diff --git a/tiled/_tests/test_pickle.py b/tiled/_tests/test_pickle.py
index 8585317d1..0de6db3c3 100644
--- a/tiled/_tests/test_pickle.py
+++ b/tiled/_tests/test_pickle.py
@@ -8,6 +8,7 @@
 from packaging.version import parse
 
 from ..client import from_context
+from ..client.cache import Cache
 from ..client.context import Context
 
 MIN_VERSION = "0.1.0a104"
@@ -24,7 +25,7 @@ def test_pickle_context():
 
 
 @pytest.mark.parametrize("structure_clients", ["numpy", "dask"])
-def test_pickle_clients(structure_clients):
+def test_pickle_clients(structure_clients, tmpdir):
     try:
         httpx.get(API_URL).raise_for_status()
     except Exception:
@@ -34,7 +35,8 @@ def test_pickle_clients(structure_clients):
             raise pytest.skip(
                 f"Server at {API_URL} is running too old a version to test against."
             )
-        client = from_context(context, structure_clients)
+        cache = Cache(tmpdir / "http_response_cache.db")
+        client = from_context(context, structure_clients, cache)
         pickle.loads(pickle.dumps(client))
         for segements in [
             ["generated"],
diff --git a/tiled/client/cache.py b/tiled/client/cache.py
index 44d85be20..9d05e27e1 100644
--- a/tiled/client/cache.py
+++ b/tiled/client/cache.py
@@ -12,7 +12,7 @@
 import appdirs
 import httpx
 
-from .utils import TiledResponse
+from .utils import SerializableLock, TiledResponse
 
 CACHE_DATABASE_SCHEMA_VERSION = 1
 
@@ -200,7 +200,7 @@ def __init__(
         self._filepath = filepath
         self._owner_thread = threading.current_thread().ident
         self._conn = _prepare_database(filepath, readonly)
-        self._lock = threading.Lock()
+        self._lock = SerializableLock()
 
     def __repr__(self):
         return f"<{type(self).__name__} {str(self._filepath)!r}>"
@@ -219,16 +219,23 @@ def write_safe(self):
         return is_main_thread or sqlite_is_safe
 
     def __getstate__(self):
-        return (self.filepath, self.capacity, self.max_item_size, self._readonly)
+        return (
+            self.filepath,
+            self.capacity,
+            self.max_item_size,
+            self._readonly,
+            self._lock,
+        )
 
     def __setstate__(self, state):
-        (filepath, capacity, max_item_size, readonly) = state
+        (filepath, capacity, max_item_size, readonly, lock) = state
         self._capacity = capacity
         self._max_item_size = max_item_size
         self._readonly = readonly
         self._filepath = filepath
         self._owner_thread = threading.current_thread().ident
         self._conn = _prepare_database(filepath, readonly)
+        self._lock = lock
 
     @property
     def readonly(self):