diff --git a/druntime/src/core/stdc/config.d b/druntime/src/core/stdc/config.d
index 9a9c29b19f7f..8033018bf66e 100644
--- a/druntime/src/core/stdc/config.d
+++ b/druntime/src/core/stdc/config.d
@@ -290,3 +290,28 @@ alias c_complex_float = __c_complex_float;
 alias c_complex_double = __c_complex_double;
 alias c_complex_real = __c_complex_real;
 }
+
+
+// Returns the mangled name for the 64-bit time_t versions of
+// functions affected by musl's transition to 64-bit time_t.
+// https://musl.libc.org/time64.html
+version (CRuntime_Musl)
+{
+    version (CRuntime_Musl_Pre_Time64)
+        enum muslRedirTime64 = false;
+    else
+    {
+        // time_t was defined as a C long in older Musl versions.
+        enum muslRedirTime64 = (c_long.sizeof == 4);
+    }
+}
+else
+    enum muslRedirTime64 = false;
+
+package(core) template muslRedirTime64Mangle(string name, string redirectedName)
+{
+    static if (muslRedirTime64)
+        enum muslRedirTime64Mangle = redirectedName;
+    else
+        enum muslRedirTime64Mangle = name;
+}
diff --git a/druntime/src/core/stdc/time.d b/druntime/src/core/stdc/time.d
index b19c3c7a899f..d7a57655fabe 100644
--- a/druntime/src/core/stdc/time.d
+++ b/druntime/src/core/stdc/time.d
@@ -30,19 +30,25 @@ nothrow:
 @nogc:
 
 ///
+pragma(mangle, muslRedirTime64Mangle!("difftime", "__difftime64"))
 pure double  difftime(time_t time1, time_t time0); // MT-Safe
 ///
+pragma(mangle, muslRedirTime64Mangle!("mktime", "__mktime64"))
 @system time_t  mktime(scope tm* timeptr); // @system: MT-Safe env locale
 ///
+pragma(mangle, muslRedirTime64Mangle!("time", "__time64"))
 time_t  time(scope time_t* timer);
 
 ///
 @system char*   asctime(const scope tm* timeptr); // @system: MT-Unsafe race:asctime locale
 ///
+pragma(mangle, muslRedirTime64Mangle!("ctime", "__ctime64"))
 @system char*   ctime(const scope time_t* timer); // @system: MT-Unsafe race:tmbuf race:asctime env locale
 ///
+pragma(mangle, muslRedirTime64Mangle!("gmtime", "__gmtime64"))
 @system tm*     gmtime(const scope time_t* timer); // @system: MT-Unsafe race:tmbuf env locale
 ///
+pragma(mangle, muslRedirTime64Mangle!("localtime", "__localtime64"))
 @system tm*     localtime(const scope time_t* timer); // @system: MT-Unsafe race:tmbuf env locale
 ///
 @system size_t  strftime(scope char* s, size_t maxsize, const scope char* format, const scope tm* timeptr); // @system: MT-Safe env locale
diff --git a/druntime/src/core/sys/posix/aio.d b/druntime/src/core/sys/posix/aio.d
index 3ea7f6a19adf..3a537a4a575b 100644
--- a/druntime/src/core/sys/posix/aio.d
+++ b/druntime/src/core/sys/posix/aio.d
@@ -8,6 +8,7 @@
  */
 module core.sys.posix.aio;
 
+import core.stdc.config;
 import core.sys.posix.signal;
 import core.sys.posix.sys.types;
 
