diff --git a/e2e/components/ComboBox/ComboBox-test.avt.e2e.js b/e2e/components/ComboBox/ComboBox-test.avt.e2e.js
new file mode 100644
index 000000000000..1b1cee7a6f4d
--- /dev/null
+++ b/e2e/components/ComboBox/ComboBox-test.avt.e2e.js
@@ -0,0 +1,118 @@
+/**
+ * Copyright IBM Corp. 2016, 2023
+ *
+ * This source code is licensed under the Apache-2.0 license found in the
+ * LICENSE file in the root directory of this source tree.
+ */
+
+'use strict';
+
+const { expect, test } = require('@playwright/test');
+const { visitStory } = require('../../test-utils/storybook');
+
+test.describe('ComboBox @avt', () => {
+  test('accessibility-checker combobox', async ({ page }) => {
+    await visitStory(page, {
+      component: 'ComboBox',
+      id: 'components-combobox--default',
+      globals: {
+        theme: 'white',
+      },
+    });
+    await expect(page).toHaveNoACViolations('ComboBox');
+  });
+
+  // Skipping now due to AVT violation, possible false positive
+  test.skip('accessibility-checker open combobox', async ({ page }) => {
+    await visitStory(page, {
+      component: 'ComboBox',
+      id: 'components-combobox--default',
+      globals: {
+        theme: 'white',
+      },
+    });
+    const combobox = page.getByRole('combobox');
+
+    await expect(combobox).toBeVisible();
+    // Tab and open the MultiSelect
+    await page.keyboard.press('Tab');
+    await expect(combobox).toBeFocused();
+    await page.keyboard.press('Enter');
+    await expect(page.getByRole('combobox', { expanded: true })).toBeVisible;
+    await expect(combobox).toBeFocused();
+
+    await expect(page).toHaveNoACViolations('ComboBox-open');
+  });
+
+  test('combobox - keyboard nav', async ({ page }) => {
+    await visitStory(page, {
+      component: 'ComboBox',
+      id: 'components-combobox--default',
+      globals: {
+        theme: 'white',
+      },
+    });
+    const combobox = page.getByRole('combobox');
+    const menu = page.getByRole('listbox');
+    const clearButton = page.getByRole('button', {
+      name: 'Clear selected item',
+    });
+    const optionOne = page.getByRole('option', {
+      name: 'An example option that is really long to show what should be done to handle long text',
+    });
+    const optionTwo = page.getByRole('option', {
+      name: 'Option 2',
+    });
+
+    await expect(combobox).toBeVisible();
+    await expect(clearButton).not.toBeVisible();
+    // Tab and open the MultiSelect with Arrow Down
+    await page.keyboard.press('Tab');
+    await expect(combobox).toBeFocused();
+    await page.keyboard.press('ArrowDown');
+    await expect(menu).toBeVisible();
+    // Close with Escape, retain focus, and open with Spacebar
+    await page.keyboard.press('Escape');
+    await expect(menu).not.toBeVisible();
+    await expect(combobox).toBeFocused();
+    await page.keyboard.press('Space');
+    await expect(menu).toBeVisible();
+    // Close and clear with Escape, retain focus, and open with Enter
+    await page.keyboard.press('Escape');
+    await page.keyboard.press('Escape');
+    await expect(menu).not.toBeVisible();
+    await expect(combobox).toBeFocused();
+    await page.keyboard.press('Enter');
+    await expect(menu).toBeVisible();
+    // Navigation inside the menu
+    // move to first option
+    await page.keyboard.press('ArrowDown');
+    await expect(optionOne).toHaveClass(
+      'cds--list-box__menu-item cds--list-box__menu-item--highlighted'
+    );
+    // select first option (should only select with enter)
+    await page.keyboard.press('Space');
+    await expect(combobox).toHaveValue(' ');
+    await page.keyboard.press('Enter');
+    await expect(combobox).toHaveValue(
+      'An example option that is really long to show what should be done to handle long text'
+    );
+    // focus comes back to the toggle button after selecting
+    await expect(combobox).toBeFocused();
+    await expect(menu).not.toBeVisible();
+    await expect(clearButton).toBeVisible();
+    // should only clear selection when escape is pressed when the menu is closed
+    await page.keyboard.press('Escape');
+    await expect(clearButton).not.toBeVisible();
+    await expect(combobox).toHaveValue('');
+    // should highlight menu items based on text input
+    await page.keyboard.press('2');
+    await expect(menu).toBeVisible();
+    await expect(optionTwo).toHaveClass(
+      'cds--list-box__menu-item cds--list-box__menu-item--highlighted'
+    );
+    // Should select and populate combobox with current filtered item
+    await page.keyboard.press('Enter');
+    await expect(combobox).toHaveValue('Option 2');
+  });
+});
diff --git a/e2e/components/ComboBox/ComboBox-test.e2e.js b/e2e/components/ComboBox/ComboBox-test.e2e.js
index d1962601558c..877ade5c9efe 100644
--- a/e2e/components/ComboBox/ComboBox-test.e2e.js
+++ b/e2e/components/ComboBox/ComboBox-test.e2e.js
@@ -7,9 +7,9 @@
 
 'use strict';
 
-const { expect, test } = require('@playwright/test');
+const { test } = require('@playwright/test');
 const { themes } = require('../../test-utils/env');
-const { snapshotStory, visitStory } = require('../../test-utils/storybook');
+const { snapshotStory } = require('../../test-utils/storybook');
 
 test.describe('ComboBox', () => {
   themes.forEach((theme) => {
@@ -31,15 +31,4 @@ test.describe('ComboBox', () => {
       });
     });
   });
-
-  test('accessibility-checker @avt', async ({ page }) => {
-    await visitStory(page, {
-      component: 'ComboBox',
-      id: 'components-combobox--default',
-      globals: {
-        theme: 'white',
-      },
-    });
-    await expect(page).toHaveNoACViolations('ComboBox');
-  });
 });