:0030154 + + + + + + cell differentiation + + + + The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. + ISBN:0198506732 + @@ -7278,8 +14385,18 @@ + Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. + biological_process + cell adhesion receptor regulator activity + GO:0030155 regulation of cell adhesion + + + + Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. + GOC:mah + @@ -7288,8 +14405,30 @@ + The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. + GO:0042115 + B lymphocyte differentiation + B-cell differentiation + B-lymphocyte differentiation + biological_process + B cell development + GO:0030183 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. B cell differentiation + + + + The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. + GOC:mah + GO_REF:0000022 + + + + + B cell development + GOC:add + @@ -7299,8 +14438,19 @@ + The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine). + melatonin metabolism + biological_process + GO:0030186 melatonin metabolic process + + + + The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine). + GOC:mah + ISBN:0198506732 + @@ -7311,8 +14461,22 @@ + The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine). + melatonin anabolism + melatonin biosynthesis + melatonin formation + melatonin synthesis + biological_process + GO:0030187 melatonin biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine). + GOC:mah + ISBN:0198506732 + @@ -7340,8 +14504,17 @@ + Any process that modulates the frequency, rate or extent of blood coagulation. + biological_process + GO:0030193 regulation of blood coagulation + + + + Any process that modulates the frequency, rate or extent of blood coagulation. + GOC:mah + @@ -7369,8 +14542,22 @@ + Any process that activates or increases the frequency, rate or extent of blood coagulation. + up regulation of blood coagulation + up-regulation of blood coagulation + upregulation of blood coagulation + activation of blood coagulation + stimulation of blood coagulation + biological_process + GO:0030194 positive regulation of blood coagulation + + + + Any process that activates or increases the frequency, rate or extent of blood coagulation. + GOC:mah + @@ -7398,8 +14585,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation. + down regulation of blood coagulation + down-regulation of blood coagulation + downregulation of blood coagulation + inhibition of blood coagulation + biological_process + GO:0030195 negative regulation of blood coagulation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation. + GOC:mah + @@ -7408,8 +14608,28 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. + extracellular matrix organisation + biological_process + extracellular matrix organization and biogenesis + GO:0030198 + + + extracellular matrix organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. + GOC:mah + + + + + extracellular matrix organization and biogenesis + GOC:mah + @@ -7417,8 +14637,18 @@ + The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. + glycosaminoglycan metabolism + biological_process + GO:0030203 glycosaminoglycan metabolic process + + + + The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. + ISBN:0192800981 + @@ -7432,8 +14662,21 @@ + The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. + keratinocyte cell differentiation + biological_process + GO:0030216 keratinocyte differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. + GOC:dph + GOC:mah + GOC:sdb_2009 + GOC:tb + @@ -7442,8 +14685,32 @@ + The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. + GO:0042112 + GO:0046652 + T lymphocyte differentiation + T-cell differentiation + T-lymphocyte differentiation + biological_process + T cell development + GO:0030217 + Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. T cell differentiation + + + + The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. + GOC:jid + GOC:mah + GO_REF:0000022 + + + + + T cell development + GOC:add + @@ -7468,8 +14735,19 @@ + Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + regulation of bone biosynthesis + regulation of bone formation + biological_process + GO:0030278 regulation of ossification + + + + Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:go_curators + @@ -7495,8 +14773,23 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + down regulation of ossification + down-regulation of ossification + downregulation of ossification + negative regulation of bone biosynthesis + negative regulation of bone formation + inhibition of ossification + biological_process + GO:0030279 negative regulation of ossification + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:go_curators + @@ -7510,8 +14803,19 @@ + The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. + bone calcification + biological_process + GO:0030282 bone mineralization + + + + The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. + GOC:mah + PMID:22936354 + @@ -7538,8 +14842,22 @@ + Any process that activates or increases the frequency, rate, extent or direction of cell growth. + up regulation of cell growth + up-regulation of cell growth + upregulation of cell growth + activation of cell growth + stimulation of cell growth + biological_process + GO:0030307 positive regulation of cell growth + + + + Any process that activates or increases the frequency, rate, extent or direction of cell growth. + GOC:go_curators + @@ -7566,8 +14884,21 @@ + Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. + down regulation of cell growth + down-regulation of cell growth + downregulation of cell growth + inhibition of cell growth + biological_process + GO:0030308 negative regulation of cell growth + + + + Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. + GOC:go_curators + @@ -7581,8 +14912,23 @@ + A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. + cellular_component + GO:0030312 + + + + + + The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. external encapsulating structure + + + + A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. + GOC:go_curators + @@ -7592,8 +14938,43 @@ + The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. + GO:0097724 + GO:1905419 + sperm motility + sperm movement + Wikipedia:Sperm_motility + flagellated sperm movement + sperm flagellum movement + sperm flagellum movement involved in flagellated sperm motility + sperm flagellum movement involved in flagellated sperm movement + biological_process + GO:0030317 flagellated sperm motility + + + + The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000060 + PMID:26680031 + + + + + sperm flagellum movement + GOC:cilia + GOC:krc + + + + + sperm flagellum movement involved in flagellated sperm movement + GOC:TermGenie + @@ -7618,8 +14999,17 @@ + Any process that modulates the frequency, rate or extent of cell migration. + biological_process + GO:0030334 regulation of cell migration + + + + Any process that modulates the frequency, rate or extent of cell migration. + GOC:go_curators + @@ -7645,8 +15035,22 @@ + Any process that activates or increases the frequency, rate or extent of cell migration. + up regulation of cell migration + up-regulation of cell migration + upregulation of cell migration + activation of cell migration + stimulation of cell migration + biological_process + GO:0030335 positive regulation of cell migration + + + + Any process that activates or increases the frequency, rate or extent of cell migration. + GOC:go_curators + @@ -7672,8 +15076,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. + down regulation of cell migration + down-regulation of cell migration + downregulation of cell migration + inhibition of cell migration + biological_process + GO:0030336 negative regulation of cell migration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. + GOC:go_curators + @@ -7681,8 +15098,19 @@ + + The expulsion of feces from the rectum. + Wikipedia:Defecation + biological_process + GO:0030421 defecation + + + + The expulsion of feces from the rectum. + GOC:mah + @@ -7690,8 +15118,20 @@ + The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. + NIF_Subcellular:sao1770195789 + Wikipedia:Axon + cellular_component + GO:0030424 axon + + + + The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. + GOC:nln + ISBN:0198506732 + @@ -7705,8 +15145,24 @@ + A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. + NIF_Subcellular:sao1211023249 + Wikipedia:Dendrite + cellular_component + GO:0030425 dendrite + + + + A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. + GOC:aruk + GOC:bc + GOC:dos + GOC:mah + GOC:nln + ISBN:0198506732 + @@ -7714,8 +15170,22 @@ + Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. + Wikipedia:Sleep + biological_process + diapause + dormancy + lethargus + GO:0030431 + sleep + + + + Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. + ISBN:0192800981 + @@ -7723,8 +15193,18 @@ + A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. + Wikipedia:Peristalsis + biological_process + GO:0030432 peristalsis + + + + A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. + ISBN:0198506732 + @@ -7750,8 +15230,17 @@ + Any process that modulates the frequency, rate or extent of bone mineralization. + biological_process + GO:0030500 regulation of bone mineralization + + + + Any process that modulates the frequency, rate or extent of bone mineralization. + GOC:go_curators + @@ -7778,8 +15267,22 @@ + Any process that activates or increases the frequency, rate or extent of bone mineralization. + up regulation of bone mineralization + up-regulation of bone mineralization + upregulation of bone mineralization + activation of bone mineralization + stimulation of bone mineralization + biological_process + GO:0030501 positive regulation of bone mineralization + + + + Any process that activates or increases the frequency, rate or extent of bone mineralization. + GOC:go_curators + @@ -7806,8 +15309,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization. + down regulation of bone mineralization + down-regulation of bone mineralization + downregulation of bone mineralization + inhibition of bone mineralization + biological_process + GO:0030502 negative regulation of bone mineralization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization. + GOC:go_curators + @@ -7832,8 +15348,17 @@ + The lipid bilayer surrounding a cytoplasmic vesicle. + cellular_component + GO:0030659 cytoplasmic vesicle membrane + + + + The lipid bilayer surrounding a cytoplasmic vesicle. + GOC:mah + @@ -7847,8 +15372,18 @@ + The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. + biological_process + GO:0030855 epithelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. + GOC:ecd + PMID:11839751 + @@ -7874,8 +15409,17 @@ + Any process that modulates the frequency, rate or extent of epithelial cell differentiation. + biological_process + GO:0030856 regulation of epithelial cell differentiation + + + + Any process that modulates the frequency, rate or extent of epithelial cell differentiation. + GOC:mah + @@ -7901,8 +15445,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. + down regulation of epithelial cell differentiation + down-regulation of epithelial cell differentiation + downregulation of epithelial cell differentiation + inhibition of epithelial cell differentiation + biological_process + GO:0030857 negative regulation of epithelial cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. + GOC:mah + @@ -7928,8 +15485,22 @@ + Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. + up regulation of epithelial cell differentiation + up-regulation of epithelial cell differentiation + upregulation of epithelial cell differentiation + activation of epithelial cell differentiation + stimulation of epithelial cell differentiation + biological_process + GO:0030858 positive regulation of epithelial cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. + GOC:mah + @@ -7937,8 +15508,24 @@ + The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. + mammogenesis + biological_process + GO:0030879 mammary gland development + + + + The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. + PMID:9576833 + + + + + mammogenesis + GOC:dph + @@ -7964,8 +15551,20 @@ + Any process that modulates the frequency, rate or extent of B cell proliferation. + regulation of B lymphocyte proliferation + regulation of B-cell proliferation + regulation of B-lymphocyte proliferation + biological_process + GO:0030888 regulation of B cell proliferation + + + + Any process that modulates the frequency, rate or extent of B cell proliferation. + GOC:mah + @@ -7992,8 +15591,24 @@ + Any process that stops, prevents or reduces the rate or extent of B cell proliferation. + down regulation of B cell proliferation + down-regulation of B cell proliferation + downregulation of B cell proliferation + negative regulation of B lymphocyte proliferation + negative regulation of B-cell proliferation + negative regulation of B-lymphocyte proliferation + inhibition of B cell proliferation + biological_process + GO:0030889 negative regulation of B cell proliferation + + + + Any process that stops, prevents or reduces the rate or extent of B cell proliferation. + GOC:mah + @@ -8020,8 +15635,25 @@ + Any process that activates or increases the rate or extent of B cell proliferation. + positive regulation of B lymphocyte proliferation + positive regulation of B-cell proliferation + positive regulation of B-lymphocyte proliferation + up regulation of B cell proliferation + up-regulation of B cell proliferation + upregulation of B cell proliferation + activation of B cell proliferation + stimulation of B cell proliferation + biological_process + GO:0030890 positive regulation of B cell proliferation + + + + Any process that activates or increases the rate or extent of B cell proliferation. + GOC:mah + @@ -8029,8 +15661,26 @@ + A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. + intraflagellar transport complex + intraflagellar transport particle + cellular_component + IFT complex + GO:0030990 + + Note that we deem cilia and microtubule-based flagella to be equivalent. intraciliary transport particle + + + + A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. + GOC:cilia + GOC:kmv + PMID:14570576 + PMID:22118932 + PMID:23945166 + @@ -8038,8 +15688,32 @@ + A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. + GO:0005578 + NIF_Subcellular:nlx_subcell_20090513 + Wikipedia:Extracellular_matrix + proteinaceous extracellular matrix + matrisome + cellular_component + GO:0031012 + + + + + extracellular matrix + + + + A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. + GOC:BHF + GOC:mah + GOC:rph + NIF_Subcellular:nlx_subcell_20090513 + PMID:21123617 + PMID:28089324 + @@ -8064,8 +15738,26 @@ + A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. + NIF_Subcellular:sao830981606 + cellular_component + intracellular membrane + GO:0031090 organelle membrane + + + + A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. + GOC:dos + GOC:mah + + + + + intracellular membrane + NIF_Subcellular:sao830981606 + @@ -8073,8 +15765,19 @@ + The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass). + Wikipedia:Regeneration_(biology) + biological_process + GO:0031099 regeneration + + + + The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass). + GOC:mah + GOC:pr + @@ -8089,8 +15792,18 @@ + Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. + Wikipedia:Biomineralization + biological_process + GO:0031214 biomineral tissue development + + + + Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. + PMID:15132736 + @@ -8116,8 +15829,19 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + regulation of cellular metabolism + biological_process + GO:0031323 + regulation of cellular metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + GOC:mah + @@ -8144,8 +15868,23 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + down regulation of cellular metabolic process + down-regulation of cellular metabolic process + downregulation of cellular metabolic process + negative regulation of cellular metabolism + inhibition of cellular metabolic process + biological_process + GO:0031324 + negative regulation of cellular metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + GOC:mah + @@ -8172,8 +15911,24 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + positive regulation of cellular metabolism + up regulation of cellular metabolic process + up-regulation of cellular metabolic process + upregulation of cellular metabolic process + activation of cellular metabolic process + stimulation of cellular metabolic process + biological_process + GO:0031325 + positive regulation of cellular metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + GOC:mah + @@ -8199,8 +15954,21 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + regulation of cellular anabolism + regulation of cellular biosynthesis + regulation of cellular formation + regulation of cellular synthesis + biological_process + GO:0031326 regulation of cellular biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:mah + @@ -8227,8 +15995,25 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + down regulation of cellular biosynthetic process + down-regulation of cellular biosynthetic process + downregulation of cellular biosynthetic process + negative regulation of cellular anabolism + negative regulation of cellular biosynthesis + negative regulation of cellular formation + negative regulation of cellular synthesis + inhibition of cellular biosynthetic process + biological_process + GO:0031327 negative regulation of cellular biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:mah + @@ -8255,8 +16040,26 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + positive regulation of cellular anabolism + positive regulation of cellular biosynthesis + positive regulation of cellular formation + positive regulation of cellular synthesis + up regulation of cellular biosynthetic process + up-regulation of cellular biosynthetic process + upregulation of cellular biosynthetic process + activation of cellular biosynthetic process + stimulation of cellular biosynthetic process + biological_process + GO:0031328 positive regulation of cellular biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:mah + @@ -8282,8 +16085,20 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + regulation of cellular breakdown + regulation of cellular catabolism + regulation of cellular degradation + biological_process + GO:0031329 regulation of cellular catabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:mah + @@ -8310,8 +16125,24 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + down regulation of cellular catabolic process + down-regulation of cellular catabolic process + downregulation of cellular catabolic process + negative regulation of cellular breakdown + negative regulation of cellular catabolism + negative regulation of cellular degradation + inhibition of cellular catabolic process + biological_process + GO:0031330 negative regulation of cellular catabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:mah + @@ -8338,8 +16169,25 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + positive regulation of cellular breakdown + positive regulation of cellular catabolism + positive regulation of cellular degradation + up regulation of cellular catabolic process + up-regulation of cellular catabolic process + upregulation of cellular catabolic process + activation of cellular catabolic process + stimulation of cellular catabolic process + biological_process + GO:0031331 positive regulation of cellular catabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:mah + @@ -8365,8 +16213,17 @@ + Any process that modulates the frequency, rate or extent of vesicle fusion. + biological_process + GO:0031338 regulation of vesicle fusion + + + + Any process that modulates the frequency, rate or extent of vesicle fusion. + GOC:mah + @@ -8393,8 +16250,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. + down regulation of vesicle fusion + down-regulation of vesicle fusion + downregulation of vesicle fusion + inhibition of vesicle fusion + biological_process + GO:0031339 negative regulation of vesicle fusion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. + GOC:mah + @@ -8421,8 +16291,22 @@ + Any process that activates or increases the frequency, rate or extent of vesicle fusion. + up regulation of vesicle fusion + up-regulation of vesicle fusion + upregulation of vesicle fusion + activation of vesicle fusion + stimulation of vesicle fusion + biological_process + GO:0031340 positive regulation of vesicle fusion + + + + Any process that activates or increases the frequency, rate or extent of vesicle fusion. + GOC:mah + @@ -8447,8 +16331,17 @@ + Any process that modulates the frequency, rate or extent of a defense response. + biological_process + GO:0031347 regulation of defense response + + + + Any process that modulates the frequency, rate or extent of a defense response. + GOC:mah + @@ -8474,8 +16367,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. + down regulation of defense response + down-regulation of defense response + downregulation of defense response + inhibition of defense response + biological_process + GO:0031348 negative regulation of defense response + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. + GOC:mah + @@ -8501,8 +16407,22 @@ + Any process that activates or increases the frequency, rate or extent of a defense response. + up regulation of defense response + up-regulation of defense response + upregulation of defense response + activation of defense response + stimulation of defense response + biological_process + GO:0031349 positive regulation of defense response + + + + Any process that activates or increases the frequency, rate or extent of a defense response. + GOC:mah + @@ -8527,17 +16447,50 @@ + A vesicle found in the cytoplasm of a cell. + GO:0016023 + NIF_Subcellular:sao180601769 + cellular_component + cytoplasmic membrane bounded vesicle + cytoplasmic membrane-enclosed vesicle + cytoplasmic, membrane-bounded vesicle + GO:0031410 + + + + + + cytoplasmic vesicle + + + + A vesicle found in the cytoplasm of a cell. + GOC:ai + GOC:mah + GOC:vesicles + - + + Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases. + buoyancy regulation + biological_process + GO:0031413 regulation of buoyancy + + + + Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases. + GOC:mah + PATO:0001420 + @@ -8551,8 +16504,20 @@ + The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. + biological_process + GO:0031424 keratinization + + + + The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. + GOC:dph + GOC:ebc + GOC:sdb_2009 + GOC:tb + @@ -8577,8 +16542,29 @@ + Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. + regulation of neurological process + regulation of neurological system process + regulation of neurophysiological process + biological_process + GO:0031644 regulation of nervous system process + + + + Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. + GOC:dph + GOC:mah + GOC:tb + + + + + regulation of neurological process + GOC:dph + GOC:tb + @@ -8604,8 +16590,33 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. + down regulation of neurological process + down-regulation of neurological process + downregulation of neurological process + negative regulation of neurological process + negative regulation of neurological system process + negative regulation of neurophysiological process + inhibition of neurological process + biological_process + GO:0031645 negative regulation of nervous system process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. + GOC:dph + GOC:mah + GOC:tb + + + + + negative regulation of neurological process + GOC:dph + GOC:tb + @@ -8631,8 +16642,34 @@ + Any process that activates or increases the frequency, rate or extent of a neurophysiological process. + positive regulation of neurological process + positive regulation of neurological system process + positive regulation of neurophysiological process + up regulation of neurological process + up-regulation of neurological process + upregulation of neurological process + activation of neurological process + stimulation of neurological process + biological_process + GO:0031646 positive regulation of nervous system process + + + + Any process that activates or increases the frequency, rate or extent of a neurophysiological process. + GOC:dph + GOC:mah + GOC:tb + + + + + positive regulation of neurological process + GOC:dph + GOC:tb + @@ -8659,8 +16696,18 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. + regulation of glucocorticoid metabolism + biological_process + GO:0031943 regulation of glucocorticoid metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. + GOC:mah + @@ -8688,8 +16735,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. + down regulation of glucocorticoid metabolic process + down-regulation of glucocorticoid metabolic process + downregulation of glucocorticoid metabolic process + negative regulation of glucocorticoid metabolism + inhibition of glucocorticoid metabolic process + biological_process + GO:0031944 negative regulation of glucocorticoid metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. + GOC:mah + @@ -8717,8 +16778,23 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. + positive regulation of glucocorticoid metabolism + up regulation of glucocorticoid metabolic process + up-regulation of glucocorticoid metabolic process + upregulation of glucocorticoid metabolic process + activation of glucocorticoid metabolic process + stimulation of glucocorticoid metabolic process + biological_process + GO:0031945 positive regulation of glucocorticoid metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. + GOC:mah + @@ -8744,8 +16820,17 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. + biological_process + GO:0031946 regulation of glucocorticoid biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. + GOC:mah + @@ -8772,8 +16857,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. + down regulation of glucocorticoid biosynthetic process + down-regulation of glucocorticoid biosynthetic process + downregulation of glucocorticoid biosynthetic process + inhibition of glucocorticoid biosynthetic process + biological_process + GO:0031947 negative regulation of glucocorticoid biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. + GOC:mah + @@ -8800,8 +16898,22 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. + up regulation of glucocorticoid biosynthetic process + up-regulation of glucocorticoid biosynthetic process + upregulation of glucocorticoid biosynthetic process + activation of glucocorticoid biosynthetic process + stimulation of glucocorticoid biosynthetic process + biological_process + GO:0031948 positive regulation of glucocorticoid biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. + GOC:mah + @@ -8826,8 +16938,19 @@ + Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. + NIF_Subcellular:sao1687101204 + cellular_component + GO:0031965 nuclear membrane + + + + Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. + GOC:mah + GOC:pz + @@ -8847,8 +16970,19 @@ + A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. + cellular_component + GO:0031967 + organelle envelope + + + + A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. + GOC:mah + GOC:pz + @@ -8856,8 +16990,18 @@ + A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. + cellular_component + GO:0031975 envelope + + + + A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. + GOC:mah + GOC:pz + @@ -8865,8 +17009,25 @@ + Any small, fluid-filled, spherical organelle enclosed by membrane. + GO:0031988 + NIF_Subcellular:sao221389602 + Wikipedia:Vesicle_(biology) + cellular_component + membrane-bounded vesicle + membrane-enclosed vesicle + GO:0031982 + vesicle + + + + Any small, fluid-filled, spherical organelle enclosed by membrane. + GOC:mah + GOC:pz + GOC:vesicles + @@ -8891,8 +17052,18 @@ + Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + locomotion during locomotory behaviour + biological_process + GO:0031987 locomotion involved in locomotory behavior + + + + Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:mah + @@ -8919,8 +17090,22 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. + up regulation of insulin secretion + up-regulation of insulin secretion + upregulation of insulin secretion + activation of insulin secretion + stimulation of insulin secretion + biological_process + GO:0032024 positive regulation of insulin secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. + GOC:mah + @@ -8945,8 +17130,19 @@ + Any process that modulates the frequency, rate or extent of a response to an external stimulus. + biological_process + GO:0032101 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of response to external stimulus + + + + Any process that modulates the frequency, rate or extent of a response to an external stimulus. + GOC:mah + @@ -8972,8 +17168,23 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. + down regulation of response to external stimulus + down-regulation of response to external stimulus + downregulation of response to external stimulus + inhibition of response to external stimulus + biological_process + GO:0032102 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. negative regulation of response to external stimulus + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. + GOC:mah + @@ -8999,8 +17210,24 @@ + Any process that activates, maintains or increases the rate of a response to an external stimulus. + up regulation of response to external stimulus + up-regulation of response to external stimulus + upregulation of response to external stimulus + activation of response to external stimulus + stimulation of response to external stimulus + biological_process + GO:0032103 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. positive regulation of response to external stimulus + + + + Any process that activates, maintains or increases the rate of a response to an external stimulus. + GOC:mah + @@ -9026,8 +17253,17 @@ + Any process that modulates the frequency, rate or extent of chondrocyte differentiation. + biological_process + GO:0032330 regulation of chondrocyte differentiation + + + + Any process that modulates the frequency, rate or extent of chondrocyte differentiation. + GOC:mah + @@ -9054,8 +17290,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. + down regulation of chondrocyte differentiation + down-regulation of chondrocyte differentiation + downregulation of chondrocyte differentiation + inhibition of chondrocyte differentiation + biological_process + GO:0032331 negative regulation of chondrocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. + GOC:mah + @@ -9082,8 +17331,22 @@ + Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. + up regulation of chondrocyte differentiation + up-regulation of chondrocyte differentiation + upregulation of chondrocyte differentiation + activation of chondrocyte differentiation + stimulation of chondrocyte differentiation + biological_process + GO:0032332 positive regulation of chondrocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. + GOC:mah + @@ -9096,8 +17359,18 @@ + The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. + aldosterone metabolism + biological_process + GO:0032341 aldosterone metabolic process + + + + The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. + PMID:16527843 + @@ -9111,8 +17384,17 @@ + The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. + biological_process + GO:0032342 aldosterone biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. + PMID:16527843 + @@ -9139,8 +17421,18 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. + regulation of aldosterone metabolism + biological_process + GO:0032344 regulation of aldosterone metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. + GOC:mah + @@ -9169,8 +17461,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. + down regulation of aldosterone metabolic process + down-regulation of aldosterone metabolic process + downregulation of aldosterone metabolic process + negative regulation of aldosterone metabolism + inhibition of aldosterone metabolic process + biological_process + GO:0032345 negative regulation of aldosterone metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. + GOC:mah + @@ -9199,8 +17505,23 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. + positive regulation of aldosterone metabolism + up regulation of aldosterone metabolic process + up-regulation of aldosterone metabolic process + upregulation of aldosterone metabolic process + activation of aldosterone metabolic process + stimulation of aldosterone metabolic process + biological_process + GO:0032346 positive regulation of aldosterone metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. + GOC:mah + @@ -9228,8 +17549,17 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. + biological_process + GO:0032347 regulation of aldosterone biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. + GOC:mah + @@ -9257,8 +17587,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. + down regulation of aldosterone biosynthetic process + down-regulation of aldosterone biosynthetic process + downregulation of aldosterone biosynthetic process + inhibition of aldosterone biosynthetic process + biological_process + GO:0032348 negative regulation of aldosterone biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. + GOC:mah + @@ -9286,8 +17629,22 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. + up regulation of aldosterone biosynthetic process + up-regulation of aldosterone biosynthetic process + upregulation of aldosterone biosynthetic process + activation of aldosterone biosynthetic process + stimulation of aldosterone biosynthetic process + biological_process + GO:0032349 positive regulation of aldosterone biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. + GOC:mah + @@ -9313,8 +17670,18 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. + regulation of hormone metabolism + biological_process + GO:0032350 regulation of hormone metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. + GOC:mah + @@ -9340,8 +17707,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone. + down regulation of hormone metabolic process + down-regulation of hormone metabolic process + downregulation of hormone metabolic process + negative regulation of hormone metabolism + inhibition of hormone metabolic process + biological_process + GO:0032351 negative regulation of hormone metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone. + GOC:mah + @@ -9367,8 +17748,23 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone. + positive regulation of hormone metabolism + up regulation of hormone metabolic process + up-regulation of hormone metabolic process + upregulation of hormone metabolic process + activation of hormone metabolic process + stimulation of hormone metabolic process + biological_process + GO:0032352 positive regulation of hormone metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone. + GOC:mah + @@ -9395,8 +17791,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. + down regulation of hormone biosynthetic process + down-regulation of hormone biosynthetic process + downregulation of hormone biosynthetic process + inhibition of hormone biosynthetic process + biological_process + GO:0032353 negative regulation of hormone biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. + GOC:ai + @@ -9422,8 +17831,17 @@ + Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0032368 regulation of lipid transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -9450,8 +17868,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + down regulation of lipid transport + down-regulation of lipid transport + downregulation of lipid transport + inhibition of lipid transport + biological_process + GO:0032369 negative regulation of lipid transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -9478,8 +17909,22 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + up regulation of lipid transport + up-regulation of lipid transport + upregulation of lipid transport + activation of lipid transport + stimulation of lipid transport + biological_process + GO:0032370 positive regulation of lipid transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -9499,8 +17944,26 @@ + An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. + GO:0000141 + GO:0030482 + cellular_component + actin cable + GO:0032432 actin filament bundle + + + + An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. + GOC:mah + + + + + actin cable + GOC:mah + @@ -9508,8 +17971,33 @@ + + Any biological process, occurring at the level of a multicellular organism, pertinent to its function. + + + + + jl + 2012-09-19T16:07:47Z + GO:0044707 + GO:0050874 + organismal physiological process + biological_process + single-multicellular organism process + GO:0032501 + + multicellular organismal process + + + + Any biological process, occurring at the level of a multicellular organism, pertinent to its function. + GOC:curators + GOC:dph + GOC:isa_complete + GOC:tb + @@ -9517,8 +18005,26 @@ + + A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. + jl + 2012-12-19T12:21:31Z + GO:0044767 + development + biological_process + single-organism developmental process + GO:0032502 + + + developmental process + + + + A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. + GOC:isa_complete + @@ -9527,8 +18033,19 @@ + The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. + biological_process + GO:0032504 + multicellular organism reproduction + + + + The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. + GOC:isa_complete + GOC:jid + @@ -9536,8 +18053,20 @@ + The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). + monocarboxylate metabolic process + monocarboxylic acid metabolism + biological_process + GO:0032787 + monocarboxylic acid metabolic process + + + + The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). + GOC:vk + @@ -9562,8 +18091,18 @@ + All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. + cellular_component + GO:0032838 plasma membrane bounded cell projection cytoplasm + + + + All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. + GOC:krc + GOC:mah + @@ -9588,8 +18127,19 @@ + All of the contents of a dendrite, excluding the surrounding plasma membrane. + https://github.com/geneontology/go-ontology/issues/14472 + dendritic cytoplasm + cellular_component + GO:0032839 dendrite cytoplasm + + + + All of the contents of a dendrite, excluding the surrounding plasma membrane. + GOC:mah + @@ -9614,8 +18164,24 @@ + Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. + regulation of localisation + biological_process + GO:0032879 regulation of localization + + + + Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. + GOC:mah + + + + + regulation of localisation + GOC:mah + @@ -9633,15 +18199,46 @@ - + + Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. + https://github.com/geneontology/go-ontology/issues/22021 + jl + 2015-01-20T14:32:14Z + GO:1903827 + regulation of cellular protein localisation + regulation of cellular protein localization + regulation of protein localisation + biological_process + GO:0032880 + regulation of protein localization + + + + Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. + GOC:dph + GOC:mah + GOC:tb + + + + + regulation of cellular protein localisation + GOC:TermGenie + + + + + regulation of protein localisation + GOC:mah + @@ -9667,8 +18264,17 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. + biological_process + GO:0032881 regulation of polysaccharide metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. + GOC:mah + @@ -9695,8 +18301,17 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. + biological_process + GO:0032885 regulation of polysaccharide biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. + GOC:mah + @@ -9721,8 +18336,17 @@ + Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. + biological_process + GO:0032886 regulation of microtubule-based process + + + + Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. + GOC:mah + @@ -9747,8 +18371,17 @@ + Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0032890 regulation of organic acid transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -9774,8 +18407,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + down regulation of organic acid transport + down-regulation of organic acid transport + downregulation of organic acid transport + inhibition of organic acid transport + biological_process + GO:0032891 negative regulation of organic acid transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -9801,8 +18447,22 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + up regulation of organic acid transport + up-regulation of organic acid transport + upregulation of organic acid transport + activation of organic acid transport + stimulation of organic acid transport + biological_process + GO:0032892 positive regulation of organic acid transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -9811,8 +18471,19 @@ + The controlled release of a substance by a cell. + Wikipedia:Secretion + cellular secretion + biological_process + GO:0032940 secretion by cell + + + + The controlled release of a substance by a cell. + GOC:mah + @@ -9821,8 +18492,25 @@ + The controlled release of a substance by a tissue. + tissue secretion + biological_process + expulsion of gland contents + GO:0032941 secretion by tissue + + + + The controlled release of a substance by a tissue. + GOC:mah + + + + + expulsion of gland contents + GOC:mah + @@ -9830,8 +18518,19 @@ + The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. + PBMC proliferation + peripheral blood mononuclear cell proliferation + biological_process + GO:0032943 mononuclear cell proliferation + + + + The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. + GOC:add + @@ -9856,8 +18555,19 @@ + Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. + regulation of PBMC proliferation + regulation of peripheral blood mononuclear cell proliferation + biological_process + GO:0032944 regulation of mononuclear cell proliferation + + + + Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. + GOC:add + @@ -9883,8 +18593,19 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation. + negative regulation of PBMC proliferation + negative regulation of peripheral blood mononuclear cell proliferation + biological_process + GO:0032945 negative regulation of mononuclear cell proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation. + GOC:add + @@ -9910,8 +18631,24 @@ + Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. + up regulation of mononuclear cell proliferation + up-regulation of mononuclear cell proliferation + upregulation of mononuclear cell proliferation + activation of mononuclear cell proliferation + positive regulation of PBMC proliferation + positive regulation of peripheral blood mononuclear cell proliferation + stimulation of mononuclear cell proliferation + biological_process + GO:0032946 positive regulation of mononuclear cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. + GOC:add + @@ -9919,8 +18656,30 @@ + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. + GO:0043234 + macromolecular complex + macromolecule complex + protein containing complex + protein complex + protein-protein complex + cellular_component + GO:0032991 + + + + + + A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. protein-containing complex + + + + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. + GOC:dos + GOC:mah + @@ -9928,8 +18687,25 @@ + Any process in which a macromolecule is transported to, or maintained in, a specific location. + macromolecule localisation + biological_process + GO:0033036 + macromolecule localization + + + + Any process in which a macromolecule is transported to, or maintained in, a specific location. + GOC:mah + + + + + macromolecule localisation + GOC:mah + @@ -9954,8 +18730,32 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. + regulation of organelle organisation + biological_process + regulation of organelle organization and biogenesis + GO:0033043 + regulation of organelle organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. + GOC:mah + + + + + regulation of organelle organisation + GOC:mah + + + + + regulation of organelle organization and biogenesis + GOC:mah + @@ -9981,8 +18781,18 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. + regulation of amine metabolism + biological_process + GO:0033238 regulation of cellular amine metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. + GOC:mah + @@ -10009,8 +18819,18 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines. + negative regulation of amine metabolism + biological_process + GO:0033239 negative regulation of cellular amine metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines. + GOC:mah + @@ -10037,8 +18857,18 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. + positive regulation of amine metabolism + biological_process + GO:0033240 positive regulation of cellular amine metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. + GOC:mah + @@ -10065,8 +18895,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. + down regulation of catecholamine secretion + down-regulation of catecholamine secretion + downregulation of catecholamine secretion + inhibition of catecholamine secretion + biological_process + GO:0033604 negative regulation of catecholamine secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. + GOC:mah + @@ -10093,8 +18936,22 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. + up regulation of catecholamine secretion + up-regulation of catecholamine secretion + upregulation of catecholamine secretion + activation of catecholamine secretion + stimulation of catecholamine secretion + biological_process + GO:0033605 positive regulation of catecholamine secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. + GOC:mah + @@ -10105,8 +18962,23 @@ + The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell. + cellular glycan biosynthesis + cellular glycan biosynthetic process + cellular polysaccharide anabolism + cellular polysaccharide biosynthesis + cellular polysaccharide formation + cellular polysaccharide synthesis + biological_process + GO:0033692 cellular polysaccharide biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell. + GOC:go_curators + @@ -10132,8 +19004,18 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. + regulation of amide metabolism + biological_process + GO:0034248 regulation of cellular amide metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. + GOC:mah + @@ -10160,8 +19042,18 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. + negative regulation of amide metabolism + biological_process + GO:0034249 negative regulation of cellular amide metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. + GOC:mah + @@ -10188,8 +19080,18 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. + positive regulation of amide metabolism + biological_process + GO:0034250 positive regulation of cellular amide metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. + GOC:mah + @@ -10197,8 +19099,25 @@ + The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. + monohydric alcohol metabolic process + primary alcohol metabolism + biological_process + GO:0034308 primary alcohol metabolic process + + + + The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. + GOC:mah + + + + + primary alcohol metabolism + GOC:mah + @@ -10207,8 +19126,46 @@ + The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. + monohydric alcohol biosynthetic process + primary alcohol anabolism + primary alcohol biosynthesis + primary alcohol formation + primary alcohol synthesis + biological_process + GO:0034309 primary alcohol biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. + GOC:mah + + + + + primary alcohol anabolism + GOC:mah + + + + + primary alcohol biosynthesis + GOC:mah + + + + + primary alcohol formation + GOC:mah + + + + + primary alcohol synthesis + GOC:mah + @@ -10218,8 +19175,17 @@ + The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. + biological_process + GO:0034637 cellular carbohydrate biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. + GOC:mah + @@ -10228,8 +19194,19 @@ + The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. + cellular nitrogen compound metabolism + biological_process + GO:0034641 + cellular nitrogen compound metabolic process + + + + The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. + GOC:mah + @@ -10239,8 +19216,53 @@ + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. + GO:0034961 + cellular biopolymer biosynthetic process + cellular macromolecule anabolism + cellular macromolecule biosynthesis + cellular macromolecule formation + cellular macromolecule synthesis + biological_process + GO:0034645 cellular macromolecule biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. + GOC:mah + + + + + cellular biopolymer biosynthetic process + GOC:mtg_chebi_dec09 + + + + + cellular macromolecule anabolism + GOC:mah + + + + + cellular macromolecule biosynthesis + GOC:mah + + + + + cellular macromolecule formation + GOC:mah + + + + + cellular macromolecule synthesis + GOC:mah + @@ -10249,8 +19271,17 @@ + The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells. + biological_process + GO:0034754 cellular hormone metabolic process + + + + The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells. + GOC:mah + @@ -10264,8 +19295,33 @@ + Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. + tube lumen formation + biological_process + lumen formation in an anatomical structure + GO:0035148 tube formation + + + + Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. + GOC:bf + + + + + tube lumen formation + GOC:dph + GOC:mah + + + + + lumen formation in an anatomical structure + GOC:dph + GOC:mah + @@ -10279,8 +19335,19 @@ + The emergence of an immature organism from a protective structure. + biological_process + GO:0035188 hatching + + + + The emergence of an immature organism from a protective structure. + GOC:dgh + GOC:isa_complete + ISBN:0198612001 + @@ -10288,8 +19355,18 @@ + The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis. + biological_process + GO:0035209 pupal development + + + + The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis. + GOC:bf + GOC:mtg_sensu + @@ -10303,8 +19380,18 @@ + The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + biological_process + GO:0035239 tube morphogenesis + + + + The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + GOC:bf + PMID:14624839 + @@ -10318,8 +19405,17 @@ + The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. + biological_process + GO:0035295 tube development + + + + The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. + PMID:12526790 + @@ -10328,8 +19424,28 @@ + The directed movement of a protein to a specific location within the extracellular region. + bf + 2010-11-09T10:25:08Z + establishment of protein localisation in extracellular region + establishment of protein localization in extracellular region + biological_process + GO:0035592 establishment of protein localization to extracellular region + + + + The directed movement of a protein to a specific location within the extracellular region. + GOC:BHF + GOC:bf + + + + + establishment of protein localisation in extracellular region + GOC:mah + @@ -10338,8 +19454,22 @@ + Any process that modulates the amount of urine excreted from the body over a unit of time. + bf + 2011-04-20T01:17:38Z + regulation of urinary volume + regulation of urine flow + biological_process + GO:0035809 regulation of urine volume + + + + Any process that modulates the amount of urine excreted from the body over a unit of time. + GOC:mtg_25march11 + GOC:yaf + @@ -10347,8 +19477,43 @@ + The regulated release of parathyroid hormone into the circulatory system. + bf + 2011-06-22T09:28:54Z + PTH secretion + parathormone secretion + parathyrin secretion + biological_process + GO:0035898 parathyroid hormone secretion + + + + The regulated release of parathyroid hormone into the circulatory system. + GOC:cjm + PMID:12171519 + PMID:21164021 + + + + + PTH secretion + PMID:12171519 + PR:000013429 + + + + + parathormone secretion + PR:000013429 + + + + + parathyrin secretion + PR:000013429 + @@ -10357,8 +19522,19 @@ + The regulated release of any steroid that acts as a hormone into the circulatory system. + bf + 2011-07-20T01:01:00Z + biological_process + GO:0035929 steroid hormone secretion + + + + The regulated release of any steroid that acts as a hormone into the circulatory system. + GOC:sl + @@ -10366,8 +19542,26 @@ + The regulated release of any corticosteroid hormone into the circulatory system. + bf + 2011-07-20T01:03:22Z + corticosteroid secretion + biological_process + GO:0035930 corticosteroid hormone secretion + + + + The regulated release of any corticosteroid hormone into the circulatory system. + GOC:sl + + + + + corticosteroid secretion + GOC:bf + @@ -10375,8 +19569,19 @@ + The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism. + bf + 2011-07-20T01:04:59Z + biological_process + GO:0035931 mineralocorticoid secretion + + + + The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism. + GOC:sl + @@ -10385,8 +19590,19 @@ + The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. + bf + 2011-07-20T01:06:24Z + biological_process + GO:0035932 aldosterone secretion + + + + The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. + GOC:sl + @@ -10394,8 +19610,19 @@ + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. + bf + 2011-12-19T01:47:22Z + biological_process + GO:0036072 direct ossification + + + + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. + GO_REF:0000034 + @@ -10403,8 +19630,19 @@ + Intramembranous ossification from the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage. + bf + 2011-12-19T01:49:38Z + biological_process + GO:0036073 perichondral ossification + + + + Intramembranous ossification from the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage. + GO_REF:0000034 + @@ -10412,8 +19650,26 @@ + Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation. + bf + 2011-12-19T01:53:16Z + indirect ossification + biological_process + GO:0036075 replacement ossification + + + + Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation. + GO_REF:0000034 + + + + + indirect ossification + GO_REF:0000034 + @@ -10421,8 +19677,27 @@ + A digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again. + bf + 2012-03-13T04:35:19Z + digestive rumination + biological_process + GO:0036147 rumination + + + + A digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again. + GOC:maf + Wikipedia:Rumination + + + + + digestive rumination + Wikipedia:Rumination + @@ -10430,8 +19705,19 @@ + The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell. + bf + 2012-03-26T01:30:32Z + biological_process + GO:0036161 calcitonin secretion + + + + The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell. + GOC:cjm + @@ -10439,8 +19725,43 @@ + A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. + bf + 2012-04-20T10:20:47Z + myocyte projection + muscle arm + myopodia + cellular_component + GO:0036194 muscle cell projection + + + + A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. + CL:0000187 + GOC:kmv + PMID:15930100 + PMID:22464329 + + + + + myocyte projection + CL:0000187 + + + + + muscle arm + GOC:kmv + + + + + myopodia + GOC:kmv + @@ -10448,8 +19769,27 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. + bf + 2012-07-20T01:05:46Z + response to lowered oxygen levels + biological_process + GO:0036293 + This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'. response to decreased oxygen levels + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. + GOC:al + + + + + response to lowered oxygen levels + GOC:bf + @@ -10463,8 +19803,26 @@ + Any of the smallest contractile units of a myofibril (striated muscle fiber). + bf + 2013-05-22T14:39:06Z + striated muscle filament + cellular_component + GO:0036379 myofilament + + + + Any of the smallest contractile units of a myofibril (striated muscle fiber). + Wikipedia:Myofilament + + + + + striated muscle filament + GOC:bf + @@ -10472,8 +19830,20 @@ + The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. + bf + 2014-07-24T10:06:19Z + cellular_component + GO:0036477 somatodendritic compartment + + + + The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. + GOC:PARL + GOC:pad + @@ -10481,8 +19851,39 @@ + Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. + bf + 2011-08-01T02:45:27Z + GO:0004872 + GO:0019041 + receptor activity + receptor activity involved in signal transduction + signalling receptor activity + molecular_function + GO:0038023 + + + + + + + + signaling receptor activity + + + + Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. + GOC:bf + GOC:signaling + + + + + receptor activity involved in signal transduction + GOC:bf + @@ -10490,8 +19891,33 @@ + + The increase in size or mass of an entire organism, a part of an organism or a cell. + GO:0048590 + biological_process + growth pattern + non-developmental growth + GO:0040007 + + + + + See also the biological process term 'cell growth ; GO:0016049'. growth + + + + The increase in size or mass of an entire organism, a part of an organism or a cell. + GOC:bf + GOC:ma + + + + + non-developmental growth + GOC:mah + @@ -10516,8 +19942,18 @@ + Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. + biological_process + GO:0040008 regulation of growth + + + + Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. + GOC:ems + GOC:mah + @@ -10525,8 +19961,21 @@ + + Self-propelled movement of a cell or organism from one location to another. + + biological_process + GO:0040011 + + locomotion + + + + Self-propelled movement of a cell or organism from one location to another. + GOC:dgh + @@ -10551,8 +20000,17 @@ + Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. + biological_process + GO:0040012 regulation of locomotion + + + + Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. + GOC:ems + @@ -10578,8 +20036,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. + down regulation of locomotion + down-regulation of locomotion + downregulation of locomotion + inhibition of locomotion + biological_process + GO:0040013 negative regulation of locomotion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. + GOC:go_curators + @@ -10593,8 +20064,18 @@ + The first few specialized divisions of an activated animal egg. + biological_process + GO:0040016 embryonic cleavage + + + + The first few specialized divisions of an activated animal egg. + GOC:clt + ISBN:0070524300 + @@ -10620,8 +20101,22 @@ + Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. + up regulation of locomotion + up-regulation of locomotion + upregulation of locomotion + activation of locomotion + stimulation of locomotion + biological_process + GO:0040017 positive regulation of locomotion + + + + Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. + GOC:go_curators + @@ -10648,8 +20143,22 @@ + Any process that activates or increases the frequency, rate or extent of embryonic development. + up regulation of embryonic development + up-regulation of embryonic development + upregulation of embryonic development + activation of embryonic development + stimulation of embryonic development + biological_process + GO:0040019 positive regulation of embryonic development + + + + Any process that activates or increases the frequency, rate or extent of embryonic development. + GOC:go_curators + @@ -10676,8 +20185,25 @@ + Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. + regulation of meiosis + biological_process + GO:0040020 regulation of meiotic nuclear division + + + + Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. + GOC:ems + GOC:ma + + + + + regulation of meiosis + GOC:vw + @@ -10685,8 +20211,18 @@ + The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0042044 + fluid transport + + + + The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -10694,8 +20230,24 @@ + The behavior of an organism in response to an odor. + behavioral response to scent + behavioral response to smell + behavioural response to odour + behavioural response to scent + behavioural response to smell + olfactory behaviour + biological_process + GO:0042048 olfactory behavior + + + + The behavior of an organism in response to an odor. + GOC:jid + GOC:pr + @@ -10709,8 +20261,20 @@ + The series of events that restore integrity to a damaged tissue, following an injury. + Wikipedia:Wound_healing + biological_process + GO:0042060 + wound healing + + + + The series of events that restore integrity to a damaged tissue, following an injury. + GOC:bf + PMID:15269788 + @@ -10736,8 +20300,18 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. + regulation of catecholamine metabolism + biological_process + GO:0042069 regulation of catecholamine metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. + GOC:go_curators + @@ -10762,8 +20336,19 @@ + The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). + biological_process + GO:0042074 cell migration involved in gastrulation + + + + The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). + GOC:jl + ISBN:0878932437 + http://www.cellmigration.org/ + @@ -10772,8 +20357,21 @@ + The expansion of a B cell population by cell division. Follows B cell activation. + GO:0042114 + B lymphocyte proliferation + B-cell proliferation + B-lymphocyte proliferation + biological_process + GO:0042100 B cell proliferation + + + + The expansion of a B cell population by cell division. Follows B cell activation. + GOC:jl + @@ -10781,8 +20379,21 @@ + The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. + T lymphocyte activation + T-cell activation + T-lymphocyte activation + biological_process + GO:0042110 T cell activation + + + + The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. + GOC:mgi_curators + ISBN:0781735149 + @@ -10790,8 +20401,21 @@ + The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. + B lymphocyte activation + B-cell activation + B-lymphocyte activation + biological_process + GO:0042113 B cell activation + + + + The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. + GOC:mgi_curators + ISBN:0781735149 + @@ -10816,8 +20440,19 @@ + Any process that modulates the frequency, rate or extent of cell proliferation. + + biological_process + regulation of cell proliferation + GO:0042127 regulation of cell population proliferation + + + + Any process that modulates the frequency, rate or extent of cell proliferation. + GOC:jl + @@ -10827,8 +20462,20 @@ + The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + ketone metabolism + biological_process + GO:0042180 + cellular ketone metabolic process + + + + The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + GOC:jl + ISBN:0787650153 + @@ -10839,8 +20486,21 @@ + The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + ketone anabolism + ketone biosynthesis + ketone formation + ketone synthesis + biological_process + GO:0042181 ketone biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + GOC:go_curators + @@ -10848,8 +20508,32 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. + response to chemical stimulus + response to chemical substance + biological_process + GO:0042221 + + + + + + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to chemical + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. + GOC:jl + + + + + response to chemical stimulus + GOC:dos + @@ -10858,8 +20542,17 @@ + The regrowth of lost or destroyed tissues. + biological_process + GO:0042246 tissue regeneration + + + + The regrowth of lost or destroyed tissues. + GOC:curators + @@ -10880,15 +20573,30 @@ - + Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. + down regulation of circadian sleep/wake cycle, sleep + down-regulation of circadian sleep/wake cycle, sleep + downregulation of circadian sleep/wake cycle, sleep + negative regulation of sleep + inhibition of circadian sleep/wake cycle, sleep + biological_process + GO:0042321 negative regulation of circadian sleep/wake cycle, sleep + + + + Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. + GOC:go_curators + GOC:jl + ISBN:0192800981 + @@ -10914,8 +20622,22 @@ + Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep. + down regulation of circadian sleep/wake cycle, non-REM sleep + down-regulation of circadian sleep/wake cycle, non-REM sleep + downregulation of circadian sleep/wake cycle, non-REM sleep + negative regulation of non-REM sleep + inhibition of circadian sleep/wake cycle, non-REM sleep + biological_process + GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep + + + + Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep. + GOC:jl + @@ -10925,8 +20647,19 @@ + The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. + thyroid hormone metabolism + biological_process + GO:0042403 thyroid hormone metabolic process + + + + The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. + GOC:jl + ISBN:0198506732 + @@ -10937,8 +20670,19 @@ + The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. + serotonin metabolism + biological_process + GO:0042428 serotonin metabolic process + + + + The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. + GOC:jl + ISBN:0198506732 + @@ -10950,8 +20694,26 @@ + The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. + GO:0042434 + indole and derivative metabolic process + indole and derivative metabolism + indole-containing compound metabolism + ketole metabolic process + ketole metabolism + indole derivative metabolic process + indole derivative metabolism + biological_process + GO:0042430 indole-containing compound metabolic process + + + + The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. + GOC:jl + GOC:mah + @@ -10964,8 +20726,23 @@ + The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. + indole derivative biosynthesis + indole derivative biosynthetic process + indole-containing compound anabolism + indole-containing compound biosynthesis + indole-containing compound formation + indole-containing compound synthesis + biological_process + GO:0042435 indole-containing compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. + GOC:jl + @@ -10974,8 +20751,20 @@ + The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. + + hormone metabolism + biological_process + GO:0042445 + hormone metabolic process + + + + The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. + GOC:jl + @@ -10984,8 +20773,21 @@ + The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. + hormone anabolism + hormone biosynthesis + hormone formation + hormone synthesis + biological_process + GO:0042446 hormone biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. + GOC:jl + @@ -10993,8 +20795,30 @@ + Any biological process involved in the maintenance of an internal steady state. + GO:0032844 + GO:0032845 + GO:0032846 + homeostasis + activation of homeostatic process + inhibition of homeostatic process + biological_process + negative regulation of homeostatic process + positive regulation of homeostatic process + regulation of homeostatic process + GO:0042592 + + + homeostatic process + + + + Any biological process involved in the maintenance of an internal steady state. + GOC:jl + ISBN:0395825172 + @@ -11003,8 +20827,17 @@ + The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. + biological_process + GO:0042698 ovulation cycle + + + + The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. + ISBN:0721662544 + @@ -11020,8 +20853,18 @@ + The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta. + biological_process + GO:0042701 progesterone secretion + + + + The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta. + GOC:jl + ISBN:0395825172 + @@ -11035,8 +20878,18 @@ + The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract. + biological_process + GO:0042713 sperm ejaculation + + + + The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract. + GOC:jl + http://www.cogsci.princeton.edu/~wn/ + @@ -11044,8 +20897,18 @@ + The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. + biological_process + GO:0042745 circadian sleep/wake cycle + + + + The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. + GOC:jl + http://www.sleepquest.com + @@ -11059,8 +20922,18 @@ + All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions. + biological_process + GO:0042748 circadian sleep/wake cycle, non-REM sleep + + + + All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions. + GOC:jl + http://www.sleepquest.com + @@ -11080,15 +20953,23 @@ - + Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle. + biological_process + GO:0042749 regulation of circadian sleep/wake cycle + + + + Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle. + GOC:jl + @@ -11113,8 +20994,19 @@ + Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. + biological_process + GO:0042752 regulation of circadian rhythm + + + + Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. + GOC:dph + GOC:jl + GOC:tb + @@ -11140,8 +21032,22 @@ + Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. + up regulation of circadian rhythm + up-regulation of circadian rhythm + upregulation of circadian rhythm + activation of circadian rhythm + stimulation of circadian rhythm + biological_process + GO:0042753 positive regulation of circadian rhythm + + + + Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. + GOC:go_curators + @@ -11167,8 +21073,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior. + down regulation of circadian rhythm + down-regulation of circadian rhythm + downregulation of circadian rhythm + inhibition of circadian rhythm + biological_process + GO:0042754 negative regulation of circadian rhythm + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior. + GOC:go_curators + @@ -11176,8 +21095,19 @@ + The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0042886 + amide transport + + + + The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + ISBN:0198506732 + @@ -11185,8 +21115,26 @@ + A prolongation or process extending from a cell, e.g. a flagellum or axon. + cell process + cellular process + cellular projection + cellular_component + GO:0042995 + + + + + cell projection + + + + A prolongation or process extending from a cell, e.g. a flagellum or axon. + GOC:jl + http://www.cogsci.princeton.edu/~wn/ + @@ -11194,8 +21142,38 @@ + A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. + + NIF_Subcellular:sao867568886 + neuron process + neuron protrusion + neuronal cell projection + neurite + cellular_component + nerve fiber + GO:0043005 + neuron projection + + + + A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. + GOC:jl + http://www.cogsci.princeton.edu/~wn/ + + + + + neuron protrusion + NIF_Subcellular:sao250931889 + + + + + nerve fiber + GOC:dph + @@ -11203,8 +21181,17 @@ + The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. + biological_process + GO:0043009 chordate embryonic development + + + + The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. + GOC:mtg_sensu + @@ -11218,8 +21205,23 @@ + The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. + NIF_Subcellular:sao1044911821 + Wikipedia:Soma_(biology) + neuron cell body + neuronal cell soma + cellular_component + GO:0043025 + + Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. neuronal cell body + + + + The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. + GOC:go_curators + @@ -11227,8 +21229,32 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. + extracellular structure organisation + extracellular structure organization and biogenesis + biological_process + GO:0043062 + + extracellular structure organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. + GOC:ai + GOC:dph + GOC:jl + GOC:mah + + + + + extracellular structure organization and biogenesis + GOC:dph + GOC:jl + GOC:mah + @@ -11236,8 +21262,19 @@ + The nucleus of a germ cell, a reproductive cell in multicellular organisms. + germ-cell nucleus + cellular_component + GO:0043073 germ cell nucleus + + + + The nucleus of a germ cell, a reproductive cell in multicellular organisms. + CL:0000586 + GOC:go_curators + @@ -11251,8 +21288,19 @@ + The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. + Wikipedia:Erection#Penile_erection + biological_process + GO:0043084 penile erection + + + + The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. + GOC:jl + Wikipedia:Penile_erection + @@ -11260,8 +21308,30 @@ + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GO:0043283 + GO:0044259 + biopolymer metabolic process + macromolecule metabolism + organismal macromolecule metabolism + multicellular organismal macromolecule metabolic process + biological_process + GO:0043170 + macromolecule metabolic process + + + + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah + + + + + biopolymer metabolic process + GOC:mtg_chebi_dec09 + @@ -11269,8 +21339,38 @@ + An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. + FMA:62983 + NIF_Subcellular:sao593830697 + Wikipedia:Myelin + Schwann cell myelin sheath + astrocyte sheath + oligodendrocyte myelin sheath + cellular_component + GO:0043209 myelin sheath + + + + An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. + GOC:cjm + GOC:jl + NIF_Subcellular:sao593830697 + Wikipedia:Myelin + + + + + astrocyte sheath + NIF_Subcellular:nlx_subcell_20090204 + + + + + oligodendrocyte myelin sheath + NIF_Subcellular:sao1279474730 + @@ -11278,8 +21378,23 @@ + Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. + NIF_Subcellular:sao1539965131 + Wikipedia:Organelle + cellular_component + GO:0043226 + + + + organelle + + + + Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. + GOC:go_curators + @@ -11304,8 +21419,19 @@ + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + NIF_Subcellular:sao414196390 + membrane-enclosed organelle + cellular_component + GO:0043227 membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + GOC:go_curators + @@ -11313,8 +21439,22 @@ + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. + https://github.com/geneontology/go-ontology/issues/21881 + NIF_Subcellular:sao1456184038 + non-membrane-enclosed organelle + biological condensate + cellular_component + GO:0043228 + non-membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. + GOC:go_curators + @@ -11339,8 +21479,18 @@ + Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + cellular_component + GO:0043229 + intracellular organelle + + + + Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + GOC:go_curators + @@ -11365,8 +21515,19 @@ + Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. + cellular_component + GO:0043230 + extracellular organelle + + + + Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. + GOC:jl + PMID:9914479 + @@ -11386,8 +21547,19 @@ + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + intracellular membrane-enclosed organelle + cellular_component + GO:0043231 + intracellular membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + GOC:go_curators + @@ -11407,8 +21579,19 @@ + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. + intracellular non-membrane-enclosed organelle + cellular_component + GO:0043232 + intracellular non-membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. + GOC:go_curators + @@ -11434,8 +21617,21 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. + regulation of carbohydrate anabolism + regulation of carbohydrate biosynthesis + regulation of carbohydrate formation + regulation of carbohydrate synthesis + biological_process + GO:0043255 regulation of carbohydrate biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. + GOC:jl + @@ -11455,8 +21651,18 @@ + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. + extracellular non-membrane-enclosed organelle + cellular_component + GO:0043264 extracellular non-membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. + GOC:jl + @@ -11481,8 +21687,17 @@ + Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0043269 regulation of ion transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + @@ -11508,8 +21723,22 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + up regulation of ion transport + up-regulation of ion transport + upregulation of ion transport + activation of ion transport + stimulation of ion transport + biological_process + GO:0043270 positive regulation of ion transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + @@ -11535,8 +21764,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + down regulation of ion transport + down-regulation of ion transport + downregulation of ion transport + inhibition of ion transport + biological_process + GO:0043271 negative regulation of ion transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + @@ -11551,8 +21793,19 @@ + Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. + contractile fibre + cellular_component + GO:0043292 contractile fiber + + + + Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. + GOC:go_curators + ISBN:0815316194 + @@ -11560,8 +21813,28 @@ + A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. + apical cell junction complex + apical junction + cellular_component + GO:0043296 apical junction complex + + + + A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. + GOC:go_curators + GOC:kmv + PMID:12525486 + PMID:15196556 + + + + + apical cell junction complex + GOC:mah + @@ -11569,8 +21842,24 @@ + The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). + keto acid metabolic process + keto acid metabolism + ketoacid metabolic process + ketoacid metabolism + oxo acid metabolic process + oxo acid metabolism + oxoacid metabolism + biological_process + GO:0043436 oxoacid metabolic process + + + + The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). + Wikipedia:Oxyacid + @@ -11595,8 +21884,17 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. + biological_process + GO:0043467 regulation of generation of precursor metabolites and energy + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. + GOC:jl + @@ -11622,8 +21920,17 @@ + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. + biological_process + GO:0043470 regulation of carbohydrate catabolic process + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. + GOC:mlg + @@ -11651,8 +21958,17 @@ + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. + biological_process + GO:0043471 regulation of cellular carbohydrate catabolic process + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. + GOC:jl + @@ -11677,8 +21993,17 @@ + Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. + biological_process + GO:0043576 regulation of respiratory gaseous exchange + + + + Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. + GOC:jl + @@ -11686,8 +22011,21 @@ + The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. + + + animal skin development + biological_process + GO:0043588 skin development + + + + The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. + GOC:jl + UBERON:0002097 + @@ -11695,8 +22033,19 @@ + The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. + amide metabolism + biological_process + GO:0043603 + cellular amide metabolic process + + + + The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. + GOC:curators + @@ -11705,8 +22054,17 @@ + The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. + biological_process + GO:0043604 amide biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. + GOC:curators + @@ -11714,8 +22072,18 @@ + The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. + + biological_process + GO:0043616 keratinocyte proliferation + + + + The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. + CL:0000311 + @@ -11723,8 +22091,20 @@ + The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). + dicarboxylate metabolic process + dicarboxylate metabolism + dicarboxylic acid metabolism + biological_process + GO:0043648 dicarboxylic acid metabolic process + + + + The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). + ISBN:0198506732 + @@ -11733,8 +22113,17 @@ + The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal. + biological_process + GO:0043695 detection of pheromone + + + + The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal. + GOC:mah + @@ -11742,8 +22131,18 @@ + The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. + glucan metabolism + biological_process + GO:0044042 glucan metabolic process + + + + The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. + GOC:jl + @@ -11768,8 +22167,17 @@ + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. + biological_process + GO:0044057 regulation of system process + + + + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. + GOC:jl + @@ -11794,8 +22202,17 @@ + Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + biological_process + GO:0044058 regulation of digestive system process + + + + Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:jl + @@ -11820,8 +22237,18 @@ + Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. + regulation of endocrine system process + biological_process + GO:0044060 regulation of endocrine process + + + + Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. + GOC:jl + @@ -11847,8 +22274,17 @@ + Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. + biological_process + GO:0044062 regulation of excretion + + + + Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. + GOC:jl + @@ -11874,8 +22310,17 @@ + Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. + biological_process + GO:0044065 regulation of respiratory system process + + + + Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. + GOC:jl + @@ -11900,8 +22345,17 @@ + Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0044070 regulation of anion transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + @@ -11926,8 +22380,19 @@ + Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + jl + 2009-04-21T04:07:27Z + biological_process + GO:0044092 negative regulation of molecular function + + + + Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + GO:jl + @@ -11952,8 +22417,19 @@ + Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + jl + 2009-04-21T04:11:06Z + biological_process + GO:0044093 positive regulation of molecular function + + + + Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + GO:jl + @@ -11962,8 +22438,19 @@ + The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. + jl + 2009-07-15T11:55:44Z + biological_process + GO:0044106 cellular amine metabolic process + + + + The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. + GOC:jl + @@ -11972,8 +22459,26 @@ + The chemical reactions and pathways by which individual cells transform chemical substances. + cellular metabolism + biological_process + intermediary metabolism + GO:0044237 + cellular metabolic process + + + + The chemical reactions and pathways by which individual cells transform chemical substances. + GOC:go_curators + + + + + intermediary metabolism + GOC:mah + @@ -11981,8 +22486,20 @@ + The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + primary metabolism + biological_process + GO:0044238 + primary metabolic process + + + + The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + GOC:go_curators + http://www.metacyc.org + @@ -11992,8 +22509,20 @@ + The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells. + cellular polysaccharide breakdown + cellular polysaccharide catabolism + cellular polysaccharide degradation + biological_process + GO:0044247 cellular polysaccharide catabolic process + + + + The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells. + GOC:jl + @@ -12002,8 +22531,20 @@ + The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + cellular breakdown + cellular catabolism + cellular degradation + biological_process + GO:0044248 cellular catabolic process + + + + The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:jl + @@ -12012,8 +22553,21 @@ + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + cellular anabolism + cellular biosynthesis + cellular formation + cellular synthesis + biological_process + GO:0044249 cellular biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:jl + @@ -12022,8 +22576,26 @@ + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. + GO:0034960 + cellular biopolymer metabolic process + cellular macromolecule metabolism + biological_process + GO:0044260 cellular macromolecule metabolic process + + + + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. + GOC:mah + + + + + cellular biopolymer metabolic process + GOC:mtg_chebi_dec09 + @@ -12032,8 +22604,21 @@ + The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + GO:0006092 + cellular carbohydrate metabolism + main pathways of carbohydrate metabolic process + main pathways of carbohydrate metabolism + biological_process + GO:0044262 cellular carbohydrate metabolic process + + + + The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + GOC:jl + @@ -12043,8 +22628,20 @@ + The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells. + cellular glycan metabolic process + cellular glycan metabolism + cellular polysaccharide metabolism + biological_process + GO:0044264 cellular polysaccharide metabolic process + + + + The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells. + GOC:jl + @@ -12053,8 +22650,22 @@ + The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. + nitrogen compound anabolism + nitrogen compound biosynthesis + nitrogen compound formation + nitrogen compound synthesis + biological_process + GO:0044271 cellular nitrogen compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. + GOC:jl + ISBN:0198506732 + @@ -12064,8 +22675,20 @@ + The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + cellular carbohydrate breakdown + cellular carbohydrate catabolism + cellular carbohydrate degradation + biological_process + GO:0044275 cellular carbohydrate catabolic process + + + + The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + GOC:jl + @@ -12073,8 +22696,26 @@ + The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. + jl + 2010-01-26T12:05:20Z + small molecule metabolism + biological_process + GO:0044281 + + + + Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. small molecule metabolic process + + + + The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. + GOC:curators + GOC:pde + GOC:vw + @@ -12083,8 +22724,24 @@ + The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. + jl + 2010-01-26T12:06:49Z + small molecule biosynthesis + biological_process + GO:0044283 + + Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. small molecule biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. + GOC:curators + GOC:pde + GOC:vw + @@ -12092,8 +22749,25 @@ + The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. + + jl + 2010-02-05T10:37:16Z + FBbt:00005107 + FMA:67301 + Wikipedia:Cell_body + cell soma + cellular_component + GO:0044297 + Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. cell body + + + + The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. + GOC:go_curators + @@ -12101,8 +22775,23 @@ + Distinctive, unmyelinated axons produced by granule cells. + jl + 2010-02-05T11:23:55Z + NIF_Subcellular:nlx_subcell_20090601 + dentate gyrus mossy fibre + granule cell axon + cellular_component + GO:0044302 dentate gyrus mossy fiber + + + + Distinctive, unmyelinated axons produced by granule cells. + NIF_Subcellular:nlx_subcell_20090601 + PMID:17765709 + @@ -12110,9 +22799,20 @@ - + A biological process that directly contributes to the process of producing new individuals, involving another organism. + jl + 2012-09-19T15:56:30Z + biological_process + GO:0044703 + multi-organism reproductive process + + + + A biological process that directly contributes to the process of producing new individuals, involving another organism. + GOC:jl + @@ -12120,9 +22820,20 @@ - + A multicellular organism process which involves another multicellular organism of the same or different species. + https://github.com/geneontology/go-ontology/issues/21459 + jl + 2012-09-19T16:06:16Z + biological_process + GO:0044706 multi-multicellular organism process + + + + A multicellular organism process which involves another multicellular organism of the same or different species. + GOC:jl + @@ -12130,8 +22841,26 @@ + + + + + + A distinct period or stage in a biological process or cycle. + jl + 2014-07-16T13:12:40Z + biological_process + GO:0044848 + + Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase. biological phase + + + + A distinct period or stage in a biological process or cycle. + GOC:jl + @@ -12145,8 +22874,22 @@ + The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. + Wikipedia:Thymocyte + T lymphocyte selection + T-cell selection + T-lymphocyte selection + biological_process + GO:0045058 T cell selection + + + + The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. + ISBN:0781735149 + PMID:12414722 + @@ -12154,8 +22897,19 @@ + A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. + cellular_component + acidic keratin + basic/neutral keratin + GO:0045095 keratin filament + + + + A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. + ISBN:0716731363 + @@ -12163,8 +22917,17 @@ + Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. + cellular_component + GO:0045111 intermediate filament cytoskeleton + + + + Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. + ISBN:0716731363 + @@ -12184,8 +22947,17 @@ + The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. + biological_process + GO:0045137 development of primary sexual characteristics + + + + The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. + GOC:ai + @@ -12194,8 +22966,26 @@ + The directed movement of a protein to a specific location. + establishment of protein localisation + protein positioning + protein recruitment + biological_process + GO:0045184 establishment of protein localization + + + + The directed movement of a protein to a specific location. + GOC:bf + + + + + establishment of protein localisation + GOC:mah + @@ -12220,8 +23010,19 @@ + Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. + regulation of sleep + biological_process + GO:0045187 regulation of circadian sleep/wake cycle, sleep + + + + Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. + GOC:jl + ISBN:0192800981 + @@ -12246,8 +23047,18 @@ + Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep. + regulation of non-REM sleep + biological_process + GO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep + + + + Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep. + GOC:go_curators + @@ -12255,8 +23066,31 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. + external encapsulating structure organisation + external encapsulating structure organization and biogenesis + biological_process + GO:0045229 + external encapsulating structure organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. + GOC:ai + GOC:dph + GOC:jl + GOC:mah + + + + + external encapsulating structure organization and biogenesis + GOC:dph + GOC:jl + GOC:mah + @@ -12265,8 +23099,20 @@ + A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. + Wikipedia:Immunologic_activation + immune cell activation + leucocyte activation + biological_process + GO:0045321 leukocyte activation + + + + A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. + GOC:add + @@ -12276,8 +23122,18 @@ + The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. + biological_process + GO:0045443 juvenile hormone secretion + + + + The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. + GOC:go_curators + ISBN:0198547684 + @@ -12303,8 +23159,28 @@ + Any process that modulates the frequency, rate or extent of B cell differentiation. + regulation of B lymphocyte differentiation + regulation of B-cell differentiation + regulation of B-lymphocyte differentiation + biological_process + regulation of B cell development + GO:0045577 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. regulation of B cell differentiation + + + + Any process that modulates the frequency, rate or extent of B cell differentiation. + GOC:go_curators + + + + + regulation of B cell development + GOC:add + @@ -12331,8 +23207,32 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation. + down regulation of B cell differentiation + down-regulation of B cell differentiation + downregulation of B cell differentiation + negative regulation of B lymphocyte differentiation + negative regulation of B-cell differentiation + negative regulation of B-lymphocyte differentiation + inhibition of B cell differentiation + biological_process + negative regulation of B cell development + GO:0045578 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. negative regulation of B cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation. + GOC:go_curators + + + + + negative regulation of B cell development + GOC:add + @@ -12359,8 +23259,33 @@ + Any process that activates or increases the frequency, rate or extent of B cell differentiation. + positive regulation of B lymphocyte differentiation + positive regulation of B-cell differentiation + positive regulation of B-lymphocyte differentiation + up regulation of B cell differentiation + up-regulation of B cell differentiation + upregulation of B cell differentiation + activation of B cell differentiation + stimulation of B cell differentiation + biological_process + positive regulation of B cell development + GO:0045579 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. positive regulation of B cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of B cell differentiation. + GOC:go_curators + + + + + positive regulation of B cell development + GOC:add + @@ -12386,8 +23311,28 @@ + Any process that modulates the frequency, rate or extent of T cell differentiation. + regulation of T lymphocyte differentiation + regulation of T-cell differentiation + regulation of T-lymphocyte differentiation + biological_process + regulation of T cell development + GO:0045580 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. regulation of T cell differentiation + + + + Any process that modulates the frequency, rate or extent of T cell differentiation. + GOC:go_curators + + + + + regulation of T cell development + GOC:add + @@ -12414,8 +23359,32 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. + down regulation of T cell differentiation + down-regulation of T cell differentiation + downregulation of T cell differentiation + negative regulation of T lymphocyte differentiation + negative regulation of T-cell differentiation + negative regulation of T-lymphocyte differentiation + inhibition of T cell differentiation + biological_process + negative regulation of T cell development + GO:0045581 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. negative regulation of T cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. + GOC:go_curators + + + + + negative regulation of T cell development + GOC:add + @@ -12442,8 +23411,33 @@ + Any process that activates or increases the frequency, rate or extent of T cell differentiation. + positive regulation of T lymphocyte differentiation + positive regulation of T-cell differentiation + positive regulation of T-lymphocyte differentiation + up regulation of T cell differentiation + up-regulation of T cell differentiation + upregulation of T cell differentiation + activation of T cell differentiation + stimulation of T cell differentiation + biological_process + positive regulation of T cell development + GO:0045582 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. positive regulation of T cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of T cell differentiation. + GOC:go_curators + + + + + positive regulation of T cell development + GOC:add + @@ -12469,8 +23463,17 @@ + Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. + biological_process + GO:0045595 regulation of cell differentiation + + + + Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. + GOC:go_curators + @@ -12497,8 +23500,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. + down regulation of cell differentiation + down-regulation of cell differentiation + downregulation of cell differentiation + inhibition of cell differentiation + biological_process + GO:0045596 negative regulation of cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. + GOC:go_curators + @@ -12525,8 +23541,22 @@ + Any process that activates or increases the frequency, rate or extent of cell differentiation. + up regulation of cell differentiation + up-regulation of cell differentiation + upregulation of cell differentiation + activation of cell differentiation + stimulation of cell differentiation + biological_process + GO:0045597 positive regulation of cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of cell differentiation. + GOC:go_curators + @@ -12552,8 +23582,25 @@ + Any process that modulates the frequency, rate or extent of epidermal cell differentiation. + biological_process + regulation of hypodermal cell differentiation + GO:0045604 regulation of epidermal cell differentiation + + + + Any process that modulates the frequency, rate or extent of epidermal cell differentiation. + GOC:go_curators + + + + + regulation of hypodermal cell differentiation + GOC:kmv + GOC:rk + @@ -12580,8 +23627,29 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. + down regulation of epidermal cell differentiation + down-regulation of epidermal cell differentiation + downregulation of epidermal cell differentiation + inhibition of epidermal cell differentiation + biological_process + negative regulation of hypodermal cell differentiation + GO:0045605 negative regulation of epidermal cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. + GOC:go_curators + + + + + negative regulation of hypodermal cell differentiation + GOC:kmv + GOC:rk + @@ -12608,8 +23676,30 @@ + Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. + up regulation of epidermal cell differentiation + up-regulation of epidermal cell differentiation + upregulation of epidermal cell differentiation + activation of epidermal cell differentiation + stimulation of epidermal cell differentiation + biological_process + positive regulation of hypodermal cell differentiation + GO:0045606 positive regulation of epidermal cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. + GOC:go_curators + + + + + positive regulation of hypodermal cell differentiation + GOC:kmv + GOC:rk + @@ -12634,8 +23724,17 @@ + Any process that modulates the frequency, rate or extent of keratinocyte differentiation. + biological_process + GO:0045616 regulation of keratinocyte differentiation + + + + Any process that modulates the frequency, rate or extent of keratinocyte differentiation. + GOC:go_curators + @@ -12662,8 +23761,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation. + down regulation of keratinocyte differentiation + down-regulation of keratinocyte differentiation + downregulation of keratinocyte differentiation + inhibition of keratinocyte differentiation + biological_process + GO:0045617 negative regulation of keratinocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation. + GOC:go_curators + @@ -12690,8 +23802,22 @@ + Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. + up regulation of keratinocyte differentiation + up-regulation of keratinocyte differentiation + upregulation of keratinocyte differentiation + activation of keratinocyte differentiation + stimulation of keratinocyte differentiation + biological_process + GO:0045618 positive regulation of keratinocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. + GOC:go_curators + @@ -12717,8 +23843,25 @@ + Any process that modulates the frequency, rate or extent of lymphocyte differentiation. + biological_process + regulation of lymphocyte development + GO:0045619 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. regulation of lymphocyte differentiation + + + + Any process that modulates the frequency, rate or extent of lymphocyte differentiation. + GOC:go_curators + + + + + regulation of lymphocyte development + GOC:add + @@ -12745,8 +23888,29 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. + down regulation of lymphocyte differentiation + down-regulation of lymphocyte differentiation + downregulation of lymphocyte differentiation + inhibition of lymphocyte differentiation + biological_process + negative regulation of lymphocyte development + GO:0045620 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. negative regulation of lymphocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. + GOC:go_curators + + + + + negative regulation of lymphocyte development + GOC:add + @@ -12773,8 +23937,30 @@ + Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. + up regulation of lymphocyte differentiation + up-regulation of lymphocyte differentiation + upregulation of lymphocyte differentiation + activation of lymphocyte differentiation + stimulation of lymphocyte differentiation + biological_process + positive regulation of lymphocyte development + GO:0045621 + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. positive regulation of lymphocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. + GOC:go_curators + + + + + positive regulation of lymphocyte development + GOC:add + @@ -12799,8 +23985,26 @@ + Any process that modulates the frequency, rate or extent of epidermis development. + regulation of epidermal development + biological_process + regulation of hypodermis development + GO:0045682 regulation of epidermis development + + + + Any process that modulates the frequency, rate or extent of epidermis development. + GOC:go_curators + + + + + regulation of hypodermis development + GOC:kmv + GOC:rk + @@ -12826,8 +24030,30 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. + down regulation of epidermis development + down-regulation of epidermis development + downregulation of epidermis development + negative regulation of epidermal development + inhibition of epidermis development + biological_process + negative regulation of hypodermis development + GO:0045683 negative regulation of epidermis development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. + GOC:go_curators + + + + + negative regulation of hypodermis development + GOC:kmv + GOC:rk + @@ -12853,8 +24079,31 @@ + Any process that activates or increases the frequency, rate or extent of epidermis development. + positive regulation of epidermal development + up regulation of epidermis development + up-regulation of epidermis development + upregulation of epidermis development + activation of epidermis development + stimulation of epidermis development + biological_process + positive regulation of hypodermis development + GO:0045684 positive regulation of epidermis development + + + + Any process that activates or increases the frequency, rate or extent of epidermis development. + GOC:go_curators + + + + + positive regulation of hypodermis development + GOC:kmv + GOC:rk + @@ -12881,8 +24130,25 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + down regulation of glycogen biosynthetic process + down-regulation of glycogen biosynthetic process + downregulation of glycogen biosynthetic process + negative regulation of glycogen anabolism + negative regulation of glycogen biosynthesis + negative regulation of glycogen formation + negative regulation of glycogen synthesis + inhibition of glycogen biosynthetic process + biological_process + GO:0045719 negative regulation of glycogen biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + GOC:go_curators + @@ -12910,8 +24176,26 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + positive regulation of glycogen anabolism + positive regulation of glycogen biosynthesis + positive regulation of glycogen formation + positive regulation of glycogen synthesis + up regulation of glycogen biosynthetic process + up-regulation of glycogen biosynthetic process + upregulation of glycogen biosynthetic process + activation of glycogen biosynthetic process + stimulation of glycogen biosynthetic process + biological_process + GO:0045725 positive regulation of glycogen biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + GOC:go_curators + @@ -12938,8 +24222,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid. + down regulation of amino acid metabolic process + down-regulation of amino acid metabolic process + downregulation of amino acid metabolic process + negative regulation of amino acid metabolism + inhibition of amino acid metabolic process + biological_process + GO:0045763 negative regulation of cellular amino acid metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid. + GOC:go_curators + @@ -12966,8 +24264,23 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid. + positive regulation of amino acid metabolism + up regulation of amino acid metabolic process + up-regulation of amino acid metabolic process + upregulation of amino acid metabolic process + activation of amino acid metabolic process + stimulation of amino acid metabolic process + biological_process + GO:0045764 positive regulation of cellular amino acid metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid. + GOC:go_curators + @@ -12993,8 +24306,17 @@ + Any process that modulates the frequency, rate or extent of angiogenesis. + biological_process + GO:0045765 regulation of angiogenesis + + + + Any process that modulates the frequency, rate or extent of angiogenesis. + GOC:go_curators + @@ -13020,8 +24342,22 @@ + Any process that activates or increases angiogenesis. + up regulation of angiogenesis + up-regulation of angiogenesis + upregulation of angiogenesis + activation of angiogenesis + stimulation of angiogenesis + biological_process + GO:0045766 positive regulation of angiogenesis + + + + Any process that activates or increases angiogenesis. + GOC:go_curators + @@ -13047,8 +24383,24 @@ + Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + positive regulation of bone biosynthesis + positive regulation of bone formation + up regulation of ossification + up-regulation of ossification + upregulation of ossification + activation of ossification + stimulation of ossification + biological_process + GO:0045778 positive regulation of ossification + + + + Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:go_curators + @@ -13074,8 +24426,22 @@ + Any process that activates or increases the frequency, rate or extent of cell adhesion. + up regulation of cell adhesion + up-regulation of cell adhesion + upregulation of cell adhesion + activation of cell adhesion + stimulation of cell adhesion + biological_process + GO:0045785 positive regulation of cell adhesion + + + + Any process that activates or increases the frequency, rate or extent of cell adhesion. + GOC:go_curators + @@ -13101,8 +24467,25 @@ + Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. + down regulation of progression through cell cycle + down-regulation of progression through cell cycle + downregulation of progression through cell cycle + negative regulation of cell cycle progression + negative regulation of progression through cell cycle + inhibition of progression through cell cycle + biological_process + GO:0045786 negative regulation of cell cycle + + + + Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. + GOC:dph + GOC:go_curators + GOC:tb + @@ -13128,8 +24511,31 @@ + Any process that activates or increases the rate or extent of progression through the cell cycle. + positive regulation of cell cycle progression + positive regulation of progression through cell cycle + up regulation of progression through cell cycle + up-regulation of progression through cell cycle + upregulation of progression through cell cycle + activation of progression through cell cycle + stimulation of progression through cell cycle + biological_process + GO:0045787 positive regulation of cell cycle + + + + Any process that activates or increases the rate or extent of progression through the cell cycle. + GOC:go_curators + + + + + positive regulation of progression through cell cycle + GOC:dph + GOC:tb + @@ -13156,8 +24562,31 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + down regulation of glycogen catabolic process + down-regulation of glycogen catabolic process + downregulation of glycogen catabolic process + negative regulation of glycogen breakdown + negative regulation of glycogen catabolism + negative regulation of glycogen degradation + negative regulation of glycogenolysis + inhibition of glycogen catabolic