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From [email protected] Tue Dec 19 10:25:40 2000
Date: Tue, 19 Dec 2000 09:38:11 -0500 (EST)
From: [email protected]
Reply-To: [email protected]
Subject: SCIENCE (DEC 8 2000)
##################################################3616070.1#
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# Institute for Scientific Information #
# Table of Contents Alerting Services #
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Account Number: 14615 ISI Order Number: 0000224733
ISI Product Code: JT
Number of Articles in Issue: 50
To purchase the full text of a document, provide the information
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TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Middle school achievement - Asia stays on top, US in middle in new
global rankings
AU - Holden,C.
U1 - News Item
SP - 1866
EP - 1866
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Toxicology - Panel urges further study of biotech corn
AU - Kaiser,J.
U1 - News Item
SP - 1867
EP - 1867
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Infectious diseases - Polio outbreak raises questions about vaccine
AU - Greensfelder,L.
U1 - News Item
SP - 1867
EP - 1869
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Molecular biology - EMBL rescued from the financial brink
AU - Frank,L.
U1 - News Item
SP - 1869
EP - 1869
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Eastern European science - Program for elites draws praise, fire
AU - Stone,R.
U1 - News Item
SP - 1870
EP - 1870
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Hepatitis C - New 'replicon' yields viral proteins
AU - Marshall,E.
U1 - News Item
SP - 1870
EP - 1871
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Paleontology - Tiny, feathered dino is most birdlike yet
AU - Stokstad,E.
U1 - News Item
SP - 1871
EP - 1872
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Japan - Human cloning ban allows some research
AU - Normile,D.
U1 - News Item
SP - 1872
EP - 1872
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Research ethics - Studies trace patchwork of conflict policies
AU - Agnew,B.
U1 - News Item
SP - 1873
EP - 1873
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Marine environment - Clinton creates huge Hawaiian Coral Haven
AU - Malakoff,D.
U1 - News Item
SP - 1873
EP - 1873
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Chemistry - Crystals branch out into exotic shapes
AU - Service,R.F.
U1 - News Item
SP - 1875
EP - 1875
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Virology: Probing HIV's elusive activities within the host cell
AU - Chicurel,M.
U1 - News Item
SP - 1876
EP - 1879
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Capitalizing on HIV's talents for gene therapy
AU -
U1 - News Item
SP - 1878
EP - 1878
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Planetary science - A dripping wet early Mars emerging from new
pictures
AU - Kerr,R.A.
U1 - News Item
SP - 1879
EP - 1880
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Infectious diseases - Has Leishmaniasis become endemic in the US?
AU - Enserink,M.
U1 - News Item
SP - 1881
EP - 1883
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Mathematics - Taking the measure of the wildest dance on earth
AU - Mackenzie,D.
U1 - News Item
SP - 1883
EP - 1884
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Meeting - AAS High-Energy Astrophysics Division - X-rays hit the spot
for astrophysicists
AU - Irion,R.
U1 - News Item
SP - 1884
EP - 1885
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Good news at State
AU - Good,M.
U1 - Editorial Material
SP - 1893
EP - 1893
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - How much does one vote count in an election?
AU - Bunnett,J.F.
U1 - Letter
SP - 1895
EP - 1895
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - "Kyoto forests" and a broader perspective on management
AU - Borden,J.H.
U1 - Letter
SP - 1895
EP - 1895
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - "Kyoto forests" and a broader perspective on management
AU - Marland,G.
AU - Schlamadinger,B.
AU - Matthews,R.
U1 - Letter
SP - 1895
EP - 1896
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - "Kyoto forests" and a broader perspective on management - Response
AU - Schulze,E.D.
AU - Wirth,C.
AU - Heimann,M.
U1 - Letter
SP - 1896
EP - 1896
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Safety data crucial for biological control insect agents
AU - Pemberton,R.W.
AU - Strong,D.R.
U1 - Letter
SP - 1896
EP - 1897
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Ritalin tests for preschoolers
AU - Greenhill,L.L.
U1 - Letter
SP - 1897
EP - 1897
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Evolutionary biology - In search of biological weirdness (vol 290, pg
1077, 2000)
AU - Pennisi,E.
U1 - Correction
SP - 1897
EP - 1897
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Archaeology - New site suggests Anasazi exodus (vol 290, pg 914, 2000)
AU - Muro,M.
U1 - Correction
SP - 1897
EP - 1897
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Public health - Surveillance and privacy
AU - Bayer,R.
AU - Fairchild,A.L.
U1 - Article
SP - 1898
EP - 1899
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - George Gaylord Simpson - Paleontologist and evolutionist, by L.F.
Laporte
AU - Eldredge,N.
U1 - Book Review
SP - 1900
EP - 1901
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Cell biology - Actin up with Rac1
AU - Colley,N.J.
