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mobio-edit.owl
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mobio-edit.owl
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Prefix(:=<http://purl.obolibrary.org/obo/mobio.owl#>)
Prefix(obo:=<http://purl.obolibrary.org/obo/>)
Prefix(owl:=<http://www.w3.org/2002/07/owl#>)
Prefix(rdf:=<http://www.w3.org/1999/02/22-rdf-syntax-ns#>)
Prefix(xml:=<http://www.w3.org/XML/1998/namespace>)
Prefix(xsd:=<http://www.w3.org/2001/XMLSchema#>)
Prefix(foaf:=<http://xmlns.com/foaf/0.1/>)
Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
Prefix(dcterms:=<http://purl.org/dc/terms/>)
Prefix(oboInOwl:=<http://www.geneontology.org/formats/oboInOwl#>)
Ontology(<http://purl.obolibrary.org/obo/mobio.owl>
Import(<http://purl.obolibrary.org/obo/mobio/imports/bfo_import.owl>)
Import(<http://purl.obolibrary.org/obo/mobio/imports/go_import.owl>)
Import(<http://purl.obolibrary.org/obo/mobio/imports/ro_import.owl>)
Import(<http://purl.obolibrary.org/obo/mobio/imports/so_import.owl>)
Annotation(dcterms:description "None")
Annotation(dcterms:license <https://creativecommons.org/licenses/unspecified>)
Annotation(dcterms:title "Mobilome Ontology")
Declaration(Class(obo:BFO_0000001))
Declaration(Class(obo:BFO_0000030))
Declaration(Class(obo:MOBIO_0000001))
Declaration(Class(obo:MOBIO_0000002))
Declaration(Class(obo:MOBIO_0000003))
Declaration(Class(obo:MOBIO_0000004))
Declaration(Class(obo:MOBIO_0000006))
Declaration(Class(obo:MOBIO_0000007))
Declaration(Class(obo:MOBIO_0000008))
Declaration(Class(obo:MOBIO_0000009))
Declaration(Class(obo:MOBIO_0000010))
Declaration(Class(obo:MOBIO_0000011))
Declaration(Class(obo:MOBIO_0000012))
Declaration(Class(obo:MOBIO_0000013))
Declaration(Class(obo:MOBIO_0000014))
Declaration(Class(obo:MOBIO_0000015))
Declaration(Class(obo:MOBIO_0000016))
Declaration(Class(obo:MOBIO_0000017))
Declaration(Class(obo:MOBIO_0000019))
Declaration(Class(obo:MOBIO_0000020))
Declaration(Class(obo:MOBIO_0000021))
Declaration(Class(obo:MOBIO_0000022))
Declaration(Class(obo:MOBIO_0000023))
Declaration(Class(obo:MOBIO_0000024))
Declaration(Class(obo:MOBIO_0000025))
Declaration(Class(obo:MOBIO_0000026))
Declaration(Class(obo:MOBIO_0000027))
Declaration(Class(obo:MOBIO_0000028))
Declaration(Class(obo:MOBIO_0000029))
Declaration(Class(obo:MOBIO_0000030))
Declaration(Class(obo:MOBIO_0000031))
Declaration(Class(obo:MOBIO_0000032))
Declaration(Class(obo:MOBIO_0000033))
Declaration(Class(obo:MOBIO_0000034))
Declaration(Class(obo:MOBIO_0000035))
Declaration(Class(obo:MOBIO_0000036))
Declaration(Class(obo:MOBIO_0000037))
Declaration(Class(obo:MOBIO_0000038))
Declaration(Class(obo:MOBIO_0000039))
Declaration(Class(obo:MOBIO_0000040))
Declaration(Class(obo:MOBIO_0000041))
Declaration(Class(obo:MOBIO_0000042))
Declaration(Class(obo:MOBIO_0000043))
Declaration(Class(obo:MOBIO_0000044))
Declaration(Class(obo:MOBIO_0000045))
Declaration(Class(obo:MOBIO_0000046))
Declaration(Class(obo:MOBIO_0000047))
Declaration(Class(obo:MOBIO_0000048))
Declaration(Class(obo:MOBIO_0000049))
Declaration(Class(obo:MOBIO_0000050))
Declaration(Class(obo:MOBIO_0000051))
Declaration(Class(obo:MOBIO_0000052))
Declaration(Class(obo:MOBIO_0000053))
Declaration(Class(obo:MOBIO_0000054))
Declaration(Class(obo:MOBIO_0000055))
Declaration(Class(obo:MOBIO_0000056))
Declaration(Class(obo:MOBIO_0000057))
Declaration(Class(obo:MOBIO_0000058))
Declaration(Class(obo:MOBIO_0000059))
Declaration(Class(obo:MOBIO_0000060))
Declaration(Class(obo:MOBIO_0000061))
Declaration(Class(obo:MOBIO_0000062))
Declaration(Class(obo:MOBIO_0000063))
Declaration(Class(obo:MOBIO_0000064))
Declaration(Class(obo:MOBIO_0000065))
Declaration(Class(obo:MOBIO_0000066))
Declaration(Class(obo:MOBIO_0000067))
Declaration(Class(obo:MOBIO_0000068))
Declaration(Class(obo:MOBIO_0000069))
Declaration(Class(obo:MOBIO_0000070))
Declaration(Class(obo:MOBIO_0000071))
Declaration(Class(obo:MOBIO_0000072))