process + biological_process + GO:0045818 negative regulation of glycogen catabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + GOC:go_curators + + + + + negative regulation of glycogenolysis + GOC:sl + @@ -13184,8 +24613,32 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + positive regulation of glycogen breakdown + positive regulation of glycogen catabolism + positive regulation of glycogen degradation + positive regulation of glycogenolysis + up regulation of glycogen catabolic process + up-regulation of glycogen catabolic process + upregulation of glycogen catabolic process + activation of glycogen catabolic process + stimulation of glycogen catabolic process + biological_process + GO:0045819 positive regulation of glycogen catabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + GOC:go_curators + + + + + positive regulation of glycogenolysis + GOC:sl + @@ -13211,8 +24664,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. + down regulation of heart contraction + down-regulation of heart contraction + downregulation of heart contraction + inhibition of heart contraction + biological_process + negative regulation of cardiac contraction + GO:0045822 negative regulation of heart contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. + GOC:go_curators + @@ -13238,8 +24705,23 @@ + Any process that activates or increases the frequency, rate or extent of heart contraction. + positive regulation of cardiac contraction + up regulation of heart contraction + up-regulation of heart contraction + upregulation of heart contraction + activation of heart contraction + stimulation of heart contraction + biological_process + GO:0045823 positive regulation of heart contraction + + + + Any process that activates or increases the frequency, rate or extent of heart contraction. + GOC:go_curators + @@ -13265,8 +24747,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. + down regulation of lipid metabolic process + down-regulation of lipid metabolic process + downregulation of lipid metabolic process + negative regulation of lipid metabolism + inhibition of lipid metabolic process + biological_process + GO:0045833 negative regulation of lipid metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. + GOC:go_curators + @@ -13292,8 +24788,23 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. + positive regulation of lipid metabolism + up regulation of lipid metabolic process + up-regulation of lipid metabolic process + upregulation of lipid metabolic process + activation of lipid metabolic process + stimulation of lipid metabolic process + biological_process + GO:0045834 positive regulation of lipid metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. + GOC:go_curators + @@ -13321,8 +24832,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. + down regulation of meiosis + down-regulation of meiosis + downregulation of meiosis + negative regulation of meiosis + inhibition of meiosis + biological_process + GO:0045835 negative regulation of meiotic nuclear division + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. + GOC:go_curators + @@ -13350,8 +24875,23 @@ + Any process that activates or increases the frequency, rate or extent of meiosis. + positive regulation of meiosis + up regulation of meiosis + up-regulation of meiosis + upregulation of meiosis + activation of meiosis + stimulation of meiosis + biological_process + GO:0045836 positive regulation of meiotic nuclear division + + + + Any process that activates or increases the frequency, rate or extent of meiosis. + GOC:go_curators + @@ -13377,8 +24917,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. + down regulation of carbohydrate metabolic process + down-regulation of carbohydrate metabolic process + downregulation of carbohydrate metabolic process + negative regulation of carbohydrate metabolism + inhibition of carbohydrate metabolic process + biological_process + GO:0045912 negative regulation of carbohydrate metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. + GOC:go_curators + @@ -13404,8 +24958,23 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. + positive regulation of carbohydrate metabolism + up regulation of carbohydrate metabolic process + up-regulation of carbohydrate metabolic process + upregulation of carbohydrate metabolic process + activation of carbohydrate metabolic process + stimulation of carbohydrate metabolic process + biological_process + GO:0045913 positive regulation of carbohydrate metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. + GOC:go_curators + @@ -13431,8 +25000,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. + down regulation of catecholamine metabolic process + down-regulation of catecholamine metabolic process + downregulation of catecholamine metabolic process + negative regulation of catecholamine metabolism + inhibition of catecholamine metabolic process + biological_process + GO:0045914 negative regulation of catecholamine metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. + GOC:go_curators + @@ -13458,8 +25041,23 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. + positive regulation of catecholamine metabolism + up regulation of catecholamine metabolic process + up-regulation of catecholamine metabolic process + upregulation of catecholamine metabolic process + activation of catecholamine metabolic process + stimulation of catecholamine metabolic process + biological_process + GO:0045915 positive regulation of catecholamine metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. + GOC:go_curators + @@ -13485,8 +25083,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. + down regulation of exocytosis + down-regulation of exocytosis + downregulation of exocytosis + inhibition of exocytosis + biological_process + GO:0045920 negative regulation of exocytosis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. + GOC:go_curators + @@ -13512,8 +25123,22 @@ + Any process that activates or increases the frequency, rate or extent of exocytosis. + up regulation of exocytosis + up-regulation of exocytosis + upregulation of exocytosis + activation of exocytosis + stimulation of exocytosis + biological_process + GO:0045921 positive regulation of exocytosis + + + + Any process that activates or increases the frequency, rate or extent of exocytosis. + GOC:go_curators + @@ -13539,8 +25164,21 @@ + Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. + down regulation of growth + down-regulation of growth + downregulation of growth + inhibition of growth + biological_process + GO:0045926 negative regulation of growth + + + + Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. + GOC:go_curators + @@ -13566,8 +25204,22 @@ + Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. + up regulation of growth + up-regulation of growth + upregulation of growth + activation of growth + stimulation of growth + biological_process + GO:0045927 positive regulation of growth + + + + Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. + GOC:go_curators + @@ -13593,8 +25245,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. + down regulation of muscle contraction + down-regulation of muscle contraction + downregulation of muscle contraction + inhibition of muscle contraction + biological_process + GO:0045932 negative regulation of muscle contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. + GOC:go_curators + @@ -13620,8 +25285,22 @@ + Any process that activates or increases the frequency, rate or extent of muscle contraction. + up regulation of muscle contraction + up-regulation of muscle contraction + upregulation of muscle contraction + activation of muscle contraction + stimulation of muscle contraction + biological_process + GO:0045933 positive regulation of muscle contraction + + + + Any process that activates or increases the frequency, rate or extent of muscle contraction. + GOC:go_curators + @@ -13642,15 +25321,29 @@ - + Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. + positive regulation of sleep + up regulation of circadian sleep/wake cycle, sleep + up-regulation of circadian sleep/wake cycle, sleep + upregulation of circadian sleep/wake cycle, sleep + activation of circadian sleep/wake cycle, sleep + stimulation of circadian sleep/wake cycle, sleep + biological_process + GO:0045938 positive regulation of circadian sleep/wake cycle, sleep + + + + Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. + GOC:go_curators + @@ -13676,8 +25369,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. + down regulation of steroid metabolic process + down-regulation of steroid metabolic process + downregulation of steroid metabolic process + negative regulation of steroid metabolism + inhibition of steroid metabolic process + biological_process + GO:0045939 negative regulation of steroid metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. + GOC:go_curators + @@ -13703,8 +25410,23 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. + positive regulation of steroid metabolism + up regulation of steroid metabolic process + up-regulation of steroid metabolic process + upregulation of steroid metabolic process + activation of steroid metabolic process + stimulation of steroid metabolic process + biological_process + GO:0045940 positive regulation of steroid metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. + GOC:go_curators + @@ -13732,8 +25454,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone. + down regulation of juvenile hormone secretion + down-regulation of juvenile hormone secretion + downregulation of juvenile hormone secretion + inhibition of juvenile hormone secretion + biological_process + GO:0045972 negative regulation of juvenile hormone secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone. + GOC:go_curators + @@ -13760,8 +25495,22 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone. + up regulation of juvenile hormone secretion + up-regulation of juvenile hormone secretion + upregulation of juvenile hormone secretion + activation of juvenile hormone secretion + stimulation of juvenile hormone secretion + biological_process + GO:0045973 positive regulation of juvenile hormone secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone. + GOC:go_curators + @@ -13787,8 +25536,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. + down regulation of smooth muscle contraction + down-regulation of smooth muscle contraction + downregulation of smooth muscle contraction + inhibition of smooth muscle contraction + biological_process + smooth muscle relaxation + GO:0045986 negative regulation of smooth muscle contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. + GOC:go_curators + @@ -13814,8 +25577,22 @@ + Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. + up regulation of smooth muscle contraction + up-regulation of smooth muscle contraction + upregulation of smooth muscle contraction + activation of smooth muscle contraction + stimulation of smooth muscle contraction + biological_process + GO:0045987 positive regulation of smooth muscle contraction + + + + Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. + GOC:go_curators + @@ -13841,8 +25618,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. + down regulation of striated muscle contraction + down-regulation of striated muscle contraction + downregulation of striated muscle contraction + inhibition of striated muscle contraction + biological_process + GO:0045988 negative regulation of striated muscle contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. + GOC:go_curators + @@ -13868,8 +25658,22 @@ + Any process that activates or increases the frequency, rate or extent of striated muscle contraction. + up regulation of striated muscle contraction + up-regulation of striated muscle contraction + upregulation of striated muscle contraction + activation of striated muscle contraction + stimulation of striated muscle contraction + biological_process + GO:0045989 positive regulation of striated muscle contraction + + + + Any process that activates or increases the frequency, rate or extent of striated muscle contraction. + GOC:go_curators + @@ -13896,8 +25700,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. + down regulation of embryonic development + down-regulation of embryonic development + downregulation of embryonic development + inhibition of embryonic development + biological_process + GO:0045992 negative regulation of embryonic development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. + GOC:go_curators + @@ -13922,8 +25739,17 @@ + Any process that modulates the frequency, rate or extent of embryonic development. + biological_process + GO:0045995 regulation of embryonic development + + + + Any process that modulates the frequency, rate or extent of embryonic development. + GOC:go_curators + @@ -13949,8 +25775,23 @@ + Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep. + positive regulation of non-REM sleep + up regulation of circadian sleep/wake cycle, non-REM sleep + up-regulation of circadian sleep/wake cycle, non-REM sleep + upregulation of circadian sleep/wake cycle, non-REM sleep + activation of circadian sleep/wake cycle, non-REM sleep + stimulation of circadian sleep/wake cycle, non-REM sleep + biological_process + GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep + + + + Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep. + GOC:go_curators + @@ -13960,8 +25801,21 @@ + The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. + alcohol anabolism + alcohol biosynthesis + alcohol formation + alcohol synthesis + biological_process + GO:0046165 alcohol biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. + GOC:ai + @@ -13971,8 +25825,21 @@ + The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O. + aldehyde anabolism + aldehyde biosynthesis + aldehyde formation + aldehyde synthesis + biological_process + GO:0046184 aldehyde biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O. + GOC:ai + @@ -13981,8 +25848,21 @@ + The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. + carboxylic acid anabolism + carboxylic acid biosynthesis + carboxylic acid formation + carboxylic acid synthesis + biological_process + GO:0046394 carboxylic acid biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. + ISBN:0198506732 + @@ -13990,8 +25870,19 @@ + The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). + heterocycle metabolism + biological_process + GO:0046483 + heterocycle metabolic process + + + + The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). + ISBN:0198506732 + @@ -14001,8 +25892,20 @@ + The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin. + Wikipedia:Salivation + salivation + biological_process + GO:0046541 saliva secretion + + + + The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin. + GOC:curators + UBERON:0001836 + @@ -14016,8 +25919,17 @@ + The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. + biological_process + GO:0046545 development of primary female sexual characteristics + + + + The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. + GOC:ai + @@ -14025,8 +25937,18 @@ + A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. + biological_process + GO:0046649 lymphocyte activation + + + + A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. + GOC:mgi_curators + ISBN:0781735149 + @@ -14035,8 +25957,17 @@ + The expansion of a lymphocyte population by cell division. + biological_process + GO:0046651 lymphocyte proliferation + + + + The expansion of a lymphocyte population by cell division. + GOC:ai + @@ -14050,8 +25981,17 @@ + The establishment of the sex of a female organism by physical differentiation. + biological_process + GO:0046660 female sex differentiation + + + + The establishment of the sex of a female organism by physical differentiation. + GOC:bf + @@ -14078,8 +26018,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. + down regulation of insulin secretion + down-regulation of insulin secretion + downregulation of insulin secretion + inhibition of insulin secretion + biological_process + GO:0046676 negative regulation of insulin secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. + GOC:ai + @@ -14095,8 +26048,18 @@ + Any process that contributes to the success of sperm fertilization in multiply-mated females. + Wikipedia:Sperm_competition + biological_process + GO:0046692 sperm competition + + + + Any process that contributes to the success of sperm fertilization in multiply-mated females. + PMID:10885514 + @@ -14104,8 +26067,17 @@ + The controlled release of acid by a cell or a tissue. + biological_process + GO:0046717 acid secretion + + + + The controlled release of acid by a cell or a tissue. + GOC:ai + @@ -14113,8 +26085,18 @@ + The directed movement of isoprenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. + biological_process + GO:0046864 + isoprenoid transport + + + + The directed movement of isoprenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. + GOC:ai + @@ -14122,8 +26104,17 @@ + The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups. + biological_process + GO:0046865 terpenoid transport + + + + The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups. + GOC:ai + @@ -14150,8 +26141,17 @@ + Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue. + biological_process + GO:0046877 regulation of saliva secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue. + GOC:ai + @@ -14178,8 +26178,22 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of saliva. + up regulation of saliva secretion + up-regulation of saliva secretion + upregulation of saliva secretion + activation of saliva secretion + stimulation of saliva secretion + biological_process + GO:0046878 positive regulation of saliva secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of saliva. + GOC:ai + @@ -14188,8 +26202,17 @@ + The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. + biological_process + GO:0046879 hormone secretion + + + + The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. + ISBN:0198506732 + @@ -14217,8 +26240,17 @@ + Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. + biological_process + GO:0046883 regulation of hormone secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. + GOC:ai + @@ -14244,8 +26276,21 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. + regulation of hormone anabolism + regulation of hormone biosynthesis + regulation of hormone formation + regulation of hormone synthesis + biological_process + GO:0046885 regulation of hormone biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. + GOC:ai + @@ -14272,8 +26317,26 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. + positive regulation of hormone anabolism + positive regulation of hormone biosynthesis + positive regulation of hormone formation + positive regulation of hormone synthesis + up regulation of hormone biosynthetic process + up-regulation of hormone biosynthetic process + upregulation of hormone biosynthetic process + activation of hormone biosynthetic process + stimulation of hormone biosynthetic process + biological_process + GO:0046886 positive regulation of hormone biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. + GOC:ai + @@ -14301,8 +26364,22 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. + up regulation of hormone secretion + up-regulation of hormone secretion + upregulation of hormone secretion + activation of hormone secretion + stimulation of hormone secretion + biological_process + GO:0046887 positive regulation of hormone secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. + GOC:ai + @@ -14330,8 +26407,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. + down regulation of hormone secretion + down-regulation of hormone secretion + downregulation of hormone secretion + inhibition of hormone secretion + biological_process + GO:0046888 negative regulation of hormone secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. + GOC:ai + @@ -14358,8 +26448,33 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + positive regulation of lipid anabolism + positive regulation of lipid biosynthesis + positive regulation of lipid formation + positive regulation of lipid synthesis + positive regulation of lipogenesis + up regulation of lipid biosynthetic process + up-regulation of lipid biosynthetic process + upregulation of lipid biosynthetic process + activation of lipid biosynthetic process + stimulation of lipid biosynthetic process + biological_process + GO:0046889 positive regulation of lipid biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + GOC:ai + + + + + positive regulation of lipogenesis + GOC:sl + @@ -14385,8 +26500,28 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + regulation of lipid anabolism + regulation of lipid biosynthesis + regulation of lipid formation + regulation of lipid synthesis + regulation of lipogenesis + biological_process + GO:0046890 regulation of lipid biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + GOC:ai + + + + + regulation of lipogenesis + GOC:sl + @@ -14394,8 +26529,18 @@ + The controlled release of a substance by a cell or a tissue. + biological_process + GO:0046903 + secretion + + + + The controlled release of a substance by a cell or a tissue. + GOC:ai + @@ -14403,8 +26548,17 @@ + The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). + biological_process + GO:0046942 carboxylic acid transport + + + + The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). + GOC:ai + @@ -14412,8 +26566,18 @@ + Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction. + biological_process + GO:0048232 male gamete generation + + + + Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction. + GOC:dph + GOC:jid + @@ -14429,8 +26593,27 @@ + A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. + biological_process + sperm activation + GO:0048240 + Avian spermatozoa do not require a period of capacitation, since they are competent to fertilize the egg without a prolonged sojourn in the oviduct or in a capacitation medium in vitro. Therefore, sperm capacitation can only be applied to Aves to refer to gene products involved in processes that occur prior to sperm being deposited from the avian male. The term cannot apply to processes occurring in the avian female reproductive tract. sperm capacitation + + + + A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. + GOC:jid + ISBN:978-3-642-58301-8 + PMID:11820818 + + + + + sperm activation + PMID:23180860 + @@ -14440,8 +26623,19 @@ + The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. + noradrenaline secretion + biological_process + GO:0048243 norepinephrine secretion + + + + The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. + GOC:ef + GOC:jid + @@ -14449,8 +26643,19 @@ + The creation of a single organelle from two or more organelles. + biological_process + GO:0048284 + + organelle fusion + + + + The creation of a single organelle from two or more organelles. + GOC:jid + @@ -14458,8 +26663,19 @@ + The creation of two or more organelles by division of one organelle. + biological_process + GO:0048285 + + organelle fission + + + + The creation of two or more organelles by division of one organelle. + GOC:jid + @@ -14473,8 +26689,17 @@ + The process in which the anatomical structures of the mesoderm are generated and organized. + biological_process + GO:0048332 mesoderm morphogenesis + + + + The process in which the anatomical structures of the mesoderm are generated and organized. + GOC:go_curators + @@ -14489,8 +26714,26 @@ + The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + biological_process + terminal differentiation + GO:0048468 + cell development + + + + The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + GOC:go_curators + + + + + terminal differentiation + GOC:dph + GOC:tb + @@ -14505,8 +26748,25 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state. + biological_process + functional differentiation + GO:0048469 + cell maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state. + GOC:go_curators + + + + + functional differentiation + GOC:dph + @@ -14515,8 +26775,29 @@ + The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. + GO:0009993 + GO:0048157 + Wikipedia:Oogenesis + ovum development + biological_process + GO:0048477 oogenesis + + + + The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. + GOC:kmv + GOC:mtg_sensu + GOC:pr + + + + + ovum development + + @@ -14524,8 +26805,19 @@ + Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. + biological_process + rhythm + GO:0048511 + rhythmic process + + + + Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. + GOC:jid + @@ -14534,8 +26826,20 @@ + The specific behavior of an organism that recurs with a regularity of approximately 24 hours. + circadian rhythm behavior + biological_process + GO:0048512 circadian behavior + + + + The specific behavior of an organism that recurs with a regularity of approximately 24 hours. + GOC:bf + GOC:go_curators + GOC:pr + @@ -14543,14 +26847,21 @@ - - - - - - + Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + Wikipedia:Organogenesis + development of an organ + organogenesis + biological_process + GO:0048513 animal organ development + + + + Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GOC:dph + GOC:jid + @@ -14564,8 +26875,17 @@ + The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. + biological_process + GO:0048514 blood vessel morphogenesis + + + + The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. + GOC:jid + @@ -14581,8 +26901,19 @@ + The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. + spermatid cell differentiation + biological_process + GO:0048515 spermatid differentiation + + + + The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. + GOC:dph + GOC:jid + @@ -14607,8 +26938,25 @@ + Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GO:0043119 + positive regulation of physiological process + up regulation of biological process + up-regulation of biological process + upregulation of biological process + activation of biological process + stimulation of biological process + biological_process + GO:0048518 + positive regulation of biological process + + + + Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GOC:jid + @@ -14633,8 +26981,24 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GO:0043118 + down regulation of biological process + down-regulation of biological process + downregulation of biological process + negative regulation of physiological process + inhibition of biological process + biological_process + GO:0048519 + negative regulation of biological process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GOC:jid + @@ -14652,16 +27016,31 @@ - + + Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + up regulation of behavior + up-regulation of behavior + upregulation of behavior + activation of behavior + stimulation of behavior + biological_process + GO:0048520 positive regulation of behavior + + + + Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + GOC:jid + GOC:pr + @@ -14679,16 +27058,30 @@ - + + Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + down regulation of behavior + down-regulation of behavior + downregulation of behavior + inhibition of behavior + biological_process + GO:0048521 negative regulation of behavior + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + GOC:jid + GOC:pr + @@ -14714,8 +27107,25 @@ + Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GO:0051242 + positive regulation of cellular physiological process + up regulation of cellular process + up-regulation of cellular process + upregulation of cellular process + activation of cellular process + stimulation of cellular process + biological_process + GO:0048522 + positive regulation of cellular process + + + + Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:jid + @@ -14741,8 +27151,24 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GO:0051243 + down regulation of cellular process + down-regulation of cellular process + downregulation of cellular process + negative regulation of cellular physiological process + inhibition of cellular process + biological_process + GO:0048523 + negative regulation of cellular process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:jid + @@ -14756,8 +27182,22 @@ + The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. + haematopoietic or lymphoid organ development + haemopoietic or lymphoid organ development + hemopoietic or lymphoid organ development + biological_process + GO:0048534 hematopoietic or lymphoid organ development + + + + The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. + GOC:add + GOC:rl + ISBN:0781735149 + @@ -14782,8 +27222,17 @@ + Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + biological_process + GO:0048580 regulation of post-embryonic development + + + + Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + GOC:jid + @@ -14810,8 +27259,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + down regulation of post-embryonic development + down-regulation of post-embryonic development + downregulation of post-embryonic development + inhibition of post-embryonic development + biological_process + GO:0048581 negative regulation of post-embryonic development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + GOC:jid + @@ -14838,8 +27300,22 @@ + Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + up regulation of post-embryonic development + up-regulation of post-embryonic development + upregulation of post-embryonic development + activation of post-embryonic development + stimulation of post-embryonic development + biological_process + GO:0048582 positive regulation of post-embryonic development + + + + Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + GOC:jid + @@ -14864,8 +27340,19 @@ + Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + biological_process + GO:0048583 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of response to stimulus + + + + Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + GOC:jid + @@ -14891,8 +27378,24 @@ + Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + up regulation of response to stimulus + up-regulation of response to stimulus + upregulation of response to stimulus + activation of response to stimulus + stimulation of response to stimulus + biological_process + GO:0048584 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. positive regulation of response to stimulus + + + + Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + GOC:jid + @@ -14918,8 +27421,23 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + down regulation of response to stimulus + down-regulation of response to stimulus + downregulation of response to stimulus + inhibition of response to stimulus + biological_process + GO:0048585 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. negative regulation of response to stimulus + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + GOC:jid + @@ -14934,18 +27452,54 @@ + The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. + developmental growth of a unicellular organism + biological_process + GO:0048588 developmental cell growth + + + + The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. + GOC:go_curators + GOC:isa_complete + - + + + + + + + + + + + + + + + + + + The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. + biological_process + GO:0048589 developmental growth + + + + The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. + GOC:go_curators + @@ -14959,8 +27513,27 @@ + The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. + GO:0048828 + embryonic anatomical structure morphogenesis + biological_process + GO:0048598 embryonic morphogenesis + + + + The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. + GOC:jid + GOC:mtg_sensu + + + + + embryonic anatomical structure morphogenesis + GOC:dph + GOC:tb + @@ -14975,8 +27548,20 @@ + The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. + https://github.com/geneontology/go-ontology/issues/23445 + biological_process + GO:0048608 reproductive structure development + + + + The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. + GOC:dph + GOC:isa_complete + GOC:jid + @@ -14990,8 +27575,21 @@ + The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. + organismal reproductive process + reproductive process in a multicellular organism + biological_process + GO:0048609 multicellular organismal reproductive process + + + + The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. + GOC:dph + GOC:jid + GOC:tb + @@ -15017,8 +27615,17 @@ + Any process that modulates the frequency, rate or extent of developmental growth. + biological_process + GO:0048638 regulation of developmental growth + + + + Any process that modulates the frequency, rate or extent of developmental growth. + GOC:go_curators + @@ -15045,8 +27652,22 @@ + Any process that activates, maintains or increases the rate of developmental growth. + up regulation of developmental growth + up-regulation of developmental growth + upregulation of developmental growth + activation of developmental growth + stimulation of developmental growth + biological_process + GO:0048639 positive regulation of developmental growth + + + + Any process that activates, maintains or increases the rate of developmental growth. + GOC:go_curators + @@ -15073,8 +27694,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. + down regulation of developmental growth + down-regulation of developmental growth + downregulation of developmental growth + inhibition of developmental growth + biological_process + GO:0048640 negative regulation of developmental growth + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. + GOC:go_curators + @@ -15088,17 +27722,29 @@ + The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + formation of an anatomical structure involved in morphogenesis + biological_process + GO:0048646 + + Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. anatomical structure formation involved in morphogenesis - - - - - - - - generation of neurons - + + + + The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + GOC:dph + GOC:jid + GOC:tb + + + + + formation of an anatomical structure involved in morphogenesis + GOC:dph + GOC:tb + @@ -15112,8 +27758,28 @@ + The process in which the anatomical structures of the skeleton are generated and organized. + skeletal morphogenesis + biological_process + GO:0048705 skeletal system morphogenesis + + + + The process in which the anatomical structures of the skeleton are generated and organized. + GOC:dph + GOC:dsf + GOC:jid + GOC:tb + + + + + skeletal morphogenesis + GOC:dph + GOC:tb + @@ -15127,8 +27793,18 @@ + The process in which the anatomical structures of a tissue are generated and organized. + biological_process + GO:0048729 tissue morphogenesis + + + + The process in which the anatomical structures of a tissue are generated and organized. + GOC:dph + GOC:jid + @@ -15142,8 +27818,19 @@ + The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. + biological_process + GO:0048731 + system development + + + + The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. + GOC:dph + GOC:jid + @@ -15151,8 +27838,17 @@ + The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. + biological_process + GO:0048732 gland development + + + + The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. + GOC:jid + @@ -15167,8 +27863,27 @@ + The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. + biological_process + tubulogenesis + GO:0048754 branching morphogenesis of an epithelial tube + + + + The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. + GOC:dgh + GOC:dph + GOC:jid + + + + + tubulogenesis + GOC:dph + GOC:tb + @@ -15176,8 +27891,18 @@ + A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. + cellular_component + GO:0048770 pigment granule + + + + A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. + GOC:jid + GOC:mh + @@ -15185,8 +27910,21 @@ + The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + development of an anatomical structure + biological_process + GO:0048856 + + + anatomical structure development + + + + The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + GO_REF:0000021 + @@ -15195,24 +27933,46 @@ + A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. + biological_process + GO:0048869 cellular developmental process + + + + A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. + GOC:isa_complete + - - - - - - - - + + Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. + https://github.com/geneontology/go-ontology/issues/19809 + cell locomotion + movement of a cell + biological_process + cell movement + GO:0048870 + + + + cell motility + + + + Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. + GOC:dgh + GOC:dph + GOC:isa_complete + GOC:mlg + @@ -15221,8 +27981,17 @@ + Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. + biological_process + GO:0048871 multicellular organismal homeostasis + + + + Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. + GOC:isa_complete + @@ -15230,8 +27999,18 @@ + Any biological process involved in the maintenance of an internal steady state of a chemical. + biological_process + GO:0048878 + chemical homeostasis + + + + Any biological process involved in the maintenance of an internal steady state of a chemical. + GOC:isa_complete + @@ -15240,8 +28019,18 @@ + The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + biological_process + GO:0050432 catecholamine secretion + + + + The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:ai + GOC:ef + @@ -15267,8 +28056,17 @@ + Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. + biological_process + GO:0050433 regulation of catecholamine secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. + GOC:ai + @@ -15294,8 +28092,17 @@ + Any process that modulates the frequency, rate or extent of lymphocyte proliferation. + biological_process + GO:0050670 regulation of lymphocyte proliferation + + + + Any process that modulates the frequency, rate or extent of lymphocyte proliferation. + GOC:ai + @@ -15322,8 +28129,22 @@ + Any process that activates or increases the rate or extent of lymphocyte proliferation. + up regulation of lymphocyte proliferation + up-regulation of lymphocyte proliferation + upregulation of lymphocyte proliferation + activation of lymphocyte proliferation + stimulation of lymphocyte proliferation + biological_process + GO:0050671 positive regulation of lymphocyte proliferation + + + + Any process that activates or increases the rate or extent of lymphocyte proliferation. + GOC:ai + @@ -15350,8 +28171,21 @@ + Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation. + down regulation of lymphocyte proliferation + down-regulation of lymphocyte proliferation + downregulation of lymphocyte proliferation + inhibition of lymphocyte proliferation + biological_process + GO:0050672 negative regulation of lymphocyte proliferation + + + + Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation. + GOC:ai + @@ -15359,8 +28193,17 @@ + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. + biological_process + GO:0050673 epithelial cell proliferation + + + + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. + ISBN:0721662544 + @@ -15385,8 +28228,17 @@ + Any process that modulates the frequency, rate or extent of epithelial cell proliferation. + biological_process + GO:0050678 regulation of epithelial cell proliferation + + + + Any process that modulates the frequency, rate or extent of epithelial cell proliferation. + GOC:ai + @@ -15412,8 +28264,22 @@ + Any process that activates or increases the rate or extent of epithelial cell proliferation. + up regulation of epithelial cell proliferation + up-regulation of epithelial cell proliferation + upregulation of epithelial cell proliferation + activation of epithelial cell proliferation + stimulation of epithelial cell proliferation + biological_process + GO:0050679 positive regulation of epithelial cell proliferation + + + + Any process that activates or increases the rate or extent of epithelial cell proliferation. + GOC:ai + @@ -15439,8 +28305,21 @@ + Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. + down regulation of epithelial cell proliferation + down-regulation of epithelial cell proliferation + downregulation of epithelial cell proliferation + inhibition of epithelial cell proliferation + biological_process + GO:0050680 negative regulation of epithelial cell proliferation + + + + Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. + GOC:ai + @@ -15466,8 +28345,17 @@ + Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. + biological_process + GO:0050708 regulation of protein secretion + + + + Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. + GOC:ai + @@ -15494,8 +28382,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. + down regulation of protein secretion + down-regulation of protein secretion + downregulation of protein secretion + inhibition of protein secretion + biological_process + GO:0050709 negative regulation of protein secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. + GOC:ai + @@ -15522,8 +28423,22 @@ + Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. + up regulation of protein secretion + up-regulation of protein secretion + upregulation of protein secretion + activation of protein secretion + stimulation of protein secretion + biological_process + GO:0050714 positive regulation of protein secretion + + + + Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. + GOC:ai + @@ -15549,8 +28464,17 @@ + Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. + biological_process + GO:0050727 regulation of inflammatory response + + + + Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. + GOC:ai + @@ -15577,8 +28501,23 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. + GO:0030236 + anti-inflammatory response + down regulation of inflammatory response + down-regulation of inflammatory response + downregulation of inflammatory response + inhibition of inflammatory response + biological_process + GO:0050728 negative regulation of inflammatory response + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. + GOC:ai + @@ -15605,8 +28544,22 @@ + Any process that activates or increases the frequency, rate or extent of the inflammatory response. + up regulation of inflammatory response + up-regulation of inflammatory response + upregulation of inflammatory response + activation of inflammatory response + stimulation of inflammatory response + biological_process + GO:0050729 positive regulation of inflammatory response + + + + Any process that activates or increases the frequency, rate or extent of the inflammatory response. + GOC:ai + @@ -15626,20 +28579,23 @@ - - - - - - + Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. + biological_process + GO:0050767 regulation of neurogenesis + + + + Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. + GOC:ai + @@ -15666,8 +28622,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. + down regulation of neurogenesis + down-regulation of neurogenesis + downregulation of neurogenesis + inhibition of neurogenesis + biological_process + GO:0050768 negative regulation of neurogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. + GOC:ai + @@ -15694,8 +28663,22 @@ + Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. + up regulation of neurogenesis + up-regulation of neurogenesis + upregulation of neurogenesis + activation of neurogenesis + stimulation of neurogenesis + biological_process + GO:0050769 positive regulation of neurogenesis + + + + Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. + GOC:ai + @@ -15721,8 +28704,17 @@ + Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + biological_process + GO:0050776 regulation of immune response + + + + Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + GOC:ai + @@ -15749,8 +28741,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + down regulation of immune response + down-regulation of immune response + downregulation of immune response + inhibition of immune response + biological_process + GO:0050777 negative regulation of immune response + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + GOC:ai + @@ -15777,8 +28782,21 @@ + Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + up regulation of immune response + up-regulation of immune response + upregulation of immune response + stimulation of immune response + biological_process + GO:0050778 positive regulation of immune response + + + + Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + GOC:ai + @@ -15803,8 +28821,23 @@ + Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GO:0050791 + regulation of physiological process + biological_process + GO:0050789 + + + regulation of biological process + + + + Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GOC:ai + GOC:go_curators + @@ -15829,8 +28862,17 @@ + Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + biological_process + GO:0050793 regulation of developmental process + + + + Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:go_curators + @@ -15855,8 +28897,20 @@ + Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GO:0051244 + regulation of cellular physiological process + biological_process + GO:0050794 + regulation of cellular process + + + + Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:go_curators + @@ -15874,15 +28928,26 @@ - + + Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + regulation of behaviour + biological_process + GO:0050795 regulation of behavior + + + + Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + GOC:go_curators + GOC:pr + @@ -15908,8 +28973,17 @@ + Any process that modulates the frequency, rate or extent of the regulated release of insulin. + biological_process + GO:0050796 regulation of insulin secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of insulin. + GOC:ai + @@ -15917,8 +28991,21 @@ + Any process involved in the maintenance of an internal steady state of ions within an organism or cell. + GO:2000021 + biological_process + electrolyte homeostasis + negative regulation of crystal formation + regulation of ion homeostasis + GO:0050801 ion homeostasis + + + + Any process involved in the maintenance of an internal steady state of ions within an organism or cell. + GOC:ai + @@ -15938,8 +29025,17 @@ + The part of the circadian sleep/wake cycle where the organism is asleep. + biological_process + GO:0050802 circadian sleep/wake cycle, sleep + + + + The part of the circadian sleep/wake cycle where the organism is asleep. + GOC:ai + @@ -15965,8 +29061,22 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + regulation of steroid anabolism + regulation of steroid biosynthesis + regulation of steroid formation + regulation of steroid synthesis + regulation of steroidogenesis + biological_process + GO:0050810 regulation of steroid biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:ai + @@ -15974,8 +29084,19 @@ + The process in which a fluid solution, or part of it, changes into a solid or semisolid mass. + clotting + biological_process + GO:0050817 + coagulation + + + + The process in which a fluid solution, or part of it, changes into a solid or semisolid mass. + ISBN:0198506732 + @@ -16000,8 +29121,18 @@ + Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass. + regulation of clotting + biological_process + GO:0050818 regulation of coagulation + + + + Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass. + GOC:ai + @@ -16027,8 +29158,23 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. + down regulation of coagulation + down-regulation of coagulation + downregulation of coagulation + negative regulation of clotting + inhibition of coagulation + biological_process + anticoagulant activity + GO:0050819 negative regulation of coagulation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. + GOC:ai + @@ -16054,8 +29200,23 @@ + Any process that activates or increases the frequency, rate or extent of coagulation. + positive regulation of clotting + up regulation of coagulation + up-regulation of coagulation + upregulation of coagulation + activation of coagulation + stimulation of coagulation + biological_process + GO:0050820 positive regulation of coagulation + + + + Any process that activates or increases the frequency, rate or extent of coagulation. + GOC:ai + @@ -16080,8 +29241,20 @@ + Any process that modulates the frequency, rate or extent of T cell activation. + regulation of T lymphocyte activation + regulation of T-cell activation + regulation of T-lymphocyte activation + biological_process + GO:0050863 regulation of T cell activation + + + + Any process that modulates the frequency, rate or extent of T cell activation. + GOC:ai + @@ -16106,8 +29279,20 @@ + Any process that modulates the frequency, rate or extent of B cell activation. + regulation of B lymphocyte activation + regulation of B-cell activation + regulation of B-lymphocyte activation + biological_process + GO:0050864 regulation of B cell activation + + + + Any process that modulates the frequency, rate or extent of B cell activation. + GOC:ai + @@ -16132,8 +29317,17 @@ + Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. + biological_process + GO:0050865 regulation of cell activation + + + + Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. + GOC:ai + @@ -16159,8 +29353,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. + down regulation of cell activation + down-regulation of cell activation + downregulation of cell activation + inhibition of cell activation + biological_process + GO:0050866 negative regulation of cell activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. + GOC:ai + @@ -16186,8 +29393,22 @@ + Any process that activates or increases the frequency, rate or extent of activation. + up regulation of cell activation + up-regulation of cell activation + upregulation of cell activation + activation of cell activation + stimulation of cell activation + biological_process + GO:0050867 positive regulation of cell activation + + + + Any process that activates or increases the frequency, rate or extent of activation. + GOC:ai + @@ -16214,8 +29435,24 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation. + down regulation of T cell activation + down-regulation of T cell activation + downregulation of T cell activation + negative regulation of T lymphocyte activation + negative regulation of T-cell activation + negative regulation of T-lymphocyte activation + inhibition of T cell activation + biological_process + GO:0050868 negative regulation of T cell activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation. + GOC:ai + @@ -16241,8 +29478,24 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. + down regulation of B cell activation + down-regulation of B cell activation + downregulation of B cell activation + negative regulation of B lymphocyte activation + negative regulation of B-cell activation + negative regulation of B-lymphocyte activation + inhibition of B cell activation + biological_process + GO:0050869 negative regulation of B cell activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. + GOC:ai + @@ -16269,8 +29522,25 @@ + Any process that activates or increases the frequency, rate or extent of T cell activation. + positive regulation of T lymphocyte activation + positive regulation of T-cell activation + positive regulation of T-lymphocyte activation + up regulation of T cell activation + up-regulation of T cell activation + upregulation of T cell activation + activation of T cell activation + stimulation of T cell activation + biological_process + GO:0050870 positive regulation of T cell activation + + + + Any process that activates or increases the frequency, rate or extent of T cell activation. + GOC:ai + @@ -16296,8 +29566,25 @@ + Any process that activates or increases the frequency, rate or extent of B cell activation. + positive regulation of B lymphocyte activation + positive regulation of B-cell activation + positive regulation of B-lymphocyte activation + up regulation of B cell activation + up-regulation of B cell activation + upregulation of B cell activation + activation of B cell activation + stimulation of B cell activation + biological_process + GO:0050871 positive regulation of B cell activation + + + + Any process that activates or increases the frequency, rate or extent of B cell activation. + GOC:ai + @@ -16305,8 +29592,27 @@ + A organ system process carried out by any of the organs or tissues of neurological system. + https://github.com/geneontology/go-ontology/issues/13824 + neurological system process + neurophysiological process + biological_process + pan-neural process + GO:0050877 + + + + + nervous system process + + + + A organ system process carried out by any of the organs or tissues of neurological system. + GOC:ai + GOC:mtg_cardio + @@ -16314,8 +29620,20 @@ + Any process that modulates the levels of body fluids. + biological_process + GO:0050878 + regulation of body fluid levels + + + + Any process that modulates the levels of body fluids. + GOC:ai + GOC:dph + GOC:tb + @@ -16323,8 +29641,20 @@ + Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. + biological_process + GO:0050879 + multicellular organismal movement + + + + Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. + GOC:dph + GOC:mtg_muscle + GOC:tb + @@ -16333,8 +29663,17 @@ + The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. + biological_process + GO:0050881 musculoskeletal movement + + + + The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. + GOC:dph + @@ -16348,8 +29687,19 @@ + Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. + regulation of posture + biological_process + GO:0050884 neuromuscular process controlling posture + + + + Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. + GOC:dph + GOC:tb + @@ -16363,8 +29713,19 @@ + Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. + biological_process + regulation of balance + GO:0050885 neuromuscular process controlling balance + + + + Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. + GOC:ai + GOC:dph + @@ -16372,8 +29733,21 @@ + The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. + endocrine physiological process + endocrine physiology + biological_process + GO:0050886 + + endocrine process + + + + The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. + ISBN:0721662544 + @@ -16381,8 +29755,19 @@ + The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. + Wikipedia:Cognition + biological_process + GO:0050890 + cognition + + + + The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. + ISBN:0721619908 + @@ -16392,8 +29777,26 @@ + Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism. + biological_process + body fluid osmoregulation + GO:0050891 multicellular organismal water homeostasis + + + + Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism. + GOC:dph + GOC:tb + + + + + body fluid osmoregulation + GOC:dph + GOC:tb + @@ -16401,8 +29804,27 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. + GO:0051869 + physiological response to stimulus + biological_process + GO:0050896 + + + + + + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. + GOC:ai + GOC:bf + @@ -16410,8 +29832,19 @@ + Any process pertaining to the functions of the nervous and muscular systems of an organism. + neuromotor process + neuromuscular physiological process + biological_process + GO:0050905 neuromuscular process + + + + Any process pertaining to the functions of the nervous and muscular systems of an organism. + GOC:ai + @@ -16436,8 +29869,24 @@ + The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. + Wikipedia:Transduction_(physiology) + sensory detection of stimulus + sensory perception, sensory transduction of stimulus + sensory perception, stimulus detection + sensory transduction + biological_process + GO:0050906 detection of stimulus involved in sensory perception + + + + The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + GOC:dph + @@ -16463,8 +29912,24 @@ + The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception. + sensory detection of chemical stimulus + sensory detection of chemical stimulus during sensory perception + sensory perception, sensory detection of chemical stimulus + sensory perception, sensory transduction of chemical stimulus + sensory transduction of chemical stimulus + sensory transduction of chemical stimulus during sensory perception + biological_process + GO:0050907 detection of chemical stimulus involved in sensory perception + + + + The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception. + GOC:ai + GOC:dos + @@ -16490,8 +29955,25 @@ + The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. + sensory detection of light during visual perception + sensory detection of light stimulus during visual perception + sensory transduction of light during visual perception + sensory transduction of light stimulus during visual perception + visual perception, detection of light stimulus + visual perception, sensory transduction during perception of light + visual perception, sensory transduction of light stimulus + biological_process + GO:0050908 detection of light stimulus involved in visual perception + + + + The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + @@ -16499,8 +29981,22 @@ + The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. + Wikipedia:Taste + gustation + sense of taste + taste + taste perception + biological_process + GO:0050909 sensory perception of taste + + + + The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. + GOC:ai + @@ -16526,8 +30022,27 @@ + The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. + GO:0009592 + GO:0055128 + detection of sound + hearing, sensory transduction of sound + perception of sound, detection of mechanical stimulus + perception of sound, sensory detection of mechanical stimulus + perception of sound, sensory transduction of mechanical stimulus + sensory detection of mechanical stimulus during perception of sound + sensory transduction of mechanical stimulus during perception of sound + sensory transduction of sound + biological_process + GO:0050910 detection of mechanical stimulus involved in sensory perception of sound + + + + The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. + GOC:ai + @@ -16552,8 +30067,26 @@ + The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal. + perception of smell, detection of chemical stimulus + perception of smell, sensory detection of chemical stimulus + perception of smell, sensory transduction of chemical stimulus + sensory detection of chemical stimulus during perception of smell + sensory detection of scent + sensory detection of smell + sensory transduction of chemical stimulus during perception of smell + sensory transduction of scent + sensory transduction of smell + biological_process + GO:0050911 detection of chemical stimulus involved in sensory perception of smell + + + + The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal. + GOC:ai + @@ -16578,8 +30111,25 @@ + The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal. + taste perception + perception of taste, detection of chemical stimulus + perception of taste, sensory detection of chemical stimulus + perception of taste, sensory transduction of chemical stimulus + sensory detection of chemical stimulus during perception of taste + sensory detection of taste + sensory transduction of chemical stimulus during perception of taste + sensory transduction of taste + biological_process + GO:0050912 detection of chemical stimulus involved in sensory perception of taste + + + + The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal. + GOC:ai + @@ -16587,8 +30137,18 @@ + The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + sensory perception of thermal stimulus + biological_process + GO:0050951 sensory perception of temperature stimulus + + + + The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + @@ -16596,8 +30156,17 @@ + The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + biological_process + GO:0050952 sensory perception of electrical stimulus + + + + The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + @@ -16605,8 +30174,17 @@ + The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + biological_process + GO:0050953 sensory perception of light stimulus + + + + The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + @@ -16614,8 +30192,20 @@ + The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + mechanosensory perception + perception of mechanical stimulus + biological_process + chemi-mechanical coupling + GO:0050954 sensory perception of mechanical stimulus + + + + The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + @@ -16623,8 +30213,22 @@ + The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location. + Wikipedia:Electroreception + electroception sense + electroceptive sense + biological_process + GO:0050956 electroception + + + + The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location. + GOC:ai + PMID:10210663 + Wikipedia:Electroreception + @@ -16638,8 +30242,19 @@ + The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion. + Wikipedia:Equilibrioception + sensory perception of orientation with respect to gravity + biological_process + GO:0050957 equilibrioception + + + + The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion. + http://www.medterms.com + @@ -16647,8 +30262,29 @@ + Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning. + + + Wikipedia:Echolocation + biological sonar + perception of environment using reflected sound waves + biological_process + GO:0050959 echolocation + + + + Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning. + PMID:16005275 + Wikipedia:Animal_echolocation + + + + + biological sonar + https://en.wikipedia.org/wiki/Animal_echolocation + @@ -16674,8 +30310,32 @@ + The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception. + sensory detection of temperature stimulus + sensory detection of temperature stimulus during sensory perception + sensory detection of thermal stimulus during sensory perception + sensory perception, sensory detection of temperature stimulus + sensory perception, sensory detection of thermal stimulus + sensory perception, sensory transduction of temperature stimulus + sensory perception, sensory transduction of thermal stimulus + sensory transduction of temperature stimulus + sensory transduction of temperature stimulus during sensory perception + sensory transduction of thermal stimulus during sensory perception + sensory detection of heat stimulus during sensory perception + sensory perception, sensory detection of heat stimulus + sensory perception, sensory transduction of heat stimulus + sensory transduction of heat stimulus during sensory perception + biological_process + GO:0050961 detection of temperature stimulus involved in sensory perception + + + + The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception. + GOC:ai + GOC:dos + @@ -16701,8 +30361,24 @@ + The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. + sensory detection of light stimulus + sensory detection of light stimulus during sensory perception + sensory perception, sensory detection of light stimulus + sensory perception, sensory transduction of light stimulus + sensory transduction of light stimulus + sensory transduction of light stimulus during sensory perception + biological_process + GO:0050962 detection of light stimulus involved in sensory perception + + + + The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. + GOC:ai + GOC:dos + @@ -16728,8 +30404,24 @@ + The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception. + sensory detection of electrical stimulus + sensory detection of electrical stimulus during sensory perception + sensory perception, sensory detection of electrical stimulus + sensory perception, sensory transduction of electrical stimulus + sensory transduction of electrical stimulus + sensory transduction of electrical stimulus during sensory perception + biological_process + GO:0050963 detection of electrical stimulus involved in sensory perception + + + + The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception. + GOC:ai + GOC:dos + @@ -16754,8 +30446,32 @@ + The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal. + electroception, detection of electrical stimulus + electroception, sensory detection of electrical stimulus + electroception, sensory transduction + electroception, sensory transduction of electrical stimulus + biological_process + detection of electrical stimulus during electroreception + sensory detection of electrical stimulus during electroception + sensory transduction of electrical stimulus during electroception + GO:0050964 detection of electrical stimulus involved in electroception + + + + The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + + + + + detection of electrical stimulus during electroreception + GOC:dph + GOC:tb + @@ -16775,8 +30491,34 @@ + The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. + perception of pain, detection of temperature stimulus + perception of pain, sensory detection of temperature stimulus + perception of pain, sensory transduction of temperature stimulus + sensory detection of temperature stimulus during perception of pain + sensory detection of thermal stimulus during sensory perception of pain + sensory perception of pain, sensory detection of thermal stimulus + sensory perception of pain, sensory transduction of thermal stimulus + sensory transduction of temperature stimulus during perception of pain + sensory transduction of thermal stimulus during sensory perception of pain + biological_process + thermal nociception + GO:0050965 detection of temperature stimulus involved in sensory perception of pain + + + + The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + + + + + thermal nociception + GOC:pr + @@ -16796,8 +30538,30 @@ + The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal. + perception of pain, detection of mechanical stimulus + perception of pain, sensory detection of mechanical stimulus + perception of pain, sensory transduction of mechanical stimulus + sensory detection of mechanical stimulus during perception of pain + sensory transduction of mechanical stimulus during perception of pain + biological_process + mechanical nociception + GO:0050966 detection of mechanical stimulus involved in sensory perception of pain + + + + The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + + + + + mechanical nociception + GOC:pr + @@ -16817,8 +30581,33 @@ + The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal. + perception of pain, detection of electrical stimulus + perception of pain, sensory detection of electrical stimulus + perception of pain, sensory transduction of electrical stimulus + biological_process + detection of electrical stimulus during sensory perception of pain + sensory detection of electrical stimulus during perception of pain + sensory transduction of electrical stimulus during perception of pain + GO:0050967 detection of electrical stimulus involved in sensory perception of pain + + + + The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + GOC:dph + GOC:tb + + + + + detection of electrical stimulus during sensory perception of pain + GOC:dph + GOC:tb + @@ -16838,8 +30627,29 @@ + The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. + perception of pain, detection of chemical stimulus + perception of pain, sensory detection of chemical stimulus + perception of pain, sensory transduction of chemical stimulus + sensory detection of chemical stimulus during perception of pain + sensory transduction of chemical stimulus during perception of pain + biological_process + chemical nociception + GO:0050968 detection of chemical stimulus involved in sensory perception of pain + + + + The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. + GOC:ai + + + + + chemical nociception + GOC:pr + @@ -16864,8 +30674,23 @@ + The series of events involved in echolocation in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave. + echolocation, detection of mechanical stimulus + echolocation, sensory detection of mechanical stimulus + echolocation, sensory transduction of mechanical stimulus + sensory detection of mechanical stimulus during echolocation + sensory transduction of mechanical stimulus during echolocation + biological_process + GO:0050972 detection of mechanical stimulus involved in echolocation + + + + The series of events involved in echolocation in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave. + GOC:ai + GOC:dos + @@ -16890,8 +30715,23 @@ + The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears. + equilibrioception, detection of mechanical stimulus + equilibrioception, sensory detection of mechanical stimulus + equilibrioception, sensory transduction of mechanical stimulus + sensory detection of mechanical stimulus during equilibrioception + sensory transduction of mechanical stimulus during equilibrioception + biological_process + GO:0050973 detection of mechanical stimulus involved in equilibrioception + + + + The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears. + GOC:ai + GOC:dos + @@ -16917,8 +30757,24 @@ + The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception. + sensory detection of mechanical stimulus + sensory detection of mechanical stimulus during sensory perception + sensory perception, sensory detection of mechanical stimulus + sensory perception, sensory transduction of mechanical stimulus + sensory transduction of mechanical stimulus + sensory transduction of mechanical stimulus during sensory perception + biological_process + GO:0050974 detection of mechanical stimulus involved in sensory perception + + + + The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception. + GOC:ai + GOC:dos + @@ -16926,8 +30782,22 @@ + The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). + Wikipedia:Touch + perception of touch + tactile sense + taction + tactition + biological_process + GO:0050975 sensory perception of touch + + + + The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). + GOC:ai + @@ -16952,8 +30822,24 @@ + The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal. + perception of touch, detection of mechanical stimulus + perception of touch, sensory detection of mechanical stimulus + perception of touch, sensory transduction of mechanical stimulus + sensory detection of mechanical stimulus during perception of touch + sensory transduction of mechanical stimulus during perception of touch + tactition, sensory detection of mechanical stimulus + biological_process + GO:0050976 detection of mechanical stimulus involved in sensory perception of touch + + + + The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + @@ -16962,8 +30848,18 @@ + The series of events by which an electrical stimulus is received and converted into a molecular signal. + biological_process + GO:0050981 detection of electrical stimulus + + + + The series of events by which an electrical stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + @@ -16973,8 +30869,18 @@ + The series of events by which a mechanical stimulus is received and converted into a molecular signal. + biological_process + GO:0050982 detection of mechanical stimulus + + + + The series of events by which a mechanical stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + @@ -16999,8 +30905,17 @@ + Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + biological_process + GO:0051046 regulation of secretion + + + + Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + GOC:ai + @@ -17026,8 +30941,22 @@ + Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + up regulation of secretion + up-regulation of secretion + upregulation of secretion + activation of secretion + stimulation of secretion + biological_process + GO:0051047 positive regulation of secretion + + + + Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + GOC:ai + @@ -17053,8 +30982,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + down regulation of secretion + down-regulation of secretion + downregulation of secretion + inhibition of secretion + biological_process + GO:0051048 negative regulation of secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + GOC:ai + @@ -17079,8 +31021,18 @@ + Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0051049 + regulation of transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -17106,8 +31058,22 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + up regulation of transport + up-regulation of transport + upregulation of transport + activation of transport + stimulation of transport + biological_process + GO:0051050 positive regulation of transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -17133,8 +31099,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + down regulation of transport + down-regulation of transport + downregulation of transport + inhibition of transport + biological_process + GO:0051051 negative regulation of transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -17161,8 +31140,32 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + down regulation of lipid biosynthetic process + down-regulation of lipid biosynthetic process + downregulation of lipid biosynthetic process + negative regulation of lipid anabolism + negative regulation of lipid biosynthesis + negative regulation of lipid formation + negative regulation of lipid synthesis + negative regulation of lipogenesis + inhibition of lipid biosynthetic process + biological_process + GO:0051055 negative regulation of lipid biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + GOC:ai + + + + + negative regulation of lipogenesis + GOC:sl + @@ -17188,8 +31191,21 @@ + Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + down regulation of developmental process + down-regulation of developmental process + downregulation of developmental process + inhibition of developmental process + biological_process + GO:0051093 negative regulation of developmental process + + + + Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:ai + @@ -17215,8 +31231,22 @@ + Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + up regulation of developmental process + up-regulation of developmental process + upregulation of developmental process + activation of developmental process + stimulation of developmental process + biological_process + GO:0051094 positive regulation of developmental process + + + + Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:ai + @@ -17241,8 +31271,39 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. + regulation of cellular component organisation + biological_process + regulation of cell organisation + regulation of cell organization + regulation of cellular component organization and biogenesis + GO:0051128 regulation of cellular component organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. + GOC:ai + + + + + regulation of cell organisation + GOC:mah + + + + + regulation of cell organization + GOC:mah + + + + + regulation of cellular component organization and biogenesis + GOC:mah + @@ -17268,8 +31329,35 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. + down regulation of cell organization + down-regulation of cell organization + downregulation of cell organization + inhibition of cell organization + biological_process + negative regulation of cell organisation + negative regulation of cellular component organization and biogenesis + GO:0051129 negative regulation of cellular component organization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. + GOC:ai + + + + + negative regulation of cell organisation + GOC:mah + + + + + negative regulation of cellular component organization and biogenesis + GOC:mah + @@ -17295,8 +31383,30 @@ + Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. + positive regulation of cell organisation + up regulation of cell organization + up-regulation of cell organization + upregulation of cell organization + activation of cell organization + stimulation of cell organization + biological_process + positive regulation of cellular component organization and biogenesis + GO:0051130 positive regulation of cellular component organization + + + + Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. + GOC:ai + + + + + positive regulation of cellular component organization and biogenesis + GOC:mah + @@ -17321,8 +31431,26 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. + regulation of nitrogen metabolic process + regulation of nitrogen metabolism + biological_process + GO:0051171 regulation of nitrogen compound metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. + GOC:ai + GOC:tb + + + + + regulation of nitrogen metabolic process + GOC:tb + @@ -17348,8 +31476,30 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. + down regulation of nitrogen metabolic process + down-regulation of nitrogen metabolic process + downregulation of nitrogen metabolic process + negative regulation of nitrogen metabolic process + negative regulation of nitrogen metabolism + inhibition of nitrogen metabolic process + biological_process + GO:0051172 negative regulation of nitrogen compound metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. + GOC:ai + GOC:tb + + + + + negative regulation of nitrogen metabolic process + GOC:tb + @@ -17375,8 +31525,31 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. + positive regulation of nitrogen metabolic process + positive regulation of nitrogen metabolism + up regulation of nitrogen metabolic process + up-regulation of nitrogen metabolic process + upregulation of nitrogen metabolic process + activation of nitrogen metabolic process + stimulation of nitrogen metabolic process + biological_process + GO:0051173 positive regulation of nitrogen compound metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. + GOC:ai + GOC:tb + + + + + positive regulation of nitrogen metabolic process + GOC:tb + @@ -17384,8 +31557,42 @@ + Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. + jl + 2013-12-18T13:51:04Z + GO:1902578 + establishment and maintenance of localization + establishment and maintenance of position + localisation + establishment and maintenance of cellular component location + establishment and maintenance of substance location + establishment and maintenance of substrate location + biological_process + single organism localization + single-organism localization + GO:0051179 + localization + + + + Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. + GOC:ai + GOC:dos + + + + + localisation + GOC:mah + + + + + single organism localization + GOC:TermGenie + @@ -17405,8 +31612,25 @@ + The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + Wikipedia:Chondrogenesis + cartilage biogenesis + cartilage biosynthesis + cartilage element development + cartilage formation + cartilage organ development + chondrogenesis + biological_process + GO:0051216 cartilage development + + + + The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:cjm + PMID:23251424 + @@ -17433,8 +31657,22 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + up regulation of protein transport + up-regulation of protein transport + upregulation of protein transport + activation of protein transport + stimulation of protein transport + biological_process + GO:0051222 positive regulation of protein transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -17460,8 +31698,17 @@ + Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0051223 regulation of protein transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -17488,8 +31735,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + down regulation of protein transport + down-regulation of protein transport + downregulation of protein transport + inhibition of protein transport + biological_process + GO:0051224 negative regulation of protein transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -17497,8 +31757,29 @@ + Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. + establishment of localisation + biological_process + GO:0051234 + + + + establishment of localization + + + + Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. + GOC:ai + GOC:dos + + + + + establishment of localisation + GOC:mah + @@ -17523,8 +31804,19 @@ + Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. + biological_process + GO:0051239 regulation of multicellular organismal process + + + + Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. + GOC:ai + GOC:dph + GOC:tb + @@ -17550,8 +31842,22 @@ + Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. + up regulation of multicellular organismal process + up-regulation of multicellular organismal process + upregulation of multicellular organismal process + activation of multicellular organismal process + stimulation of multicellular organismal process + biological_process + GO:0051240 positive regulation of multicellular organismal process + + + + Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. + GOC:ai + @@ -17577,8 +31883,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. + down regulation of multicellular organismal process + down-regulation of multicellular organismal process + downregulation of multicellular organismal process + inhibition of multicellular organismal process + biological_process + GO:0051241 negative regulation of multicellular organismal process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. + GOC:ai + @@ -17603,8 +31922,17 @@ + Any process that modulates the frequency, rate or extent of lymphocyte activation. + biological_process + GO:0051249 regulation of lymphocyte activation + + + + Any process that modulates the frequency, rate or extent of lymphocyte activation. + GOC:ai + @@ -17630,8 +31958,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. + down regulation of lymphocyte activation + down-regulation of lymphocyte activation + downregulation of lymphocyte activation + inhibition of lymphocyte activation + biological_process + GO:0051250 negative regulation of lymphocyte activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. + GOC:ai + @@ -17657,89 +31998,22 @@ + Any process that activates or increases the frequency, rate or extent of lymphocyte activation. + up regulation of lymphocyte activation + up-regulation of lymphocyte activation + upregulation of lymphocyte activation + activation of lymphocyte activation + stimulation of lymphocyte activation + biological_process + GO:0051251 positive regulation of lymphocyte activation - - - - - - - - - - - - - - - - - - - - - - - - - - regulation of cellular component movement - - - - - - - - - - - - - - - - - - - - - - - - - - - negative regulation of cellular component movement - - - - - - - - - - - - - - - - - - - - - - - - - - - positive regulation of cellular component movement - + + + + Any process that activates or increases the frequency, rate or extent of lymphocyte activation. + GOC:ai + @@ -17747,8 +32021,24 @@ + The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. + Wikipedia:Cell_division + biological_process + GO:0051301 + + + + Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. cell division + + + + The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. + GOC:di + GOC:go_curators + GOC:pr + @@ -17773,8 +32063,17 @@ + Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. + biological_process + GO:0051302 regulation of cell division + + + + Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. + GOC:go_curators + @@ -17800,8 +32099,23 @@ + Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. + GO:0007126 + Wikipedia:Meiosis + biological_process + meiosis + GO:0051321 + + + Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. meiotic cell cycle + + + + Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. + GOC:ai + @@ -17826,8 +32140,27 @@ + The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity. + equilibrioception by proprioception + perception of orientation with respect to gravity by proprioception + biological_process + proprioception during equilibrioception + GO:0051355 proprioception involved in equilibrioception + + + + The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity. + GOC:ai + + + + + proprioception during equilibrioception + GOC:dph + GOC:tb + @@ -17852,8 +32185,27 @@ + The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity. + perception of orientation with respect to gravity by visual perception + equilibrioception by visual perception + biological_process + visual perception during equilibrioception + GO:0051356 visual perception involved in equilibrioception + + + + The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity. + GOC:ai + + + + + visual perception during equilibrioception + GOC:dph + GOC:tb + @@ -17879,8 +32231,32 @@ + Any process that modulates the rate or extent of progression through the meiotic cell cycle. + meiotic cell cycle modulation + meiotic cell cycle regulation + modulation of meiotic cell cycle progression + regulation of meiotic cell cycle progression + regulation of progression through meiotic cell cycle + biological_process + meiotic cell cycle regulator + GO:0051445 regulation of meiotic cell cycle + + + + Any process that modulates the rate or extent of progression through the meiotic cell cycle. + GOC:ai + GOC:dph + GOC:tb + + + + + regulation of progression through meiotic cell cycle + GOC:dph + GOC:tb + @@ -17907,8 +32283,33 @@ + Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. + positive regulation of meiotic cell cycle progression + positive regulation of progression through meiotic cell cycle + up regulation of progression through meiotic cell cycle + up-regulation of progression through meiotic cell cycle + upregulation of progression through meiotic cell cycle + activation of progression through meiotic cell cycle + stimulation of progression through meiotic cell cycle + biological_process + GO:0051446 positive regulation of meiotic cell cycle + + + + Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. + GOC:ai + GOC:dph + GOC:tb + + + + + positive regulation of progression through meiotic cell cycle + GOC:dph + GOC:tb + @@ -17935,8 +32336,32 @@ + Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. + down regulation of progression through meiotic cell cycle + down-regulation of progression through meiotic cell cycle + downregulation of progression through meiotic cell cycle + negative regulation of meiotic cell cycle progression + negative regulation of progression through meiotic cell cycle + inhibition of progression through meiotic cell cycle + biological_process + GO:0051447 negative regulation of meiotic cell cycle + + + + Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. + GOC:ai + GOC:dph + GOC:tb + + + + + negative regulation of progression through meiotic cell cycle + GOC:dph + GOC:tb + @@ -17944,8 +32369,18 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. + biological_process + response to electricity + GO:0051602 response to electrical stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. + GOC:ai + @@ -17953,27 +32388,67 @@ + The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. + stimulus detection + biological_process + perception of stimulus + stimulus sensing + GO:0051606 + detection of stimulus + + + + The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. + GOC:add + GOC:ai + GOC:dph + GOC:mah + - + - + - localization of cell - - - - - - - - - multi-organism process - + A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. + jl + 2013-12-18T14:04:32Z + GO:1902580 + cellular localisation + establishment and maintenance of cellular localization + establishment and maintenance of localization in cell or cell membrane + single organism cellular localization + intracellular localization + localization within cell + biological_process + single-organism cellular localization + GO:0051641 + + cellular localization + + + + + A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. + GOC:tb + GOC:vw + + + + + cellular localisation + GOC:mah + + + + + single organism cellular localization + GOC:TermGenie + @@ -17982,8 +32457,20 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. + biological_process + GO:0051716 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular response to stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. + GOC:bf + GOC:jl + @@ -18008,8 +32495,46 @@ + Any process that modulates the rate or extent of progression through the cell cycle. + GO:0000074 + GO:0007050 + GO:0071156 + GO:0071157 + GO:0071158 + GO:0071850 + cell cycle modulation + cell cycle regulation + control of cell cycle progression + modulation of cell cycle progression + regulation of cell cycle progression + regulation of progression through cell cycle + arrest of mitotic cell cycle progression + cell cycle arrest + mitotic cell cycle arrest + negative regulation of cell cycle arrest + positive regulation of cell cycle arrest + regulation of cell cycle arrest + biological_process + cell cycle regulator + tumor suppressor + GO:0051726 + regulation of cell cycle + + + + Any process that modulates the rate or extent of progression through the cell cycle. + GOC:ai + GOC:dph + GOC:tb + + + + + arrest of mitotic cell cycle progression + GOC:mah + @@ -18035,8 +32560,22 @@ + Any process that activates or increases the frequency, rate or extent of cell division. + up regulation of cell division + up-regulation of cell division + upregulation of cell division + activation of cell division + stimulation of cell division + biological_process + GO:0051781 positive regulation of cell division + + + + Any process that activates or increases the frequency, rate or extent of cell division. + GOC:ai + @@ -18062,8 +32601,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. + down regulation of cell division + down-regulation of cell division + downregulation of cell division + inhibition of cell division + biological_process + GO:0051782 negative regulation of cell division + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. + GOC:ai + @@ -18088,8 +32640,17 @@ + Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. + biological_process + GO:0051783 regulation of nuclear division + + + + Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. + GOC:ai + @@ -18115,8 +32676,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. + down regulation of nuclear division + down-regulation of nuclear division + downregulation of nuclear division + inhibition of nuclear division + biological_process + GO:0051784 negative regulation of nuclear division + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. + GOC:ai + @@ -18142,8 +32716,22 @@ + Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. + up regulation of nuclear division + up-regulation of nuclear division + upregulation of nuclear division + activation of nuclear division + stimulation of nuclear division + biological_process + GO:0051785 positive regulation of nuclear division + + + + Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. + GOC:ai + @@ -18168,8 +32756,17 @@ + Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. + biological_process + GO:0051930 regulation of sensory perception of pain + + + + Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. + GOC:ai + @@ -18194,8 +32791,17 @@ + Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. + biological_process + GO:0051931 regulation of sensory perception + + + + Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. + GOC:ai + @@ -18204,8 +32810,18 @@ + The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + biological_process + GO:0051937 catecholamine transport + + + + The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:ai + ISBN:0198506732 + @@ -18230,8 +32846,17 @@ + Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0051952 regulation of amine transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -18257,8 +32882,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + down regulation of amine transport + down-regulation of amine transport + downregulation of amine transport + inhibition of amine transport + biological_process + GO:0051953 negative regulation of amine transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -18284,8 +32922,22 @@ + Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + up regulation of amine transport + up-regulation of amine transport + upregulation of amine transport + activation of amine transport + stimulation of amine transport + biological_process + GO:0051954 positive regulation of amine transport + + + + Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -18310,8 +32962,17 @@ + Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + biological_process + GO:0051960 regulation of nervous system development + + + + Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + GOC:ai + @@ -18338,8 +32999,21 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + down regulation of nervous system development + down-regulation of nervous system development + downregulation of nervous system development + inhibition of nervous system development + biological_process + GO:0051961 negative regulation of nervous system development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + GOC:ai + @@ -18366,8 +33040,22 @@ + Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + up regulation of nervous system development + up-regulation of nervous system development + upregulation of nervous system development + activation of nervous system development + stimulation of nervous system development + biological_process + GO:0051962 positive regulation of nervous system development + + + + Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + GOC:ai + @@ -18379,8 +33067,18 @@ + The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. + imidazole metabolism + biological_process + GO:0052803 imidazole-containing compound metabolic process + + + + The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. + GOC:curators + @@ -18389,8 +33087,22 @@ + Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell. + biological_process + GO:0055065 + + + metal ion homeostasis + + + + Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell. + GOC:ai + GOC:jid + GOC:mah + @@ -18399,8 +33111,19 @@ + Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell. + biological_process + GO:0055067 monovalent inorganic cation homeostasis + + + + Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell. + GOC:ai + GOC:jid + GOC:mah + @@ -18409,8 +33132,20 @@ + Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell. + regulation of calcium ion concentration + biological_process + GO:0055074 calcium ion homeostasis + + + + Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell. + GOC:ceb + GOC:jid + GOC:mah + @@ -18419,8 +33154,19 @@ + Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. + biological_process + GO:0055078 sodium ion homeostasis + + + + Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. + GOC:ai + GOC:jid + GOC:mah + @@ -18428,8 +33174,19 @@ + Any process involved in the maintenance of an internal steady state of cations within an organism or cell. + biological_process + GO:0055080 cation homeostasis + + + + Any process involved in the maintenance of an internal steady state of cations within an organism or cell. + GOC:ceb + GOC:jid + GOC:mah + @@ -18455,8 +33212,17 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle contraction. + biological_process + GO:0055117 regulation of cardiac muscle contraction + + + + Any process that modulates the frequency, rate or extent of cardiac muscle contraction. + GOC:ecd + @@ -18483,8 +33249,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction. + biological_process + GO:0055118 negative regulation of cardiac muscle contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction. + GOC:ecd + @@ -18498,8 +33273,19 @@ + The transmission of vibrations via ossicles to the inner ear. + jid + 2009-10-13T10:59:39Z + biological_process + GO:0055127 vibrational conductance of sound to the inner ear + + + + The transmission of vibrations via ossicles to the inner ear. + GOC:mh + @@ -18507,8 +33293,19 @@ + An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness. + Wikipedia:Reflex + biological_process + GO:0060004 reflex + + + + An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness. + GOC:dph + ISBN:0877797099 + @@ -18516,8 +33313,17 @@ + A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness. + biological_process + GO:0060005 vestibular reflex + + + + A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness. + PMID:11784757 + @@ -18525,8 +33331,18 @@ + A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness. + biological_process + GO:0060007 linear vestibuloocular reflex + + + + A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness. + GOC:dph + PMID:11784757 + @@ -18540,8 +33356,20 @@ + The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. + heart beating + biological_process + cardiac contraction + hemolymph circulation + GO:0060047 heart contraction + + + + The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. + GOC:dph + @@ -18555,8 +33383,18 @@ + Muscle contraction of cardiac muscle tissue. + heart muscle contraction + biological_process + GO:0060048 cardiac muscle contraction + + + + Muscle contraction of cardiac muscle tissue. + GOC:dph + @@ -18581,8 +33419,17 @@ + Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury. + biological_process + GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing + + + + Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury. + GOC:dph + @@ -18607,8 +33454,18 @@ + Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. + biological_process + GO:0060055 angiogenesis involved in wound healing + + + + Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. + GOC:dph + PMID:15039218 + @@ -18617,8 +33474,20 @@ + The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body. + Wikipedia:Urination + urination + urine voiding + biological_process + GO:0060073 micturition + + + + The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body. + GOC:dph + @@ -18626,8 +33495,19 @@ + The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing. + nictitating membrane reflex + biological_process + GO:0060082 eye blink reflex + + + + The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing. + GOC:dph + PMID:2913208 + @@ -18652,8 +33532,26 @@ + The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body. + biological_process + smooth muscle contraction involved in urination + urinary bladder smooth muscle contraction involved in micturition + GO:0060083 smooth muscle contraction involved in micturition + + + + The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body. + GOC:dph + PMID:15827347 + + + + + urinary bladder smooth muscle contraction involved in micturition + GOC:dph + @@ -18661,8 +33559,22 @@ + A compound molecular function in which an effector function is controlled by one or more regulatory components. + molecular_function + GO:0060089 + + + + molecular transducer activity + + + + A compound molecular function in which an effector function is controlled by one or more regulatory components. + GOC:dos + GOC:pdt + @@ -18697,8 +33609,17 @@ + A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother. + biological_process + GO:0060136 embryonic process involved in female pregnancy + + + + A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother. + GOC:dph + @@ -18714,8 +33635,21 @@ + A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness. + milk ejection + biological_process + GO:0060156 milk ejection reflex + + + + A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness. + GOC:cjm + GOC:dph + GOC:mr + GOC:st + @@ -18723,8 +33657,19 @@ + The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur. + biological_process + GO:0060206 + + Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). estrous cycle phase + + + + The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur. + GOC:dph + @@ -18732,8 +33677,21 @@ + The estrous cycle phase in which a female is sexually receptive. + oestrus + biological_process + GO:0060209 + + Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). estrus + + + + The estrous cycle phase in which a female is sexually receptive. + GOC:dph + ISBN:0721662544 + @@ -18758,8 +33716,18 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + biological_process + GO:0060255 regulation of macromolecule metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -18784,8 +33752,27 @@ + Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. + regulation of feeding behaviour + biological_process + GO:0060259 regulation of feeding behavior + + + + Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. + GOC:BHF + GOC:dph + GOC:tb + + + + + regulation of feeding behaviour + GOC:dph + GOC:tb + @@ -18810,8 +33797,18 @@ + Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + biological_process + GO:0060284 regulation of cell development + + + + Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + GOC:dph + GOC:tb + @@ -18825,8 +33822,27 @@ + Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + GO:0071974 + cilium cell motility + microtubule-based flagellar cell motility + biological_process + ciliary cell motility + GO:0060285 + Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent. cilium-dependent cell motility + + + + Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + GOC:cilia + GOC:dgh + GOC:dph + GOC:krc + GOC:mlg + GOC:mtg_cambridge_2013 + @@ -18851,8 +33867,19 @@ + Movement of cilia mediated by motor proteins that contributes to the movement of a cell. + biological_process + GO:0060294 cilium movement involved in cell motility + + + + Movement of cilia mediated by motor proteins that contributes to the movement of a cell. + GOC:BHF + GOC:dph + GOC:tb + @@ -18878,8 +33905,63 @@ + Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility. + biological_process + GO:0060295 regulation of cilium movement involved in cell motility + + + + Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility. + GOC:BHF + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. + regulation of cellular localisation + biological_process + GO:0060341 + regulation of cellular localization + + + + + Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. + GOC:dph + GOC:tb + + + + + regulation of cellular localisation + GOC:mah + @@ -18893,8 +33975,17 @@ + The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. + biological_process + GO:0060348 bone development + + + + The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. + GOC:dph + @@ -18914,8 +34005,17 @@ + The process in which bones are generated and organized. + biological_process + GO:0060349 bone morphogenesis + + + + The process in which bones are generated and organized. + GOC:dph + @@ -18923,8 +34023,18 @@ + The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. + biological_process + GO:0060350 endochondral bone morphogenesis + + + + The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. + GOC:dph + PMID:11680679 + @@ -18949,8 +34059,17 @@ + The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. + biological_process + GO:0060351 cartilage development involved in endochondral bone morphogenesis + + + + The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. + GOC:dph + @@ -18958,8 +34077,17 @@ + Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement. + biological_process + GO:0060361 flight + + + + Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement. + GOC:dph + @@ -18985,8 +34113,19 @@ + Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. + biological_process + GO:0060405 regulation of penile erection + + + + Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. + GOC:add + GOC:dph + GOC:tb + @@ -19013,8 +34152,18 @@ + Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. + biological_process + GO:0060406 positive regulation of penile erection + + + + Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. + GOC:dph + GOC:tb + @@ -19041,8 +34190,18 @@ + Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. + biological_process + GO:0060407 negative regulation of penile erection + + + + Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. + GOC:dph + GOC:tb + @@ -19050,8 +34209,19 @@ + The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. + biological_process + GO:0060429 + epithelium development + + + + The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. + GOC:dph + GOC:mtg_lung + @@ -19078,8 +34248,18 @@ + Any process that increases the frequency, rate or extent of cardiac muscle contraction. + biological_process + GO:0060452 positive regulation of cardiac muscle contraction + + + + Any process that increases the frequency, rate or extent of cardiac muscle contraction. + GOC:dph + GOC:tb + @@ -19105,8 +34285,18 @@ + Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + biological_process + GO:0060453 regulation of gastric acid secretion + + + + Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:dph + GOC:tb + @@ -19133,8 +34323,18 @@ + Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + biological_process + GO:0060454 positive regulation of gastric acid secretion + + + + Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:dph + GOC:tb + @@ -19161,8 +34361,18 @@ + Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + biological_process + GO:0060455 negative regulation of gastric acid secretion + + + + Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:dph + GOC:tb + @@ -19188,8 +34398,18 @@ + Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + biological_process + GO:0060456 positive regulation of digestive system process + + + + Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:dph + GOC:tb + @@ -19215,8 +34435,18 @@ + Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + biological_process + GO:0060457 negative regulation of digestive system process + + + + Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:dph + GOC:tb + @@ -19242,8 +34472,20 @@ + The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence. + biological_process + positive regulation of sperm motility involved in capacitation + GO:0060474 positive regulation of flagellated sperm motility involved in capacitation + + + + The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence. + GOC:cilia + GOC:dph + GOC:krc + @@ -19268,8 +34510,26 @@ + The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. + dph + 2009-04-28T08:42:53Z + differential growth + biological_process + GO:0060560 developmental growth involved in morphogenesis + + + + The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. + GOC:dph + + + + + differential growth + GOC:dph + @@ -19278,8 +34538,19 @@ + The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + dph + 2009-04-28T09:33:36Z + biological_process + GO:0060562 epithelial tube morphogenesis + + + + The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + GOC:dph + @@ -19287,8 +34558,19 @@ + Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold. + dph + 2009-05-15T09:44:07Z + biological_process + GO:0060606 tube closure + + + + Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold. + GOC:dph + @@ -19314,8 +34596,20 @@ + Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. + dph + 2009-05-18T02:29:43Z + biological_process + GO:0060627 regulation of vesicle-mediated transport + + + + Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. + GOC:dph + GOC:tb + @@ -19334,15 +34628,26 @@ - + Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. + dph + 2009-05-18T03:07:02Z + biological_process + GO:0060632 regulation of microtubule-based movement + + + + Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. + GOC:dph + GOC:tb + @@ -19368,8 +34673,19 @@ + Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. + dph + 2009-06-05T12:41:44Z + biological_process + GO:0060688 regulation of morphogenesis of a branching structure + + + + Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. + GOC:dph + @@ -19394,8 +34710,26 @@ + Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure. + dph + 2009-07-06T09:24:53Z + cell-cell signalling involved in mammary gland development + biological_process + GO:0060764 cell-cell signaling involved in mammary gland development + + + + Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure. + GOC:dph + + + + + cell-cell signalling involved in mammary gland development + GOC:mah + @@ -19409,8 +34743,19 @@ + The regulated release of a hormone into the circulatory system. + dph + 2010-01-11T09:03:48Z + biological_process + GO:0060986 endocrine hormone secretion + + + + The regulated release of a hormone into the circulatory system. + GOC:dph + @@ -19418,8 +34763,27 @@ + An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. + dph + 2010-01-22T09:09:10Z + hepatobiliary system process + biological_process + GO:0061007 + hepaticobiliary system process + + + + An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. + GOC:dph + + + + + hepatobiliary system process + GOC:dph + @@ -19427,8 +34791,45 @@ + A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. + jl + 2010-02-08T02:43:11Z + GO:0016044 + GO:0044802 + cellular membrane organisation + cellular membrane organization + membrane organisation + biological_process + membrane organization and biogenesis + single-organism membrane organization + GO:0061024 + + + + + + membrane organization + + + + A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. + GOC:dph + GOC:tb + + + + + membrane organisation + GOC:mah + + + + + membrane organization and biogenesis + GOC:mah + @@ -19436,8 +34837,26 @@ + The membrane organization process that joins two lipid bilayers to form a single membrane. + jl + 2010-02-08T02:48:06Z + GO:0006944 + GO:0044801 + Wikipedia:Lipid_bilayer_fusion + cellular membrane fusion + biological_process + single-organism membrane fusion + GO:0061025 + membrane fusion + + + + The membrane organization process that joins two lipid bilayers to form a single membrane. + GOC:dph + GOC:tb + @@ -19462,8 +34881,19 @@ + Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + dph + 2010-02-09T03:41:35Z + biological_process + GO:0061035 regulation of cartilage development + + + + Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph + @@ -19490,8 +34920,19 @@ + Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + dph + 2010-02-09T03:41:35Z + biological_process + GO:0061036 positive regulation of cartilage development + + + + Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph + @@ -19518,8 +34959,19 @@ + Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + dph + 2010-02-09T03:41:35Z + biological_process + GO:0061037 negative regulation of cartilage development + + + + Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph + @@ -19544,8 +34996,20 @@ + Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. + dph + 2010-02-25T10:14:37Z + biological_process + GO:0061041 regulation of wound healing + + + + Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. + GOC:BHF + GOC:dph + @@ -19572,8 +35036,19 @@ + Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. + dph + 2010-02-25T10:33:30Z + biological_process + GO:0061045 negative regulation of wound healing + + + + Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. + GOC:dph + @@ -19598,8 +35073,20 @@ + Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + dph + 2010-03-11T12:59:21Z + biological_process + GO:0061062 regulation of nematode larval development + + + + Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + GOC:dph + GOC:kmv + @@ -19625,8 +35112,20 @@ + Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + dph + 2010-03-11T01:03:34Z + biological_process + GO:0061063 positive regulation of nematode larval development + + + + Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + GOC:dph + GOC:kmv + @@ -19652,8 +35151,20 @@ + Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + dph + 2010-03-11T01:04:39Z + biological_process + GO:0061064 negative regulation of nematode larval development + + + + Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + GOC:dph + GOC:kmv + @@ -19662,8 +35173,19 @@ + The process in which the anatomical structures of a branched epithelium are generated and organized. + dph + 2010-05-25T09:05:34Z + biological_process + GO:0061138 morphogenesis of a branching epithelium + + + + The process in which the anatomical structures of a branched epithelium are generated and organized. + GOC:dph + @@ -19689,8 +35211,20 @@ + Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. + dph + 2010-07-14T08:28:52Z + biological_process + GO:0061181 regulation of chondrocyte development + + + + Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. + GOC:BHF + GOC:dph + @@ -19717,8 +35251,20 @@ + Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. + dph + 2010-07-14T08:33:05Z + biological_process + GO:0061182 negative regulation of chondrocyte development + + + + Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. + GOC:BHF + GOC:dph + @@ -19726,8 +35272,19 @@ + The progression of a connective tissue over time, from its formation to the mature structure. + dph + 2012-03-22T12:53:41Z + biological_process + GO:0061448 connective tissue development + + + + The progression of a connective tissue over time, from its formation to the mature structure. + GOC:BHF + @@ -19735,8 +35292,19 @@ + The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. + dph + 2012-08-22T17:47:53Z + biological_process + GO:0061458 reproductive system development + + + + The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. + GOC:dph + @@ -19761,8 +35329,20 @@ + Any process that modulates the rate, frequency or extent of a small molecule metabolic process. + dph + 2018-03-19T14:11:54Z + regulation of small molecule metabolism + biological_process + GO:0062012 regulation of small molecule metabolic process + + + + Any process that modulates the rate, frequency or extent of a small molecule metabolic process. + GOC:vw + @@ -19788,8 +35368,20 @@ + Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. + dph + 2018-03-19T14:25:10Z + positive regulation of small molecule metabolism + biological_process + GO:0062013 positive regulation of small molecule metabolic process + + + + Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. + GOC:vw + @@ -19815,8 +35407,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. + dph + 2018-03-19T14:27:23Z + negative regulation of small molecule metabolism + biological_process + GO:0062014 negative regulation of small molecule metabolic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. + GOC:vw + @@ -19824,8 +35428,21 @@ + An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. + dph + 2018-04-13T12:47:21Z + cellular_component + GO:0062023 collagen-containing extracellular matrix + + + + An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. + GOC:BHF + GOC:rph + PMID:21123617 + @@ -19850,8 +35467,19 @@ + The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. + dph + 2019-09-13T13:48:47Z + biological_process + GO:0062149 detection of stimulus involved in sensory perception of pain + + + + The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. + PMID:19837031 + @@ -19859,8 +35487,24 @@ + Any process that modulates a measurable attribute of any biological process, quality or function. + regulation + biological_process + GO:0065007 + + biological regulation + + + + Any process that modulates a measurable attribute of any biological process, quality or function. + GOC:dph + GOC:isa_complete + GOC:mah + GOC:pr + GOC:vw + @@ -19868,8 +35512,24 @@ + Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. + regulation of biological attribute + regulation of biological characteristic + biological_process + GO:0065008 + regulation of biological quality + + + + Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. + GOC:dph + GOC:isa_complete + GOC:mah + GOC:pr + GOC:vw + @@ -19894,8 +35554,21 @@ + Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + regulation of a molecular function + biological_process + GO:0065009 + + + regulation of molecular function + + + + Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + GOC:isa_complete + @@ -19915,8 +35588,18 @@ + Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. + extracellular membrane-enclosed organelle + cellular_component + GO:0065010 extracellular membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. + GOC:isa_complete + @@ -19924,8 +35607,18 @@ + The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). + biological_process + GO:0070091 glucagon secretion + + + + The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). + GOC:BHF + GOC:rl + @@ -19950,8 +35643,18 @@ + Any process that modulates the frequency, rate or extent of the regulated release of glucagon. + biological_process + GO:0070092 regulation of glucagon secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of glucagon. + GOC:BHF + GOC:mah + @@ -19977,8 +35680,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. + down regulation of glucagon secretion + down-regulation of glucagon secretion + downregulation of glucagon secretion + inhibition of glucagon secretion + biological_process + GO:0070093 negative regulation of glucagon secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. + GOC:BHF + GOC:mah + @@ -20004,8 +35721,23 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. + up regulation of glucagon secretion + up-regulation of glucagon secretion + upregulation of glucagon secretion + activation of glucagon secretion + stimulation of glucagon secretion + biological_process + GO:0070094 positive regulation of glucagon secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. + GOC:BHF + GOC:mah + @@ -20013,8 +35745,32 @@ + A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. + Wikipedia:Tight_junction + occluding cell junction + occluding junction + cellular_component + GO:0070160 tight junction + + + + A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. + ISBN:0815332181 + + + + + occluding cell junction + GOC:mah + + + + + occluding junction + GOC:mah + @@ -20022,8 +35778,24 @@ + A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. + anchoring cell junction + cellular_component + GO:0070161 anchoring junction + + + + A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. + ISBN:0815332181 + + + + + anchoring cell junction + GOC:mah + @@ -20049,8 +35821,17 @@ + Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. + biological_process + GO:0070167 regulation of biomineral tissue development + + + + Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. + GOC:mah + @@ -20078,8 +35859,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. + biological_process + GO:0070168 negative regulation of biomineral tissue development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. + GOC:mah + @@ -20107,8 +35897,17 @@ + Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. + biological_process + GO:0070169 positive regulation of biomineral tissue development + + + + Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. + GOC:mah + @@ -20133,8 +35932,25 @@ + Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. + regulation of establishment of protein localisation + biological_process + GO:0070201 regulation of establishment of protein localization + + + + Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. + GOC:BHF + GOC:mah + + + + + regulation of establishment of protein localisation + GOC:mah + @@ -20142,8 +35958,17 @@ + The regulated release of somatostatin from secretory granules in the D cells of the pancreas. + biological_process + GO:0070253 somatostatin secretion + + + + The regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:mah + @@ -20152,8 +35977,26 @@ + The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. + mucus production + biological_process + GO:0070254 mucus secretion + + + + The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. + GOC:add + ISBN:068340007X + ISBN:0721662544 + + + + + mucus production + GOC:add + @@ -20180,8 +36023,24 @@ + Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + regulation of mucus production + biological_process + GO:0070255 regulation of mucus secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + GOC:add + + + + + regulation of mucus production + GOC:add + @@ -20208,8 +36067,24 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + negative regulation of mucus production + biological_process + GO:0070256 negative regulation of mucus secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + GOC:add + + + + + negative regulation of mucus production + GOC:add + @@ -20236,8 +36111,24 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + positive regulation of mucus production + biological_process + GO:0070257 positive regulation of mucus secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + GOC:add + + + + + positive regulation of mucus production + GOC:add + @@ -20251,8 +36142,31 @@ + The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell. + ECM constituent secretion + ECM secretion + biological_process + GO:0070278 extracellular matrix constituent secretion + + + + The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell. + GOC:mah + + + + + ECM constituent secretion + GOC:mah + + + + + ECM secretion + GOC:mah + @@ -20260,8 +36174,33 @@ + A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). + nephron absorption + renal reabsorption + biological_process + GO:0070293 renal absorption + + + + A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). + GOC:dph + GOC:mah + GOC:yaf + + + + + nephron absorption + GOC:mah + + + + + renal reabsorption + GOC:dph + @@ -20270,8 +36209,32 @@ + A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. + nephron water absorption + renal water reabsorption + biological_process + GO:0070295 renal water absorption + + + + A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. + GOC:dph + GOC:mah + + + + + nephron water absorption + GOC:mah + + + + + renal water reabsorption + GOC:dph + @@ -20279,8 +36242,32 @@ + A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located. + Wikipedia:Membrane_nanotube + non-sensory hair + imaginal disc-derived wing hair + cellular_component + GO:0070451 cell hair + + + + A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located. + PMID:11526084 + + + + + non-sensory hair + GOC:bf + + + + + imaginal disc-derived wing hair + GOC:mah + @@ -20288,8 +36275,18 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. + biological_process + GO:0070482 response to oxygen levels + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. + GOC:BHF + GOC:mah + @@ -20298,8 +36295,25 @@ + The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. + detection of reduced oxygen levels + biological_process + GO:0070483 detection of hypoxia + + + + The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. + GOC:BHF + GOC:mah + + + + + detection of reduced oxygen levels + GOC:vk + @@ -20307,8 +36321,19 @@ + The expansion of a leukocyte population by cell division. + mah + 2009-05-28T05:25:28Z + biological_process + GO:0070661 leukocyte proliferation + + + + The expansion of a leukocyte population by cell division. + GOC:add + @@ -20333,8 +36358,20 @@ + Any process that modulates the frequency, rate or extent of leukocyte proliferation. + mah + 2009-05-28T05:30:39Z + biological_process + GO:0070663 regulation of leukocyte proliferation + + + + Any process that modulates the frequency, rate or extent of leukocyte proliferation. + GOC:add + GOC:mah + @@ -20360,8 +36397,48 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. + mah + 2009-05-28T05:34:50Z + down regulation of leukocyte proliferation + down-regulation of leukocyte proliferation + downregulation of leukocyte proliferation + inhibition of leukocyte proliferation + biological_process + GO:0070664 negative regulation of leukocyte proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. + GOC:add + GOC:mah + + + + + down regulation of leukocyte proliferation + GOC:mah + + + + + down-regulation of leukocyte proliferation + GOC:mah + + + + + downregulation of leukocyte proliferation + GOC:mah + + + + + inhibition of leukocyte proliferation + GOC:mah + @@ -20387,8 +36464,83 @@ + Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. + mah + 2009-05-28T05:36:46Z + up regulation of leukocyte proliferation + up-regulation of leukocyte proliferation + upregulation of leukocyte proliferation + activation of leukocyte proliferation + stimulation of leukocyte proliferation + biological_process + GO:0070665 positive regulation of leukocyte proliferation + + + + Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. + GOC:add + GOC:mah + + + + + up regulation of leukocyte proliferation + GOC:mah + + + + + up-regulation of leukocyte proliferation + GOC:mah + + + + + upregulation of leukocyte proliferation + GOC:mah + + + + + activation of leukocyte proliferation + GOC:mah + + + + + stimulation of leukocyte proliferation + GOC:mah + + + + + + + + + + Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. + mah + 2009-06-16T04:08:29Z + cellular macromolecule localisation + biological_process + GO:0070727 + cellular macromolecule localization + + + + + Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. + GOC:mah + + + + + cellular macromolecule localisation + GOC:mah + @@ -20416,8 +36568,48 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + mah + 2009-08-14T03:09:02Z + regulation of bile acid anabolism + regulation of bile acid biosynthesis + regulation of bile acid formation + regulation of bile acid synthesis + biological_process + GO:0070857 regulation of bile acid biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + GOC:BHF + GOC:mah + + + + + regulation of bile acid anabolism + GOC:mah + + + + + regulation of bile acid biosynthesis + GOC:mah + + + + + regulation of bile acid formation + GOC:mah + + + + + regulation of bile acid synthesis + GOC:mah + @@ -20445,8 +36637,76 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + mah + 2009-08-14T03:16:40Z + down regulation of bile acid biosynthetic process + down-regulation of bile acid biosynthetic process + downregulation of bile acid biosynthetic process + negative regulation of bile acid anabolism + negative regulation of bile acid biosynthesis + negative regulation of bile acid formation + negative regulation of bile acid synthesis + inhibition of bile acid biosynthetic process + biological_process + GO:0070858 negative regulation of bile acid biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + GOC:BHF + GOC:mah + + + + + down regulation of bile acid biosynthetic process + GOC:mah + + + + + down-regulation of bile acid biosynthetic process + GOC:mah + + + + + downregulation of bile acid biosynthetic process + GOC:mah + + + + + negative regulation of bile acid anabolism + GOC:mah + + + + + negative regulation of bile acid biosynthesis + GOC:mah + + + + + negative regulation of bile acid formation + GOC:mah + + + + + negative regulation of bile acid synthesis + GOC:mah + + + + + inhibition of bile acid biosynthetic process + GOC:mah + @@ -20474,8 +36734,83 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + mah + 2009-08-14T03:22:58Z + positive regulation of bile acid anabolism + positive regulation of bile acid biosynthesis + positive regulation of bile acid formation + positive regulation of bile acid synthesis + up regulation of bile acid biosynthetic process + up-regulation of bile acid biosynthetic process + upregulation of bile acid biosynthetic process + activation of bile acid biosynthetic process + stimulation of bile acid biosynthetic process + biological_process + GO:0070859 positive regulation of bile acid biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + GOC:BHF + GOC:mah + + + + + positive regulation of bile acid anabolism + GOC:mah + + + + + positive regulation of bile acid biosynthesis + GOC:mah + + + + + positive regulation of bile acid formation + GOC:mah + + + + + positive regulation of bile acid synthesis + GOC:mah + + + + + up regulation of bile acid biosynthetic process + GOC:mah + + + + + up-regulation of bile acid biosynthetic process + GOC:mah + + + + + upregulation of bile acid biosynthetic process + GOC:mah + + + + + activation of bile acid biosynthetic process + GOC:mah + + + + + stimulation of bile acid biosynthetic process + GOC:mah + @@ -20493,7 +36828,7 @@ - + @@ -20502,8 +36837,26 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + mah + 2009-08-20T02:44:53Z + regulation of glycogen metabolism + biological_process + GO:0070873 regulation of glycogen metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + GOC:mah + + + + + regulation of glycogen metabolism + GOC:mah + @@ -20530,8 +36883,26 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + mah + 2009-08-20T02:50:41Z + negative regulation of glycogen metabolism + biological_process + GO:0070874 negative regulation of glycogen metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + GOC:mah + + + + + negative regulation of glycogen metabolism + GOC:mah + @@ -20558,8 +36929,26 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + mah + 2009-08-20T02:53:55Z + positive regulation of glycogen metabolism + biological_process + GO:0070875 positive regulation of glycogen metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + GOC:mah + + + + + positive regulation of glycogen metabolism + GOC:mah + @@ -20568,8 +36957,21 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. + mah + 2009-08-27T04:41:45Z + biological_process + GO:0070887 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular response to chemical stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. + GOC:mah + @@ -20577,8 +36979,26 @@ + The behavior in which an organism produces sounds by a mechanism involving its respiratory system. + mah + 2010-02-10T11:02:58Z + vocalisation behaviour + biological_process + GO:0071625 vocalization behavior + + + + The behavior in which an organism produces sounds by a mechanism involving its respiratory system. + GOC:mah + + + + + vocalisation behaviour + GOC:mah + @@ -20586,8 +37006,26 @@ + The process of biting and mashing food with the teeth prior to swallowing. + mah + 2010-02-10T11:19:48Z + chewing + biological_process + GO:0071626 mastication + + + + The process of biting and mashing food with the teeth prior to swallowing. + GOC:gvg + + + + + chewing + GOC:mah + @@ -20595,8 +37033,19 @@ + The developmental process in which an organism emerges from a surrounding protective structure such as an egg or pupa case. + mah + 2010-02-19T04:23:55Z + biological_process + GO:0071684 organism emergence from protective structure + + + + The developmental process in which an organism emerges from a surrounding protective structure such as an egg or pupa case. + GOC:mah + @@ -20604,8 +37053,27 @@ + Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. + mah + 2010-02-25T04:00:13Z + protein localisation in extracellular region + protein localization in extracellular region + biological_process + GO:0071692 protein localization to extracellular region + + + + Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. + GOC:mah + + + + + protein localisation in extracellular region + GOC:mah + @@ -20619,8 +37087,19 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. + mah + 2010-03-02T11:43:38Z + biological_process + GO:0071695 anatomical structure maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. + GOC:mah + @@ -20628,8 +37107,19 @@ + The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. + mah + 2010-03-08T02:15:14Z + biological_process + GO:0071702 organic substance transport + + + + The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. + GOC:mah + @@ -20637,8 +37127,22 @@ + The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. + mah + 2010-03-08T03:32:18Z + organic molecular entity metabolic process + organic molecular entity metabolism + organic substance metabolism + biological_process + GO:0071704 organic substance metabolic process + + + + The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. + GOC:mah + @@ -20646,8 +37150,19 @@ + The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + mah + 2010-03-08T03:56:28Z + biological_process + GO:0071705 nitrogen compound transport + + + + The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -20655,8 +37170,26 @@ + The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to a process of sexual reproduction. + mah + 2010-09-09T11:22:35Z + mating-type pheromone secretion + biological_process + GO:0071834 mating pheromone secretion + + + + The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to a process of sexual reproduction. + GOC:mah + + + + + mating-type pheromone secretion + GOC:vw + @@ -20664,8 +37197,37 @@ + A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. + mah + 2010-09-10T01:39:16Z + GO:0071841 + cellular component organisation or biogenesis + cellular component organisation or biogenesis at cellular level + cellular component organization or biogenesis at cellular level + biological_process + GO:0071840 + + cellular component organization or biogenesis + + + + A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. + GOC:mah + + + + + cellular component organisation or biogenesis + GOC:mah + + + + + cellular component organisation or biogenesis at cellular level + GOC:mah + @@ -20673,8 +37235,20 @@ + The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. + mah + 2010-10-04T01:51:47Z + cellular_component + GO:0071944 + cell periphery + + + + The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. + GOC:mah + @@ -20688,8 +37262,35 @@ + An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. + mah + 2010-10-11T11:44:57Z + elastic fibre + elastin fiber + cellular_component + GO:0071953 elastic fiber + + + + An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. + GOC:BHF + GOC:mah + PMID:20236620 + + + + + elastic fibre + GOC:mah + + + + + elastin fiber + GOC:BHF + @@ -20703,8 +37304,20 @@ + The developmental process pertaining to the initial formation of an epithelial tube. + https://github.com/geneontology/go-ontology/issues/22302 + mah + 2010-02-26T02:15:40Z + biological_process + GO:0072175 epithelial tube formation + + + + The developmental process pertaining to the initial formation of an epithelial tube. + GOC:mtg_kidney_jan10 + @@ -20730,8 +37343,19 @@ + Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + mah + 2010-03-01T03:43:29Z + biological_process + GO:0072201 negative regulation of mesenchymal cell proliferation + + + + Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:mtg_kidney_jan10 + @@ -20740,8 +37364,47 @@ + The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. + mah + 2010-11-02T04:51:32Z + monocarboxylic acid anabolism + monocarboxylic acid biosynthesis + monocarboxylic acid formation + monocarboxylic acid synthesis + biological_process + GO:0072330 monocarboxylic acid biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. + GOC:mah + + + + + monocarboxylic acid anabolism + GOC:mah + + + + + monocarboxylic acid biosynthesis + GOC:mah + + + + + monocarboxylic acid formation + GOC:mah + + + + + monocarboxylic acid synthesis + GOC:mah + @@ -20749,8 +37412,23 @@ + The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. + mah + 2010-11-16T11:27:39Z + GO:0072358 + cardiovascular system development + biological_process + GO:0072359 + circulatory system development + + + + The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. + GOC:mah + UBERON:0001009 + @@ -20759,8 +37437,20 @@ + Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell. + mah + 2010-12-16T03:22:48Z + biological_process + GO:0072507 + Note that this term was split from 'di-, tri-valent inorganic cation homeostasis ; GO:0055066' (sibling term 'trivalent inorganic cation homeostasis' ; GO:0072508'). divalent inorganic cation homeostasis + + + + Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell. + GOC:mah + @@ -20785,8 +37475,19 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + dhl + 2009-04-22T04:30:52Z + biological_process + GO:0080090 regulation of primary metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + PMID:19211694 + @@ -20811,8 +37512,21 @@ + Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). + dhl + 2009-05-06T04:51:28Z + biological_process + GO:0080134 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of response to stress + + + + Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). + GOC:dhl + @@ -20821,8 +37535,20 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. + tb + 2009-08-03T10:38:27Z + biological_process + GO:0090030 regulation of steroid hormone biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. + GOC:dph + GOC:tb + @@ -20832,8 +37558,20 @@ + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. + tb + 2009-08-03T10:40:32Z + biological_process + GO:0090031 positive regulation of steroid hormone biosynthetic process + + + + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. + GOC:dph + GOC:tb + @@ -20843,8 +37581,20 @@ + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. + tb + 2009-08-03T10:41:35Z + biological_process + GO:0090032 negative regulation of steroid hormone biosynthetic process + + + + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. + GOC:dph + GOC:tb + @@ -20870,8 +37620,20 @@ + Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. + tb + 2009-09-09T11:39:52Z + biological_process + GO:0090068 positive regulation of cell cycle process + + + + Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. + GOC:dph + GOC:tb + @@ -20896,8 +37658,20 @@ + Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + tb + 2009-10-23T11:21:38Z + biological_process + GO:0090087 regulation of peptide transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:dph + GOC:tb + @@ -20906,8 +37680,21 @@ + The joining of two lipid bilayers to form a single organelle membrane. + tb + 2009-12-11T11:44:58Z + biological_process + GO:0090174 organelle membrane fusion + + + + The joining of two lipid bilayers to form a single organelle membrane. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -20932,8 +37719,20 @@ + Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. + tb + 2010-02-03T11:48:13Z + biological_process + GO:0090257 regulation of muscle system process + + + + Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. + GOC:dph + GOC:tb + @@ -20958,8 +37757,19 @@ + Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + tb + 2010-02-05T02:54:14Z + biological_process + GO:0090273 regulation of somatostatin secretion + + + + Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:BHF + @@ -20985,8 +37795,19 @@ + Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + tb + 2010-02-05T02:54:14Z + biological_process + GO:0090274 positive regulation of somatostatin secretion + + + + Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:BHF + @@ -21012,8 +37833,19 @@ + Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + tb + 2010-02-05T02:54:14Z + biological_process + GO:0090275 negative regulation of somatostatin secretion + + + + Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:BHF + @@ -21039,8 +37871,19 @@ + Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + tb + 2010-02-05T02:56:39Z + biological_process + GO:0090276 regulation of peptide hormone secretion + + + + Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + GOC:tb + @@ -21067,8 +37910,19 @@ + Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + tb + 2010-02-05T02:56:39Z + biological_process + GO:0090277 positive regulation of peptide hormone secretion + + + + Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + GOC:tb + @@ -21095,8 +37949,19 @@ + Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + tb + 2010-02-05T02:56:39Z + biological_process + GO:0090278 negative regulation of peptide hormone secretion + + + + Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + GOC:tb + @@ -21122,8 +37987,19 @@ + Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. + tb + 2010-03-22T02:12:03Z + biological_process + GO:0090303 positive regulation of wound healing + + + + Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. + GOC:BHF + @@ -21149,8 +38025,21 @@ + Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + tb + 2010-05-14T10:24:29Z + biological_process + GO:0090325 regulation of locomotion involved in locomotory behavior + + + + Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:dph + GOC:kmv + GOC:tb + @@ -21177,8 +38066,21 @@ + Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + tb + 2010-05-14T10:26:58Z + biological_process + GO:0090326 positive regulation of locomotion involved in locomotory behavior + + + + Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:dph + GOC:kmv + GOC:tb + @@ -21205,8 +38107,21 @@ + Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + tb + 2010-05-14T10:26:58Z + biological_process + GO:0090327 negative regulation of locomotion involved in locomotory behavior + + + + Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:dph + GOC:kmv + GOC:tb + @@ -21233,8 +38148,20 @@ + Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue. + tb + 2010-05-14T10:37:22Z + biological_process + GO:0090328 regulation of olfactory learning + + + + Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue. + GOC:dph + GOC:tb + @@ -21243,8 +38170,19 @@ + The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents. + tb + 2014-08-12T12:13:53Z + biological_process + GO:0090594 inflammatory response to wounding + + + + The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents. + GOC:add + @@ -21258,8 +38196,21 @@ + Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory. + tb + 2016-11-11T12:20:30Z + biological_process + GO:0090713 immunological memory process + + + + Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory. + GOC:add + PMID:26086132 + PMID:26831526 + @@ -21267,8 +38218,21 @@ + Any immunological memory process that can contribute to the formation of immunological memory. + tb + 2016-11-11T12:25:47Z + biological_process + GO:0090715 immunological memory formation process + + + + Any immunological memory process that can contribute to the formation of immunological memory. + GOC:add + PMID:26086132 + PMID:26831526 + @@ -21293,8 +38257,31 @@ + All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. + pr + 2011-03-23T01:52:31Z + cilium plasm + microtubule-based flagellar matrix + microtubule-based flagellum matrix + cellular_component + cilial cytoplasm + ciliary cytoplasm + cilium cytoplasm + microtubule-based flagellar cytoplasm + microtubule-based flagellum cytoplasm + GO:0097014 + Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm". ciliary plasm + + + + All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. + GOC:BHF + GOC:cilia + GOC:dos + PMID:17895364 + @@ -21302,8 +38289,23 @@ + The chemical reactions and pathways involving the ammonium ion. + pr + 2011-09-28T04:21:30Z + ammonium ion metabolism + biological_process + ammonium metabolic process + GO:0097164 ammonium ion metabolic process + + + + The chemical reactions and pathways involving the ammonium ion. + GOC:dhl + GOC:tb + PMID:14671018 + @@ -21311,8 +38313,44 @@ + A renal system process in which fluid circulating through the body is filtered through a barrier system. + pr + 2012-01-03T03:10:17Z + biological_process + GO:0097205 renal filtration + + + + A renal system process in which fluid circulating through the body is filtered through a barrier system. + GOC:pr + GOC:sart + + + + + + + + + + The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. + https://github.com/geneontology/go-ontology/issues/22368 + pr + 2012-03-05T02:03:58Z + biological_process + GO:0097254 + renal tubular secretion + + + + + The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. + GOC:rph + PMID:25287933 + Wikipedia:Renal_secretion#Secretion + @@ -21320,8 +38358,21 @@ + A prolongation or process extending from a glial cell. + pr + 2012-10-22T13:55:54Z + cellular_component + glial process + glial projection + GO:0097386 glial cell projection + + + + A prolongation or process extending from a glial cell. + GOC:mc + @@ -21341,8 +38392,22 @@ + The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches. + pr + 2012-12-17T12:31:49Z + NIF_Subcellular:sao172297168 + cellular_component + GO:0097447 dendritic tree + + + + The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches. + GOC:aruk + GOC:bc + NIF_Subcellular:sao172297168 + @@ -21350,8 +38415,36 @@ + A prolongation or process extending from the soma of an astrocyte and wrapping around neurons. + pr + 2012-12-17T13:29:55Z + NIF_Subcellular:sao1630537580 + astrocyte process + cellular_component + peripheral astrocyte process + vellous process + GO:0097449 astrocyte projection + + + + A prolongation or process extending from the soma of an astrocyte and wrapping around neurons. + NIF_Subcellular:sao1630537580 + + + + + peripheral astrocyte process + NIF_Subcellular:sao1573004591 + PMID:12445894 + + + + + vellous process + NIF_Subcellular:sao1189060993 + @@ -21359,8 +38452,21 @@ + Terminal process of astrocyte abutting non-neuronal surfaces in the brain. + pr + 2012-12-17T13:33:55Z + NIF_Subcellular:sao388182739 + astrocyte endfoot + cellular_component + GO:0097450 astrocyte end-foot + + + + Terminal process of astrocyte abutting non-neuronal surfaces in the brain. + NIF_Subcellular:sao388182739 + @@ -21368,8 +38474,21 @@ + Axon of dentate gyrus granule cell projecting to hippocampal area CA3, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal. + pr + 2012-12-19T16:51:57Z + NIF_Subcellular:nlx_subcell_100312 + cellular_component + GO:0097457 hippocampal mossy fiber + + + + Axon of dentate gyrus granule cell projecting to hippocampal area CA3, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal. + NIF_Subcellular:nlx_subcell_100312 + PMID:17765709 + @@ -21389,8 +38508,19 @@ + Any vesicle that is part of the intracellular region. + pr + 2016-03-29T17:39:45Z + cellular_component + GO:0097708 intracellular vesicle + + + + Any vesicle that is part of the intracellular region. + GOC:vesicles + @@ -21399,8 +38529,22 @@ + Any process involved in the controlled movement of a sperm cell. + pr + 2016-09-01T12:00:45Z + sperm movement + biological_process + GO:0097722 + sperm motility + + + + Any process involved in the controlled movement of a sperm cell. + GOC:cilia + GOC:krc + @@ -21408,8 +38552,31 @@ + A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors. + pr + 2016-09-29T14:02:11Z + GO:0031513 + immotile cilium + nonmotile cilium + cellular_component + immotile primary cilium + nonmotile primary cilia + nonmotile primary cilium + sensory cilium + GO:0097730 non-motile cilium + + + + A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors. + GOC:cilia + GOC:dgh + GOC:kmv + PMID:17009929 + PMID:20144998 + PMID:22118931 + @@ -21417,8 +38584,24 @@ + A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). + pr + 2016-09-29T14:05:03Z + 9+0 immotile cilium + non-motile 9+0 cilium + primary cilium + cellular_component + GO:0097731 + This type of cilia may be present in solitary (authentic primary cilia in many cell types) or in multiple copies (e.g. in Grueneberg ganglion neurons). 9+0 non-motile cilium + + + + A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). + GOC:cilia + PMID:22118931 + @@ -21427,8 +38610,21 @@ + A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment. + pr + 2016-09-30T10:50:11Z + photoreceptor cilium + cellular_component + GO:0097733 photoreceptor cell cilium + + + + A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment. + GOC:cilia + Wikipedia:Photoreceptor_cell#Histology + @@ -21437,8 +38633,24 @@ + A vocalization behavior that is the result of learning. + dos + 2014-01-24T12:48:57Z + biological_process + GO:0098583 + Examples include human speech and learned bird song. learned vocalization behavior + + + + A vocalization behavior that is the result of learning. + GOC:BHF + GOC:dos + GOC:rl + PMID:16418265 + PMID:17035521 + @@ -21463,8 +38675,22 @@ + A membrane that is a (regional) part of the plasma membrane. + dos + 2014-03-06T11:55:32Z + region of plasma membrane + cellular_component + GO:0098590 + + Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. plasma membrane region + + + + A membrane that is a (regional) part of the plasma membrane. + GOC:dos + @@ -21472,8 +38698,24 @@ + Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned. + dos + 2014-04-10T11:34:33Z + biological_process + GO:0098598 + This grouping term is necessary because, in the absence of conditional mutations, it is not possible to use phenotypic evidence to distinguish an effect on vocal learning from an effect on learned vocalisation behavior. learned vocalization behavior or vocal learning + + + + Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned. + GOC:BHF + GOC:dos + GOC:rl + PMID:16418265 + PMID:17035521 + @@ -21481,8 +38723,21 @@ + The attachment of one cell to another cell via adhesion molecules. + dos + 2014-04-16T13:40:03Z + GO:0016337 + biological_process + single organismal cell-cell adhesion + GO:0098609 cell-cell adhesion + + + + The attachment of one cell to another cell via adhesion molecules. + GOC:dos + @@ -21507,8 +38762,17 @@ + A collagen trimer that forms networks. + cellular_component + GO:0098642 network-forming collagen trimer + + + + A collagen trimer that forms networks. + PMID:21421911 + @@ -21517,8 +38781,18 @@ + A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). + cellular_component + GO:0098643 banded collagen fibril + + + + A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). + GOC:dos + PMID:21421911 + @@ -21538,8 +38812,31 @@ + A complex of collagen trimers such as a fibril or collagen network. + Supramolecular aggregate of collagen + Supramolecular collagen assembly + cellular_component + GO:0098644 complex of collagen trimers + + + + A complex of collagen trimers such as a fibril or collagen network. + GOC:dos + + + + + Supramolecular aggregate of collagen + PMID:19693541 + + + + + Supramolecular collagen assembly + PMID:21421911 + @@ -21548,8 +38845,18 @@ + A supramolecular complex that consists of collagen triple helices associated to form a network. + cellular_component + GO:0098645 collagen network + + + + A supramolecular complex that consists of collagen triple helices associated to form a network. + GOC:dos + PMID:21421911 + @@ -21574,8 +38881,18 @@ + Any collagen timer that is part of a basement membrane. + cellular_component + GO:0098651 basement membrane collagen trimer + + + + Any collagen timer that is part of a basement membrane. + GOC:dos + PMID:21421911 + @@ -21583,8 +38900,17 @@ + Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell. + biological_process + GO:0098771 inorganic ion homeostasis + + + + Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell. + GOC:dos + @@ -21609,8 +38935,18 @@ + Any protein complex that is part of a membrane. + cellular_component + GO:0098796 + membrane protein complex + + + + Any protein complex that is part of a membrane. + GOC:dos + @@ -21635,8 +38971,17 @@ + Any protein complex that is part of the plasma membrane. + cellular_component + GO:0098797 plasma membrane protein complex + + + + Any protein complex that is part of the plasma membrane. + GOC:dos + @@ -21661,8 +39006,17 @@ + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. + biological_process + GO:0098801 regulation of renal system process + + + + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. + GOC:dos + @@ -21670,8 +39024,33 @@ + A cell projection of a podocyte (glomerular visceral epithelial cell) forming a foot-like structure projecting from a podocyte primary projection, that wraps around capillaries of a renal glomerulus. Adjacent feet (pedicels) interdigitate, leaving thin filtration slits between them, which are covered by slit diaphragms. + Wikipedia:Podocyte + pedicel + podocyte foot process + secondary podocyte projection + cellular_component + GO:0098846 podocyte foot + + + + A cell projection of a podocyte (glomerular visceral epithelial cell) forming a foot-like structure projecting from a podocyte primary projection, that wraps around capillaries of a renal glomerulus. Adjacent feet (pedicels) interdigitate, leaving thin filtration slits between them, which are covered by slit diaphragms. + PMID:25324828 + + + + + pedicel + Wikipedia:Podocyte + + + + + podocyte foot process + PMID:25324828 + @@ -21685,8 +39064,17 @@ + A cell projection supported by an assembly of actin filaments, and which lacks microtubules. + cellular_component + GO:0098858 actin-based cell projection + + + + A cell projection supported by an assembly of actin filaments, and which lacks microtubules. + PMID:15661519 + @@ -21694,8 +39082,17 @@ + A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. + cellular_component + GO:0099080 supramolecular complex + + + + A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. + GOC:dos + @@ -21703,8 +39100,17 @@ + A polymeric supramolecular structure. + cellular_component + GO:0099081 supramolecular polymer + + + + A polymeric supramolecular structure. + GOC:dos + @@ -21713,8 +39119,20 @@ + Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. + biological_process + GO:0099500 vesicle fusion to plasma membrane + + + + Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. + GOC:aruk + GOC:bc + ISBN:0071120009 + PMID:18618940 + @@ -21722,8 +39140,19 @@ + A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. + GO:0043205 + cellular_component + fibril + GO:0099512 supramolecular fiber + + + + A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. + GOC:dos + @@ -21737,8 +39166,17 @@ + A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. + cellular_component + GO:0099513 polymeric cytoskeletal fiber + + + + A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. + GOC:dos + @@ -21763,8 +39201,18 @@ + Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. + cellular_component + GO:0099568 + cytoplasmic region + + + + Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. + GOC:dos + @@ -21790,8 +39238,19 @@ + The complete extent of cell cortex that underlies some some region of the plasma membrane. + perimembrane region + cellular_component + GO:0099738 + cell cortex region + + + + The complete extent of cell cortex that underlies some some region of the plasma membrane. + GOC:dos + @@ -21817,8 +39276,22 @@ + Any process that modulates the frequency, rate or extent of the inflammatory response to wounding. + hjd + 2017-04-28T20:03:14Z + biological_process + GO:0106014 regulation of inflammatory response to wounding + + + + Any process that modulates the frequency, rate or extent of the inflammatory response to wounding. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:26022821 + @@ -21845,8 +39318,22 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding. + hjd + 2017-04-28T20:09:46Z + biological_process + GO:0106015 negative regulation of inflammatory response to wounding + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:26022821 + @@ -21873,8 +39360,22 @@ + Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding. + hjd + 2017-04-28T20:16:31Z + biological_process + GO:0106016 positive regulation of inflammatory response to wounding + + + + Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:26022821 + @@ -21901,8 +39402,19 @@ + Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis. + kmv + 2018-07-05T14:10:14Z + biological_process + GO:0110110 positive regulation of animal organ morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis. + GOC:kmv + @@ -21929,8 +39441,19 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis. + kmv + 2018-07-05T14:25:21Z + biological_process + GO:0110111 negative regulation of animal organ morphogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis. + GOC:kmv + @@ -21938,8 +39461,26 @@ + The process where mineral crystals are formed and deposited in an organized fashion in a matrix (either cellular or extracellular) by living organisms. This gives rise to inorganic compound-based structures such as skeleton, teeth, ivory, shells, cuticle, and corals as well as bacterial biomineralization products. + kmv + 2019-06-10T17:55:28Z + Wikipedia:Biomineralization + biomineralisation + mineralisation + mineralization + biomineral formation + biological_process + GO:0110148 biomineralization + + + + The process where mineral crystals are formed and deposited in an organized fashion in a matrix (either cellular or extracellular) by living organisms. This gives rise to inorganic compound-based structures such as skeleton, teeth, ivory, shells, cuticle, and corals as well as bacterial biomineralization products. + GOC:aa + PMID:24395694 + PMID:28229486 + @@ -21964,8 +39505,23 @@ + Any process that modulates the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms. + kmv + 2019-06-10T18:06:59Z + regulation of biomineralisation + regulation of mineralisation + regulation of mineralization + regulation of biomineral formation + biological_process + GO:0110149 regulation of biomineralization + + + + Any process that modulates the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms. + PMID:22992051 + @@ -21991,8 +39547,23 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms. + kmv + 2019-06-10T18:12:24Z + negative regulation of biomineralisation + negative regulation of mineralisation + negative regulation of mineralization + negative regulation of biomineral formation + biological_process + GO:0110150 negative regulation of biomineralization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms. + PMID:22992051 + @@ -22018,8 +39589,23 @@ + Any process that activates or increases the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms. + kmv + 2019-06-10T18:18:01Z + positive regulation of biomineralisation + positive regulation of mineralisation + positive regulation of mineralization + positive regulation of biomineral formation + biological_process + GO:0110151 positive regulation of biomineralization + + + + Any process that activates or increases the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms. + PMID:22992051 + @@ -22027,8 +39613,19 @@ + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. + kmv + 2019-08-12T18:01:37Z + cellular_component + GO:0110165 cellular anatomical entity + + + + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. + GOC:kmv + @@ -22053,8 +39650,20 @@ + A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. + https://github.com/geneontology/go-ontology/issues/13193 + krc + 2017-03-21T17:26:07Z + cellular_component + GO:0120025 plasma membrane bounded cell projection + + + + A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. + GOC:krc + @@ -22079,8 +39688,20 @@ + All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. + https://github.com/geneontology/go-ontology/issues/14472 + krc + 2017-11-01T18:58:12Z + cellular_component + GO:0120111 neuron projection cytoplasm + + + + All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. + GOC:ha + @@ -22089,8 +39710,21 @@ + The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. + https://github.com/geneontology/go-ontology/issues/16000 + krc + 2019-05-20T22:34:00Z + biological_process + GO:0120178 steroid hormone biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. + GOC:krc + GOC:nln + @@ -22098,8 +39732,22 @@ + The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C). + https://github.com/geneontology/go-ontology/issues/19936 + krc + 2020-09-02T23:13:44Z + alkene substituted compound metabolic process + alkene substituted compound metabolism + biological_process + GO:0120254 olefinic compound metabolic process + + + + The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C). + GOC:krc + @@ -22108,8 +39756,55 @@ + The chemical reactions and pathways resulting in the formation of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C). + https://github.com/geneontology/go-ontology/issues/19936 + krc + 2020-09-02T23:30:20Z + alkene substituted compound anabolic process + alkene substituted compound anabolism + alkene substituted compound biosynthesis + alkene substituted compound biosynthetic process + alkene substituted compound synthesis + biological_process + GO:0120255 olefinic compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C). + GOC:krc + + + + + alkene substituted compound anabolic process + GOC:krc + + + + + alkene substituted compound anabolism + GOC:krc + + + + + alkene substituted compound biosynthesis + GOC:krc + + + + + alkene substituted compound biosynthetic process + GOC:krc + + + + + alkene substituted compound synthesis + GOC:krc + @@ -22129,8 +39824,22 @@ + One of the two nuclear divisions that occur as part of the meiotic cell cycle. + https://github.com/geneontology/go-ontology/issues/19910 + pg + 2017-03-23T09:40:00Z + meiosis + biological_process + GO:0140013 + meiotic nuclear division + + + + One of the two nuclear divisions that occur as part of the meiotic cell cycle. + PMID:9334324 + @@ -22155,8 +39864,20 @@ + The cellular processes that contribute to exocytosis. + pg + 2017-05-15T13:20:45Z + biological_process + GO:0140029 + exocytic process + + + + The cellular processes that contribute to exocytosis. + Wikipedia:Exocytosis + @@ -22165,8 +39886,20 @@ + The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. + pg + 2019-05-22T11:20:45Z + efflux + biological_process + GO:0140352 export from cell + + + + The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. + GOC:pg + @@ -22175,8 +39908,20 @@ + The directed movement of a lipid from a cell, into the extracellular region. + pg + 2019-05-22T11:33:07Z + lipid efflux + biological_process + GO:0140353 lipid export from cell + + + + The directed movement of a lipid from a cell, into the extracellular region. + GOC:pg + @@ -22201,8 +39946,21 @@ + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. + pg + 2020-09-09T05:12:38Z + nuclear complex + cellular_component + GO:0140513 + nuclear protein-containing complex + + + + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. + GOC:pg + @@ -22228,8 +39986,19 @@ + Any process that modulates the frequency, rate or extent of hemostasis. + jl + 2012-01-19T03:23:38Z + biological_process + GO:1900046 regulation of hemostasis + + + + Any process that modulates the frequency, rate or extent of hemostasis. + GOC:TermGenie + @@ -22255,8 +40024,47 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis. + jl + 2012-01-19T03:23:42Z + down regulation of hemostasis + down-regulation of hemostasis + downregulation of hemostasis + inhibition of hemostasis + biological_process + GO:1900047 negative regulation of hemostasis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis. + GOC:TermGenie + + + + + down regulation of hemostasis + GOC:TermGenie + + + + + down-regulation of hemostasis + GOC:TermGenie + + + + + downregulation of hemostasis + GOC:TermGenie + + + + + inhibition of hemostasis + GOC:TermGenie + @@ -22282,8 +40090,47 @@ + Any process that activates or increases