diff --git a/BUILD b/BUILD
index b55ca8a569ef2..bde7f174e6a35 100644
--- a/BUILD
+++ b/BUILD
@@ -3005,6 +3005,7 @@ grpc_cc_library(
     ],
     external_deps = [
         "absl/base:core_headers",
+        "absl/cleanup",
         "absl/container:flat_hash_set",
         "absl/container:inlined_vector",
         "absl/functional:any_invocable",
diff --git a/src/core/ext/filters/client_channel/client_channel.cc b/src/core/ext/filters/client_channel/client_channel.cc
index ed07a090030cf..6cfd4c48fcd87 100644
--- a/src/core/ext/filters/client_channel/client_channel.cc
+++ b/src/core/ext/filters/client_channel/client_channel.cc
@@ -29,6 +29,7 @@
 #include <utility>
 #include <vector>
 
+#include "absl/cleanup/cleanup.h"
 #include "absl/status/status.h"
 #include "absl/status/statusor.h"
 #include "absl/strings/cord.h"
@@ -661,12 +662,6 @@ class ClientChannel::SubchannelWrapper : public SubchannelInterface {
     GRPC_CHANNEL_STACK_UNREF(chand_->owning_stack_, "SubchannelWrapper");
   }
 
-  void Orphan() override {
-    // Make sure we release the last ref inside the WorkSerializer, so
-    // that we can update the channel's subchannel maps.
-    chand_->work_serializer_->Run([self = WeakRef()]() {}, DEBUG_LOCATION);
-  }
-
   void WatchConnectivityState(
       std::unique_ptr<ConnectivityStateWatcherInterface> watcher) override
       ABSL_EXCLUSIVE_LOCKS_REQUIRED(*chand_->work_serializer_) {
@@ -2775,34 +2770,47 @@ void ClientChannel::LoadBalancedCall::AddCallToLbQueuedCallsLocked() {
 
 absl::optional<absl::Status> ClientChannel::LoadBalancedCall::PickSubchannel(
     bool was_queued) {
+  // We may accumulate multiple pickers here, because if a picker says
+  // to queue the call, we check again to see if the picker has been
+  // updated before we queue it.
+  // We need to unref pickers in the WorkSerializer.
+  std::vector<RefCountedPtr<LoadBalancingPolicy::SubchannelPicker>> pickers;
+  auto cleanup = absl::MakeCleanup([&]() {
+    chand_->work_serializer_->Run(
+        [pickers = std::move(pickers)]() mutable {
+          for (auto& picker : pickers) {
+            picker.reset(DEBUG_LOCATION, "PickSubchannel");
+          }
+        },
+        DEBUG_LOCATION);
+  });
   // Grab mutex and take a ref to the picker.
   if (GRPC_TRACE_FLAG_ENABLED(grpc_client_channel_lb_call_trace)) {
     gpr_log(GPR_INFO, "chand=%p lb_call=%p: grabbing LB mutex to get picker",
             chand_, this);
   }
-  RefCountedPtr<LoadBalancingPolicy::SubchannelPicker> picker;
   {
     MutexLock lock(&chand_->lb_mu_);
-    picker = chand_->picker_;
+    pickers.emplace_back(chand_->picker_);
   }
   while (true) {
     // Do pick.
     if (GRPC_TRACE_FLAG_ENABLED(grpc_client_channel_lb_call_trace)) {
       gpr_log(GPR_INFO, "chand=%p lb_call=%p: performing pick with picker=%p",
-              chand_, this, picker.get());
+              chand_, this, pickers.back().get());
     }
     grpc_error_handle error;
-    bool pick_complete = PickSubchannelImpl(picker.get(), &error);
+    bool pick_complete = PickSubchannelImpl(pickers.back().get(), &error);
     if (!pick_complete) {
       MutexLock lock(&chand_->lb_mu_);
       // If picker has been swapped out since we grabbed it, try again.
-      if (picker != chand_->picker_) {
+      if (chand_->picker_ != pickers.back()) {
         if (GRPC_TRACE_FLAG_ENABLED(grpc_client_channel_lb_call_trace)) {
           gpr_log(GPR_INFO,
                   "chand=%p lb_call=%p: pick not complete, but picker changed",
                   chand_, this);
         }
-        picker = chand_->picker_;
+        pickers.emplace_back(chand_->picker_);
         continue;
       }
       // Otherwise queue the pick to try again later when we get a new picker.
diff --git a/src/core/ext/filters/client_channel/lb_policy/weighted_round_robin/weighted_round_robin.cc b/src/core/ext/filters/client_channel/lb_policy/weighted_round_robin/weighted_round_robin.cc
index 89c4c1bd847c4..4d3a47c1d5b0c 100644
--- a/src/core/ext/filters/client_channel/lb_policy/weighted_round_robin/weighted_round_robin.cc
+++ b/src/core/ext/filters/client_channel/lb_policy/weighted_round_robin/weighted_round_robin.cc
@@ -608,7 +608,9 @@ void WeightedRoundRobin::Picker::BuildSchedulerAndStartTimerLocked() {
   // Start timer.
   WeakRefCountedPtr<Picker> self = WeakRef();
   timer_handle_ = wrr_->channel_control_helper()->GetEventEngine()->RunAfter(
-      config_->weight_update_period(), [self = std::move(self)]() mutable {
+      config_->weight_update_period(),
+      [self = std::move(self),
+       work_serializer = wrr_->work_serializer()]() mutable {
         ApplicationCallbackExecCtx callback_exec_ctx;
         ExecCtx exec_ctx;
         {
@@ -621,7 +623,8 @@ void WeightedRoundRobin::Picker::BuildSchedulerAndStartTimerLocked() {
             self->BuildSchedulerAndStartTimerLocked();
           }
         }
-        self.reset();
+        // Release the picker ref inside the WorkSerializer.
+        work_serializer->Run([self = std::move(self)]() {}, DEBUG_LOCATION);
       });
 }