diff --git a/conf/genouest.config b/conf/genouest.config
index 801b9fb24..6a16056cb 100644
--- a/conf/genouest.config
+++ b/conf/genouest.config
@@ -8,7 +8,7 @@ params {
 singularity {
   enabled = true
   autoMounts = true
-  runOptions = '-B /scratch:/scratch -B /local:/local -B /db:/db'
+  runOptions = '-B /scratch:/scratch -B /local:/local -B /db:/db -B /groups:/groups'
 }
 
 process {
@@ -18,7 +18,7 @@ process {
 params {
   igenomes_ignore = true
   igenomesIgnore = true //deprecated
-  max_memory = 750.GB
-  max_cpus = 80
+  max_memory = 3000.GB
+  max_cpus = 160
   max_time = 336.h
 }
diff --git a/conf/vai.config b/conf/vai.config
index fcc63b340..73faa4e6f 100644
--- a/conf/vai.config
+++ b/conf/vai.config
@@ -4,17 +4,31 @@ params {
   config_profile_url = 'https://vanandelinstitute.sharepoint.com/sites/SC/SitePages/HPC3-High-Performance-Cluster-and-Cloud-Computing.aspx'
   max_memory = 250.GB
   max_cpus = 40
-  max_time = 640.h
-}
-
-process {
-  beforeScript = 'alias singularity=/varidata/research/software/singularity/singularity-ce-3.8.2/bin/singularity'
-  executor = 'pbs'
-  queue = { task.time <= 48.h ? 'shortq' : 'longq' }
-  maxRetries = 2
+  max_time = 336.h
 }
 
 singularity {
   enabled = true
   autoMounts = true
 }
+
+// See if we can find evidence that we're on the new HPC
+def new_cluster = false
+try {
+    new_cluster = ['/bin/bash', '-c', 'echo $HOSTNAME'].execute().text.trim() ==~ /(compute|submit)[0-9]{3}/
+} catch (java.io.IOException e) {
+    System.err.println("WARNING: Couldn't figure out which cluster we're on, defaulting to old (PBS) cluster")
+}
+
+if (new_cluster) {
+    System.out.println("Using VAI institutional configuration for new HPC cluster")
+} else {
+    System.out.println("Using VAI institutional configuration for old HPC cluster")
+}
+
+
+process {
+  beforeScript = { new_cluster ? '' : 'module load VARI/singularity' }()
+  executor = { new_cluster ? 'slurm' : 'pbs' }()
+  queue = { new_cluster ? 'long' : { task.time <= 48.h ? 'shortq' : 'longq' } }()
+}
diff --git a/conf/vsc_ugent.config b/conf/vsc_ugent.config
index 502b1f928..4e485df84 100644
--- a/conf/vsc_ugent.config
+++ b/conf/vsc_ugent.config
@@ -1,5 +1,26 @@
+// Set up the Tier 1 parameter
+params.validationSchemaIgnoreParams = params.validationSchemaIgnoreParams.toString() + ",tier1_project"
+if (!params.tier1_project) {
+    params.tier1_project = null
+}
+
+// Get the hostname and check some values for tier1
+def hostname = "doduo"
+try {
+    hostname = ['/bin/bash', '-c', 'sinfo --local -N -h | head -n 1 | cut -d " " -f1'].execute().text.trim()
+} catch (java.io.IOException e) {
+    System.err.println("WARNING: Could not run sinfo to determine current cluster, defaulting to doduo")
+}
+
+if(!params.tier1_project && hostname.contains("dodrio")){
+    System.err.println("Please specify your project with --tier1_project in your Nextflow command or with params.tier1_project in your config file.")
+    System.exit(1)
+}
+
 // Define the Scratch directory
-def scratch_dir = System.getenv("VSC_SCRATCH_VO_USER") ?: System.getenv("VSC_SCRATCH")
+def scratch_dir =   System.getenv("VSC_SCRATCH_PROJECTS_BASE") ? "${System.getenv("VSC_SCRATCH_PROJECTS_BASE")}/${params.tier1_project}" : // Tier 1 scratch
+                    System.getenv("VSC_SCRATCH_VO_USER") ?: // VO scratch
+                    System.getenv("VSC_SCRATCH") // user scratch
 
 // Specify the work directory
 workDir = "$scratch_dir/work"
@@ -35,7 +56,7 @@ env {
 
 // AWS maximum retries for errors (This way the pipeline doesn't fail if the download fails one time)
 aws {
-        maxErrorRetry = 3
+    maxErrorRetry = 3
 }
 
 // Define profiles for each cluster
@@ -120,6 +141,142 @@ profiles {
         }
     }
 