Declaration(Class(obo:MOBIO_0000073))
Declaration(Class(obo:MOBIO_0000074))
Declaration(Class(obo:MOBIO_0000075))
Declaration(Class(obo:MOBIO_0000076))
Declaration(Class(obo:MOBIO_0000077))
Declaration(Class(obo:MOBIO_0000078))
Declaration(Class(obo:MOBIO_0000079))
Declaration(Class(obo:MOBIO_0000080))
Declaration(Class(obo:MOBIO_0000081))
Declaration(Class(obo:MOBIO_0000082))
Declaration(Class(obo:MOBIO_0000083))
Declaration(Class(obo:MOBIO_0000084))
Declaration(Class(obo:MOBIO_0000085))
Declaration(Class(obo:MOBIO_0000086))
Declaration(Class(obo:MOBIO_0000087))
Declaration(Class(obo:MOBIO_0000088))
Declaration(Class(obo:MOBIO_0000089))
Declaration(Class(obo:MOBIO_0000090))
Declaration(Class(obo:MOBIO_0000091))
Declaration(Class(obo:MOBIO_0000092))
Declaration(Class(obo:MOBIO_0000093))
Declaration(Class(obo:MOBIO_0000094))
Declaration(Class(obo:MOBIO_0000095))
Declaration(Class(obo:MOBIO_0000096))
Declaration(Class(obo:MOBIO_0000097))
Declaration(Class(obo:MOBIO_0000098))
Declaration(Class(obo:MOBIO_0000099))
Declaration(Class(obo:MOBIO_0000100))
Declaration(Class(obo:MOBIO_0000101))
Declaration(Class(obo:MOBIO_0000102))
Declaration(Class(obo:MOBIO_0000103))
Declaration(Class(obo:MOBIO_0000104))
Declaration(Class(obo:MOBIO_0000105))
Declaration(Class(obo:MOBIO_0000106))
Declaration(Class(obo:MOBIO_0000108))
Declaration(Class(obo:MOBIO_0000109))
Declaration(Class(obo:MOBIO_0000110))
Declaration(Class(obo:MOBIO_0000111))
Declaration(Class(obo:MOBIO_0000112))
Declaration(Class(obo:MOBIO_0000113))
Declaration(Class(obo:MOBIO_0000114))
Declaration(Class(obo:MOBIO_0000115))
Declaration(Class(obo:MOBIO_0000116))
Declaration(Class(obo:MOBIO_0000117))
Declaration(Class(obo:MOBIO_0000118))
Declaration(Class(obo:MOBIO_0000119))
Declaration(Class(obo:MOBIO_0000120))
Declaration(Class(obo:MOBIO_0000121))
Declaration(Class(obo:MOBIO_0000122))
Declaration(Class(obo:MOBIO_0000123))
Declaration(Class(obo:MOBIO_0000124))
Declaration(Class(obo:MOBIO_0000125))
Declaration(Class(obo:MOBIO_0000126))
Declaration(Class(obo:MOBIO_0000127))
Declaration(Class(obo:MOBIO_0000128))
Declaration(Class(obo:MOBIO_0000129))
Declaration(Class(obo:MOBIO_0000130))
Declaration(Class(obo:MOBIO_0000131))
Declaration(Class(obo:MOBIO_0000132))
Declaration(Class(obo:MOBIO_0000133))
Declaration(Class(obo:MOBIO_0000134))
Declaration(Class(obo:MOBIO_0000135))
Declaration(Class(obo:MOBIO_0000136))
Declaration(Class(obo:MOBIO_0000137))
Declaration(Class(obo:MOBIO_0000138))
Declaration(Class(obo:MOBIO_0000139))
Declaration(Class(obo:MOBIO_0000140))
Declaration(Class(obo:MOBIO_0000141))
Declaration(Class(obo:MOBIO_0000142))
Declaration(Class(obo:MOBIO_0000143))
Declaration(Class(obo:MOBIO_0000144))
Declaration(Class(obo:MOBIO_0000145))
Declaration(Class(obo:MOBIO_0000146))
Declaration(Class(obo:MOBIO_0000147))
Declaration(Class(obo:MOBIO_0000148))
Declaration(Class(obo:MOBIO_0000149))
Declaration(Class(obo:MOBIO_0000150))
Declaration(Class(obo:MOBIO_0000151))
Declaration(Class(obo:MOBIO_0000152))
Declaration(Class(obo:MOBIO_0000153))
Declaration(Class(obo:MOBIO_0000154))
Declaration(Class(obo:MOBIO_0000155))
Declaration(Class(obo:MOBIO_0000156))
Declaration(Class(obo:MOBIO_0000157))
Declaration(Class(obo:MOBIO_0000158))
Declaration(Class(obo:MOBIO_0000159))
Declaration(Class(obo:MOBIO_0000160))
Declaration(Class(obo:MOBIO_0000161))
Declaration(Class(obo:MOBIO_0000162))
Declaration(Class(obo:MOBIO_0000163))
Declaration(Class(obo:MOBIO_0000164))
Declaration(Class(obo:MOBIO_0000165))
Declaration(Class(obo:MOBIO_0000166))
Declaration(Class(obo:MOBIO_0000167))
Declaration(Class(obo:MOBIO_0000168))
Declaration(Class(obo:MOBIO_0000169))
Declaration(Class(obo:MOBIO_0000170))
Declaration(Class(obo:MOBIO_0000171))
Declaration(Class(obo:MOBIO_0000172))
Declaration(Class(obo:MOBIO_0000173))
Declaration(Class(obo:MOBIO_0000174))
Declaration(Class(obo:MOBIO_0000175))