the frequency, rate or extent of hemostasis. + jl + 2012-01-19T03:23:45Z + up regulation of hemostasis + up-regulation of hemostasis + upregulation of hemostasis + activation of hemostasis + biological_process + GO:1900048 positive regulation of hemostasis + + + + Any process that activates or increases the frequency, rate or extent of hemostasis. + GOC:TermGenie + + + + + up regulation of hemostasis + GOC:TermGenie + + + + + up-regulation of hemostasis + GOC:TermGenie + + + + + upregulation of hemostasis + GOC:TermGenie + + + + + activation of hemostasis + GOC:TermGenie + @@ -22310,8 +40157,26 @@ + Any process that modulates the frequency, rate or extent of plasma cell differentiation. + bf + 2012-02-15T10:46:00Z + biological_process + regulation of plasma cell development + GO:1900098 regulation of plasma cell differentiation + + + + Any process that modulates the frequency, rate or extent of plasma cell differentiation. + GOC:TermGenie + + + + + regulation of plasma cell development + GOC:TermGenie + @@ -22339,8 +40204,82 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of plasma cell differentiation. + bf + 2012-02-15T10:46:05Z + down regulation of plasma cell differentiation + down-regulation of plasma cell differentiation + downregulation of plasma cell differentiation + inhibition of plasma cell differentiation + biological_process + down regulation of plasma cell development + down-regulation of plasma cell development + downregulation of plasma cell development + inhibition of plasma cell development + negative regulation of plasma cell development + GO:1900099 negative regulation of plasma cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of plasma cell differentiation. + GOC:TermGenie + + + + + down regulation of plasma cell differentiation + GOC:TermGenie + + + + + down-regulation of plasma cell differentiation + GOC:TermGenie + + + + + downregulation of plasma cell differentiation + GOC:TermGenie + + + + + inhibition of plasma cell differentiation + GOC:TermGenie + + + + + down regulation of plasma cell development + GOC:TermGenie + + + + + down-regulation of plasma cell development + GOC:TermGenie + + + + + downregulation of plasma cell development + GOC:TermGenie + + + + + inhibition of plasma cell development + GOC:TermGenie + + + + + negative regulation of plasma cell development + GOC:TermGenie + @@ -22368,8 +40307,82 @@ + Any process that activates or increases the frequency, rate or extent of plasma cell differentiation. + bf + 2012-02-15T10:46:08Z + up regulation of plasma cell differentiation + up-regulation of plasma cell differentiation + upregulation of plasma cell differentiation + activation of plasma cell differentiation + biological_process + activation of plasma cell development + positive regulation of plasma cell development + up regulation of plasma cell development + up-regulation of plasma cell development + upregulation of plasma cell development + GO:1900100 positive regulation of plasma cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of plasma cell differentiation. + GOC:TermGenie + + + + + up regulation of plasma cell differentiation + GOC:TermGenie + + + + + up-regulation of plasma cell differentiation + GOC:TermGenie + + + + + upregulation of plasma cell differentiation + GOC:TermGenie + + + + + activation of plasma cell differentiation + GOC:TermGenie + + + + + activation of plasma cell development + GOC:TermGenie + + + + + positive regulation of plasma cell development + GOC:TermGenie + + + + + up regulation of plasma cell development + GOC:TermGenie + + + + + up-regulation of plasma cell development + GOC:TermGenie + + + + + upregulation of plasma cell development + GOC:TermGenie + @@ -22377,8 +40390,30 @@ + The chemical reactions and pathways involving carbohydrate derivative. + bf + 2012-07-12T04:05:09Z + carbohydrate derivative metabolism + biological_process + GO:1901135 + + + + carbohydrate derivative metabolic process + + + + The chemical reactions and pathways involving carbohydrate derivative. + GOC:TermGenie + + + + + carbohydrate derivative metabolism + GOC:TermGenie + @@ -22387,8 +40422,47 @@ + The chemical reactions and pathways resulting in the formation of carbohydrate derivative. + bf + 2012-07-12T04:05:39Z + carbohydrate derivative anabolism + carbohydrate derivative biosynthesis + carbohydrate derivative formation + carbohydrate derivative synthesis + biological_process + GO:1901137 carbohydrate derivative biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of carbohydrate derivative. + GOC:TermGenie + + + + + carbohydrate derivative anabolism + GOC:TermGenie + + + + + carbohydrate derivative biosynthesis + GOC:TermGenie + + + + + carbohydrate derivative formation + GOC:TermGenie + + + + + carbohydrate derivative synthesis + GOC:TermGenie + @@ -22413,8 +40487,35 @@ + Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form. + bf + 2012-07-16T03:29:30Z + expression of extracellular matrix proteins + biological_process + extracellular matrix protein production + GO:1901148 gene expression involved in extracellular matrix organization + + + + Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form. + GOC:TermGenie + GOC:pg + PMID:18668558 + + + + + expression of extracellular matrix proteins + GOC:bf + + + + + extracellular matrix protein production + GOC:pg + @@ -22422,8 +40523,26 @@ + The chemical reactions and pathways involving primary amino compound. + bf + 2012-07-18T04:44:39Z + primary amino compound metabolism + biological_process + GO:1901160 primary amino compound metabolic process + + + + The chemical reactions and pathways involving primary amino compound. + GOC:TermGenie + + + + + primary amino compound metabolism + GOC:TermGenie + @@ -22449,8 +40568,29 @@ + Any process that modulates the frequency, rate or extent of flagellated sperm motility. + hjd + 2012-08-22T20:50:14Z + regulation of sperm motility + regulation of sperm movement + biological_process + GO:1901317 regulation of flagellated sperm motility + + + + Any process that modulates the frequency, rate or extent of flagellated sperm motility. + GOC:TermGenie + GOC:cilia + GOC:krc + + + + + regulation of sperm movement + GOC:TermGenie + @@ -22478,8 +40618,85 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility. + hjd + 2012-08-22T20:50:35Z + down regulation of sperm motility + down regulation of sperm movement + down-regulation of sperm motility + down-regulation of sperm movement + downregulation of sperm motility + downregulation of sperm movement + inhibition of sperm movement + negative regulation of sperm motility + negative regulation of sperm movement + inhibition of sperm motility + biological_process + GO:1901318 negative regulation of flagellated sperm motility + + + + Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility. + GOC:TermGenie + GOC:cilia + GOC:krc + + + + + down regulation of sperm motility + GOC:TermGenie + + + + + down regulation of sperm movement + GOC:TermGenie + + + + + down-regulation of sperm motility + GOC:TermGenie + + + + + down-regulation of sperm movement + GOC:TermGenie + + + + + downregulation of sperm motility + GOC:TermGenie + + + + + downregulation of sperm movement + GOC:TermGenie + + + + + inhibition of sperm movement + GOC:TermGenie + + + + + negative regulation of sperm movement + GOC:TermGenie + + + + + inhibition of sperm motility + GOC:TermGenie + @@ -22504,8 +40721,26 @@ + Any process that modulates the frequency, rate or extent of vasculature development. + bf + 2012-09-06T09:16:15Z + biological_process + regulation of vascular system development + GO:1901342 regulation of vasculature development + + + + Any process that modulates the frequency, rate or extent of vasculature development. + GOC:TermGenie + + + + + regulation of vascular system development + GOC:TermGenie + @@ -22532,8 +40767,82 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. + bf + 2012-09-06T09:17:24Z + down regulation of vasculature development + down-regulation of vasculature development + downregulation of vasculature development + inhibition of vasculature development + biological_process + down regulation of vascular system development + down-regulation of vascular system development + downregulation of vascular system development + inhibition of vascular system development + negative regulation of vascular system development + GO:1901343 negative regulation of vasculature development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. + GOC:TermGenie + + + + + down regulation of vasculature development + GOC:TermGenie + + + + + down-regulation of vasculature development + GOC:TermGenie + + + + + downregulation of vasculature development + GOC:TermGenie + + + + + inhibition of vasculature development + GOC:TermGenie + + + + + down regulation of vascular system development + GOC:TermGenie + + + + + down-regulation of vascular system development + GOC:TermGenie + + + + + downregulation of vascular system development + GOC:TermGenie + + + + + inhibition of vascular system development + GOC:TermGenie + + + + + negative regulation of vascular system development + GOC:TermGenie + @@ -22541,8 +40850,26 @@ + The chemical reactions and pathways involving organic cyclic compound. + bf + 2012-09-14T09:03:51Z + organic cyclic compound metabolism + biological_process + GO:1901360 organic cyclic compound metabolic process + + + + The chemical reactions and pathways involving organic cyclic compound. + GOC:TermGenie + + + + + organic cyclic compound metabolism + GOC:TermGenie + @@ -22551,8 +40878,47 @@ + The chemical reactions and pathways resulting in the formation of organic cyclic compound. + bf + 2012-09-14T09:05:22Z + organic cyclic compound anabolism + organic cyclic compound biosynthesis + organic cyclic compound formation + organic cyclic compound synthesis + biological_process + GO:1901362 organic cyclic compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of organic cyclic compound. + GOC:TermGenie + + + + + organic cyclic compound anabolism + GOC:TermGenie + + + + + organic cyclic compound biosynthesis + GOC:TermGenie + + + + + organic cyclic compound formation + GOC:TermGenie + + + + + organic cyclic compound synthesis + GOC:TermGenie + @@ -22561,8 +40927,27 @@ + The chemical reactions and pathways involving organonitrogen compound. + pr + 2012-11-04T15:17:52Z + organonitrogen compound metabolism + biological_process + GO:1901564 organonitrogen compound metabolic process + + + + The chemical reactions and pathways involving organonitrogen compound. + GOC:TermGenie + GOC:pr + + + + + organonitrogen compound metabolism + GOC:TermGenie + @@ -22571,8 +40956,48 @@ + The chemical reactions and pathways resulting in the formation of organonitrogen compound. + pr + 2012-11-04T15:18:00Z + organonitrogen compound anabolism + organonitrogen compound biosynthesis + organonitrogen compound formation + organonitrogen compound synthesis + biological_process + GO:1901566 organonitrogen compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of organonitrogen compound. + GOC:TermGenie + GOC:pr + + + + + organonitrogen compound anabolism + GOC:TermGenie + + + + + organonitrogen compound biosynthesis + GOC:TermGenie + + + + + organonitrogen compound formation + GOC:TermGenie + + + + + organonitrogen compound synthesis + GOC:TermGenie + @@ -22581,8 +41006,45 @@ + The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon. + pr + 2012-11-05T11:04:36Z + organic molecular entity breakdown + organic molecular entity catabolic process + organic molecular entity catabolism + organic molecular entity degradation + organic substance breakdown + organic substance catabolism + organic substance degradation + biological_process + GO:1901575 organic substance catabolic process + + + + The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon. + GOC:TermGenie + GOC:pr + + + + + organic molecular entity breakdown + GOC:TermGenie + + + + + organic molecular entity catabolism + GOC:TermGenie + + + + + organic molecular entity degradation + GOC:TermGenie + @@ -22591,8 +41053,53 @@ + The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. + pr + 2012-11-05T11:04:40Z + organic molecular entity anabolism + organic molecular entity biosynthesis + organic molecular entity biosynthetic process + organic molecular entity formation + organic molecular entity synthesis + organic substance anabolism + organic substance biosynthesis + organic substance formation + organic substance synthesis + biological_process + GO:1901576 organic substance biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. + GOC:TermGenie + GOC:pr + + + + + organic molecular entity anabolism + GOC:TermGenie + + + + + organic molecular entity biosynthesis + GOC:TermGenie + + + + + organic molecular entity formation + GOC:TermGenie + + + + + organic molecular entity synthesis + GOC:TermGenie + @@ -22600,8 +41107,26 @@ + The chemical reactions and pathways involving an alpha-amino acid. + tb + 2012-11-08T17:39:50Z + alpha-amino acid metabolism + biological_process + GO:1901605 alpha-amino acid metabolic process + + + + The chemical reactions and pathways involving an alpha-amino acid. + GOC:TermGenie + + + + + alpha-amino acid metabolism + GOC:TermGenie + @@ -22609,8 +41134,27 @@ + The chemical reactions and pathways involving organic hydroxy compound. + pr + 2012-11-13T12:54:27Z + organic hydroxy compound metabolism + biological_process + GO:1901615 organic hydroxy compound metabolic process + + + + The chemical reactions and pathways involving organic hydroxy compound. + GOC:TermGenie + GOC:pr + + + + + organic hydroxy compound metabolism + GOC:TermGenie + @@ -22619,8 +41163,48 @@ + The chemical reactions and pathways resulting in the formation of organic hydroxy compound. + pr + 2012-11-13T12:54:36Z + organic hydroxy compound anabolism + organic hydroxy compound biosynthesis + organic hydroxy compound formation + organic hydroxy compound synthesis + biological_process + GO:1901617 organic hydroxy compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of organic hydroxy compound. + GOC:TermGenie + GOC:pr + + + + + organic hydroxy compound anabolism + GOC:TermGenie + + + + + organic hydroxy compound biosynthesis + GOC:TermGenie + + + + + organic hydroxy compound formation + GOC:TermGenie + + + + + organic hydroxy compound synthesis + GOC:TermGenie + @@ -22628,8 +41212,21 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. + pr + 2012-12-13T15:11:37Z + response to oxygen molecular entity + biological_process + GO:1901700 response to oxygen-containing compound + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. + GOC:TermGenie + GOC:pr + @@ -22654,8 +41251,23 @@ + Any process that modulates the frequency, rate or extent of cilium-dependent cell motility. + jl + 2013-03-27T14:42:38Z + regulation of cilium cell motility + biological_process + regulation of ciliary cell motility + GO:1902019 regulation of cilium-dependent cell motility + + + + Any process that modulates the frequency, rate or extent of cilium-dependent cell motility. + GOC:TermGenie + GOC:cilia + GOC:jl + @@ -22681,8 +41293,51 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility. + jl + 2013-03-27T14:42:42Z + down regulation of ciliary cell motility + down-regulation of ciliary cell motility + downregulation of ciliary cell motility + negative regulation of cilium cell motility + inhibition of ciliary cell motility + biological_process + negative regulation of ciliary cell motility + GO:1902020 negative regulation of cilium-dependent cell motility + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility. + GOC:TermGenie + GOC:cilia + GOC:jl + + + + + down regulation of ciliary cell motility + GOC:TermGenie + + + + + down-regulation of ciliary cell motility + GOC:TermGenie + + + + + downregulation of ciliary cell motility + GOC:TermGenie + + + + + inhibition of ciliary cell motility + GOC:TermGenie + @@ -22710,8 +41365,87 @@ + Any process that activates or increases the frequency, rate or extent of flagellated sperm motility. + bf + 2013-04-29T09:15:25Z + activation of sperm movement + positive regulation of sperm motility + positive regulation of sperm movement + up regulation of sperm motility + up regulation of sperm movement + up-regulation of sperm motility + up-regulation of sperm movement + upregulation of sperm motility + upregulation of sperm movement + activation of sperm motility + biological_process + GO:1902093 positive regulation of flagellated sperm motility + + + + Any process that activates or increases the frequency, rate or extent of flagellated sperm motility. + GOC:TermGenie + GOC:cilia + GOC:jh2 + GOC:krc + PMID:7513657 + + + + + activation of sperm movement + GOC:TermGenie + + + + + positive regulation of sperm movement + GOC:TermGenie + + + + + up regulation of sperm motility + GOC:TermGenie + + + + + up regulation of sperm movement + GOC:TermGenie + + + + + up-regulation of sperm motility + GOC:TermGenie + + + + + up-regulation of sperm movement + GOC:TermGenie + + + + + upregulation of sperm motility + GOC:TermGenie + + + + + upregulation of sperm movement + GOC:TermGenie + + + + + activation of sperm motility + GOC:TermGenie + @@ -22737,8 +41471,34 @@ + Any process that modulates the frequency, rate or extent of leukocyte differentiation. + pr + 2013-05-02T17:32:42Z + regulation of immune cell differentiation + regulation of leucocyte differentiation + biological_process + GO:1902105 regulation of leukocyte differentiation + + + + Any process that modulates the frequency, rate or extent of leukocyte differentiation. + GOC:TermGenie + GOC:add + + + + + regulation of immune cell differentiation + GOC:TermGenie + + + + + regulation of leucocyte differentiation + GOC:TermGenie + @@ -22765,8 +41525,118 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. + pr + 2013-05-02T17:32:47Z + down regulation of immune cell differentiation + down regulation of leucocyte differentiation + down regulation of leukocyte differentiation + down-regulation of immune cell differentiation + down-regulation of leucocyte differentiation + down-regulation of leukocyte differentiation + downregulation of immune cell differentiation + downregulation of leucocyte differentiation + downregulation of leukocyte differentiation + negative regulation of immune cell differentiation + negative regulation of leucocyte differentiation + inhibition of immune cell differentiation + inhibition of leucocyte differentiation + inhibition of leukocyte differentiation + biological_process + GO:1902106 negative regulation of leukocyte differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. + GOC:TermGenie + GOC:add + + + + + down regulation of immune cell differentiation + GOC:TermGenie + + + + + down regulation of leucocyte differentiation + GOC:TermGenie + + + + + down regulation of leukocyte differentiation + GOC:TermGenie + + + + + down-regulation of immune cell differentiation + GOC:TermGenie + + + + + down-regulation of leucocyte differentiation + GOC:TermGenie + + + + + down-regulation of leukocyte differentiation + GOC:TermGenie + + + + + downregulation of immune cell differentiation + GOC:TermGenie + + + + + downregulation of leucocyte differentiation + GOC:TermGenie + + + + + downregulation of leukocyte differentiation + GOC:TermGenie + + + + + negative regulation of immune cell differentiation + GOC:TermGenie + + + + + negative regulation of leucocyte differentiation + GOC:TermGenie + + + + + inhibition of immune cell differentiation + GOC:TermGenie + + + + + inhibition of leucocyte differentiation + GOC:TermGenie + + + + + inhibition of leukocyte differentiation + GOC:TermGenie + @@ -22793,8 +41663,118 @@ + Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. + pr + 2013-05-02T17:32:52Z + positive regulation of immune cell differentiation + positive regulation of leucocyte differentiation + up regulation of immune cell differentiation + up regulation of leucocyte differentiation + up regulation of leukocyte differentiation + up-regulation of immune cell differentiation + up-regulation of leucocyte differentiation + up-regulation of leukocyte differentiation + upregulation of immune cell differentiation + upregulation of leucocyte differentiation + upregulation of leukocyte differentiation + activation of immune cell differentiation + activation of leucocyte differentiation + activation of leukocyte differentiation + biological_process + GO:1902107 positive regulation of leukocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. + GOC:TermGenie + GOC:add + + + + + positive regulation of immune cell differentiation + GOC:TermGenie + + + + + positive regulation of leucocyte differentiation + GOC:TermGenie + + + + + up regulation of immune cell differentiation + GOC:TermGenie + + + + + up regulation of leucocyte differentiation + GOC:TermGenie + + + + + up regulation of leukocyte differentiation + GOC:TermGenie + + + + + up-regulation of immune cell differentiation + GOC:TermGenie + + + + + up-regulation of leucocyte differentiation + GOC:TermGenie + + + + + up-regulation of leukocyte differentiation + GOC:TermGenie + + + + + upregulation of immune cell differentiation + GOC:TermGenie + + + + + upregulation of leucocyte differentiation + GOC:TermGenie + + + + + upregulation of leukocyte differentiation + GOC:TermGenie + + + + + activation of immune cell differentiation + GOC:TermGenie + + + + + activation of leucocyte differentiation + GOC:TermGenie + + + + + activation of leukocyte differentiation + GOC:TermGenie + @@ -22821,8 +41801,28 @@ + Any process that modulates the frequency, rate or extent of sperm capacitation. + hjd + 2013-11-12T21:17:03Z + biological_process + regulation of sperm activation + GO:1902490 regulation of sperm capacitation + + + + Any process that modulates the frequency, rate or extent of sperm capacitation. + GOC:TermGenie + GOC:hjd + PMID:22539676 + + + + + regulation of sperm activation + GOC:TermGenie + @@ -22850,8 +41850,84 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation. + hjd + 2013-11-12T21:17:12Z + down regulation of sperm capacitation + down-regulation of sperm capacitation + downregulation of sperm capacitation + inhibition of sperm capacitation + biological_process + down regulation of sperm activation + down-regulation of sperm activation + downregulation of sperm activation + inhibition of sperm activation + negative regulation of sperm activation + GO:1902491 negative regulation of sperm capacitation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation. + GOC:TermGenie + GOC:hjd + PMID:22539676 + + + + + down regulation of sperm capacitation + GOC:TermGenie + + + + + down-regulation of sperm capacitation + GOC:TermGenie + + + + + downregulation of sperm capacitation + GOC:TermGenie + + + + + inhibition of sperm capacitation + GOC:TermGenie + + + + + down regulation of sperm activation + GOC:TermGenie + + + + + down-regulation of sperm activation + GOC:TermGenie + + + + + downregulation of sperm activation + GOC:TermGenie + + + + + inhibition of sperm activation + GOC:TermGenie + + + + + negative regulation of sperm activation + GOC:TermGenie + @@ -22879,8 +41955,84 @@ + Any process that activates or increases the frequency, rate or extent of sperm capacitation. + hjd + 2013-11-12T21:17:21Z + up regulation of sperm capacitation + up-regulation of sperm capacitation + upregulation of sperm capacitation + activation of sperm capacitation + biological_process + activation of sperm activation + positive regulation of sperm activation + up regulation of sperm activation + up-regulation of sperm activation + upregulation of sperm activation + GO:1902492 positive regulation of sperm capacitation + + + + Any process that activates or increases the frequency, rate or extent of sperm capacitation. + GOC:TermGenie + GOC:hjd + PMID:22539676 + + + + + up regulation of sperm capacitation + GOC:TermGenie + + + + + up-regulation of sperm capacitation + GOC:TermGenie + + + + + upregulation of sperm capacitation + GOC:TermGenie + + + + + activation of sperm capacitation + GOC:TermGenie + + + + + activation of sperm activation + GOC:TermGenie + + + + + positive regulation of sperm activation + GOC:TermGenie + + + + + up regulation of sperm activation + GOC:TermGenie + + + + + up-regulation of sperm activation + GOC:TermGenie + + + + + upregulation of sperm activation + GOC:TermGenie + @@ -22906,8 +42058,189 @@ + Any process that activates or increases the frequency, rate or extent of response to water deprivation. + tb + 2013-12-19T00:31:58Z + positive regulation of response to dehydration + positive regulation of response to drought + positive regulation of response to thirst + up regulation of response to dehydration + up regulation of response to drought + up regulation of response to thirst + up regulation of response to water deprivation + up-regulation of response to dehydration + up-regulation of response to drought + up-regulation of response to thirst + up-regulation of response to water deprivation + upregulation of response to dehydration + upregulation of response to drought + upregulation of response to thirst + upregulation of response to water deprivation + activation of response to dehydration + activation of response to drought + activation of response to thirst + activation of response to water deprivation + biological_process + activation of drought tolerance + positive regulation of drought tolerance + up regulation of drought tolerance + up-regulation of drought tolerance + upregulation of drought tolerance + GO:1902584 positive regulation of response to water deprivation + + + + Any process that activates or increases the frequency, rate or extent of response to water deprivation. + GOC:TermGenie + GO_REF:0000058 + PMID:24198318 + + + + + positive regulation of response to dehydration + GOC:TermGenie + + + + + positive regulation of response to drought + GOC:TermGenie + + + + + positive regulation of response to thirst + GOC:TermGenie + + + + + up regulation of response to dehydration + GOC:TermGenie + + + + + up regulation of response to drought + GOC:TermGenie + + + + + up regulation of response to thirst + GOC:TermGenie + + + + + up regulation of response to water deprivation + GOC:TermGenie + + + + + up-regulation of response to dehydration + GOC:TermGenie + + + + + up-regulation of response to drought + GOC:TermGenie + + + + + up-regulation of response to thirst + GOC:TermGenie + + + + + up-regulation of response to water deprivation + GOC:TermGenie + + + + + upregulation of response to dehydration + GOC:TermGenie + + + + + upregulation of response to drought + GOC:TermGenie + + + + + upregulation of response to thirst + GOC:TermGenie + + + + + upregulation of response to water deprivation + GOC:TermGenie + + + + + activation of response to dehydration + GOC:TermGenie + + + + + activation of response to drought + GOC:TermGenie + + + + + activation of response to thirst + GOC:TermGenie + + + + + activation of response to water deprivation + GOC:TermGenie + + + + + activation of drought tolerance + GOC:TermGenie + + + + + positive regulation of drought tolerance + GOC:TermGenie + + + + + up regulation of drought tolerance + GOC:TermGenie + + + + + up-regulation of drought tolerance + GOC:TermGenie + + + + + upregulation of drought tolerance + GOC:TermGenie + @@ -22934,8 +42267,21 @@ + Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. + mr + 2014-02-26T15:36:15Z + biological_process + GO:1902738 regulation of chondrocyte differentiation involved in endochondral bone morphogenesis + + + + Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. + GOC:TermGenie + GO_REF:0000058 + PMID:8662546 + @@ -22962,8 +42308,50 @@ + Any process that activates or increases the frequency, rate or extent of chondrocyte development. + mr + 2014-03-07T17:45:55Z + up regulation of chondrocyte development + up-regulation of chondrocyte development + upregulation of chondrocyte development + activation of chondrocyte development + biological_process + GO:1902761 positive regulation of chondrocyte development + + + + Any process that activates or increases the frequency, rate or extent of chondrocyte development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16575901 + + + + + up regulation of chondrocyte development + GOC:TermGenie + + + + + up-regulation of chondrocyte development + GOC:TermGenie + + + + + upregulation of chondrocyte development + GOC:TermGenie + + + + + activation of chondrocyte development + GOC:TermGenie + @@ -22989,8 +42377,51 @@ + Any process that modulates the frequency, rate or extent of alcohol biosynthetic process. + tt + 2014-04-22T21:55:03Z + regulation of solventogenesis + regulation of alcohol anabolism + regulation of alcohol biosynthesis + regulation of alcohol formation + regulation of alcohol synthesis + biological_process + GO:1902930 regulation of alcohol biosynthetic process + + + + Any process that modulates the frequency, rate or extent of alcohol biosynthetic process. + GOC:TermGenie + GOC:mengo_curators + GO_REF:0000058 + PMID:23332010 + + + + + regulation of alcohol anabolism + GOC:TermGenie + + + + + regulation of alcohol biosynthesis + GOC:TermGenie + + + + + regulation of alcohol formation + GOC:TermGenie + + + + + regulation of alcohol synthesis + GOC:TermGenie + @@ -23017,8 +42448,191 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process. + tt + 2014-04-22T21:55:13Z + negative regulation of solventogenesis + down regulation of alcohol anabolism + down regulation of alcohol biosynthesis + down regulation of alcohol biosynthetic process + down regulation of alcohol formation + down regulation of alcohol synthesis + down-regulation of alcohol anabolism + down-regulation of alcohol biosynthesis + down-regulation of alcohol biosynthetic process + down-regulation of alcohol formation + down-regulation of alcohol synthesis + downregulation of alcohol anabolism + downregulation of alcohol biosynthesis + downregulation of alcohol biosynthetic process + downregulation of alcohol formation + downregulation of alcohol synthesis + negative regulation of alcohol anabolism + negative regulation of alcohol biosynthesis + negative regulation of alcohol formation + negative regulation of alcohol synthesis + inhibition of alcohol anabolism + inhibition of alcohol biosynthesis + inhibition of alcohol biosynthetic process + inhibition of alcohol formation + inhibition of alcohol synthesis + biological_process + GO:1902931 negative regulation of alcohol biosynthetic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process. + GOC:TermGenie + GOC:mengo_curators + GO_REF:0000058 + PMID:23332010 + + + + + down regulation of alcohol anabolism + GOC:TermGenie + + + + + down regulation of alcohol biosynthesis + GOC:TermGenie + + + + + down regulation of alcohol biosynthetic process + GOC:TermGenie + + + + + down regulation of alcohol formation + GOC:TermGenie + + + + + down regulation of alcohol synthesis + GOC:TermGenie + + + + + down-regulation of alcohol anabolism + GOC:TermGenie + + + + + down-regulation of alcohol biosynthesis + GOC:TermGenie + + + + + down-regulation of alcohol biosynthetic process + GOC:TermGenie + + + + + down-regulation of alcohol formation + GOC:TermGenie + + + + + down-regulation of alcohol synthesis + GOC:TermGenie + + + + + downregulation of alcohol anabolism + GOC:TermGenie + + + + + downregulation of alcohol biosynthesis + GOC:TermGenie + + + + + downregulation of alcohol biosynthetic process + GOC:TermGenie + + + + + downregulation of alcohol formation + GOC:TermGenie + + + + + downregulation of alcohol synthesis + GOC:TermGenie + + + + + negative regulation of alcohol anabolism + GOC:TermGenie + + + + + negative regulation of alcohol biosynthesis + GOC:TermGenie + + + + + negative regulation of alcohol formation + GOC:TermGenie + + + + + negative regulation of alcohol synthesis + GOC:TermGenie + + + + + inhibition of alcohol anabolism + GOC:TermGenie + + + + + inhibition of alcohol biosynthesis + GOC:TermGenie + + + + + inhibition of alcohol biosynthetic process + GOC:TermGenie + + + + + inhibition of alcohol formation + GOC:TermGenie + + + + + inhibition of alcohol synthesis + GOC:TermGenie + @@ -23045,8 +42659,191 @@ + Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process. + tt + 2014-04-22T21:55:19Z + positive regulation of solventogenesis + positive regulation of alcohol anabolism + positive regulation of alcohol biosynthesis + positive regulation of alcohol formation + positive regulation of alcohol synthesis + up regulation of alcohol anabolism + up regulation of alcohol biosynthesis + up regulation of alcohol biosynthetic process + up regulation of alcohol formation + up regulation of alcohol synthesis + up-regulation of alcohol anabolism + up-regulation of alcohol biosynthesis + up-regulation of alcohol biosynthetic process + up-regulation of alcohol formation + up-regulation of alcohol synthesis + upregulation of alcohol anabolism + upregulation of alcohol biosynthesis + upregulation of alcohol biosynthetic process + upregulation of alcohol formation + upregulation of alcohol synthesis + activation of alcohol anabolism + activation of alcohol biosynthesis + activation of alcohol biosynthetic process + activation of alcohol formation + activation of alcohol synthesis + biological_process + GO:1902932 positive regulation of alcohol biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process. + GOC:TermGenie + GOC:mengo_curators + GO_REF:0000058 + PMID:23332010 + + + + + positive regulation of alcohol anabolism + GOC:TermGenie + + + + + positive regulation of alcohol biosynthesis + GOC:TermGenie + + + + + positive regulation of alcohol formation + GOC:TermGenie + + + + + positive regulation of alcohol synthesis + GOC:TermGenie + + + + + up regulation of alcohol anabolism + GOC:TermGenie + + + + + up regulation of alcohol biosynthesis + GOC:TermGenie + + + + + up regulation of alcohol biosynthetic process + GOC:TermGenie + + + + + up regulation of alcohol formation + GOC:TermGenie + + + + + up regulation of alcohol synthesis + GOC:TermGenie + + + + + up-regulation of alcohol anabolism + GOC:TermGenie + + + + + up-regulation of alcohol biosynthesis + GOC:TermGenie + + + + + up-regulation of alcohol biosynthetic process + GOC:TermGenie + + + + + up-regulation of alcohol formation + GOC:TermGenie + + + + + up-regulation of alcohol synthesis + GOC:TermGenie + + + + + upregulation of alcohol anabolism + GOC:TermGenie + + + + + upregulation of alcohol biosynthesis + GOC:TermGenie + + + + + upregulation of alcohol biosynthetic process + GOC:TermGenie + + + + + upregulation of alcohol formation + GOC:TermGenie + + + + + upregulation of alcohol synthesis + GOC:TermGenie + + + + + activation of alcohol anabolism + GOC:TermGenie + + + + + activation of alcohol biosynthesis + GOC:TermGenie + + + + + activation of alcohol biosynthetic process + GOC:TermGenie + + + + + activation of alcohol formation + GOC:TermGenie + + + + + activation of alcohol synthesis + GOC:TermGenie + @@ -23071,8 +42868,22 @@ + Any process that modulates the frequency, rate or extent of bone development. + mr + 2014-05-13T22:41:53Z + biological_process + GO:1903010 regulation of bone development + + + + Any process that modulates the frequency, rate or extent of bone development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:22510437 + @@ -23099,8 +42910,50 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of bone development. + mr + 2014-05-13T22:42:00Z + down regulation of bone development + down-regulation of bone development + downregulation of bone development + inhibition of bone development + biological_process + GO:1903011 negative regulation of bone development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of bone development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:22510437 + + + + + down regulation of bone development + GOC:TermGenie + + + + + down-regulation of bone development + GOC:TermGenie + + + + + downregulation of bone development + GOC:TermGenie + + + + + inhibition of bone development + GOC:TermGenie + @@ -23127,8 +42980,50 @@ + Any process that activates or increases the frequency, rate or extent of bone development. + mr + 2014-05-13T22:42:06Z + up regulation of bone development + up-regulation of bone development + upregulation of bone development + activation of bone development + biological_process + GO:1903012 positive regulation of bone development + + + + Any process that activates or increases the frequency, rate or extent of bone development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:22510437 + + + + + up regulation of bone development + GOC:TermGenie + + + + + up-regulation of bone development + GOC:TermGenie + + + + + upregulation of bone development + GOC:TermGenie + + + + + activation of bone development + GOC:TermGenie + @@ -23153,8 +43048,29 @@ + Any process that modulates the frequency, rate or extent of response to wounding. + kmv + 2014-05-18T01:28:46Z + regulation of physiological response to wounding + biological_process + GO:1903034 regulation of response to wounding + + + + Any process that modulates the frequency, rate or extent of response to wounding. + GOC:TermGenie + GOC:kmv + GO_REF:0000058 + pmid:19164535 + + + + + regulation of physiological response to wounding + GOC:TermGenie + @@ -23180,8 +43096,85 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding. + kmv + 2014-05-18T01:28:52Z + down regulation of physiological response to wounding + down regulation of response to wounding + down-regulation of physiological response to wounding + down-regulation of response to wounding + downregulation of physiological response to wounding + downregulation of response to wounding + negative regulation of physiological response to wounding + inhibition of physiological response to wounding + inhibition of response to wounding + biological_process + GO:1903035 negative regulation of response to wounding + + + + Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding. + GOC:TermGenie + GOC:kmv + GO_REF:0000058 + pmid:19164535 + + + + + down regulation of physiological response to wounding + GOC:TermGenie + + + + + down regulation of response to wounding + GOC:TermGenie + + + + + down-regulation of physiological response to wounding + GOC:TermGenie + + + + + down-regulation of response to wounding + GOC:TermGenie + + + + + downregulation of physiological response to wounding + GOC:TermGenie + + + + + downregulation of response to wounding + GOC:TermGenie + + + + + negative regulation of physiological response to wounding + GOC:TermGenie + + + + + inhibition of physiological response to wounding + GOC:TermGenie + + + + + inhibition of response to wounding + GOC:TermGenie + @@ -23207,8 +43200,85 @@ + Any process that activates or increases the frequency, rate or extent of response to wounding. + kmv + 2014-05-18T01:28:58Z + positive regulation of physiological response to wounding + up regulation of physiological response to wounding + up regulation of response to wounding + up-regulation of physiological response to wounding + up-regulation of response to wounding + upregulation of physiological response to wounding + upregulation of response to wounding + activation of physiological response to wounding + activation of response to wounding + biological_process + GO:1903036 positive regulation of response to wounding + + + + Any process that activates or increases the frequency, rate or extent of response to wounding. + GOC:TermGenie + GOC:kmv + GO_REF:0000058 + pmid:19164535 + + + + + positive regulation of physiological response to wounding + GOC:TermGenie + + + + + up regulation of physiological response to wounding + GOC:TermGenie + + + + + up regulation of response to wounding + GOC:TermGenie + + + + + up-regulation of physiological response to wounding + GOC:TermGenie + + + + + up-regulation of response to wounding + GOC:TermGenie + + + + + upregulation of physiological response to wounding + GOC:TermGenie + + + + + upregulation of response to wounding + GOC:TermGenie + + + + + activation of physiological response to wounding + GOC:TermGenie + + + + + activation of response to wounding + GOC:TermGenie + @@ -23233,8 +43303,38 @@ + Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion. + rl + 2014-05-19T15:29:58Z + regulation of leukocyte adhesion + regulation of leukocyte cell adhesion + biological_process + GO:1903037 + Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion regulation of leukocyte cell-cell adhesion + + + + Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:21106532 + + + + + regulation of leukocyte adhesion + GOC:TermGenie + + + + + regulation of leukocyte cell adhesion + GOC:TermGenie + @@ -23260,8 +43360,122 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion. + rl + 2014-05-19T15:30:05Z + down regulation of leukocyte adhesion + down regulation of leukocyte cell adhesion + down regulation of leukocyte cell-cell adhesion + down-regulation of leukocyte adhesion + down-regulation of leukocyte cell adhesion + down-regulation of leukocyte cell-cell adhesion + downregulation of leukocyte adhesion + downregulation of leukocyte cell adhesion + downregulation of leukocyte cell-cell adhesion + negative regulation of leukocyte adhesion + negative regulation of leukocyte cell adhesion + inhibition of leukocyte adhesion + inhibition of leukocyte cell adhesion + inhibition of leukocyte cell-cell adhesion + biological_process + GO:1903038 + Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion negative regulation of leukocyte cell-cell adhesion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:21106532 + + + + + down regulation of leukocyte adhesion + GOC:TermGenie + + + + + down regulation of leukocyte cell adhesion + GOC:TermGenie + + + + + down regulation of leukocyte cell-cell adhesion + GOC:TermGenie + + + + + down-regulation of leukocyte adhesion + GOC:TermGenie + + + + + down-regulation of leukocyte cell adhesion + GOC:TermGenie + + + + + down-regulation of leukocyte cell-cell adhesion + GOC:TermGenie + + + + + downregulation of leukocyte adhesion + GOC:TermGenie + + + + + downregulation of leukocyte cell adhesion + GOC:TermGenie + + + + + downregulation of leukocyte cell-cell adhesion + GOC:TermGenie + + + + + negative regulation of leukocyte adhesion + GOC:TermGenie + + + + + negative regulation of leukocyte cell adhesion + GOC:TermGenie + + + + + inhibition of leukocyte adhesion + GOC:TermGenie + + + + + inhibition of leukocyte cell adhesion + GOC:TermGenie + + + + + inhibition of leukocyte cell-cell adhesion + GOC:TermGenie + @@ -23287,8 +43501,122 @@ + Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion. + rl + 2014-05-19T15:30:15Z + positive regulation of leukocyte adhesion + positive regulation of leukocyte cell adhesion + up regulation of leukocyte adhesion + up regulation of leukocyte cell adhesion + up regulation of leukocyte cell-cell adhesion + up-regulation of leukocyte adhesion + up-regulation of leukocyte cell adhesion + up-regulation of leukocyte cell-cell adhesion + upregulation of leukocyte adhesion + upregulation of leukocyte cell adhesion + upregulation of leukocyte cell-cell adhesion + activation of leukocyte adhesion + activation of leukocyte cell adhesion + activation of leukocyte cell-cell adhesion + biological_process + GO:1903039 + Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion positive regulation of leukocyte cell-cell adhesion + + + + Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:21106532 + + + + + positive regulation of leukocyte adhesion + GOC:TermGenie + + + + + positive regulation of leukocyte cell adhesion + GOC:TermGenie + + + + + up regulation of leukocyte adhesion + GOC:TermGenie + + + + + up regulation of leukocyte cell adhesion + GOC:TermGenie + + + + + up regulation of leukocyte cell-cell adhesion + GOC:TermGenie + + + + + up-regulation of leukocyte adhesion + GOC:TermGenie + + + + + up-regulation of leukocyte cell adhesion + GOC:TermGenie + + + + + up-regulation of leukocyte cell-cell adhesion + GOC:TermGenie + + + + + upregulation of leukocyte adhesion + GOC:TermGenie + + + + + upregulation of leukocyte cell adhesion + GOC:TermGenie + + + + + upregulation of leukocyte cell-cell adhesion + GOC:TermGenie + + + + + activation of leukocyte adhesion + GOC:TermGenie + + + + + activation of leukocyte cell adhesion + GOC:TermGenie + + + + + activation of leukocyte cell-cell adhesion + GOC:TermGenie + @@ -23315,8 +43643,22 @@ + Any process that modulates the frequency, rate or extent of chondrocyte hypertrophy. + mr + 2014-05-20T21:23:13Z + biological_process + GO:1903041 regulation of chondrocyte hypertrophy + + + + Any process that modulates the frequency, rate or extent of chondrocyte hypertrophy. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:23928032 + @@ -23344,8 +43686,50 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte hypertrophy. + mr + 2014-05-20T21:23:19Z + down regulation of chondrocyte hypertrophy + down-regulation of chondrocyte hypertrophy + downregulation of chondrocyte hypertrophy + inhibition of chondrocyte hypertrophy + biological_process + GO:1903042 negative regulation of chondrocyte hypertrophy + + + + Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte hypertrophy. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:23928032 + + + + + down regulation of chondrocyte hypertrophy + GOC:TermGenie + + + + + down-regulation of chondrocyte hypertrophy + GOC:TermGenie + + + + + downregulation of chondrocyte hypertrophy + GOC:TermGenie + + + + + inhibition of chondrocyte hypertrophy + GOC:TermGenie + @@ -23373,8 +43757,50 @@ + Any process that activates or increases the frequency, rate or extent of chondrocyte hypertrophy. + mr + 2014-05-20T21:23:25Z + up regulation of chondrocyte hypertrophy + up-regulation of chondrocyte hypertrophy + upregulation of chondrocyte hypertrophy + activation of chondrocyte hypertrophy + biological_process + GO:1903043 positive regulation of chondrocyte hypertrophy + + + + Any process that activates or increases the frequency, rate or extent of chondrocyte hypertrophy. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:23928032 + + + + + up regulation of chondrocyte hypertrophy + GOC:TermGenie + + + + + up-regulation of chondrocyte hypertrophy + GOC:TermGenie + + + + + upregulation of chondrocyte hypertrophy + GOC:TermGenie + + + + + activation of chondrocyte hypertrophy + GOC:TermGenie + @@ -23400,8 +43826,23 @@ + A process that is part of the meiotic cell cycle. + jl + 2014-05-22T14:22:28Z + biological_process + GO:1903046 + + meiotic cell cycle process + + + + A process that is part of the meiotic cell cycle. + GOC:TermGenie + GOC:mtg_cell_cycle + GO_REF:0000060 + @@ -23426,8 +43867,37 @@ + Any process that modulates the frequency, rate or extent of extracellular matrix organization. + rl + 2014-05-23T17:15:41Z + regulation of extracellular matrix organisation + biological_process + regulation of extracellular matrix organization and biogenesis + GO:1903053 regulation of extracellular matrix organization + + + + Any process that modulates the frequency, rate or extent of extracellular matrix organization. