diff --git a/tiled/adapters/hdf5.py b/tiled/adapters/hdf5.py
index 544edc765..cd5489594 100644
--- a/tiled/adapters/hdf5.py
+++ b/tiled/adapters/hdf5.py
@@ -115,7 +115,7 @@ def from_uri(
         access_policy=None,
     ):
         filepath = path_from_uri(data_uri)
-        cache_key = (cls.__module__, cls.__name__, filepath)
+        cache_key = (h5py.File, filepath, "r", swmr, libver)
         file = with_resource_cache(
             cache_key, h5py.File, filepath, "r", swmr=swmr, libver=libver
         )
diff --git a/tiled/adapters/tiff.py b/tiled/adapters/tiff.py
index 75364e4cf..338548c5b 100644
--- a/tiled/adapters/tiff.py
+++ b/tiled/adapters/tiff.py
@@ -32,7 +32,7 @@ def __init__(
         if not isinstance(data_uri, str):
             raise Exception
         filepath = path_from_uri(data_uri)
-        cache_key = (type(self).__module__, type(self).__qualname__, filepath)
+        cache_key = (tifffile.TiffFile, filepath)
         self._file = with_resource_cache(cache_key, tifffile.TiffFile, filepath)
         self.specs = specs or []
         self._provided_metadata = metadata or {}