Declaration(Class(obo:MOBIO_0000176))
Declaration(Class(obo:MOBIO_0000177))
Declaration(Class(obo:MOBIO_0000178))
Declaration(Class(obo:MOBIO_0000179))
Declaration(Class(obo:MOBIO_0000180))
Declaration(Class(obo:MOBIO_0000181))
Declaration(Class(obo:MOBIO_0000182))
Declaration(Class(obo:MOBIO_0000183))
Declaration(Class(obo:MOBIO_0000184))
Declaration(Class(obo:MOBIO_0000185))
Declaration(Class(obo:MOBIO_0000186))
Declaration(Class(obo:MOBIO_0000187))
Declaration(Class(obo:MOBIO_0000188))
Declaration(Class(obo:MOBIO_0000190))
Declaration(Class(obo:MOBIO_0000191))
Declaration(Class(obo:MOBIO_0000192))
Declaration(Class(obo:MOBIO_0000193))
Declaration(Class(obo:MOBIO_0000194))
Declaration(Class(obo:MOBIO_0000195))
Declaration(Class(obo:MOBIO_0000196))
Declaration(Class(obo:MOBIO_0000197))
Declaration(Class(obo:MOBIO_0000198))
Declaration(Class(obo:MOBIO_0000199))
Declaration(Class(obo:MOBIO_0000200))
Declaration(Class(obo:MOBIO_0000201))
Declaration(Class(obo:MOBIO_0000202))
Declaration(Class(obo:MOBIO_0000203))
Declaration(Class(obo:MOBIO_0000204))
Declaration(Class(obo:MOBIO_0000205))
Declaration(Class(obo:MOBIO_0000206))
Declaration(Class(obo:MOBIO_0000207))
Declaration(Class(obo:MOBIO_0000208))
Declaration(Class(obo:MOBIO_0000209))
Declaration(Class(obo:MOBIO_0000210))
Declaration(Class(obo:MOBIO_0000211))
Declaration(Class(obo:MOBIO_0000212))
Declaration(Class(obo:MOBIO_0000213))
Declaration(Class(obo:MOBIO_0000214))
Declaration(Class(obo:MOBIO_0000215))
Declaration(Class(obo:MOBIO_0000216))
Declaration(Class(obo:MOBIO_0000217))
Declaration(Class(obo:MOBIO_0000218))
Declaration(Class(obo:MOBIO_0000219))
Declaration(Class(obo:MOBIO_0000220))
Declaration(Class(obo:MOBIO_0000221))
Declaration(Class(obo:MOBIO_0000222))
Declaration(ObjectProperty(obo:BFO_0000050))
Declaration(ObjectProperty(obo:RO_0000056))
Declaration(ObjectProperty(obo:RO_0002211))
Declaration(AnnotationProperty(obo:IAO_0000115))
Declaration(AnnotationProperty(dcterms:description))
Declaration(AnnotationProperty(dcterms:license))
Declaration(AnnotationProperty(dcterms:title))
Declaration(AnnotationProperty(oboInOwl:hasDbXref))
Declaration(AnnotationProperty(oboInOwl:hasExactSynonym))
Declaration(AnnotationProperty(oboInOwl:id))
Declaration(AnnotationProperty(rdfs:label))
Declaration(AnnotationProperty(foaf:mbox))
############################
# Annotation Properties
############################
# Annotation Property: obo:IAO_0000115 (definition)
AnnotationAssertion(rdfs:label obo:IAO_0000115 "definition")
# Annotation Property: oboInOwl:hasDbXref (database_cross_reference)
AnnotationAssertion(rdfs:label oboInOwl:hasDbXref "database_cross_reference")
# Annotation Property: oboInOwl:hasExactSynonym (has_exact_synonym)
AnnotationAssertion(rdfs:label oboInOwl:hasExactSynonym "has_exact_synonym")
############################
# Object Properties
############################
# Object Property: obo:BFO_0000050 (part of)
AnnotationAssertion(oboInOwl:hasDbXref obo:BFO_0000050 "RO:part_of")
AnnotationAssertion(rdfs:label obo:BFO_0000050 "part_of")
# Object Property: obo:RO_0000056 (participates in)
AnnotationAssertion(oboInOwl:hasDbXref obo:RO_0000056 "RO:participates_in")
AnnotationAssertion(rdfs:label obo:RO_0000056 "participates_in")
# Object Property: obo:RO_0002211 (regulates)
AnnotationAssertion(oboInOwl:hasDbXref obo:RO_0002211 "RO:regulates")
AnnotationAssertion(rdfs:label obo:RO_0002211 "regulates")
############################
# Classes
############################
# Class: obo:MOBIO_0000001 (mobile genetic element)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000001 "Mobile genetic elements (MGEs) are a type of genetic material, a segment of DNA or RNA, that is capable of movement around a genome or that can be transferred from one species or replicon to another. These include transposons, plasmids, bacteriophages, and genomic islands. The mechanism of movement may be self-encoded or may rely on other enzymes and structures, such as a pilus. In bacteria, MGEs are often associated with the movement of antibiotic resistance genes and virulence factors from one species to another, for example by plasmid-mediated transfer.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000001 "mobile genetic element")
SubClassOf(obo:MOBIO_0000001 obo:BFO_0000030)