U1 - Editorial Material
SP - 1902
EP - 1903
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Computing - Screen savers of the world unite!
AU - Shirts,M.
AU - Pande,V.S.
U1 - Editorial Material
SP - 1903
EP - 1904
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Development - Hear, hear, for the inner ear
AU - Graham,A.
U1 - Editorial Material
SP - 1904
EP - 1905
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Paleoclimate - Glacial climate instability
AU - Labeyrie,L.
U1 - Editorial Material
SP - 1905
EP - 1907
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Optics - The Internet of tomorrow
AU - Joiner,S.
U1 - Editorial Material
SP - 1907
EP - 1908
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Neuroscience - Noise makes sense in neuronal computing
AU - Volgushev,M.
AU - Eysel,U.T.
U1 - Editorial Material
SP - 1908
EP - 1909
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Geophysics - Subduction and slab detachment in the Mediterranean-
Carpathian region
AU - Wortel,M.J.R.
AU - Spakman,W.
U1 - Review
SP - 1910
EP - 1917
N2 - Seismic tomography models of the three-dimensional upper mantle
velocity structure of the Mediterranean-Carpathian region provide a
better understanding of the lithospheric processes governing its
geodynamical evolution. Slab detachment, in particular lateral
migration of this process along the plate boundary, is a key element
in the lithospheric dynamics of the region during the last 20 to 30
million years. It strongly affects arc and trench migration, and
causes along-strike variations in vertical motions, stress fields,
and magmatism. In a terminal-stage subduction zone, involving
collision and suturing, slab detachment is the natural last stage in
the gravitational settling of subducted lithosphere.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Piecing together the biggest puzzle all
AU - Rees,M.J.
U1 - Article
SP - 1919
EP - 1925
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Sedimentary rocks of early Mars
AU - Malin,M.C.
AU - Edgett,K.S.
U1 - Article
SP - 1927
EP - 1937
N2 - Layered and massive outcrops on Mars, some as thick as 4 kilometers,
display the geomorphic attributes and stratigraphic relations of
sedimentary rock. Repeated beds in some locations imply a dynamic
depositional environment during early martian history. Subaerial
(such as eolian, impact, and volcaniclastic) and subaqueous processes
may have contributed to the formation of the layers. Affinity for
impact craters suggests dominance of lacustrine deposition;
alternatively, the materials were deposited in a dry, subaerial
setting in which atmospheric density, and variations thereof mimic a
subaqueous depositional environment. The source regions and transport
paths for the materials are not preserved.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Planar hexacoordinate carbon: A viable possibility
AU - Exner,K.
AU - Schleyer,P.V.
U1 - Article
SP - 1937
EP - 1940
N2 - The viability of molecules with planar hexacoordinate carbon atoms is
demonstrated by density-functional theory (DFT) calculations for CB62-
, a CB6H2 isomer, and three C3B4 minima. All of these species have
six pi electrons and are aromatic. Although other C3B4 isomers are
lower in energy, the activation barriers for the rearrangements of
the three planar carbon C3B4 minima into more stable isomers are
appreciable, and experimental observation should be possible. High-
Level ab initio calculations confirm the DFT results. The planar
hexacoordination in these species does not violate the octet rule
because six partial bonds to the central carbons are involved.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Geodynamic evidence for a chemically depleted continental tectosphere
AU - Forte,A.M.
AU - Perry,H.K.C.
U1 - Article
SP - 1940
EP - 1944
N2 - The tectosphere, namely the portions of Earth's mantle Lying below
cratons, has a thermochemical structure that differs from average
suboceanic mantle. The tectosphere is thought to be depleted in its
basaltic components and to have an intrinsic buoyancy that balances
the mass increase associated with its colder temperature relative to
suboceanic mantle. Inversions of a large set of geodynamic data
related to mantle convection, using tomography-based mantle flow
models, indicate that the tectosphere is chemically depleted and
relatively cold to 250 kilometers depth below Earth's surface. The
approximate equilibrium between thermal and chemical buoyancy
contributes to cratonic stability over geological time.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Teleconvection: Remotely driven thermal convection in rotating
stratified spherical layers
AU - Zhang,K.K.
AU - Schubert,G.
U1 - Article
SP - 1944
EP - 1947
N2 - We report the discovery of a convective phenomenon found to occur in
a rotating spherical system in which an inner convectively unstable
fluid layer is bounded by a corotating outer convectively stable
fluid layer. Although convection is thermally driven in the unstable
interior, the resulting convective motions concentrate primarily in
the stable outer region. This phenomenon, which we term
teleconvection, suggests that fluid motions observed at the "surface"
of a planet (such as Jupiter's alternating zonal winds) may be driven
by an energy source located deep inside the planet.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Rapid changes in the hydrologic cycle of the tropical Atlantic during
the last glacial
AU - Peterson,L.C.
