diff --git a/library_generation/owlbot/templates/clirr/clirr-ignored-differences.xml.j2 b/library_generation/owlbot/templates/clirr/clirr-ignored-differences.xml.j2
index 6528981704..3fc907802f 100644
--- a/library_generation/owlbot/templates/clirr/clirr-ignored-differences.xml.j2
+++ b/library_generation/owlbot/templates/clirr/clirr-ignored-differences.xml.j2
@@ -15,5 +15,66 @@
     <differenceType>7012</differenceType>
     <className>{{proto_path}}/*OrBuilder</className>
     <method>boolean has*(*)</method>
+  </difference>
+  <!-- The following 7006 exemptions are related to Protobuf 4.27.4 upgrade -->
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>{{proto_path}}/**</className>
+    <method>* getDefaultInstanceForType()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>{{proto_path}}/**</className>
+    <method>* addRepeatedField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>{{proto_path}}/**</className>
+    <method>* clear()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>{{proto_path}}/**</className>
+    <method>* clearField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>{{proto_path}}/**</className>
+    <method>* clearOneof(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>{{proto_path}}/**</className>
+    <method>* clone()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>{{proto_path}}/**</className>
+    <method>* mergeUnknownFields(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>{{proto_path}}/**</className>
+    <method>* setField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>{{proto_path}}/**</className>
+    <method>* setRepeatedField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>{{proto_path}}/**</className>
+    <method>* setUnknownFields(*)</method>
+    <to>**</to>
   </difference>{% endfor %}
 </differences>