# Class: obo:MOBIO_0000002 (plasmid)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000002 "A plasmid is a small, circular, double-stranded DNA molecule that is distinct from a cell's chromosomal DNA. Plasmids naturally exist in bacterial cells, and they also occur in some eukaryotes. Often, the genes carried in plasmids provide bacteria with genetic advantages, such as antibiotic resistance. Plasmids have a wide range of lengths, from roughly one thousand DNA base pairs to hundreds of thousands of base pairs.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000002 "plasmid")
SubClassOf(obo:MOBIO_0000002 obo:MOBIO_0000001)
# Class: obo:MOBIO_0000003 (transposable element)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000003 "A transposable element (TE or transposon) is a DNA sequence that can change its position within a genome, sometimes creating or reversing mutations and altering the cell's genome size. Transposition often results in duplication of the same genetic material. Transposons were originally discovered as \"jumping genes\" by Barbara McClintock.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000003 "transposon")
AnnotationAssertion(rdfs:label obo:MOBIO_0000003 "transposable element")
SubClassOf(obo:MOBIO_0000003 obo:MOBIO_0000001)
SubClassOf(obo:MOBIO_0000003 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000002))
# Class: obo:MOBIO_0000004 (bacteriophage)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000004 "Bacteriophage are viral infectious agents with bacterial host organisms. Bacteriophage infect and replicate inside bacterial host cells, causing cell lysis as viral particles replicate. Bacteriophage are involved in DNA transfer between host organisms at low frequency through transduction: when segments of host DNA is accidentally packaged with the viral DNA, then integrated into a new host genome and later inherited.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000004 "bacteriophage")
SubClassOf(obo:MOBIO_0000004 obo:MOBIO_0000001)
# Class: obo:MOBIO_0000006 (Col Plasmids)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000006 "These plasmids contain genes that code for bacteriocins, proteins that can kill other bacteria.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000006 "Col Plasmids")
SubClassOf(obo:MOBIO_0000006 obo:MOBIO_0000002)
# Class: obo:MOBIO_0000007 (Fertility F-Plasmids)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000007 "Fertility F-plasmids contain tra genes and are capable of conjugation resulting in the expression of sex pilli.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000007 "Fertility F-Plasmids")
SubClassOf(obo:MOBIO_0000007 obo:MOBIO_0000002)
# Class: obo:MOBIO_0000008 (Resistance Plasmids)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000008 "These plasmids contain genes that provide resistance against antibiotics or poisons. Historically known as R-factors, before the nature of plasmids was understood.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000008 "Resistance Plasmids")
SubClassOf(obo:MOBIO_0000008 obo:MOBIO_0000002)
# Class: obo:MOBIO_0000009 (Degradative Plasmids)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000009 "These plasmids enable the digestion of unusual substances, e.g. toluene and salicylic acid.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000009 "Degradative Plasmids")
SubClassOf(obo:MOBIO_0000009 obo:MOBIO_0000002)
