diff --git a/src/wp-includes/class-wp-theme.php b/src/wp-includes/class-wp-theme.php
index a664a1ea0bee0..e6eeb8ca5dfaf 100644
--- a/src/wp-includes/class-wp-theme.php
+++ b/src/wp-includes/class-wp-theme.php
@@ -1974,7 +1974,7 @@ private function get_pattern_cache() {
 		if ( ! $this->exists() ) {
 			return false;
 		}
-		$pattern_data = wp_cache_get( 'wp_theme_patterns_' . $this->stylesheet );
+		$pattern_data = wp_cache_get( 'wp_theme_patterns_' . $this->stylesheet, 'theme_files' );
 		if ( is_array( $pattern_data ) && $pattern_data['version'] === $this->get( 'Version' ) ) {
 			return $pattern_data['patterns'];
 		}
@@ -1993,7 +1993,7 @@ private function set_pattern_cache( array $patterns ) {
 			'version'  => $this->get( 'Version' ),
 			'patterns' => $patterns,
 		);
-		wp_cache_set( 'wp_theme_patterns_' . $this->stylesheet, $pattern_data );
+		wp_cache_set( 'wp_theme_patterns_' . $this->stylesheet, $pattern_data, 'theme_files' );
 	}
 
 	/**
@@ -2002,7 +2002,7 @@ private function set_pattern_cache( array $patterns ) {
 	 * @since 6.4.0
 	 */
 	public function delete_pattern_cache() {
-		wp_cache_delete( 'wp_theme_patterns_' . $this->stylesheet );
+		wp_cache_delete( 'wp_theme_patterns_' . $this->stylesheet, 'theme_files' );
 	}
 
 	/**
diff --git a/src/wp-includes/load.php b/src/wp-includes/load.php
index c1885987687d5..d10aff376fd57 100644
--- a/src/wp-includes/load.php
+++ b/src/wp-includes/load.php
@@ -875,6 +875,7 @@ function wp_start_object_cache() {
 				'site-options',
 				'site-queries',
 				'site-transient',
+				'theme_files',
 				'rss',
 				'users',
 				'user-queries',
diff --git a/src/wp-includes/ms-blogs.php b/src/wp-includes/ms-blogs.php
index 4a251cf300c1b..b9575b3beff70 100644
--- a/src/wp-includes/ms-blogs.php
+++ b/src/wp-includes/ms-blogs.php
@@ -565,6 +565,7 @@ function switch_to_blog( $new_blog_id, $deprecated = null ) {
 						'site-options',
 						'site-queries',
 						'site-transient',
+						'theme_files',
 						'rss',
 						'users',
 						'user-queries',
@@ -658,6 +659,7 @@ function restore_current_blog() {
 						'site-options',
 						'site-queries',
 						'site-transient',
+						'theme_files',
 						'rss',
 						'users',
 						'user-queries',
diff --git a/src/wp-includes/theme.php b/src/wp-includes/theme.php
index 0b0df6c7b06f0..c8cbc60cc6ce5 100644
--- a/src/wp-includes/theme.php
+++ b/src/wp-includes/theme.php
@@ -837,8 +837,10 @@ function switch_theme( $stylesheet ) {
 	update_option( 'theme_switched', $old_theme->get_stylesheet() );
 
 	// Clear pattern caches.
-	$new_theme->delete_pattern_cache();
-	$old_theme->delete_pattern_cache();
+	if ( ! is_multisite() ) {
+		$new_theme->delete_pattern_cache();
+		$old_theme->delete_pattern_cache();
+	}
 
 	// Set autoload=no for the old theme, autoload=yes for the switched theme.
 	$theme_mods_options = array(
diff --git a/tests/phpunit/includes/abstract-testcase.php b/tests/phpunit/includes/abstract-testcase.php
index 3600722f4448d..f5a80cf29b308 100644
--- a/tests/phpunit/includes/abstract-testcase.php
+++ b/tests/phpunit/includes/abstract-testcase.php
@@ -412,6 +412,7 @@ public static function flush_cache() {
 				'site-options',
 				'site-queries',
 				'site-transient',
+				'theme_files',
 				'rss',
 				'users',
 				'user-queries',
diff --git a/tests/phpunit/tests/theme/wpThemeGetBlockPatterns.php b/tests/phpunit/tests/theme/wpThemeGetBlockPatterns.php
index caaf189a16a04..45b4083262932 100644
--- a/tests/phpunit/tests/theme/wpThemeGetBlockPatterns.php
+++ b/tests/phpunit/tests/theme/wpThemeGetBlockPatterns.php
@@ -86,6 +86,7 @@ public function test_delete_pattern_cache() {
 
 	/**
 	 * @ticket 59490
+	 * @group ms-excluded
 	 */
 	public function test_should_clear_cache_after_switching_theme() {
 		switch_theme( 'block-theme' );