AU - Haug,G.H.
AU - Hughen,K.A.
AU - Rohl,U.
U1 - Article
SP - 1947
EP - 1951
N2 - Sedimentary time series of color reflectance and major element
chemistry from the anoxic Cariaco Basin off the coast of northern
Venezuela record large and abrupt shifts in the hydrologic cycle of
the tropical Atlantic during the past 90,000 years. Marine
productivity maxima and increased precipitation and riverine
discharge from northern South America are closely linked to
interstadial (warm) climate events of marine isotope stage 3, as
recorded in Greenland ice cores. Increased precipitation at this
latitude during interstadials suggests the potential for greater
moisture export from the Atlantic to Pacific, which could have
affected the salinity balance of the Atlantic and increased
thermohaline heat transport to high northern latitudes. This supports
the notion that tropical feedbacks played an important role in
modulating global climate during the last glacial period.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Synchronous radiocarbon and climate shifts during the last
deglaciation
AU - Hughen,K.A.
AU - Southon,J.R.
AU - Lehman,S.J.
AU - Overpeck,J.T.
U1 - Article
SP - 1951
EP - 1954
N2 - Radiocarbon data from the Cariaco Basin provide calibration of the
carbon-14 time scale across the period of deglaciation (15,000 to
10,000 years ago) with resolution available previously only from
Holocene tree rings. Reconstructed changes in atmospheric carbon-14
are larger than previously thought, with the largest change occurring
simultaneously with the sudden climatic cooling of the Younger Dryas
event. Carbon-14 and published beryllium-10 data together suggest
that concurrent climate and carbon-14 changes were predominantly the
result of abrupt shifts in deep ocean ventilation.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - A primitive enantiornithine bird and the origin of feathers
AU - Zhang,F.C.
AU - Zhou,Z.H.
U1 - Article
SP - 1955
EP - 1959
N2 - A fossil enantiornithine bird, Protopteryx fengningensis gen. et sp.
nov., was collected from the Early Cretaceous Yixian Formation of
Northern China. it provides fossil evidence of a triosseal canal in
early birds. The manus and the alular digit are long, as in
Archaeopteryx and Confuciusornis, but are relatively short in other
enantiornithines. The alula or bastard wing is attached to an
unreduced alular digit. The two central tail feathers are scalelike
without branching. This type of feather may suggest that modern
feathers evolved through the following stages: (i) elongated scale,
(ii) central shaft, (iii) barbs, and finally (iv) barbules and
barbicel.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Glucose-dependent insulin release from genetically engineered K cells
AU - Cheung,A.T.
AU - Dayanandan,B.
AU - Lewis,J.T.
AU - Korbutt,G.S.
AU - Rajotte,R.V.
AU - Bryer-Ash,M.
AU - Boylan,M.O.
AU - Wolfe,M.M.
AU - Kieffer,T.J.
U1 - Article
SP - 1959
EP - 1962
N2 - Genetic engineering of non-beta cells to release insulin upon feeding
could be a therapeutic modality for patients with diabetes. A tumor-
derived K-cell line was induced to produce human insulin by providing
the cells with the human insulin gene linked tb the 5'-regulatory
region of the gene encoding glucose-dependent insulinotropic
polypeptide (GIP). Mice expressing this transgene produced human
insulin specifically in gut K cells. This insulin protected the mice
from developing diabetes and maintained glucose tolerance after
destruction of the native insulin-producing beta cells.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Response to RAG-mediated V(D)J cleavage by NBS1 and gamma-H2AX
AU - Chen,H.T.
AU - Bhandoola,A.
AU - Difilippantonio,M.J.
AU - Zhu,J.
AU - Brown,M.J.
AU - Tai,X.G.
AU - Rogakou,E.P.
AU - Brotz,T.M.
AU - Bonner,W.M.
AU - Ried,T.
AU - Nussenzweig,A.
U1 - Article
SP - 1962
EP - 1964
N2 - Genetic disorders affecting cellular responses to DNA damage are
characterized by high rates of translocations involving antigen
receptor loci and increased susceptibility to lymphoid malignancies.
We report that the Nijmegen breakage syndrome protein (NBS1) and
histone gamma -H2AX, which associate with irradiation-induced DNA
double-strand breaks (DSBs), are also found at sites of V(D)J
(variable, diversity, joining) recombination-induced DSBs. In
developing thymocytes, NBS1 and gamma -H2AX form nuclear foci that
colocalize with the T cell receptor alpha locus in response to
recombination activating gene (RAG) protein-mediated V(D)J cleavage.
Our results suggest that surveillance of T cell receptor
recombination intermediates by NBS1 and gamma -H2AX may be important
for preventing oncogenic translocations.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Identification of synergistic signals initiating inner ear development
AU - Ladher,R.K.