@@ -392,6 +393,7 @@ else
     int aio_fsync(int op, aiocb* aiocbp);
     int aio_error(const(aiocb)* aiocbp);
     ssize_t aio_return(aiocb* aiocbp);
+    pragma(mangle, muslRedirTime64Mangle!("aio_suspend", "__aio_suspend_time64"))
     int aio_suspend(const(aiocb*)* aiocb_list, int nitems, const(timespec)* timeout);
     int aio_cancel(int fd, aiocb* aiocbp);
     int lio_listio(int mode, const(aiocb*)* aiocb_list, int nitems, sigevent* sevp);
diff --git a/druntime/src/core/sys/posix/dlfcn.d b/druntime/src/core/sys/posix/dlfcn.d
index 5797b8fd35d8..f4bd2d8ba92f 100644
--- a/druntime/src/core/sys/posix/dlfcn.d
+++ b/druntime/src/core/sys/posix/dlfcn.d
@@ -177,6 +177,38 @@ version (CRuntime_Glibc)
         void* dli_saddr;
     }
 }
+else
+version (CRuntime_Musl)
+{
+    enum RTLD_LAZY   = 1;
+    enum RTLD_NOW    = 2;
+    enum RTLD_NOLOAD = 4;
+    enum RTLD_NODELETE = 4096;
+    enum RTLD_GLOBAL = 256;
+    enum RTLD_LOCAL  = 0;
+
+    enum RTLD_NEXT    = cast(void *)-1;
+    enum RTLD_DEFAULT = cast(void *)0;
+
+    enum RTLD_DI_LINKMAP = 2;
+
+    int    dlclose(void *);
+    char  *dlerror();
+    void  *dlopen(const(char) *, int);
+
+    pragma(mangle, muslRedirTime64Mangle!("dlsym", "__dlsym_time64"))
+    void  *dlsym(void *__restrict, const(char) *__restrict);
+
+    struct Dl_info
+    {
+        const(char)* dli_fname;
+        void* dli_fbase;
+        const(char)* dli_sname;
+        void* dli_saddr;
+    }
+    int dladdr(const(void) *, Dl_info *);
+    int dlinfo(void *, int, void *);
+}
 else version (Darwin)
 {
     enum RTLD_LAZY      = 0x00001;
diff --git a/druntime/src/core/sys/posix/mqueue.d b/druntime/src/core/sys/posix/mqueue.d
index ac697bf8b9be..eae50d27d835 100644
--- a/druntime/src/core/sys/posix/mqueue.d
+++ b/druntime/src/core/sys/posix/mqueue.d
@@ -178,6 +178,7 @@ ssize_t mq_receive (mqd_t mqdes, char* msg_ptr, size_t msg_len, uint* msg_prio);
  *   On success, mq_receive() returns the number of bytes in the received
  *   message; on error, -1 is returned, with errno set to indicate the error
  */
+pragma(mangle, muslRedirTime64Mangle!("mq_timedreceive", "__mq_timedreceive_time64"))
 ssize_t mq_timedreceive (mqd_t mqdes, char* msg_ptr, size_t msg_len,
                          uint* msg_prio, const(timespec)* abs_timeout);
 
