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Design patterns for describing protein molecular attributes for UniProtKB/Swiss-Prot #219

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rays22 opened this issue Feb 15, 2023 · 1 comment
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Design patterns for describing protein molecular attributes for UniProtKB/Swiss-Prot #219

rays22 opened this issue Feb 15, 2023 · 1 comment
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rays22 commented Feb 15, 2023 •
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SIB curators are moving from free text annotation describing the effects of variation on protein structure and function, e.g. "reduces protein stability", "interferes with zinc binding". They have figured out a data model that composes a direction (+,-,etc), an attribute (stability, activity, affinity), and optionally an existing entity (protein, chemical, GO term).

  • Investigate if OBA compatible design patterns would be appropriate.
    • Also investigate gaps in PATO that would be needed to accomplish this
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rays22 commented Feb 15, 2023 •
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@rays22 rays22 self-assigned this Feb 15, 2023
@rays22 rays22 mentioned this issue Feb 15, 2023
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