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:22357537 + + + + + regulation of extracellular matrix organisation + GOC:TermGenie + + + + + regulation of extracellular matrix organization and biogenesis + GOC:TermGenie + @@ -23453,8 +43923,121 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. + rl + 2014-05-23T17:15:47Z + down regulation of extracellular matrix organisation + down regulation of extracellular matrix organization + down-regulation of extracellular matrix organisation + down-regulation of extracellular matrix organization + downregulation of extracellular matrix organisation + downregulation of extracellular matrix organization + negative regulation of extracellular matrix organisation + inhibition of extracellular matrix organisation + inhibition of extracellular matrix organization + biological_process + down regulation of extracellular matrix organization and biogenesis + down-regulation of extracellular matrix organization and biogenesis + downregulation of extracellular matrix organization and biogenesis + inhibition of extracellular matrix organization and biogenesis + negative regulation of extracellular matrix organization and biogenesis + GO:1903054 negative regulation of extracellular matrix organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:22357537 + + + + + down regulation of extracellular matrix organisation + GOC:TermGenie + + + + + down regulation of extracellular matrix organization + GOC:TermGenie + + + + + down-regulation of extracellular matrix organisation + GOC:TermGenie + + + + + down-regulation of extracellular matrix organization + GOC:TermGenie + + + + + downregulation of extracellular matrix organisation + GOC:TermGenie + + + + + downregulation of extracellular matrix organization + GOC:TermGenie + + + + + negative regulation of extracellular matrix organisation + GOC:TermGenie + + + + + inhibition of extracellular matrix organisation + GOC:TermGenie + + + + + inhibition of extracellular matrix organization + GOC:TermGenie + + + + + down regulation of extracellular matrix organization and biogenesis + GOC:TermGenie + + + + + down-regulation of extracellular matrix organization and biogenesis + GOC:TermGenie + + + + + downregulation of extracellular matrix organization and biogenesis + GOC:TermGenie + + + + + inhibition of extracellular matrix organization and biogenesis + GOC:TermGenie + + + + + negative regulation of extracellular matrix organization and biogenesis + GOC:TermGenie + @@ -23480,8 +44063,121 @@ + Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. + rl + 2014-05-23T17:15:53Z + positive regulation of extracellular matrix organisation + up regulation of extracellular matrix organisation + up regulation of extracellular matrix organization + up-regulation of extracellular matrix organisation + up-regulation of extracellular matrix organization + upregulation of extracellular matrix organisation + upregulation of extracellular matrix organization + activation of extracellular matrix organisation + activation of extracellular matrix organization + biological_process + activation of extracellular matrix organization and biogenesis + positive regulation of extracellular matrix organization and biogenesis + up regulation of extracellular matrix organization and biogenesis + up-regulation of extracellular matrix organization and biogenesis + upregulation of extracellular matrix organization and biogenesis + GO:1903055 positive regulation of extracellular matrix organization + + + + Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:22357537 + + + + + positive regulation of extracellular matrix organisation + GOC:TermGenie + + + + + up regulation of extracellular matrix organisation + GOC:TermGenie + + + + + up regulation of extracellular matrix organization + GOC:TermGenie + + + + + up-regulation of extracellular matrix organisation + GOC:TermGenie + + + + + up-regulation of extracellular matrix organization + GOC:TermGenie + + + + + upregulation of extracellular matrix organisation + GOC:TermGenie + + + + + upregulation of extracellular matrix organization + GOC:TermGenie + + + + + activation of extracellular matrix organisation + GOC:TermGenie + + + + + activation of extracellular matrix organization + GOC:TermGenie + + + + + activation of extracellular matrix organization and biogenesis + GOC:TermGenie + + + + + positive regulation of extracellular matrix organization and biogenesis + GOC:TermGenie + + + + + up regulation of extracellular matrix organization and biogenesis + GOC:TermGenie + + + + + up-regulation of extracellular matrix organization and biogenesis + GOC:TermGenie + + + + + upregulation of extracellular matrix organization and biogenesis + GOC:TermGenie + @@ -23489,8 +44185,22 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell. + cls + 2014-06-25T15:47:09Z + biological_process + GO:1903131 mononuclear cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell. + CL:0000842 + GOC:TermGenie + GO_REF:0000086 + PMID:24759906 + @@ -23515,8 +44225,28 @@ + Any process that modulates the frequency, rate or extent of cell maturation. + jl + 2014-09-15T13:31:23Z + biological_process + regulation of functional differentiation + GO:1903429 regulation of cell maturation + + + + Any process that modulates the frequency, rate or extent of cell maturation. + GOC:TermGenie + GO_REF:0000058 + PMID:17459944 + + + + + regulation of functional differentiation + GOC:TermGenie + @@ -23542,8 +44272,84 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation. + jl + 2014-09-15T13:31:32Z + down regulation of cell maturation + down-regulation of cell maturation + downregulation of cell maturation + inhibition of cell maturation + biological_process + down regulation of functional differentiation + down-regulation of functional differentiation + downregulation of functional differentiation + inhibition of functional differentiation + negative regulation of functional differentiation + GO:1903430 negative regulation of cell maturation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation. + GOC:TermGenie + GO_REF:0000058 + PMID:17459944 + + + + + down regulation of cell maturation + GOC:TermGenie + + + + + down-regulation of cell maturation + GOC:TermGenie + + + + + downregulation of cell maturation + GOC:TermGenie + + + + + inhibition of cell maturation + GOC:TermGenie + + + + + down regulation of functional differentiation + GOC:TermGenie + + + + + down-regulation of functional differentiation + GOC:TermGenie + + + + + downregulation of functional differentiation + GOC:TermGenie + + + + + inhibition of functional differentiation + GOC:TermGenie + + + + + negative regulation of functional differentiation + GOC:TermGenie + @@ -23569,8 +44375,84 @@ + Any process that activates or increases the frequency, rate or extent of cell maturation. + jl + 2014-09-15T13:31:41Z + up regulation of cell maturation + up-regulation of cell maturation + upregulation of cell maturation + activation of cell maturation + biological_process + activation of functional differentiation + positive regulation of functional differentiation + up regulation of functional differentiation + up-regulation of functional differentiation + upregulation of functional differentiation + GO:1903431 positive regulation of cell maturation + + + + Any process that activates or increases the frequency, rate or extent of cell maturation. + GOC:TermGenie + GO_REF:0000058 + PMID:17459944 + + + + + up regulation of cell maturation + GOC:TermGenie + + + + + up-regulation of cell maturation + GOC:TermGenie + + + + + upregulation of cell maturation + GOC:TermGenie + + + + + activation of cell maturation + GOC:TermGenie + + + + + activation of functional differentiation + GOC:TermGenie + + + + + positive regulation of functional differentiation + GOC:TermGenie + + + + + up regulation of functional differentiation + GOC:TermGenie + + + + + up-regulation of functional differentiation + GOC:TermGenie + + + + + upregulation of functional differentiation + GOC:TermGenie + @@ -23597,8 +44479,22 @@ + Any process that modulates the frequency, rate or extent of lactation. + mr + 2014-09-24T14:44:13Z + biological_process + GO:1903487 regulation of lactation + + + + Any process that modulates the frequency, rate or extent of lactation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:19563620 + @@ -23626,8 +44522,50 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lactation. + mr + 2014-09-24T14:44:22Z + down regulation of lactation + down-regulation of lactation + downregulation of lactation + inhibition of lactation + biological_process + GO:1903488 negative regulation of lactation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lactation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:19563620 + + + + + down regulation of lactation + GOC:TermGenie + + + + + down-regulation of lactation + GOC:TermGenie + + + + + downregulation of lactation + GOC:TermGenie + + + + + inhibition of lactation + GOC:TermGenie + @@ -23655,8 +44593,50 @@ + Any process that activates or increases the frequency, rate or extent of lactation. + mr + 2014-09-24T14:44:30Z + up regulation of lactation + up-regulation of lactation + upregulation of lactation + activation of lactation + biological_process + GO:1903489 positive regulation of lactation + + + + Any process that activates or increases the frequency, rate or extent of lactation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:19563620 + + + + + up regulation of lactation + GOC:TermGenie + + + + + up-regulation of lactation + GOC:TermGenie + + + + + upregulation of lactation + GOC:TermGenie + + + + + activation of lactation + GOC:TermGenie + @@ -23681,8 +44661,29 @@ + Any process that modulates the frequency, rate or extent of blood circulation. + mr + 2014-10-06T18:38:56Z + biological_process + regulation of hemolymph circulation + GO:1903522 regulation of blood circulation + + + + Any process that modulates the frequency, rate or extent of blood circulation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:10659969 + + + + + regulation of hemolymph circulation + GOC:TermGenie + @@ -23708,8 +44709,85 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. + mr + 2014-10-06T18:39:05Z + down regulation of blood circulation + down-regulation of blood circulation + downregulation of blood circulation + inhibition of blood circulation + biological_process + down regulation of hemolymph circulation + down-regulation of hemolymph circulation + downregulation of hemolymph circulation + inhibition of hemolymph circulation + negative regulation of hemolymph circulation + GO:1903523 negative regulation of blood circulation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:10659969 + + + + + down regulation of blood circulation + GOC:TermGenie + + + + + down-regulation of blood circulation + GOC:TermGenie + + + + + downregulation of blood circulation + GOC:TermGenie + + + + + inhibition of blood circulation + GOC:TermGenie + + + + + down regulation of hemolymph circulation + GOC:TermGenie + + + + + down-regulation of hemolymph circulation + GOC:TermGenie + + + + + downregulation of hemolymph circulation + GOC:TermGenie + + + + + inhibition of hemolymph circulation + GOC:TermGenie + + + + + negative regulation of hemolymph circulation + GOC:TermGenie + @@ -23735,8 +44813,85 @@ + Any process that activates or increases the frequency, rate or extent of blood circulation. + mr + 2014-10-06T18:39:13Z + up regulation of blood circulation + up-regulation of blood circulation + upregulation of blood circulation + activation of blood circulation + biological_process + activation of hemolymph circulation + positive regulation of hemolymph circulation + up regulation of hemolymph circulation + up-regulation of hemolymph circulation + upregulation of hemolymph circulation + GO:1903524 positive regulation of blood circulation + + + + Any process that activates or increases the frequency, rate or extent of blood circulation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:10659969 + + + + + up regulation of blood circulation + GOC:TermGenie + + + + + up-regulation of blood circulation + GOC:TermGenie + + + + + upregulation of blood circulation + GOC:TermGenie + + + + + activation of blood circulation + GOC:TermGenie + + + + + activation of hemolymph circulation + GOC:TermGenie + + + + + positive regulation of hemolymph circulation + GOC:TermGenie + + + + + up regulation of hemolymph circulation + GOC:TermGenie + + + + + up-regulation of hemolymph circulation + GOC:TermGenie + + + + + upregulation of hemolymph circulation + GOC:TermGenie + @@ -23762,8 +44917,29 @@ + Any process that modulates the frequency, rate or extent of secretion by cell. + pm + 2014-10-08T13:24:59Z + regulation of cellular secretion + biological_process + GO:1903530 regulation of secretion by cell + + + + Any process that modulates the frequency, rate or extent of secretion by cell. + GOC:TermGenie + GOC:pm + GO_REF:0000058 + PMID:12130530 + + + + + regulation of cellular secretion + GOC:TermGenie + @@ -23790,8 +44966,85 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. + pm + 2014-10-08T13:25:08Z + down regulation of cellular secretion + down regulation of secretion by cell + down-regulation of cellular secretion + down-regulation of secretion by cell + downregulation of cellular secretion + downregulation of secretion by cell + negative regulation of cellular secretion + inhibition of cellular secretion + inhibition of secretion by cell + biological_process + GO:1903531 negative regulation of secretion by cell + + + + Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. + GOC:TermGenie + GOC:pm + GO_REF:0000058 + PMID:12130530 + + + + + down regulation of cellular secretion + GOC:TermGenie + + + + + down regulation of secretion by cell + GOC:TermGenie + + + + + down-regulation of cellular secretion + GOC:TermGenie + + + + + down-regulation of secretion by cell + GOC:TermGenie + + + + + downregulation of cellular secretion + GOC:TermGenie + + + + + downregulation of secretion by cell + GOC:TermGenie + + + + + negative regulation of cellular secretion + GOC:TermGenie + + + + + inhibition of cellular secretion + GOC:TermGenie + + + + + inhibition of secretion by cell + GOC:TermGenie + @@ -23818,8 +45071,85 @@ + Any process that activates or increases the frequency, rate or extent of secretion by cell. + pm + 2014-10-08T13:25:17Z + positive regulation of cellular secretion + up regulation of cellular secretion + up regulation of secretion by cell + up-regulation of cellular secretion + up-regulation of secretion by cell + upregulation of cellular secretion + upregulation of secretion by cell + activation of cellular secretion + activation of secretion by cell + biological_process + GO:1903532 positive regulation of secretion by cell + + + + Any process that activates or increases the frequency, rate or extent of secretion by cell. + GOC:TermGenie + GOC:pm + GO_REF:0000058 + PMID:12130530 + + + + + positive regulation of cellular secretion + GOC:TermGenie + + + + + up regulation of cellular secretion + GOC:TermGenie + + + + + up regulation of secretion by cell + GOC:TermGenie + + + + + up-regulation of cellular secretion + GOC:TermGenie + + + + + up-regulation of secretion by cell + GOC:TermGenie + + + + + upregulation of cellular secretion + GOC:TermGenie + + + + + upregulation of secretion by cell + GOC:TermGenie + + + + + activation of cellular secretion + GOC:TermGenie + + + + + activation of secretion by cell + GOC:TermGenie + @@ -23839,8 +45169,29 @@ + Any vesicle that is part of the extracellular region. + jl + 2014-10-22T14:26:11Z + cellular_component + microparticle + GO:1903561 extracellular vesicle + + + + Any vesicle that is part of the extracellular region. + GOC:TermGenie + GOC:pm + GO_REF:0000064 + PMID:24769233 + + + + + microparticle + GOC:vesicles + @@ -23866,8 +45217,52 @@ + Any process that modulates the frequency, rate or extent of hemopoiesis. + pad + 2014-12-04T15:34:13Z + regulation of blood cell biosynthesis + regulation of blood cell formation + regulation of haemopoiesis + regulation of hematopoiesis + biological_process + GO:1903706 + An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. regulation of hemopoiesis + + + + Any process that modulates the frequency, rate or extent of hemopoiesis. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:20080761 + + + + + regulation of blood cell biosynthesis + GOC:TermGenie + + + + + regulation of blood cell formation + GOC:TermGenie + + + + + regulation of haemopoiesis + GOC:TermGenie + + + + + regulation of hematopoiesis + GOC:TermGenie + @@ -23895,8 +45290,192 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. + pad + 2014-12-04T15:34:21Z + down regulation of blood cell biosynthesis + down regulation of blood cell formation + down regulation of haemopoiesis + down regulation of hematopoiesis + down regulation of hemopoiesis + down-regulation of blood cell biosynthesis + down-regulation of blood cell formation + down-regulation of haemopoiesis + down-regulation of hematopoiesis + down-regulation of hemopoiesis + downregulation of blood cell biosynthesis + downregulation of blood cell formation + downregulation of haemopoiesis + downregulation of hematopoiesis + downregulation of hemopoiesis + negative regulation of blood cell biosynthesis + negative regulation of blood cell formation + negative regulation of haemopoiesis + negative regulation of hematopoiesis + inhibition of blood cell biosynthesis + inhibition of blood cell formation + inhibition of haemopoiesis + inhibition of hematopoiesis + inhibition of hemopoiesis + biological_process + GO:1903707 + An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. negative regulation of hemopoiesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:20080761 + + + + + down regulation of blood cell biosynthesis + GOC:TermGenie + + + + + down regulation of blood cell formation + GOC:TermGenie + + + + + down regulation of haemopoiesis + GOC:TermGenie + + + + + down regulation of hematopoiesis + GOC:TermGenie + + + + + down regulation of hemopoiesis + GOC:TermGenie + + + + + down-regulation of blood cell biosynthesis + GOC:TermGenie + + + + + down-regulation of blood cell formation + GOC:TermGenie + + + + + down-regulation of haemopoiesis + GOC:TermGenie + + + + + down-regulation of hematopoiesis + GOC:TermGenie + + + + + down-regulation of hemopoiesis + GOC:TermGenie + + + + + downregulation of blood cell biosynthesis + GOC:TermGenie + + + + + downregulation of blood cell formation + GOC:TermGenie + + + + + downregulation of haemopoiesis + GOC:TermGenie + + + + + downregulation of hematopoiesis + GOC:TermGenie + + + + + downregulation of hemopoiesis + GOC:TermGenie + + + + + negative regulation of blood cell biosynthesis + GOC:TermGenie + + + + + negative regulation of blood cell formation + GOC:TermGenie + + + + + negative regulation of haemopoiesis + GOC:TermGenie + + + + + negative regulation of hematopoiesis + GOC:TermGenie + + + + + inhibition of blood cell biosynthesis + GOC:TermGenie + + + + + inhibition of blood cell formation + GOC:TermGenie + + + + + inhibition of haemopoiesis + GOC:TermGenie + + + + + inhibition of hematopoiesis + GOC:TermGenie + + + + + inhibition of hemopoiesis + GOC:TermGenie + @@ -23924,8 +45503,192 @@ + Any process that activates or increases the frequency, rate or extent of hemopoiesis. + pad + 2014-12-04T15:34:30Z + positive regulation of blood cell biosynthesis + positive regulation of blood cell formation + positive regulation of haemopoiesis + positive regulation of hematopoiesis + up regulation of blood cell biosynthesis + up regulation of blood cell formation + up regulation of haemopoiesis + up regulation of hematopoiesis + up regulation of hemopoiesis + up-regulation of blood cell biosynthesis + up-regulation of blood cell formation + up-regulation of haemopoiesis + up-regulation of hematopoiesis + up-regulation of hemopoiesis + upregulation of blood cell biosynthesis + upregulation of blood cell formation + upregulation of haemopoiesis + upregulation of hematopoiesis + upregulation of hemopoiesis + activation of blood cell biosynthesis + activation of blood cell formation + activation of haemopoiesis + activation of hematopoiesis + activation of hemopoiesis + biological_process + GO:1903708 + An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. positive regulation of hemopoiesis + + + + Any process that activates or increases the frequency, rate or extent of hemopoiesis. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:20080761 + + + + + positive regulation of blood cell biosynthesis + GOC:TermGenie + + + + + positive regulation of blood cell formation + GOC:TermGenie + + + + + positive regulation of haemopoiesis + GOC:TermGenie + + + + + positive regulation of hematopoiesis + GOC:TermGenie + + + + + up regulation of blood cell biosynthesis + GOC:TermGenie + + + + + up regulation of blood cell formation + GOC:TermGenie + + + + + up regulation of haemopoiesis + GOC:TermGenie + + + + + up regulation of hematopoiesis + GOC:TermGenie + + + + + up regulation of hemopoiesis + GOC:TermGenie + + + + + up-regulation of blood cell biosynthesis + GOC:TermGenie + + + + + up-regulation of blood cell formation + GOC:TermGenie + + + + + up-regulation of haemopoiesis + GOC:TermGenie + + + + + up-regulation of hematopoiesis + GOC:TermGenie + + + + + up-regulation of hemopoiesis + GOC:TermGenie + + + + + upregulation of blood cell biosynthesis + GOC:TermGenie + + + + + upregulation of blood cell formation + GOC:TermGenie + + + + + upregulation of haemopoiesis + GOC:TermGenie + + + + + upregulation of hematopoiesis + GOC:TermGenie + + + + + upregulation of hemopoiesis + GOC:TermGenie + + + + + activation of blood cell biosynthesis + GOC:TermGenie + + + + + activation of blood cell formation + GOC:TermGenie + + + + + activation of haemopoiesis + GOC:TermGenie + + + + + activation of hematopoiesis + GOC:TermGenie + + + + + activation of hemopoiesis + GOC:TermGenie + @@ -23951,8 +45714,49 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. + sl + 2015-01-12T21:50:20Z + down regulation of anion transport + down-regulation of anion transport + downregulation of anion transport + inhibition of anion transport + biological_process + GO:1903792 negative regulation of anion transport + + + + Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. + GOC:TermGenie + GO_REF:0000058 + PMID:11336802 + + + + + down regulation of anion transport + GOC:TermGenie + + + + + down-regulation of anion transport + GOC:TermGenie + + + + + downregulation of anion transport + GOC:TermGenie + + + + + inhibition of anion transport + GOC:TermGenie + @@ -23978,8 +45782,245 @@ + Any process that activates or increases the frequency, rate or extent of anion transport. + sl + 2015-01-12T21:50:30Z + up regulation of anion transport + up-regulation of anion transport + upregulation of anion transport + activation of anion transport + biological_process + GO:1903793 positive regulation of anion transport + + + + Any process that activates or increases the frequency, rate or extent of anion transport. + GOC:TermGenie + GO_REF:0000058 + PMID:11336802 + + + + + up regulation of anion transport + GOC:TermGenie + + + + + up-regulation of anion transport + GOC:TermGenie + + + + + upregulation of anion transport + GOC:TermGenie + + + + + activation of anion transport + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. + https://github.com/geneontology/go-ontology/issues/22021 + jl + 2015-01-20T14:32:24Z + down regulation of cellular protein localisation + down regulation of cellular protein localization + down-regulation of cellular protein localisation + down-regulation of cellular protein localization + downregulation of cellular protein localisation + downregulation of cellular protein localization + negative regulation of cellular protein localisation + negative regulation of cellular protein localization + inhibition of cellular protein localisation + inhibition of cellular protein localization + biological_process + GO:1903828 + negative regulation of protein localization + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + + + + + down regulation of cellular protein localisation + GOC:TermGenie + + + + + down regulation of cellular protein localization + GOC:TermGenie + + + + + down-regulation of cellular protein localisation + GOC:TermGenie + + + + + down-regulation of cellular protein localization + GOC:TermGenie + + + + + downregulation of cellular protein localisation + GOC:TermGenie + + + + + downregulation of cellular protein localization + GOC:TermGenie + + + + + negative regulation of cellular protein localisation + GOC:TermGenie + + + + + inhibition of cellular protein localisation + GOC:TermGenie + + + + + inhibition of cellular protein localization + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of a protein localization. + https://github.com/geneontology/go-ontology/issues/22021 + jl + 2015-01-20T14:32:33Z + positive regulation of cellular protein localisation + positive regulation of cellular protein localization + up regulation of cellular protein localisation + up regulation of cellular protein localization + up-regulation of cellular protein localisation + up-regulation of cellular protein localization + upregulation of cellular protein localisation + upregulation of cellular protein localization + biological_process + GO:1903829 + positive regulation of protein localization + + + + + Any process that activates or increases the frequency, rate or extent of a protein localization. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + + + + + positive regulation of cellular protein localisation + GOC:TermGenie + + + + + up regulation of cellular protein localisation + GOC:TermGenie + + + + + up regulation of cellular protein localization + GOC:TermGenie + + + + + up-regulation of cellular protein localisation + GOC:TermGenie + + + + + up-regulation of cellular protein localization + GOC:TermGenie + + + + + upregulation of cellular protein localisation + GOC:TermGenie + + + + + upregulation of cellular protein localization + GOC:TermGenie + @@ -24005,8 +46046,49 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. + sl + 2015-02-17T20:26:24Z + down regulation of respiratory gaseous exchange + down-regulation of respiratory gaseous exchange + downregulation of respiratory gaseous exchange + inhibition of respiratory gaseous exchange + biological_process + GO:1903941 negative regulation of respiratory gaseous exchange + + + + Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. + GOC:TermGenie + GO_REF:0000058 + PMID:22819705 + + + + + down regulation of respiratory gaseous exchange + GOC:TermGenie + + + + + down-regulation of respiratory gaseous exchange + GOC:TermGenie + + + + + downregulation of respiratory gaseous exchange + GOC:TermGenie + + + + + inhibition of respiratory gaseous exchange + GOC:TermGenie + @@ -24032,8 +46114,49 @@ + Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. + sl + 2015-02-17T20:26:35Z + up regulation of respiratory gaseous exchange + up-regulation of respiratory gaseous exchange + upregulation of respiratory gaseous exchange + activation of respiratory gaseous exchange + biological_process + GO:1903942 positive regulation of respiratory gaseous exchange + + + + Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. + GOC:TermGenie + GO_REF:0000058 + PMID:22819705 + + + + + up regulation of respiratory gaseous exchange + GOC:TermGenie + + + + + up-regulation of respiratory gaseous exchange + GOC:TermGenie + + + + + upregulation of respiratory gaseous exchange + GOC:TermGenie + + + + + activation of respiratory gaseous exchange + GOC:TermGenie + @@ -24060,8 +46183,84 @@ + Any process that activates or increases the frequency, rate or extent of vasculature development. + sl + 2015-03-06T22:17:04Z + up regulation of vasculature development + up-regulation of vasculature development + upregulation of vasculature development + activation of vasculature development + biological_process + activation of vascular system development + positive regulation of vascular system development + up regulation of vascular system development + up-regulation of vascular system development + upregulation of vascular system development + GO:1904018 positive regulation of vasculature development + + + + Any process that activates or increases the frequency, rate or extent of vasculature development. + GOC:TermGenie + GO_REF:0000058 + PMID:21472453 + + + + + up regulation of vasculature development + GOC:TermGenie + + + + + up-regulation of vasculature development + GOC:TermGenie + + + + + upregulation of vasculature development + GOC:TermGenie + + + + + activation of vasculature development + GOC:TermGenie + + + + + activation of vascular system development + GOC:TermGenie + + + + + positive regulation of vascular system development + GOC:TermGenie + + + + + up regulation of vascular system development + GOC:TermGenie + + + + + up-regulation of vascular system development + GOC:TermGenie + + + + + upregulation of vascular system development + GOC:TermGenie + @@ -24087,8 +46286,119 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. + sl + 2015-03-18T20:33:57Z + down regulation of nociception + down regulation of sensory perception of pain + down-regulation of nociception + down-regulation of sensory perception of pain + downregulation of nociception + downregulation of sensory perception of pain + negative regulation of nociception + down regulation of perception of physiological pain + down-regulation of perception of physiological pain + downregulation of perception of physiological pain + inhibition of nociception + inhibition of perception of physiological pain + inhibition of sensory perception of pain + negative regulation of perception of physiological pain + biological_process + GO:1904057 negative regulation of sensory perception of pain + + + + Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. + GOC:TermGenie + GO_REF:0000058 + PMID:17167094 + + + + + down regulation of nociception + GOC:TermGenie + + + + + down regulation of sensory perception of pain + GOC:TermGenie + + + + + down-regulation of nociception + GOC:TermGenie + + + + + down-regulation of sensory perception of pain + GOC:TermGenie + + + + + downregulation of nociception + GOC:TermGenie + + + + + downregulation of sensory perception of pain + GOC:TermGenie + + + + + negative regulation of nociception + GOC:TermGenie + + + + + down regulation of perception of physiological pain + GOC:TermGenie + + + + + down-regulation of perception of physiological pain + GOC:TermGenie + + + + + downregulation of perception of physiological pain + GOC:TermGenie + + + + + inhibition of nociception + GOC:TermGenie + + + + + inhibition of perception of physiological pain + GOC:TermGenie + + + + + inhibition of sensory perception of pain + GOC:TermGenie + + + + + negative regulation of perception of physiological pain + GOC:TermGenie + @@ -24114,8 +46424,119 @@ + Any process that activates or increases the frequency, rate or extent of sensory perception of pain. + sl + 2015-03-18T20:34:03Z + positive regulation of nociception + up regulation of nociception + up regulation of sensory perception of pain + up-regulation of nociception + up-regulation of sensory perception of pain + upregulation of nociception + upregulation of sensory perception of pain + activation of nociception + activation of perception of physiological pain + activation of sensory perception of pain + positive regulation of perception of physiological pain + up regulation of perception of physiological pain + up-regulation of perception of physiological pain + upregulation of perception of physiological pain + biological_process + GO:1904058 positive regulation of sensory perception of pain + + + + Any process that activates or increases the frequency, rate or extent of sensory perception of pain. + GOC:TermGenie + GO_REF:0000058 + PMID:17167094 + + + + + positive regulation of nociception + GOC:TermGenie + + + + + up regulation of nociception + GOC:TermGenie + + + + + up regulation of sensory perception of pain + GOC:TermGenie + + + + + up-regulation of nociception + GOC:TermGenie + + + + + up-regulation of sensory perception of pain + GOC:TermGenie + + + + + upregulation of nociception + GOC:TermGenie + + + + + upregulation of sensory perception of pain + GOC:TermGenie + + + + + activation of nociception + GOC:TermGenie + + + + + activation of perception of physiological pain + GOC:TermGenie + + + + + activation of sensory perception of pain + GOC:TermGenie + + + + + positive regulation of perception of physiological pain + GOC:TermGenie + + + + + up regulation of perception of physiological pain + GOC:TermGenie + + + + + up-regulation of perception of physiological pain + GOC:TermGenie + + + + + upregulation of perception of physiological pain + GOC:TermGenie + @@ -24140,8 +46561,23 @@ + Any cytoplasm that is part of a axon. + https://github.com/geneontology/go-ontology/issues/14472 + sl + 2015-04-06T18:13:14Z + axoplasm + cellular_component + GO:1904115 axon cytoplasm + + + + Any cytoplasm that is part of a axon. + GOC:TermGenie + GO_REF:0000064 + PMID:18667152 + @@ -24168,8 +46604,28 @@ + Any process that modulates the frequency, rate or extent of bile acid metabolic process. + bf + 2015-05-20T11:04:28Z + regulation of bile acid metabolism + biological_process + GO:1904251 regulation of bile acid metabolic process + + + + Any process that modulates the frequency, rate or extent of bile acid metabolic process. + GOC:TermGenie + GOC:bf + GO_REF:0000058 + + + + + regulation of bile acid metabolism + GOC:TermGenie + @@ -24197,8 +46653,84 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. + bf + 2015-05-20T11:04:35Z + down regulation of bile acid metabolic process + down regulation of bile acid metabolism + down-regulation of bile acid metabolic process + down-regulation of bile acid metabolism + downregulation of bile acid metabolic process + downregulation of bile acid metabolism + negative regulation of bile acid metabolism + inhibition of bile acid metabolic process + inhibition of bile acid metabolism + biological_process + GO:1904252 negative regulation of bile acid metabolic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. + GOC:TermGenie + GOC:bf + GO_REF:0000058 + + + + + down regulation of bile acid metabolic process + GOC:TermGenie + + + + + down regulation of bile acid metabolism + GOC:TermGenie + + + + + down-regulation of bile acid metabolic process + GOC:TermGenie + + + + + down-regulation of bile acid metabolism + GOC:TermGenie + + + + + downregulation of bile acid metabolic process + GOC:TermGenie + + + + + downregulation of bile acid metabolism + GOC:TermGenie + + + + + negative regulation of bile acid metabolism + GOC:TermGenie + + + + + inhibition of bile acid metabolic process + GOC:TermGenie + + + + + inhibition of bile acid metabolism + GOC:TermGenie + @@ -24226,8 +46758,84 @@ + Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. + bf + 2015-05-20T11:04:40Z + positive regulation of bile acid metabolism + up regulation of bile acid metabolic process + up regulation of bile acid metabolism + up-regulation of bile acid metabolic process + up-regulation of bile acid metabolism + upregulation of bile acid metabolic process + upregulation of bile acid metabolism + activation of bile acid metabolic process + activation of bile acid metabolism + biological_process + GO:1904253 positive regulation of bile acid metabolic process + + + + Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. + GOC:TermGenie + GOC:bf + GO_REF:0000058 + + + + + positive regulation of bile acid metabolism + GOC:TermGenie + + + + + up regulation of bile acid metabolic process + GOC:TermGenie + + + + + up regulation of bile acid metabolism + GOC:TermGenie + + + + + up-regulation of bile acid metabolic process + GOC:TermGenie + + + + + up-regulation of bile acid metabolism + GOC:TermGenie + + + + + upregulation of bile acid metabolic process + GOC:TermGenie + + + + + upregulation of bile acid metabolism + GOC:TermGenie + + + + + activation of bile acid metabolic process + GOC:TermGenie + + + + + activation of bile acid metabolism + GOC:TermGenie + @@ -24254,8 +46862,35 @@ + Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition. + sl + 2015-06-10T18:46:11Z + biological_process + regulation of smooth muscle contraction involved in urination + regulation of urinary bladder smooth muscle contraction involved in micturition + GO:1904318 regulation of smooth muscle contraction involved in micturition + + + + Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition. + GOC:TermGenie + GO_REF:0000058 + PMID:18562635 + + + + + regulation of smooth muscle contraction involved in urination + GOC:TermGenie + + + + + regulation of urinary bladder smooth muscle contraction involved in micturition + GOC:TermGenie + @@ -24281,8 +46916,119 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition. + sl + 2015-06-10T18:46:17Z + down regulation of smooth muscle contraction involved in micturition + down-regulation of smooth muscle contraction involved in micturition + downregulation of smooth muscle contraction involved in micturition + inhibition of smooth muscle contraction involved in micturition + biological_process + down regulation of smooth muscle contraction involved in urination + down regulation of urinary bladder smooth muscle contraction involved in micturition + down-regulation of smooth muscle contraction involved in urination + down-regulation of urinary bladder smooth muscle contraction involved in micturition + downregulation of smooth muscle contraction involved in urination + downregulation of urinary bladder smooth muscle contraction involved in micturition + inhibition of smooth muscle contraction involved in urination + inhibition of urinary bladder smooth muscle contraction involved in micturition + negative regulation of smooth muscle contraction involved in urination + negative regulation of urinary bladder smooth muscle contraction involved in micturition + GO:1904319 negative regulation of smooth muscle contraction involved in micturition + + + + Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition. + GOC:TermGenie + GO_REF:0000058 + PMID:18562635 + + + + + down regulation of smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + down-regulation of smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + downregulation of smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + inhibition of smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + down regulation of smooth muscle contraction involved in urination + GOC:TermGenie + + + + + down regulation of urinary bladder smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + down-regulation of smooth muscle contraction involved in urination + GOC:TermGenie + + + + + down-regulation of urinary bladder smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + downregulation of smooth muscle contraction involved in urination + GOC:TermGenie + + + + + downregulation of urinary bladder smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + inhibition of smooth muscle contraction involved in urination + GOC:TermGenie + + + + + inhibition of urinary bladder smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + negative regulation of smooth muscle contraction involved in urination + GOC:TermGenie + + + + + negative regulation of urinary bladder smooth muscle contraction involved in micturition + GOC:TermGenie + @@ -24308,8 +47054,119 @@ + Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition. + sl + 2015-06-10T18:46:23Z + up regulation of smooth muscle contraction involved in micturition + up-regulation of smooth muscle contraction involved in micturition + upregulation of smooth muscle contraction involved in micturition + activation of smooth muscle contraction involved in micturition + biological_process + activation of smooth muscle contraction involved in urination + activation of urinary bladder smooth muscle contraction involved in micturition + positive regulation of smooth muscle contraction involved in urination + positive regulation of urinary bladder smooth muscle contraction involved in micturition + up regulation of smooth muscle contraction involved in urination + up regulation of urinary bladder smooth muscle contraction involved in micturition + up-regulation of smooth muscle contraction involved in urination + up-regulation of urinary bladder smooth muscle contraction involved in micturition + upregulation of smooth muscle contraction involved in urination + upregulation of urinary bladder smooth muscle contraction involved in micturition + GO:1904320 positive regulation of smooth muscle contraction involved in micturition + + + + Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition. + GOC:TermGenie + GO_REF:0000058 + PMID:18562635 + + + + + up regulation of smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + up-regulation of smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + upregulation of smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + activation of smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + activation of smooth muscle contraction involved in urination + GOC:TermGenie + + + + + activation of urinary bladder smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + positive regulation of smooth muscle contraction involved in urination + GOC:TermGenie + + + + + positive regulation of urinary bladder smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + up regulation of smooth muscle contraction involved in urination + GOC:TermGenie + + + + + up regulation of urinary bladder smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + up-regulation of smooth muscle contraction involved in urination + GOC:TermGenie + + + + + up-regulation of urinary bladder smooth muscle contraction involved in micturition + GOC:TermGenie + + + + + upregulation of smooth muscle contraction involved in urination + GOC:TermGenie + + + + + upregulation of urinary bladder smooth muscle contraction involved in micturition + GOC:TermGenie + @@ -24334,8 +47191,21 @@ + Any process that modulates the frequency, rate or extent of calcitonin secretion. + sl + 2015-06-15T17:54:52Z + biological_process + GO:1904362 regulation of calcitonin secretion + + + + Any process that modulates the frequency, rate or extent of calcitonin secretion. + GOC:TermGenie + GO_REF:0000058 + PMID:11278900 + @@ -24361,8 +47231,49 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion. + sl + 2015-06-15T17:54:58Z + down regulation of calcitonin secretion + down-regulation of calcitonin secretion + downregulation of calcitonin secretion + inhibition of calcitonin secretion + biological_process + GO:1904363 negative regulation of calcitonin secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion. + GOC:TermGenie + GO_REF:0000058 + PMID:11278900 + + + + + down regulation of calcitonin secretion + GOC:TermGenie + + + + + down-regulation of calcitonin secretion + GOC:TermGenie + + + + + downregulation of calcitonin secretion + GOC:TermGenie + + + + + inhibition of calcitonin secretion + GOC:TermGenie + @@ -24388,8 +47299,49 @@ + Any process that activates or increases the frequency, rate or extent of calcitonin secretion. + sl + 2015-06-15T17:55:05Z + up regulation of calcitonin secretion + up-regulation of calcitonin secretion + upregulation of calcitonin secretion + activation of calcitonin secretion + biological_process + GO:1904364 positive regulation of calcitonin secretion + + + + Any process that activates or increases the frequency, rate or extent of calcitonin secretion. + GOC:TermGenie + GO_REF:0000058 + PMID:11278900 + + + + + up regulation of calcitonin secretion + GOC:TermGenie + + + + + up-regulation of calcitonin secretion + GOC:TermGenie + + + + + upregulation of calcitonin secretion + GOC:TermGenie + + + + + activation of calcitonin secretion + GOC:TermGenie + @@ -24407,16 +47359,162 @@ - + + Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. + mec + 2016-02-05T09:59:24Z + down regulation of establishment of protein localisation + down regulation of establishment of protein localization + down regulation of protein positioning + down regulation of protein recruitment + down-regulation of establishment of protein localisation + down-regulation of establishment of protein localization + down-regulation of protein positioning + down-regulation of protein recruitment + downregulation of establishment of protein localisation + downregulation of establishment of protein localization + downregulation of protein positioning + downregulation of protein recruitment + negative regulation of establishment of protein localisation + negative regulation of protein positioning + negative regulation of protein recruitment + inhibition of establishment of protein localisation + inhibition of establishment of protein localization + inhibition of protein positioning + inhibition of protein recruitment + biological_process + GO:1904950 negative regulation of establishment of protein localization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. + GOC:TermGenie + GO_REF:0000058 + PMID:22761445 + + + + + down regulation of establishment of protein localisation + GOC:TermGenie + + + + + down regulation of establishment of protein localization + GOC:TermGenie + + + + + down regulation of protein positioning + GOC:TermGenie + + + + + down regulation of protein recruitment + GOC:TermGenie + + + + + down-regulation of establishment of protein localisation + GOC:TermGenie + + + + + down-regulation of establishment of protein localization + GOC:TermGenie + + + + + down-regulation of protein positioning + GOC:TermGenie + + + + + down-regulation of protein recruitment + GOC:TermGenie + + + + + downregulation of establishment of protein localisation + GOC:TermGenie + + + + + downregulation of establishment of protein localization + GOC:TermGenie + + + + + downregulation of protein positioning + GOC:TermGenie + + + + + downregulation of protein recruitment + GOC:TermGenie + + + + + negative regulation of establishment of protein localisation + GOC:TermGenie + + + + + negative regulation of protein positioning + GOC:TermGenie + + + + + negative regulation of protein recruitment + GOC:TermGenie + + + + + inhibition of establishment of protein localisation + GOC:TermGenie + + + + + inhibition of establishment of protein localization + GOC:TermGenie + + + + + inhibition of protein positioning + GOC:TermGenie + + + + + inhibition of protein recruitment + GOC:TermGenie + @@ -24434,16 +47532,162 @@ - + + Any process that activates or increases the frequency, rate or extent of establishment of protein localization. + mec + 2016-02-05T09:59:32Z + positive regulation of establishment of protein localisation + positive regulation of protein positioning + positive regulation of protein recruitment + up regulation of establishment of protein localisation + up regulation of establishment of protein localization + up regulation of protein positioning + up regulation of protein recruitment + up-regulation of establishment of protein localisation + up-regulation of establishment of protein localization + up-regulation of protein positioning + up-regulation of protein recruitment + upregulation of establishment of protein localisation + upregulation of establishment of protein localization + upregulation of protein positioning + upregulation of protein recruitment + activation of establishment of protein localisation + activation of establishment of protein localization + activation of protein positioning + activation of protein recruitment + biological_process + GO:1904951 positive regulation of establishment of protein localization + + + + Any process that activates or increases the frequency, rate or extent of establishment of protein localization. + GOC:TermGenie + GO_REF:0000058 + PMID:22761445 + + + + + positive regulation of establishment of protein localisation + GOC:TermGenie + + + + + positive regulation of protein positioning + GOC:TermGenie + + + + + positive regulation of protein recruitment + GOC:TermGenie + + + + + up regulation of establishment of protein localisation + GOC:TermGenie + + + + + up regulation of establishment of protein localization + GOC:TermGenie + + + + + up regulation of protein positioning + GOC:TermGenie + + + + + up regulation of protein recruitment + GOC:TermGenie + + + + + up-regulation of establishment of protein localisation + GOC:TermGenie + + + + + up-regulation of establishment of protein localization + GOC:TermGenie + + + + + up-regulation of protein positioning + GOC:TermGenie + + + + + up-regulation of protein recruitment + GOC:TermGenie + + + + + upregulation of establishment of protein localisation + GOC:TermGenie + + + + + upregulation of establishment of protein localization + GOC:TermGenie + + + + + upregulation of protein positioning + GOC:TermGenie + + + + + upregulation of protein recruitment + GOC:TermGenie + + + + + activation of establishment of protein localisation + GOC:TermGenie + + + + + activation of establishment of protein localization + GOC:TermGenie + + + + + activation of protein positioning + GOC:TermGenie + + + + + activation of protein recruitment + GOC:TermGenie + @@ -24469,8 +47713,23 @@ + Any process that modulates the frequency, rate or extent of epithelial tube formation. + bhm + 2016-06-20T09:35:41Z + biological_process + GO:1905276 + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). regulation of epithelial tube formation + + + + Any process that modulates the frequency, rate or extent of epithelial tube formation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + @@ -24497,8 +47756,51 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. + bhm + 2016-06-20T09:35:49Z + down regulation of epithelial tube formation + down-regulation of epithelial tube formation + downregulation of epithelial tube formation + inhibition of epithelial tube formation + biological_process + GO:1905277 + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). negative regulation of epithelial tube formation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + + + + + down regulation of epithelial tube formation + GOC:TermGenie + + + + + down-regulation of epithelial tube formation + GOC:TermGenie + + + + + downregulation of epithelial tube formation + GOC:TermGenie + + + + + inhibition of epithelial tube formation + GOC:TermGenie + @@ -24525,8 +47827,51 @@ + Any process that activates or increases the frequency, rate or extent of epithelial tube formation. + bhm + 2016-06-20T09:35:57Z + up regulation of epithelial tube formation + up-regulation of epithelial tube formation + upregulation of epithelial tube formation + activation of epithelial tube formation + biological_process + GO:1905278 + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). positive regulation of epithelial tube formation + + + + Any process that activates or increases the frequency, rate or extent of epithelial tube formation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + + + + + up regulation of epithelial tube formation + GOC:TermGenie + + + + + up-regulation of epithelial tube formation + GOC:TermGenie + + + + + upregulation of epithelial tube formation + GOC:TermGenie + + + + + activation of epithelial tube formation + GOC:TermGenie + @@ -24551,8 +47896,30 @@ + Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. + bhm + 2016-07-22T07:13:49Z + regulation of epithelium morphogenesis + biological_process + GO:1905330 + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). regulation of morphogenesis of an epithelium + + + + Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + + + + + regulation of epithelium morphogenesis + GOC:TermGenie + @@ -24578,8 +47945,86 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. + bhm + 2016-07-22T07:13:57Z + down regulation of epithelium morphogenesis + down regulation of morphogenesis of an epithelium + down-regulation of epithelium morphogenesis + down-regulation of morphogenesis of an epithelium + downregulation of epithelium morphogenesis + downregulation of morphogenesis of an epithelium + negative regulation of epithelium morphogenesis + inhibition of epithelium morphogenesis + inhibition of morphogenesis of an epithelium + biological_process + GO:1905331 + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). negative regulation of morphogenesis of an epithelium + + + + Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + + + + + down regulation of epithelium morphogenesis + GOC:TermGenie + + + + + down regulation of morphogenesis of an epithelium + GOC:TermGenie + + + + + down-regulation of epithelium morphogenesis + GOC:TermGenie + + + + + down-regulation of morphogenesis of an epithelium + GOC:TermGenie + + + + + downregulation of epithelium morphogenesis + GOC:TermGenie + + + + + downregulation of morphogenesis of an epithelium + GOC:TermGenie + + + + + negative regulation of epithelium morphogenesis + GOC:TermGenie + + + + + inhibition of epithelium morphogenesis + GOC:TermGenie + + + + + inhibition of morphogenesis of an epithelium + GOC:TermGenie + @@ -24605,8 +48050,86 @@ + Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. + bhm + 2016-07-22T07:14:05Z + positive regulation of epithelium morphogenesis + up regulation of epithelium morphogenesis + up regulation of morphogenesis of an epithelium + up-regulation of epithelium morphogenesis + up-regulation of morphogenesis of an epithelium + upregulation of epithelium morphogenesis + upregulation of morphogenesis of an epithelium + activation of epithelium morphogenesis + activation of morphogenesis of an epithelium + biological_process + GO:1905332 + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). positive regulation of morphogenesis of an epithelium + + + + Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + + + + + positive regulation of epithelium morphogenesis + GOC:TermGenie + + + + + up regulation of epithelium morphogenesis + GOC:TermGenie + + + + + up regulation of morphogenesis of an epithelium + GOC:TermGenie + + + + + up-regulation of epithelium morphogenesis + GOC:TermGenie + + + + + up-regulation of morphogenesis of an epithelium + GOC:TermGenie + + + + + upregulation of epithelium morphogenesis + GOC:TermGenie + + + + + upregulation of morphogenesis of an epithelium + GOC:TermGenie + + + + + activation of epithelium morphogenesis + GOC:TermGenie + + + + + activation of morphogenesis of an epithelium + GOC:TermGenie + @@ -24633,8 +48156,31 @@ + Any process that modulates the frequency, rate or extent of blood vessel branching. + nc + 2016-10-12T14:19:33Z + regulation of branching involved in blood vessel morphogenesis + biological_process + GO:1905553 regulation of blood vessel branching + + + + Any process that modulates the frequency, rate or extent of blood vessel branching. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + + + + + regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie + @@ -24661,8 +48207,87 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. + nc + 2016-10-12T14:19:41Z + down regulation of branching involved in blood vessel morphogenesis + down regulation of patterning of blood vessels + down-regulation of branching involved in blood vessel morphogenesis + down-regulation of patterning of blood vessels + downregulation of branching involved in blood vessel morphogenesis + downregulation of patterning of blood vessels + negative regulation of branching involved in blood vessel morphogenesis + inhibition of branching involved in blood vessel morphogenesis + inhibition of patterning of blood vessels + biological_process + GO:1905554 negative regulation of vessel branching + + + + Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + + + + + down regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie + + + + + down regulation of patterning of blood vessels + GOC:TermGenie + + + + + down-regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie + + + + + down-regulation of patterning of blood vessels + GOC:TermGenie + + + + + downregulation of branching involved in blood vessel morphogenesis + GOC:TermGenie + + + + + downregulation of patterning of blood vessels + GOC:TermGenie + + + + + negative regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie + + + + + inhibition of branching involved in blood vessel morphogenesis + GOC:TermGenie + + + + + inhibition of patterning of blood vessels + GOC:TermGenie + @@ -24689,8 +48314,87 @@ + Any process that activates or increases the frequency, rate or extent of blood vessel branching. + nc + 2016-10-12T14:19:49Z + positive regulation of branching involved in blood vessel morphogenesis + up regulation of branching involved in blood vessel morphogenesis + up regulation of patterning of blood vessels + up-regulation of branching involved in blood vessel morphogenesis + up-regulation of patterning of blood vessels + upregulation of branching involved in blood vessel morphogenesis + upregulation of patterning of blood vessels + activation of branching involved in blood vessel morphogenesis + activation of patterning of blood vessels + biological_process + GO:1905555 positive regulation of blood vessel branching + + + + Any process that activates or increases the frequency, rate or extent of blood vessel branching. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + + + + + positive regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie + + + + + up regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie + + + + + up regulation of patterning of blood vessels + GOC:TermGenie + + + + + up-regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie + + + + + up-regulation of patterning of blood vessels + GOC:TermGenie + + + + + upregulation of branching involved in blood vessel morphogenesis + GOC:TermGenie + + + + + upregulation of patterning of blood vessels + GOC:TermGenie + + + + + activation of branching involved in blood vessel morphogenesis + GOC:TermGenie + + + + + activation of patterning of blood vessels + GOC:TermGenie + @@ -24717,8 +48421,84 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion. + pga + 2016-12-09T10:24:00Z + down regulation of saliva secretion + down regulation of salivation + down-regulation of saliva secretion + down-regulation of salivation + downregulation of saliva secretion + downregulation of salivation + negative regulation of salivation + inhibition of saliva secretion + inhibition of salivation + biological_process + GO:1905747 negative regulation of saliva secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion. + GOC:TermGenie + GO_REF:0000058 + PMID:23419067 + + + + + down regulation of saliva secretion + GOC:TermGenie + + + + + down regulation of salivation + GOC:TermGenie + + + + + down-regulation of saliva secretion + GOC:TermGenie + + + + + down-regulation of salivation + GOC:TermGenie + + + + + downregulation of saliva secretion + GOC:TermGenie + + + + + downregulation of salivation + GOC:TermGenie + + + + + negative regulation of salivation + GOC:TermGenie + + + + + inhibition of saliva secretion + GOC:TermGenie + + + + + inhibition of salivation + GOC:TermGenie + @@ -24744,8 +48524,63 @@ + Any process that modulates the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. + hbye + 2017-01-09T15:11:04Z + regulation of perception of touch, detection of mechanical stimulus + regulation of perception of touch, sensory detection of mechanical stimulus + regulation of perception of touch, sensory transduction of mechanical stimulus + regulation of sensory detection of mechanical stimulus during perception of touch + regulation of sensory transduction of mechanical stimulus during perception of touch + regulation of tactition, sensory detection of mechanical stimulus + biological_process + GO:1905787 regulation of detection of mechanical stimulus involved in sensory perception of touch + + + + Any process that modulates the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. + GOC:TermGenie + GO_REF:0000058 + PMID:8692859 + + + + + regulation of perception of touch, detection of mechanical stimulus + GOC:TermGenie + + + + + regulation of perception of touch, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + regulation of perception of touch, sensory transduction of mechanical stimulus + GOC:TermGenie + + + + + regulation of sensory detection of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + regulation of sensory transduction of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + regulation of tactition, sensory detection of mechanical stimulus + GOC:TermGenie + @@ -24772,8 +48607,259 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. + hbye + 2017-01-09T15:11:14Z + down regulation of detection of mechanical stimulus involved in sensory perception of touch + down regulation of perception of touch, detection of mechanical stimulus + down regulation of perception of touch, sensory detection of mechanical stimulus + down regulation of perception of touch, sensory transduction of mechanical stimulus + down regulation of sensory detection of mechanical stimulus during perception of touch + down regulation of sensory transduction of mechanical stimulus during perception of touch + down regulation of tactition, sensory detection of mechanical stimulus + down-regulation of detection of mechanical stimulus involved in sensory perception of touch + down-regulation of perception of touch, detection of mechanical stimulus + down-regulation of perception of touch, sensory detection of mechanical stimulus + down-regulation of perception of touch, sensory transduction of mechanical stimulus + down-regulation of sensory detection of mechanical stimulus during perception of touch + down-regulation of sensory transduction of mechanical stimulus during perception of touch + down-regulation of tactition, sensory detection of mechanical stimulus + downregulation of detection of mechanical stimulus involved in sensory perception of touch + downregulation of perception of touch, detection of mechanical stimulus + downregulation of perception of touch, sensory detection of mechanical stimulus + downregulation of perception of touch, sensory transduction of mechanical stimulus + downregulation of sensory detection of mechanical stimulus during perception of touch + downregulation of sensory transduction of mechanical stimulus during perception of touch + downregulation of tactition, sensory detection of mechanical stimulus + negative regulation of perception of touch, detection of mechanical stimulus + negative regulation of perception of touch, sensory detection of mechanical stimulus + negative regulation of perception of touch, sensory transduction of mechanical stimulus + negative regulation of sensory detection of mechanical stimulus during perception of touch + negative regulation of sensory transduction of mechanical stimulus during perception of touch + negative regulation of tactition, sensory detection of mechanical stimulus + inhibition of detection of mechanical stimulus involved in sensory perception of touch + inhibition of perception of touch, detection of mechanical stimulus + inhibition of perception of touch, sensory detection of mechanical stimulus + inhibition of perception of touch, sensory transduction of mechanical stimulus + inhibition of sensory detection of mechanical stimulus during perception of touch + inhibition of sensory transduction of mechanical stimulus during perception of touch + inhibition of tactition, sensory detection of mechanical stimulus + biological_process + GO:1905788 negative regulation of detection of mechanical stimulus involved in sensory perception of touch + + + + Any process that stops, prevents or reduces the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. + GOC:TermGenie + GO_REF:0000058 + PMID:8692859 + + + + + down regulation of detection of mechanical stimulus involved in sensory perception of touch + GOC:TermGenie + + + + + down regulation of perception of touch, detection of mechanical stimulus + GOC:TermGenie + + + + + down regulation of perception of touch, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + down regulation of perception of touch, sensory transduction of mechanical stimulus + GOC:TermGenie + + + + + down regulation of sensory detection of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + down regulation of sensory transduction of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + down regulation of tactition, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + down-regulation of detection of mechanical stimulus involved in sensory perception of touch + GOC:TermGenie + + + + + down-regulation of perception of touch, detection of mechanical stimulus + GOC:TermGenie + + + + + down-regulation of perception of touch, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + down-regulation of perception of touch, sensory transduction of mechanical stimulus + GOC:TermGenie + + + + + down-regulation of sensory detection of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + down-regulation of sensory transduction of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + down-regulation of tactition, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + downregulation of detection of mechanical stimulus involved in sensory perception of touch + GOC:TermGenie + + + + + downregulation of perception of touch, detection of mechanical stimulus + GOC:TermGenie + + + + + downregulation of perception of touch, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + downregulation of perception of touch, sensory transduction of mechanical stimulus + GOC:TermGenie + + + + + downregulation of sensory detection of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + downregulation of sensory transduction of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + downregulation of tactition, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + negative regulation of perception of touch, detection of mechanical stimulus + GOC:TermGenie + + + + + negative regulation of perception of touch, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + negative regulation of perception of touch, sensory transduction of mechanical stimulus + GOC:TermGenie + + + + + negative regulation of sensory detection of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + negative regulation of sensory transduction of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + negative regulation of tactition, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + inhibition of detection of mechanical stimulus involved in sensory perception of touch + GOC:TermGenie + + + + + inhibition of perception of touch, detection of mechanical stimulus + GOC:TermGenie + + + + + inhibition of perception of touch, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + inhibition of perception of touch, sensory transduction of mechanical stimulus + GOC:TermGenie + + + + + inhibition of sensory detection of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + inhibition of sensory transduction of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + inhibition of tactition, sensory detection of mechanical stimulus + GOC:TermGenie + @@ -24800,8 +48886,259 @@ + Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. + hbye + 2017-01-09T15:11:23Z + positive regulation of perception of touch, detection of mechanical stimulus + positive regulation of perception of touch, sensory detection of mechanical stimulus + positive regulation of perception of touch, sensory transduction of mechanical stimulus + positive regulation of sensory detection of mechanical stimulus during perception of touch + positive regulation of sensory transduction of mechanical stimulus during perception of touch + positive regulation of tactition, sensory detection of mechanical stimulus + up regulation of detection of mechanical stimulus involved in sensory perception of touch + up regulation of perception of touch, detection of mechanical stimulus + up regulation of perception of touch, sensory detection of mechanical stimulus + up regulation of perception of touch, sensory transduction of mechanical stimulus + up regulation of sensory detection of mechanical stimulus during perception of touch + up regulation of sensory transduction of mechanical stimulus during perception of touch + up regulation of tactition, sensory detection of mechanical stimulus + up-regulation of detection of mechanical stimulus involved in sensory perception of touch + up-regulation of perception of touch, detection of mechanical stimulus + up-regulation of perception of touch, sensory detection of mechanical stimulus + up-regulation of perception of touch, sensory transduction of mechanical stimulus + up-regulation of sensory detection of mechanical stimulus during perception of touch + up-regulation of sensory transduction of mechanical stimulus during perception of touch + up-regulation of tactition, sensory detection of mechanical stimulus + upregulation of detection of mechanical stimulus involved in sensory perception of touch + upregulation of perception of touch, detection of mechanical stimulus + upregulation of perception of touch, sensory detection of mechanical stimulus + upregulation of perception of touch, sensory transduction of mechanical stimulus + upregulation of sensory detection of mechanical stimulus during perception of touch + upregulation of sensory transduction of mechanical stimulus during perception of touch + upregulation of tactition, sensory detection of mechanical stimulus + activation of detection of mechanical stimulus involved in sensory perception of touch + activation of perception of touch, detection of mechanical stimulus + activation of perception of touch, sensory detection of mechanical stimulus + activation of perception of touch, sensory transduction of mechanical stimulus + activation of sensory detection of mechanical stimulus during perception of touch + activation of sensory transduction of mechanical stimulus during perception of touch + activation of tactition, sensory detection of mechanical stimulus + biological_process + GO:1905789 positive regulation of detection of mechanical stimulus involved in sensory perception of touch + + + + Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. + GOC:TermGenie + GO_REF:0000058 + PMID:8692859 + + + + + positive regulation of perception of touch, detection of mechanical stimulus + GOC:TermGenie + + + + + positive regulation of perception of touch, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + positive regulation of perception of touch, sensory transduction of mechanical stimulus + GOC:TermGenie + + + + + positive regulation of sensory detection of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + positive regulation of sensory transduction of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + positive regulation of tactition, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + up regulation of detection of mechanical stimulus involved in sensory perception of touch + GOC:TermGenie + + + + + up regulation of perception of touch, detection of mechanical stimulus + GOC:TermGenie + + + + + up regulation of perception of touch, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + up regulation of perception of touch, sensory transduction of mechanical stimulus + GOC:TermGenie + + + + + up regulation of sensory detection of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + up regulation of sensory transduction of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + up regulation of tactition, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + up-regulation of detection of mechanical stimulus involved in sensory perception of touch + GOC:TermGenie + + + + + up-regulation of perception of touch, detection of mechanical stimulus + GOC:TermGenie + + + + + up-regulation of perception of touch, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + up-regulation of perception of touch, sensory transduction of mechanical stimulus + GOC:TermGenie + + + + + up-regulation of sensory detection of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + up-regulation of sensory transduction of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + up-regulation of tactition, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + upregulation of detection of mechanical stimulus involved in sensory perception of touch + GOC:TermGenie + + + + + upregulation of perception of touch, detection of mechanical stimulus + GOC:TermGenie + + + + + upregulation of perception of touch, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + upregulation of perception of touch, sensory transduction of mechanical stimulus + GOC:TermGenie + + + + + upregulation of sensory detection of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + upregulation of sensory transduction of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + upregulation of tactition, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + activation of detection of mechanical stimulus involved in sensory perception of touch + GOC:TermGenie + + + + + activation of perception of touch, detection of mechanical stimulus + GOC:TermGenie + + + + + activation of perception of touch, sensory detection of mechanical stimulus + GOC:TermGenie + + + + + activation of perception of touch, sensory transduction of mechanical stimulus + GOC:TermGenie + + + + + activation of sensory detection of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + activation of sensory transduction of mechanical stimulus during perception of touch + GOC:TermGenie + + + + + activation of tactition, sensory detection of mechanical stimulus + GOC:TermGenie + @@ -24828,8 +49165,28 @@ + Any process that modulates the frequency, rate or extent of oogenesis. + hbye + 2017-01-31T09:31:05Z + regulation of ovum development + biological_process + GO:1905879 regulation of oogenesis + + + + Any process that modulates the frequency, rate or extent of oogenesis. + GOC:TermGenie + GO_REF:0000058 + PMID:26434723 + + + + + regulation of ovum development + GOC:TermGenie + @@ -24857,8 +49214,84 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis. + hbye + 2017-01-31T09:31:15Z + down regulation of oogenesis + down regulation of ovum development + down-regulation of oogenesis + down-regulation of ovum development + downregulation of oogenesis + downregulation of ovum development + negative regulation of ovum development + inhibition of oogenesis + inhibition of ovum development + biological_process + GO:1905880 negative regulation of oogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis. + GOC:TermGenie + GO_REF:0000058 + PMID:26434723 + + + + + down regulation of oogenesis + GOC:TermGenie + + + + + down regulation of ovum development + GOC:TermGenie + + + + + down-regulation of oogenesis + GOC:TermGenie + + + + + down-regulation of ovum development + GOC:TermGenie + + + + + downregulation of oogenesis + GOC:TermGenie + + + + + downregulation of ovum development + GOC:TermGenie + + + + + negative regulation of ovum development + GOC:TermGenie + + + + + inhibition of oogenesis + GOC:TermGenie + + + + + inhibition of ovum development + GOC:TermGenie + @@ -24886,8 +49319,84 @@ + Any process that activates or increases the frequency, rate or extent of oogenesis. + hbye + 2017-01-31T09:31:23Z + positive regulation of ovum development + up regulation of oogenesis + up regulation of ovum development + up-regulation of oogenesis + up-regulation of ovum development + upregulation of oogenesis + upregulation of ovum development + activation of oogenesis + activation of ovum development + biological_process + GO:1905881 positive regulation of oogenesis + + + + Any process that activates or increases the frequency, rate or extent of oogenesis. + GOC:TermGenie + GO_REF:0000058 + PMID:26434723 + + + + + positive regulation of ovum development + GOC:TermGenie + + + + + up regulation of oogenesis + GOC:TermGenie + + + + + up regulation of ovum development + GOC:TermGenie + + + + + up-regulation of oogenesis + GOC:TermGenie + + + + + up-regulation of ovum development + GOC:TermGenie + + + + + upregulation of oogenesis + GOC:TermGenie + + + + + upregulation of ovum development + GOC:TermGenie + + + + + activation of oogenesis + GOC:TermGenie + + + + + activation of ovum development + GOC:TermGenie + @@ -24912,8 +49421,24 @@ + Any process that modulates the frequency, rate or extent of mesoderm formation. + rph + 2017-02-03T12:28:20Z + biological_process + GO:1905902 regulation of mesoderm formation + + + + Any process that modulates the frequency, rate or extent of mesoderm formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23939491 + @@ -24939,8 +49464,52 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. + rph + 2017-02-03T12:28:29Z + down regulation of mesoderm formation + down-regulation of mesoderm formation + downregulation of mesoderm formation + inhibition of mesoderm formation + biological_process + GO:1905903 negative regulation of mesoderm formation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23939491 + + + + + down regulation of mesoderm formation + GOC:TermGenie + + + + + down-regulation of mesoderm formation + GOC:TermGenie + + + + + downregulation of mesoderm formation + GOC:TermGenie + + + + + inhibition of mesoderm formation + GOC:TermGenie + @@ -24966,8 +49535,52 @@ + Any process that activates or increases the frequency, rate or extent of mesoderm formation. + rph + 2017-02-03T12:28:38Z + up regulation of mesoderm formation + up-regulation of mesoderm formation + upregulation of mesoderm formation + activation of mesoderm formation + biological_process + GO:1905904 positive regulation of mesoderm formation + + + + Any process that activates or increases the frequency, rate or extent of mesoderm formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23939491 + + + + + up regulation of mesoderm formation + GOC:TermGenie + + + + + up-regulation of mesoderm formation + GOC:TermGenie + + + + + upregulation of mesoderm formation + GOC:TermGenie + + + + + activation of mesoderm formation + GOC:TermGenie + @@ -24993,8 +49606,28 @@ + Any process that modulates the frequency, rate or extent of gonad development. + hbye + 2017-02-09T17:01:50Z + regulation of gonadogenesis + biological_process + GO:1905939 regulation of gonad development + + + + Any process that modulates the frequency, rate or extent of gonad development. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + + + + + regulation of gonadogenesis + GOC:TermGenie + @@ -25022,8 +49655,84 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of gonad development. + hbye + 2017-02-09T17:01:59Z + down regulation of gonad development + down regulation of gonadogenesis + down-regulation of gonad development + down-regulation of gonadogenesis + downregulation of gonad development + downregulation of gonadogenesis + negative regulation of gonadogenesis + inhibition of gonad development + inhibition of gonadogenesis + biological_process + GO:1905940 negative regulation of gonad development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gonad development. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + + + + + down regulation of gonad development + GOC:TermGenie + + + + + down regulation of gonadogenesis + GOC:TermGenie + + + + + down-regulation of gonad development + GOC:TermGenie + + + + + down-regulation of gonadogenesis + GOC:TermGenie + + + + + downregulation of gonad development + GOC:TermGenie + + + + + downregulation of gonadogenesis + GOC:TermGenie + + + + + negative regulation of gonadogenesis + GOC:TermGenie + + + + + inhibition of gonad development + GOC:TermGenie + + + + + inhibition of gonadogenesis + GOC:TermGenie + @@ -25051,8 +49760,84 @@ + Any process that activates or increases the frequency, rate or extent of gonad development. + hbye + 2017-02-09T17:02:08Z + positive regulation of gonadogenesis + up regulation of gonad development + up regulation of gonadogenesis + up-regulation of gonad development + up-regulation of gonadogenesis + upregulation of gonad development + upregulation of gonadogenesis + activation of gonad development + activation of gonadogenesis + biological_process + GO:1905941 positive regulation of gonad development + + + + Any process that activates or increases the frequency, rate or extent of gonad development. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + + + + + positive regulation of gonadogenesis + GOC:TermGenie + + + + + up regulation of gonad development + GOC:TermGenie + + + + + up regulation of gonadogenesis + GOC:TermGenie + + + + + up-regulation of gonad development + GOC:TermGenie + + + + + up-regulation of gonadogenesis + GOC:TermGenie + + + + + upregulation of gonad development + GOC:TermGenie + + + + + upregulation of gonadogenesis + GOC:TermGenie + + + + + activation of gonad development + GOC:TermGenie + + + + + activation of gonadogenesis + GOC:TermGenie + @@ -25077,8 +49862,28 @@ + Any process that modulates the frequency, rate or extent of lipid localization. + rz + 2017-02-21T12:12:22Z + regulation of lipid localisation + biological_process + GO:1905952 regulation of lipid localization + + + + Any process that modulates the frequency, rate or extent of lipid localization. + GOC:TermGenie + GO_REF:0000058 + PMID:17564681 + + + + + regulation of lipid localisation + GOC:TermGenie + @@ -25104,8 +49909,84 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. + rz + 2017-02-21T12:12:41Z + down regulation of lipid localisation + down regulation of lipid localization + down-regulation of lipid localisation + down-regulation of lipid localization + downregulation of lipid localisation + downregulation of lipid localization + negative regulation of lipid localisation + inhibition of lipid localisation + inhibition of lipid localization + biological_process + GO:1905953 negative regulation of lipid localization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. + GOC:TermGenie + GO_REF:0000058 + PMID:17564681 + + + + + down regulation of lipid localisation + GOC:TermGenie + + + + + down regulation of lipid localization + GOC:TermGenie + + + + + down-regulation of lipid localisation + GOC:TermGenie + + + + + down-regulation of lipid localization + GOC:TermGenie + + + + + downregulation of lipid localisation + GOC:TermGenie + + + + + downregulation of lipid localization + GOC:TermGenie + + + + + negative regulation of lipid localisation + GOC:TermGenie + + + + + inhibition of lipid localisation + GOC:TermGenie + + + + + inhibition of lipid localization + GOC:TermGenie + @@ -25131,8 +50012,84 @@ + Any process that activates or increases the frequency, rate or extent of lipid localization. + rz + 2017-02-21T12:12:49Z + positive regulation of lipid localisation + up regulation of lipid localisation + up regulation of lipid localization + up-regulation of lipid localisation + up-regulation of lipid localization + upregulation of lipid localisation + upregulation of lipid localization + activation of lipid localisation + activation of lipid localization + biological_process + GO:1905954 positive regulation of lipid localization + + + + Any process that activates or increases the frequency, rate or extent of lipid localization. + GOC:TermGenie + GO_REF:0000058 + PMID:17564681 + + + + + positive regulation of lipid localisation + GOC:TermGenie + + + + + up regulation of lipid localisation + GOC:TermGenie + + + + + up regulation of lipid localization + GOC:TermGenie + + + + + up-regulation of lipid localisation + GOC:TermGenie + + + + + up-regulation of lipid localization + GOC:TermGenie + + + + + upregulation of lipid localisation + GOC:TermGenie + + + + + upregulation of lipid localization + GOC:TermGenie + + + + + activation of lipid localisation + GOC:TermGenie + + + + + activation of lipid localization + GOC:TermGenie + @@ -25140,8 +50097,20 @@ + The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature. + sl + 2015-08-31T18:19:49Z + biological_process + GO:1990845 adaptive thermogenesis + + + + The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature. + PMID:17260010 + PMID:20363363 + @@ -25167,8 +50136,19 @@ + Any process that modulates the frequency, rate or extent of multicellular organismal development. + tb + 2010-08-05T11:25:59Z + biological_process + GO:2000026 regulation of multicellular organismal development + + + + Any process that modulates the frequency, rate or extent of multicellular organismal development. + GOC:obol + @@ -25193,8 +50173,26 @@ + Any process that modulates the frequency, rate or extent of animal organ morphogenesis. + tb + 2010-08-05T11:26:27Z + biological_process + regulation of histogenesis and organogenesis + GO:2000027 regulation of animal organ morphogenesis + + + + Any process that modulates the frequency, rate or extent of animal organ morphogenesis. + GOC:obol + + + + + regulation of histogenesis and organogenesis + GOC:obol + @@ -25219,8 +50217,26 @@ + Any process that modulates the frequency, rate or extent of stem cell division. + tb + 2010-08-05T11:34:53Z + regulation of stem cell renewal + biological_process + GO:2000035 regulation of stem cell division + + + + Any process that modulates the frequency, rate or extent of stem cell division. + GOC:obol + + + + + regulation of stem cell renewal + GOC:obol + @@ -25245,8 +50261,47 @@ + Any process that modulates the frequency, rate or extent of response to water deprivation. + tb + 2010-08-23T11:32:32Z + regulation of response to dehydration + regulation of response to drought + regulation of response to thirst + biological_process + regulation of drought tolerance + GO:2000070 regulation of response to water deprivation + + + + Any process that modulates the frequency, rate or extent of response to water deprivation. + GOC:obol + + + + + regulation of response to dehydration + GOC:obol + + + + + regulation of response to drought + GOC:obol + + + + + regulation of response to thirst + GOC:obol + + + + + regulation of drought tolerance + GOC:obol + @@ -25272,8 +50327,54 @@ + Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process. + tb + 2010-09-15T08:55:45Z + regulation of cellular biopolymer biosynthetic process + regulation of cellular macromolecule anabolism + regulation of cellular macromolecule biosynthesis + regulation of cellular macromolecule formation + regulation of cellular macromolecule synthesis + biological_process + GO:2000112 regulation of cellular macromolecule biosynthetic process + + + + Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process. + GOC:obol + + + + + regulation of cellular biopolymer biosynthetic process + GOC:obol + + + + + regulation of cellular macromolecule anabolism + GOC:obol + + + + + regulation of cellular macromolecule biosynthesis + GOC:obol + + + + + regulation of cellular macromolecule formation + GOC:obol + + + + + regulation of cellular macromolecule synthesis + GOC:obol + @@ -25300,8 +50401,54 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process. + tb + 2010-09-15T08:55:48Z + negative regulation of cellular biopolymer biosynthetic process + negative regulation of cellular macromolecule anabolism + negative regulation of cellular macromolecule biosynthesis + negative regulation of cellular macromolecule formation + negative regulation of cellular macromolecule synthesis + biological_process + GO:2000113 negative regulation of cellular macromolecule biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process. + GOC:obol + + + + + negative regulation of cellular biopolymer biosynthetic process + GOC:obol + + + + + negative regulation of cellular macromolecule anabolism + GOC:obol + + + + + negative regulation of cellular macromolecule biosynthesis + GOC:obol + + + + + negative regulation of cellular macromolecule formation + GOC:obol + + + + + negative regulation of cellular macromolecule synthesis + GOC:obol + @@ -25320,15 +50467,47 @@ - + + Any process that modulates the frequency, rate or extent of cell motility. + mah + 2010-10-01T09:41:21Z + regulation of cell locomotion + regulation of movement of a cell + biological_process + regulation of cell movement + GO:2000145 regulation of cell motility + + + + Any process that modulates the frequency, rate or extent of cell motility. + GOC:mah + + + + + regulation of cell locomotion + GOC:obol + + + + + regulation of movement of a cell + GOC:obol + + + + + regulation of cell movement + GOC:obol + @@ -25347,7 +50526,7 @@ - + @@ -25355,8 +50534,40 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. + mah + 2010-10-01T09:41:26Z + negative regulation of cell locomotion + negative regulation of movement of a cell + biological_process + negative regulation of cell movement + GO:2000146 negative regulation of cell motility + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. + GOC:mah + + + + + negative regulation of cell locomotion + GOC:obol + + + + + negative regulation of movement of a cell + GOC:obol + + + + + negative regulation of cell movement + GOC:obol + @@ -25375,7 +50586,7 @@ - + @@ -25383,8 +50594,40 @@ + Any process that activates or increases the frequency, rate or extent of cell motility. + mah + 2010-10-01T09:41:30Z + positive regulation of cell locomotion + positive regulation of movement of a cell + biological_process + positive regulation of cell movement + GO:2000147 positive regulation of cell motility + + + + Any process that activates or increases the frequency, rate or extent of cell motility. + GOC:mah + + + + + positive regulation of cell locomotion + GOC:obol + + + + + positive regulation of movement of a cell + GOC:obol + + + + + positive regulation of cell movement + GOC:obol + @@ -25410,8 +50653,21 @@ + Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility. + mah + 2010-10-04T12:41:05Z + biological_process + positive regulation of ciliary cell motility + GO:2000155 positive regulation of cilium-dependent cell motility + + + + Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility. + GOC:cilia + GOC:jl + @@ -25437,8 +50693,20 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. + dph + 2010-10-13T12:46:31Z + biological_process + GO:2000181 negative regulation of blood vessel morphogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. + GOC:dph + GOC:yaf + @@ -25464,8 +50732,33 @@ + Any process that modulates the frequency, rate or extent of female gonad development. + yaf + 2010-10-19T10:45:34Z + regulation of ovarian development + regulation of ovary development + biological_process + GO:2000194 regulation of female gonad development + + + + Any process that modulates the frequency, rate or extent of female gonad development. + GOC:obol + + + + + regulation of ovarian development + GOC:obol + + + + + regulation of ovary development + GOC:obol + @@ -25491,8 +50784,33 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development. + yaf + 2010-10-19T10:45:38Z + negative regulation of ovarian development + negative regulation of ovary development + biological_process + GO:2000195 negative regulation of female gonad development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development. + GOC:obol + + + + + negative regulation of ovarian development + GOC:obol + + + + + negative regulation of ovary development + GOC:obol + @@ -25518,8 +50836,33 @@ + Any process that activates or increases the frequency, rate or extent of female gonad development. + yaf + 2010-10-19T10:45:41Z + positive regulation of ovarian development + positive regulation of ovary development + biological_process + GO:2000196 positive regulation of female gonad development + + + + Any process that activates or increases the frequency, rate or extent of female gonad development. + GOC:obol + + + + + positive regulation of ovarian development + GOC:obol + + + + + positive regulation of ovary development + GOC:obol + @@ -25544,8 +50887,40 @@ + Any process that modulates the frequency, rate or extent of glutamate metabolic process. + mah + 2010-11-03T02:43:51Z + regulation of glutamate metabolism + regulation of glutamic acid metabolic process + regulation of glutamic acid metabolism + biological_process + GO:2000211 regulation of glutamate metabolic process + + + + Any process that modulates the frequency, rate or extent of glutamate metabolic process. + GOC:sl + + + + + regulation of glutamate metabolism + GOC:obol + + + + + regulation of glutamic acid metabolic process + GOC:obol + + + + + regulation of glutamic acid metabolism + GOC:obol + @@ -25571,8 +50946,40 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process. + mah + 2010-11-03T02:43:55Z + negative regulation of glutamate metabolism + negative regulation of glutamic acid metabolic process + negative regulation of glutamic acid metabolism + biological_process + GO:2000212 negative regulation of glutamate metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process. + GOC:sl + + + + + negative regulation of glutamate metabolism + GOC:obol + + + + + negative regulation of glutamic acid metabolic process + GOC:obol + + + + + negative regulation of glutamic acid metabolism + GOC:obol + @@ -25598,8 +51005,40 @@ + Any process that activates or increases the frequency, rate or extent of glutamate metabolic process. + mah + 2010-11-03T02:43:59Z + positive regulation of glutamate metabolism + positive regulation of glutamic acid metabolic process + positive regulation of glutamic acid metabolism + biological_process + GO:2000213 positive regulation of glutamate metabolic process + + + + Any process that activates or increases the frequency, rate or extent of glutamate metabolic process. + GOC:sl + + + + + positive regulation of glutamate metabolism + GOC:obol + + + + + positive regulation of glutamic acid metabolic process + GOC:obol + + + + + positive regulation of glutamic acid metabolism + GOC:obol + @@ -25624,8 +51063,19 @@ + Any process that modulates the frequency, rate or extent of reproductive process. + mah + 2010-11-10T02:44:02Z + biological_process + GO:2000241 regulation of reproductive process + + + + Any process that modulates the frequency, rate or extent of reproductive process. + GOC:mah + @@ -25651,8 +51101,19 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. + mah + 2010-11-10T02:44:05Z + biological_process + GO:2000242 negative regulation of reproductive process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. + GOC:mah + @@ -25678,8 +51139,19 @@ + Any process that activates or increases the frequency, rate or extent of reproductive process. + mah + 2010-11-10T02:44:08Z + biological_process + GO:2000243 positive regulation of reproductive process + + + + Any process that activates or increases the frequency, rate or extent of reproductive process. + GOC:mah + @@ -25705,8 +51177,54 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior. + yaf + 2010-11-18T11:24:14Z + negative regulation of behavioral response to food + negative regulation of behavioural response to food + negative regulation of feeding behaviour + biological_process + negative regulation of drinking + negative regulation of eating + GO:2000252 negative regulation of feeding behavior + + + + Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior. + GOC:obol + + + + + negative regulation of behavioral response to food + GOC:obol + + + + + negative regulation of behavioural response to food + GOC:obol + + + + + negative regulation of feeding behaviour + GOC:obol + + + + + negative regulation of drinking + GOC:obol + + + + + negative regulation of eating + GOC:obol + @@ -25732,8 +51250,54 @@ + Any process that activates or increases the frequency, rate or extent of feeding behavior. + yaf + 2010-11-18T11:24:18Z + positive regulation of behavioral response to food + positive regulation of behavioural response to food + positive regulation of feeding behaviour + biological_process + positive regulation of drinking + positive regulation of eating + GO:2000253 positive regulation of feeding behavior + + + + Any process that activates or increases the frequency, rate or extent of feeding behavior. + GOC:obol + + + + + positive regulation of behavioral response to food + GOC:obol + + + + + positive regulation of behavioural response to food + GOC:obol + + + + + positive regulation of feeding behaviour + GOC:obol + + + + + positive regulation of drinking + GOC:obol + + + + + positive regulation of eating + GOC:obol + @@ -25759,8 +51323,21 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity. + bf + 2010-12-02T09:28:47Z + negative regulation of receptor activity + negative regulation of signalling receptor activity + biological_process + GO:2000272 negative regulation of signaling receptor activity + + + + Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity. + GOC:obol + @@ -25786,8 +51363,20 @@ + Any process that activates or increases the frequency, rate or extent of signaling receptor activity. + bf + 2010-12-02T09:28:50Z + positive regulation of signalling receptor activity + biological_process + GO:2000273 positive regulation of signaling receptor activity + + + + Any process that activates or increases the frequency, rate or extent of signaling receptor activity. + GOC:obol + @@ -25805,6 +51394,7 @@ + @@ -25812,8 +51402,19 @@ + Any process that modulates the frequency, rate or extent of defecation. + bf + 2010-12-21T09:23:08Z + biological_process + GO:2000292 regulation of defecation + + + + Any process that modulates the frequency, rate or extent of defecation. + GOC:obol + @@ -25832,7 +51433,7 @@ - + @@ -25840,8 +51441,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of defecation. + bf + 2010-12-21T09:23:13Z + biological_process + GO:2000293 negative regulation of defecation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of defecation. + GOC:obol + @@ -25860,7 +51472,7 @@ - + @@ -25868,8 +51480,19 @@ + Any process that activates or increases the frequency, rate or extent of defecation. + bf + 2010-12-21T09:23:16Z + biological_process + GO:2000294 positive regulation of defecation + + + + Any process that activates or increases the frequency, rate or extent of defecation. + GOC:obol + @@ -25894,8 +51517,19 @@ + Any process that modulates the frequency, rate or extent of mesoderm development. + vk + 2011-02-15T03:09:46Z + biological_process + GO:2000380 regulation of mesoderm development + + + + Any process that modulates the frequency, rate or extent of mesoderm development. + GOC:BHF + @@ -25921,8 +51555,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. + vk + 2011-02-15T03:10:02Z + biological_process + GO:2000381 negative regulation of mesoderm development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. + GOC:BHF + @@ -25948,8 +51593,19 @@ + Any process that activates or increases the frequency, rate or extent of mesoderm development. + vk + 2011-02-15T03:10:12Z + biological_process + GO:2000382 positive regulation of mesoderm development + + + + Any process that activates or increases the frequency, rate or extent of mesoderm development. + GOC:BHF + @@ -25974,8 +51630,19 @@ + Any process that modulates the frequency, rate or extent of ectoderm development. + vk + 2011-02-15T03:17:10Z + biological_process + GO:2000383 regulation of ectoderm development + + + + Any process that modulates the frequency, rate or extent of ectoderm development. + GOC:BHF + @@ -26001,8 +51668,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. + vk + 2011-02-15T03:17:27Z + biological_process + GO:2000384 negative regulation of ectoderm development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. + GOC:BHF + @@ -26028,8 +51706,19 @@ + Any process that activates or increases the frequency, rate or extent of ectoderm development. + vk + 2011-02-15T03:17:39Z + biological_process + GO:2000385 positive regulation of ectoderm development + + + + Any process that activates or increases the frequency, rate or extent of ectoderm development. + GOC:BHF + @@ -26055,8 +51744,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. + yaf + 2011-04-01T04:10:08Z + biological_process + GO:2000542 negative regulation of gastrulation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. + GOC:obol + @@ -26082,8 +51782,19 @@ + Any process that activates or increases the frequency, rate or extent of gastrulation. + yaf + 2011-04-01T04:10:15Z + biological_process + GO:2000543 positive regulation of gastrulation + + + + Any process that activates or increases the frequency, rate or extent of gastrulation. + GOC:obol + @@ -26110,8 +51821,19 @@ + Any process that modulates the frequency, rate or extent of thyroid hormone generation. + yaf + 2011-04-18T10:12:14Z + biological_process + GO:2000609 regulation of thyroid hormone generation + + + + Any process that modulates the frequency, rate or extent of thyroid hormone generation. + GOC:obol + @@ -26139,8 +51861,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation. + yaf + 2011-04-18T10:12:19Z + biological_process + GO:2000610 negative regulation of thyroid hormone generation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation. + GOC:obol + @@ -26168,8 +51901,19 @@ + Any process that activates or increases the frequency, rate or extent of thyroid hormone generation. + yaf + 2011-04-18T10:12:22Z + biological_process + GO:2000611 positive regulation of thyroid hormone generation + + + + Any process that activates or increases the frequency, rate or extent of thyroid hormone generation. + GOC:obol + @@ -26194,8 +51938,26 @@ + Any process that modulates the frequency, rate or extent of grooming behavior. + rl + 2011-07-14T04:48:12Z + regulation of grooming behaviour + biological_process + GO:2000821 regulation of grooming behavior + + + + Any process that modulates the frequency, rate or extent of grooming behavior. + GOC:BHF + + + + + regulation of grooming behaviour + GOC:obol + @@ -26221,8 +51983,40 @@ + Any process that modulates the frequency, rate or extent of parathyroid hormone secretion. + bf + 2011-07-26T08:37:53Z + regulation of PTH secretion + regulation of parathormone secretion + regulation of parathyrin secretion + biological_process + GO:2000828 regulation of parathyroid hormone secretion + + + + Any process that modulates the frequency, rate or extent of parathyroid hormone secretion. + GOC:obol + + + + + regulation of PTH secretion + GOC:obol + + + + + regulation of parathormone secretion + GOC:obol + + + + + regulation of parathyrin secretion + GOC:obol + @@ -26249,8 +52043,40 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion. + bf + 2011-07-26T08:37:57Z + negative regulation of PTH secretion + negative regulation of parathormone secretion + negative regulation of parathyrin secretion + biological_process + GO:2000829 negative regulation of parathyroid hormone secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion. + GOC:obol + + + + + negative regulation of PTH secretion + GOC:obol + + + + + negative regulation of parathormone secretion + GOC:obol + + + + + negative regulation of parathyrin secretion + GOC:obol + @@ -26277,8 +52103,40 @@ + Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion. + bf + 2011-07-26T08:38:00Z + positive regulation of PTH secretion + positive regulation of parathormone secretion + positive regulation of parathyrin secretion + biological_process + GO:2000830 positive regulation of parathyroid hormone secretion + + + + Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion. + GOC:obol + + + + + positive regulation of PTH secretion + GOC:obol + + + + + positive regulation of parathormone secretion + GOC:obol + + + + + positive regulation of parathyrin secretion + GOC:obol + @@ -26305,8 +52163,19 @@ + Any process that modulates the frequency, rate or extent of steroid hormone secretion. + bf + 2011-07-26T08:38:46Z + biological_process + GO:2000831 regulation of steroid hormone secretion + + + + Any process that modulates the frequency, rate or extent of steroid hormone secretion. + GOC:sl + @@ -26334,8 +52203,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion. + bf + 2011-07-26T08:38:50Z + biological_process + GO:2000832 negative regulation of steroid hormone secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion. + GOC:sl + @@ -26363,8 +52243,19 @@ + Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. + bf + 2011-07-26T08:38:51Z + biological_process + GO:2000833 positive regulation of steroid hormone secretion + + + + Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. + GOC:sl + @@ -26389,8 +52280,26 @@ + Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion. + bf + 2011-07-26T08:43:38Z + biological_process + regulation of corticosteroid secretion + GO:2000846 regulation of corticosteroid hormone secretion + + + + Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion. + GOC:sl + + + + + regulation of corticosteroid secretion + GOC:obol + @@ -26416,8 +52325,26 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion. + bf + 2011-07-26T08:43:42Z + biological_process + negative regulation of corticosteroid secretion + GO:2000847 negative regulation of corticosteroid hormone secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion. + GOC:sl + + + + + negative regulation of corticosteroid secretion + GOC:obol + @@ -26443,8 +52370,26 @@ + Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion. + bf + 2011-07-26T08:43:45Z + biological_process + positive regulation of corticosteroid secretion + GO:2000848 positive regulation of corticosteroid hormone secretion + + + + Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion. + GOC:sl + + + + + positive regulation of corticosteroid secretion + GOC:obol + @@ -26469,8 +52414,19 @@ + Any process that modulates the frequency, rate or extent of mineralocorticoid secretion. + bf + 2011-07-26T08:46:38Z + biological_process + GO:2000855 regulation of mineralocorticoid secretion + + + + Any process that modulates the frequency, rate or extent of mineralocorticoid secretion. + GOC:sl + @@ -26496,8 +52452,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion. + bf + 2011-07-26T08:46:42Z + biological_process + GO:2000856 negative regulation of mineralocorticoid secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion. + GOC:sl + @@ -26523,8 +52490,19 @@ + Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion. + bf + 2011-07-26T08:46:45Z + biological_process + GO:2000857 positive regulation of mineralocorticoid secretion + + + + Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion. + GOC:sl + @@ -26549,8 +52527,19 @@ + Any process that modulates the frequency, rate or extent of aldosterone secretion. + bf + 2011-07-26T08:47:27Z + biological_process + GO:2000858 regulation of aldosterone secretion + + + + Any process that modulates the frequency, rate or extent of aldosterone secretion. + GOC:sl + @@ -26576,8 +52565,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion. + bf + 2011-07-26T08:47:31Z + biological_process + GO:2000859 negative regulation of aldosterone secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion. + GOC:sl + @@ -26603,8 +52603,19 @@ + Any process that activates or increases the frequency, rate or extent of aldosterone secretion. + bf + 2011-07-26T08:47:34Z + biological_process + GO:2000860 positive regulation of aldosterone secretion + + + + Any process that activates or increases the frequency, rate or extent of aldosterone secretion. + GOC:sl + @@ -26630,8 +52641,19 @@ + Any process that modulates the frequency, rate or extent of progesterone secretion. + bf + 2011-07-26T08:51:14Z + biological_process + GO:2000870 regulation of progesterone secretion + + + + Any process that modulates the frequency, rate or extent of progesterone secretion. + GOC:sl + @@ -26658,8 +52680,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of progesterone secretion. + bf + 2011-07-26T08:51:19Z + biological_process + GO:2000871 negative regulation of progesterone secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of progesterone secretion. + GOC:sl + @@ -26686,8 +52719,19 @@ + Any process that activates or increases the frequency, rate or extent of progesterone secretion. + bf + 2011-07-26T08:51:22Z + biological_process + GO:2000872 positive regulation of progesterone secretion + + + + Any process that activates or increases the frequency, rate or extent of progesterone secretion. + GOC:sl + @@ -26714,8 +52758,19 @@ + Any process that modulates the frequency, rate or extent of renal water transport. + yaf + 2011-10-24T11:37:51Z + biological_process + GO:2001151 regulation of renal water transport + + + + Any process that modulates the frequency, rate or extent of renal water transport. + GOC:obol + @@ -26742,8 +52797,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport. + yaf + 2011-10-24T11:37:57Z + biological_process + GO:2001152 negative regulation of renal water transport + + + + Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport. + GOC:obol + @@ -26770,67 +52836,19 @@ + Any process that activates or increases the frequency, rate or extent of renal water transport. + yaf + 2011-10-24T11:38:01Z + biological_process + GO:2001153 positive regulation of renal water transport - - - - - - - preceded by - - - precedes - - - bearer of - - - participates_in - - - bounding layer of - - - immediately_preceded_by - - - overlaps - - - has component - - - capable of - - - capable of part of - - - adjacent to - - - starts with - - - ends with - - - output of - - - produces - - - produced by - + + + + Any process that activates or increases the frequency, rate or extent of renal water transport. + GOC:obol + diff --git a/src/ontology/imports/ncbitaxon_import.owl b/src/ontology/imports/ncbitaxon_import.owl index 9e1c06dce2..f74d5d1f06 100644 --- a/src/ontology/imports/ncbitaxon_import.owl +++ b/src/ontology/imports/ncbitaxon_import.owl @@ -1,6 +1,7 @@ - - 2022-06-15 + + + 2022-08-19 @@ -1310,6 +1312,26 @@ + + + + + + GC_ID:1 + ncbi_taxonomy + Ophidiimorpharia + NCBITaxon:1489873 + Ophidiaria + + + + + Ophidiimorpharia + + + + + @@ -1323,6 +1345,47 @@ + + + + + + GC_ID:1 + ncbi_taxonomy + Stiassnyiformes + NCBITaxon:1489908 + Ovalentaria + + + + + Stiassnyiformes + + + + + + + + + + + NCBITaxon:32456 + GC_ID:1 + ncbi_taxonomy + Atherinomorpha + NCBITaxon:1489913 + Atherinomorphae + + + + + Atherinomorpha + + + + + @@ -1383,6 +1446,19 @@ + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:181400 + Bythitoidei + + + + @@ -1488,6 +1564,33 @@ + + + + + + GC_ID:1 + beavers and others + ncbi_taxonomy + Sciurognathi + NCBITaxon:1963757 + Castorimorpha + + + + + beavers and others + + + + + + Sciurognathi + + + + + @@ -1515,6 +1618,19 @@ + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:1963761 + Dipodoidea + + + + @@ -1827,6 +1943,26 @@ + + + + + + GC_ID:1 + beavers + ncbi_taxonomy + NCBITaxon:29132 + Castoridae + + + + + beavers + + + + + @@ -1933,6 +2069,26 @@ + + + + + + GC_ID:1 + jerboas + ncbi_taxonomy + NCBITaxon:30648 + Dipodidae + + + + + jerboas + + + + + @@ -2218,14 +2374,14 @@ - ape - + apes + - apes - + ape + @@ -2738,6 +2894,19 @@ + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:35737 + Dipodinae + + + + @@ -2970,6 +3139,39 @@ + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:40150 + Monodon + + + + + + + + + + GC_ID:1 + narwhal + ncbi_taxonomy + NCBITaxon:40151 + Monodon monoceros + + + + + narwhal + + + + + @@ -3255,6 +3457,19 @@ + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:43453 + Caecilia + + + + @@ -3431,6 +3646,19 @@ + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:48867 + Jaculus + + + + @@ -3478,6 +3706,26 @@ + + + + + + GC_ID:1 + lesser Egyptian jerboa + ncbi_taxonomy + NCBITaxon:51337 + Jaculus jaculus + + + + + lesser Egyptian jerboa + + + + + @@ -3859,6 +4107,54 @@ + + + + + + GC_ID:1 + Neandertal + Neandertal man + Neanderthal + Neanderthal man + ncbi_taxonomy + Homo neanderthalensis + NCBITaxon:63221 + Homo sapiens neanderthalensis + + + + + Neandertal + + + + + + Neandertal man + + + + + + Neanderthal + + + + + + Neanderthal man + + + + + + Homo neanderthalensis + + + + + @@ -4423,22 +4719,22 @@ GC_ID:1 - wasps, ants, and bees + wasps, ants & bees ncbi_taxonomy - wasps, ants, and bees + wasps, ants & bees NCBITaxon:7400 Apocrita - wasps, ants, and bees + wasps, ants & bees - wasps, ants, and bees + wasps, ants & bees @@ -4453,7 +4749,7 @@ Aculeata ncbi_taxonomy NCBITaxon:7434 - Aculeata <wasps, ants, and bees> + Aculeata <wasps, ants & bees> @@ -5759,6 +6055,19 @@ + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:8075 + Atheriniformes + + + + @@ -6126,6 +6435,55 @@ + + + + + + NCBITaxon:30377 + GC_ID:1 + ncbi_taxonomy + caecilians + NCBITaxon:8445 + Gymnophiona + + + + + caecilians + + + + + + + + + + + NCBITaxon:264007 + GC_ID:1 + true caecilians + ncbi_taxonomy + Caeciliinae + NCBITaxon:8446 + Caeciliidae + + + + + true caecilians + + + + + + Caeciliinae + + + + + @@ -6329,7 +6687,7 @@ lepidosaurs ncbi_taxonomy Reptilia - lizards + lizards & snakes reptiles NCBITaxon:8504 Lepidosauria @@ -6349,7 +6707,7 @@ - lizards + lizards & snakes @@ -6361,6 +6719,107 @@ + + + + + + GC_ID:1 + beaked reptiles + rhynchocephalians + ncbi_taxonomy + Rhynchocephalia + Rhynchosauria + NCBITaxon:8505 + Sphenodontia + + + + + beaked reptiles + + + + + + rhynchocephalians + + + + + + Rhynchocephalia + + + + + + Rhynchosauria + + + + + + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:8506 + Sphenodontidae + + + + + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:8507 + Sphenodon + + + + + + + + + + GC_ID:1 + hatteria + tuatara + ncbi_taxonomy + Hatteria punctata + NCBITaxon:8508 + Sphenodon punctatus + + + + + hatteria + + + + + + tuatara + + + + + + Hatteria punctata + + + + + @@ -6842,6 +7301,7 @@ chickens ncbi_taxonomy Gallus gallus domesticus + Phasianus gallus NCBITaxon:9031 Gallus gallus @@ -6875,6 +7335,12 @@ Gallus gallus domesticus + + + + Phasianus gallus + + @@ -7223,6 +7689,7 @@ ncbi_taxonomy Sarcophilus laniarius Sarcophilus laniarius (Owen, 1838) + Ursinus harrisii NCBITaxon:9305 Sarcophilus harrisii @@ -7244,6 +7711,12 @@ Sarcophilus laniarius (Owen, 1838) + + + + Ursinus harrisii + + @@ -7270,6 +7743,7 @@ ncbi_taxonomy Macropus rufus Megaleia rufa + kangurus rufus NCBITaxon:9321 Osphranter rufus @@ -7291,6 +7765,12 @@ Megaleia rufa + + + + kangurus rufus + + @@ -7693,6 +8173,26 @@ + + + + + + GC_ID:1 + cusk-eels and others + ncbi_taxonomy + NCBITaxon:94929 + Ophidiiformes + + + + + cusk-eels and others + + + + + @@ -8269,6 +8769,19 @@ + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:9747 + Monodontidae + + + + diff --git a/src/ontology/imports/ro_import.owl b/src/ontology/imports/ro_import.owl index ba52fc5246..0f244867df 100644 --- a/src/ontology/imports/ro_import.owl +++ b/src/ontology/imports/ro_import.owl @@ -5212,3 +5212,4 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase + diff --git a/src/patterns/definitions.owl b/src/patterns/definitions.owl index 4de29b2dab..9bd6611db3 100644 --- a/src/patterns/definitions.owl +++ b/src/patterns/definitions.owl @@ -7,8 +7,8 @@ Prefix(rdfs:=) Ontology( - -Annotation(owl:versionInfo "2022-06-20"^^xsd:string) + +Annotation(owl:versionInfo "2022-08-19"^^xsd:string) ) \ No newline at end of file