@@ -216,5 +217,6 @@ int mq_send (mqd_t mqdes, const(char)* msg_ptr, size_t msg_len, uint msg_prio);
  *   with errno set to indicate the error.
  *
  */
+pragma(mangle, muslRedirTime64Mangle!("mq_timedsend", "__mq_timedsend_time64"))
 int mq_timedsend (mqd_t mqdes, const(char)* msg_ptr, size_t msg_len,
                    uint msg_prio, const(timespec)* abs_timeout);
diff --git a/druntime/src/core/sys/posix/sched.d b/druntime/src/core/sys/posix/sched.d
index f6f0a58e3592..ba7ab8984a9c 100644
--- a/druntime/src/core/sys/posix/sched.d
+++ b/druntime/src/core/sys/posix/sched.d
@@ -65,7 +65,10 @@ version (linux)
         {
             int sched_priority;
             int __reserved1;
-            timespec[2] __reserved2;
+            static if (muslRedirTime64)
+                c_long[2] __reserved2;
+            else
+                timespec[2] __reserved2;
             int __reserved3;
         }
     }
@@ -282,6 +285,7 @@ else version (CRuntime_Musl)
 {
     int sched_get_priority_max(int);
     int sched_get_priority_min(int);
+    pragma(mangle, muslRedirTime64Mangle!("sched_rr_get_interval", "__sched_rr_get_interval_time64"))
     int sched_rr_get_interval(pid_t, timespec*);
 }
 else version (CRuntime_UClibc)
diff --git a/druntime/src/core/sys/posix/semaphore.d b/druntime/src/core/sys/posix/semaphore.d
index d755f86c9cc8..4f3b6e951c33 100644
--- a/druntime/src/core/sys/posix/semaphore.d
+++ b/druntime/src/core/sys/posix/semaphore.d
@@ -216,6 +216,7 @@ else version (CRuntime_Bionic)
 }
 else version (CRuntime_Musl)
 {
+    pragma(mangle, muslRedirTime64Mangle!("sem_timedwait", "__sem_timedwait_time64"))
     int sem_timedwait(sem_t*, const scope timespec*);
 }
 else version (CRuntime_UClibc)
diff --git a/druntime/src/core/sys/posix/signal.d b/druntime/src/core/sys/posix/signal.d
index 542e83a1679d..f722bc4df628 100644
--- a/druntime/src/core/sys/posix/signal.d
+++ b/druntime/src/core/sys/posix/signal.d
@@ -2990,6 +2990,7 @@ else version (CRuntime_Bionic)
 else version (CRuntime_Musl)
 {
     int sigqueue(pid_t, int, const sigval);
+    pragma(mangle, muslRedirTime64Mangle!("sigtimedwait", "__sigtimedwait_time64"))
     int sigtimedwait(const scope sigset_t*, siginfo_t*, const scope timespec*);
     int sigwaitinfo(const scope sigset_t*, siginfo_t*);
 }
diff --git a/druntime/src/core/sys/posix/sys/resource.d b/druntime/src/core/sys/posix/sys/resource.d
index 1f46f03e14d9..b997f112e4d0 100644
--- a/druntime/src/core/sys/posix/sys/resource.d
+++ b/druntime/src/core/sys/posix/sys/resource.d
@@ -547,6 +547,7 @@ else version (CRuntime_Musl)
     int setrlimit(int, const scope rlimit*);
     alias getrlimit getrlimit64;
     alias setrlimit setrlimit64;
+    pragma(mangle, muslRedirTime64Mangle!("getrusage", "__getrusage_time64"))
     int getrusage(int, rusage*);
 }
 else version (Solaris)
diff --git a/druntime/src/core/sys/posix/sys/select.d b/druntime/src/core/sys/posix/sys/select.d
index 06b094093ed5..dd05d08dde6b 100644
--- a/druntime/src/core/sys/posix/sys/select.d
+++ b/druntime/src/core/sys/posix/sys/select.d
@@ -501,7 +501,9 @@ else version (CRuntime_Musl)
     {
         fdset.fds_bits[0 .. $] = 0;
     }
+    pragma(mangle, muslRedirTime64Mangle!("pselect", "__pselect_time64"))
     int pselect(int, fd_set*, fd_set*, fd_set*, const scope timespec*, const scope sigset_t*);
+    pragma(mangle, muslRedirTime64Mangle!("select", "__select_time64"))
     int select(int, fd_set*, fd_set*, fd_set*, timeval*);
 }
 else version (CRuntime_UClibc)
diff --git a/druntime/src/core/sys/posix/sys/stat.d b/druntime/src/core/sys/posix/sys/stat.d
index ecc98ccf0ed8..4bcba2a6116c 100644
--- a/druntime/src/core/sys/posix/sys/stat.d
+++ b/druntime/src/core/sys/posix/sys/stat.d
@@ -1890,8 +1890,11 @@ else version (CRuntime_Bionic)
 }
 else version (CRuntime_Musl)
 {
+    pragma(mangle, muslRedirTime64Mangle!("stat", "__stat_time64"))
     int stat(const scope char*, stat_t*);
+    pragma(mangle, muslRedirTime64Mangle!("fstat", "__fstat_time64"))
     int fstat(int, stat_t*);
+    pragma(mangle, muslRedirTime64Mangle!("lstat", "__lstat_time64"))
     int lstat(const scope char*, stat_t*);
 