+    cpu_rome {
+        params {
+            config_profile_description = 'HPC_DODRIO_cpu_rome profile for use on the Dodrio/cpu_rome cluster of the VSC HPC.'
+            config_profile_contact = 'ict@cmgg.be'
+            config_profile_url = 'https://www.ugent.be/hpc/en'
+            max_memory = 256.GB
+            max_cpus = 128
+            max_time = "3day"
+        }
+
+        process {
+            executor = 'slurm'
+            queue = 'dodrio/cpu_rome'
+            clusterOptions = "-A ${params.tier1_project}"
+        }
+    }
+
+    cpu_rome_512 {
+        params {
+            config_profile_description = 'HPC_DODRIO_cpu_rome_512 profile for use on the Dodrio/cpu_rome_512 cluster of the VSC HPC.'
+            config_profile_contact = 'ict@cmgg.be'
+            config_profile_url = 'https://www.ugent.be/hpc/en'
+            max_memory = 512.GB
+            max_cpus = 128
+            max_time = "3day"
+        }
+
+        process {
+            executor = 'slurm'
+            queue = 'dodrio/cpu_rome_512'
+            clusterOptions = "-A ${params.tier1_project}"
+        }
+    }
+
+    cpu_milan {
+        params {
+            config_profile_description = 'HPC_DODRIO_cpu_milan profile for use on the Dodrio/cpu_milan cluster of the VSC HPC.'
+            config_profile_contact = 'ict@cmgg.be'
+            config_profile_url = 'https://www.ugent.be/hpc/en'
+            max_memory = 256.GB
+            max_cpus = 128
+            max_time = "3day"
+        }
+
+        process {
+            executor = 'slurm'
+            queue = 'dodrio/cpu_milan'
+            clusterOptions = "-A ${params.tier1_project}"
+        }
+    }
+
+    gpu_rome_a100_40 {
+        params {
+            config_profile_description = 'HPC_DODRIO_gpu_rome_a100_40 profile for use on the Dodrio/gpu_rome_a100_40 cluster of the VSC HPC.'
+            config_profile_contact = 'ict@cmgg.be'
+            config_profile_url = 'https://www.ugent.be/hpc/en'
+            max_memory = 256.GB
+            max_cpus = 48
+            max_time = "3day"
+        }
+
+        process {
+            executor = 'slurm'
+            queue = 'dodrio/gpu_rome_a100_40'
+            clusterOptions = "-A ${params.tier1_project}"
+        }
+    }
+
+    gpu_rome_a100_80 {
+        params {
+            config_profile_description = 'HPC_DODRIO_gpu_rome_a100_80 profile for use on the Dodrio/gpu_rome_a100_80 cluster of the VSC HPC.'
+            config_profile_contact = 'ict@cmgg.be'
+            config_profile_url = 'https://www.ugent.be/hpc/en'
+            max_memory = 512.GB
+            max_cpus = 48
+            max_time = "3day"
+        }
+
+        process {
+            executor = 'slurm'
+            queue = 'dodrio/gpu_rome_a100_80'
+            clusterOptions = "-A ${params.tier1_project}"
+        }
+    }
+
+    debug_rome {
+        params {
+            config_profile_description = 'HPC_DODRIO_debug_rome profile for use on the Dodrio/debug_rome cluster of the VSC HPC.'
+            config_profile_contact = 'ict@cmgg.be'
+            config_profile_url = 'https://www.ugent.be/hpc/en'
+            max_memory = 256.GB
+            max_cpus = 48
+            max_time = "3day"
+        }
+
+        process {
+            executor = 'slurm'
+            queue = 'dodrio/debug_rome'
+            clusterOptions = "-A ${params.tier1_project}"
+        }
+    }
+
+    cpu_rome_all {
+        params {
+            config_profile_description = 'HPC_DODRIO_cpu_rome_all profile for use on the Dodrio/cpu_rome_all cluster of the VSC HPC.'
+            config_profile_contact = 'ict@cmgg.be'
+            config_profile_url = 'https://www.ugent.be/hpc/en'
+            max_memory = 250.GB
+            max_cpus = 128
+            max_time = "3day"
+        }
+
+        process {
+            executor = 'slurm'
+            queue = 'dodrio/cpu_rome_all'
+            clusterOptions = "-A ${params.tier1_project}"
+        }
+    }
+
+    gpu_rome_a100 {
+        params {
+            config_profile_description = 'HPC_DODRIO_gpu_rome_a100 profile for use on the Dodrio/gpu_rome_a100 cluster of the VSC HPC.'
+            config_profile_contact = 'ict@cmgg.be'
+            config_profile_url = 'https://www.ugent.be/hpc/en'
+            max_memory = 384.GB
+            max_cpus = 48
+            max_time = "3day"
+        }
+
+        process {
+            executor = 'slurm'
+            queue = 'dodrio/gpu_rome_a100'
+            clusterOptions = "-A ${params.tier1_project}"
+        }
+    }
+
     stub {
         params {
             config_profile_description = 'Stub profile for the VSC HPC. Please also specify the `-stub` argument when using this profile.'
diff --git a/docs/genouest.md b/docs/genouest.md
index 85341efa5..0c5492484 100644
--- a/docs/genouest.md
+++ b/docs/genouest.md
@@ -8,10 +8,10 @@ To use, run the pipeline with `-profile genouest`. This will download and launch
 
 Nextflow is installed on the GenOuest cluster. Some documentation is available on the [GenOuest website](https://www.genouest.org/howto/#nextflow).
 
-You need to activate it like this:
+You need to activate it like this (or any more recent version in the same directory):
 
 ```bash
-source /local/env/envnextflow-19.07.0.sh
+source /local/env/envnextflow-22.10.4.sh
 ```
 
 Nextflow manages each process as a separate job that is submitted to the cluster by using the sbatch command.
@@ -22,7 +22,7 @@ Nextflow shouldn't run directly on the submission node but on a compute node. Ru
 srun --pty bash
 
 # Load the dependencies if not done before
-source /local/env/envnextflow-19.07.0.sh
+source /local/env/envnextflow-22.10.4.sh
 
 # Run a downloaded/git-cloned nextflow workflow from
 nextflow run \\