diff --git a/.cargo/config.toml b/.cargo/config.toml
index 47f74e34dc77..9c7d3a7588eb 100644
--- a/.cargo/config.toml
+++ b/.cargo/config.toml
@@ -7,6 +7,3 @@ dev = "run --package uv-dev"
 # See: https://github.com/astral-sh/ruff/issues/11503
 [target.'cfg(all(target_env = "msvc", target_os = "windows"))']
 rustflags = ["-C", "target-feature=+crt-static"]
-
-[target.powerpc64le-unknown-linux-musl]
-lto = "off"
diff --git a/.github/workflows/build-binaries.yml b/.github/workflows/build-binaries.yml
index 045df2e119f1..aa5142ca3e3f 100644
--- a/.github/workflows/build-binaries.yml
+++ b/.github/workflows/build-binaries.yml
@@ -593,7 +593,7 @@ jobs:
         with:
           target: ${{ matrix.platform.target }}
           manylinux: musllinux_1_1
-          args: --release --locked --out dist --features self-update ${{ matrix.platform.arch == 'aarch64' && '--compatibility 2_17' || ''}}
+          args: ${{ matrix.platform.arch == 'ppc64le' && '--profile release-no-lto' || '--release'}} --locked --out dist --features self-update ${{ matrix.platform.arch == 'aarch64' && '--compatibility 2_17' || ''}}
           docker-options: ${{ matrix.platform.maturin_docker_options }}
           rust-toolchain: ${{ matrix.platform.toolchain || 'stable' }}
         env:
diff --git a/Cargo.toml b/Cargo.toml
index 1da88e1e21fe..87d43c895785 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -210,6 +210,11 @@ rest_pat_in_fully_bound_structs = "warn"
 strip = true
 lto = "fat"
 
+# This profile disables LTO and is used for ppc64le musl cross builds which fail otherwise
+[profile.release-no-lto]
+inherits = "release"
+lto = false
+
 # This profile is meant to mimic the `release` profile as closely as
 # possible, but using settings that are more beneficial for iterative
 # development. That is, the `release` profile is intended for actually