AU - Anakwe,K.U.
AU - Gurney,A.L.
AU - Schoenwolf,G.C.
AU - Francis-West,P.H.
U1 - Article
SP - 1965
EP - 1967
N2 - Tissue manipulation experiments in amphibians more than 50 years ago
showed that induction of the inner ear requires two signals: a
mesodermal signal followed by a neural signal. However, the molecules
mediating this process have remained elusive. We present evidence for
mesodermal initiation of otic development in higher Vertebrates and
show that the mesoderm can direct terminal differentiation of the
inner ear in rostral ectoderm. Furthermore, we demonstrate the
synergistic interactions of the extracellular polypeptide ligands FGF-
19 and Wnt-8c as mediators of mesodermal and neural signals,
respectively, initiating inner ear development.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - The contribution of noise to contrast invariance of orientation
tuning in cat visual cortex
AU - Anderson,J.S.
AU - Lampl,I.
AU - Gillespie,D.C.
AU - Ferster,D.
U1 - Article
SP - 1968
EP - 1972
N2 - Feedforward models of visual cortex appear to be inconsistent with a
well-known property of cortical cells: contrast invariance of
orientation tuning. The models' fixed threshold broadens orientation
tuning as contrast increases, whereas in real cells tuning width is
invariant with contrast. We have compared the orientation tuning of
spike and membrane potential responses in single cells. Both are
contrast invariant, yet a threshold-linear relation applied to the
membrane potential accurately predicts the orientation tuning of
spike responses. The key to this apparent paradox lies in the
noisiness of the membrane potential. Responses that are subthreshold
on average are still capable of generating spikes on individual
trials. Unlike the iceberg effect, contrast invariance remains intact
even as threshold narrows orientation selectivity. Noise may, by
extension, smooth the average relation between membrane potential and
spike rate throughout the brain.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Efficient initiation of HCV RNA replication in cell culture
AU - Blight,K.J.
AU - Kolykhalov,A.A.
AU - Rice,C.M.
U1 - Article
SP - 1972
EP - 1974
N2 - Hepatitis C virus (HCV) infection is a global health problem
affecting an estimated 170 million individuals worldwide. We report
the identification of multiple independent adaptive mutations that
cluster in the HCV nonstructural protein NS5A and confer increased
replicative ability in vitro. Among these adaptive mutations were a
single amino acid substitution that allowed HCV RNA replication in
10% of transfected hepatoma cells and a deletion of 47 amino acids
encompassing the interferon (IFN) sensitivity determining region
(ISDR). Independent of the ISDR, IFN-alpha rapidly inhibited HCV RNA
replication in vitro. This work establishes a robust, cell-based
system for genetic and functional analyses of HCV replication.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Multigenerational cortical inheritance of the Rax2 protein in
orienting polarity and division in yeast
AU - Chen,T.
AU - Hiroko,T.
AU - Chaudhuri,A.
AU - Inose,F.
AU - Lord,M.
AU - Tanaka,S.
AU - Chant,J.
AU - Fujita,A.
U1 - Article
SP - 1975
EP - 1978
N2 - Diploid yeast cells repeatedly polarize and bud from their poles,
probably because of highly stable marks of unknown composition. Here,
Rax2, a membrane protein, was shown to behave as such a mark. The
Rax2 protein itself was inherited immutably at the cell cortex for
multiple generations, and Rax2 was shown to have a half-life
exceeding several generations. The persistent inheritance of cortical
protein markers would provide a means to couple a cell's history to
the future development of a precise morphogenetic form.
ER -
TY - JFULL
VL - 290
IS - 5498
U4 - 382EL
Y1 - 2000/12/08/
JF - SCIENCE
SN - 0036-8075
T1 - Rescue of photoreceptor degeneration in rhodopsin-null Drosophila
mutants by activated Rac1
AU - Chang,H.Y.
AU - Ready,D.F.
U1 - Article
SP - 1978
EP - 1980
N2 - Rhodopsin is essential for photoreceptor morphogenesis;
photoreceptors lacking rhodopsin degenerate in humans, mice, and
Drosophila. Here we report that transgenic expression of a dominant-
active Drosophila Rho guanosine triphosphatase, Drac1, rescued
photoreceptor morphogenesis in rhodopsin-null mutants; expression of
dominant-negative Drac1 resulted in a phenotype similar to that seen
in rhodopsin-null mutants. Drac1 was localized in a specialization of
the photoreceptor cortical actin cytoskeleton, which was lost in
rhodopsin-null mutants. Thus, rhodopsin appears to organize the actin
cytoskeleton through Drac1, contributing a structural support-
essential for photoreceptor morphogenesis.
ER -
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