     alias fstat fstat64;
diff --git a/druntime/src/core/sys/posix/sys/time.d b/druntime/src/core/sys/posix/sys/time.d
index b536eedc14fe..dda4caf0bf36 100644
--- a/druntime/src/core/sys/posix/sys/time.d
+++ b/druntime/src/core/sys/posix/sys/time.d
@@ -89,7 +89,9 @@ else version (CRuntime_Musl)
         time_t      tv_sec;
         suseconds_t tv_usec;
     }
+    pragma(mangle, muslRedirTime64Mangle!("gettimeofday", "__gettimeofday_time64"))
     int gettimeofday(timeval*, void*);
+    pragma(mangle, muslRedirTime64Mangle!("utimes", "__utimes_time64"))
     int utimes(const scope char*, ref const(timeval)[2]);
 }
 else version (Darwin)
diff --git a/druntime/src/core/sys/posix/time.d b/druntime/src/core/sys/posix/time.d
index af52002b1aaf..f49764d1964a 100644
--- a/druntime/src/core/sys/posix/time.d
+++ b/druntime/src/core/sys/posix/time.d
@@ -83,6 +83,7 @@ else version (CRuntime_Bionic)
 }
 else version (CRuntime_Musl)
 {
+    pragma(mangle, muslRedirTime64Mangle!("timegm", "__timegm_time64"))
     time_t timegm(tm*);
 }
 else version (CRuntime_UClibc)
@@ -483,15 +484,21 @@ else version (CRuntime_Musl)
 
     int nanosleep(const scope timespec*, timespec*);
 
+    pragma(mangle, muslRedirTime64Mangle!("clock_getres", "__clock_getres_time64"))
     int clock_getres(clockid_t, timespec*);
+    pragma(mangle, muslRedirTime64Mangle!("clock_gettime", "__clock_gettime64"))
     int clock_gettime(clockid_t, timespec*);
+    pragma(mangle, muslRedirTime64Mangle!("clock_settime", "__clock_settime64"))
     int clock_settime(clockid_t, const scope timespec*);
+    pragma(mangle, muslRedirTime64Mangle!("clock_nanosleep", "__clock_nanosleep_time64"))
     int clock_nanosleep(clockid_t, int, const scope timespec*, timespec*);
     int clock_getcpuclockid(pid_t, clockid_t *);
 
     int timer_create(clockid_t, sigevent*, timer_t*);
     int timer_delete(timer_t);
+    pragma(mangle, muslRedirTime64Mangle!("timer_gettime", "__timer_gettime64"))
     int timer_gettime(timer_t, itimerspec*);
+    pragma(mangle, muslRedirTime64Mangle!("timer_settime", "__timer_settime64"))
     int timer_settime(timer_t, int, const scope itimerspec*, itimerspec*);
     int timer_getoverrun(timer_t);
 }
@@ -596,8 +603,11 @@ else version (CRuntime_Bionic)
 else version (CRuntime_Musl)
 {
     char* asctime_r(const scope tm*, char*);
+    pragma(mangle, muslRedirTime64Mangle!("ctime_r", "__ctime64_r"))
     char* ctime_r(const scope time_t*, char*);
+    pragma(mangle, muslRedirTime64Mangle!("gmtime_r", "__gmtime64_r"))
     tm*   gmtime_r(const scope time_t*, tm*);
+    pragma(mangle, muslRedirTime64Mangle!("localtime_r", "__localtime64_r"))
     tm*   localtime_r(const scope time_t*, tm*);
 }
 else version (CRuntime_UClibc)
diff --git a/druntime/src/core/sys/posix/utime.d b/druntime/src/core/sys/posix/utime.d
index fcec7af3fde0..e7059d712838 100644
--- a/druntime/src/core/sys/posix/utime.d
+++ b/druntime/src/core/sys/posix/utime.d
@@ -62,6 +62,7 @@ else version (CRuntime_Musl)
         time_t  modtime;
     }
 
+    pragma(mangle, muslRedirTime64Mangle!("utime", "__utime64"))
     int utime(const scope char*, const scope utimbuf*);
 }
 else version (Darwin)