# Class: obo:MOBIO_0000010 (Virulence Plasmids)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000010 "which turn the bacterium into a pathogen")
AnnotationAssertion(rdfs:label obo:MOBIO_0000010 "Virulence Plasmids")
SubClassOf(obo:MOBIO_0000010 obo:MOBIO_0000002)
# Class: obo:MOBIO_0000011 (mechanism of plasmid maintenance)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000011 "The set of specific processes that needed for plasmid partition, stability, replication, and mobility. These are all processes that allow for the plasmid to move between organisms.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000011 "mechanism of plasmid maintenance")
SubClassOf(obo:MOBIO_0000011 obo:BFO_0000015)
# Class: obo:MOBIO_0000012 (mechanism of replication)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000012 "Any process or set of processes through which plasmid replication is initiated.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000012 "mechanism of replication")
SubClassOf(obo:MOBIO_0000012 obo:MOBIO_0000011)
# Class: obo:MOBIO_0000013 (theta type)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000013 "Replication by the Theta Mechanism - opening of the strands followed by RNA priming")
AnnotationAssertion(rdfs:label obo:MOBIO_0000013 "theta type")
SubClassOf(obo:MOBIO_0000013 obo:MOBIO_0000012)
# Class: obo:MOBIO_0000014 (strand displacement)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000014 "strand displacement replication. Opening of the strands followed by RNA priming")
AnnotationAssertion(rdfs:label obo:MOBIO_0000014 "strand displacement")
SubClassOf(obo:MOBIO_0000014 obo:MOBIO_0000012)
# Class: obo:MOBIO_0000015 (rolling circle replication)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000015 "A mechanism of plasmid replication in which the two strands are asynchronously copied, with one strand initially forming a single-stranded circle.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000015 "rolling circle replication")
SubClassOf(obo:MOBIO_0000015 obo:MOBIO_0000012)
# Class: obo:MOBIO_0000016 (process or mechanism of genetic mobility)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000016 "Molecular mechanisms involved in the intracellular and intercellular transfer, integration, stabilization and recombination of mobile genetic elements.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000016 "process or mechanism of genetic mobility")
SubClassOf(obo:MOBIO_0000016 obo:BFO_0000015)
# Class: obo:MOBIO_0000017 (conjugative transfer)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000017 "Conjugation is the process by which one bacterium transfers genetic material to another through direct contact. During conjugation, one bacterium serves as the donor of the genetic material, and the other serves as the recipient.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000017 "Conjugation")
AnnotationAssertion(rdfs:label obo:MOBIO_0000017 "conjugative transfer")
SubClassOf(obo:MOBIO_0000017 obo:MOBIO_0000196)
# Class: obo:MOBIO_0000019 (mechanism of stabilization)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000019 "Stabilization mechanisms facilitate and promote the survival of plasmids in their host cells. This includes mechanisms that allow for the survival of the host cell itself in harsh conditions.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000019 "mechanism of stabilization")
SubClassOf(obo:MOBIO_0000019 obo:MOBIO_0000011)
# Class: obo:MOBIO_0000020 (transformation)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000020 "Transformation refers to process of free DNA uptake by competent cells and subsequent integration and functional expression of genes. Extracellular DNA continually enters the environment upon release from decomposing cells, disrupted cells, viral particles or excretion from living cells.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000020 "transformation")
SubClassOf(obo:MOBIO_0000020 obo:MOBIO_0000016)
# Class: obo:MOBIO_0000021 (Toxin-antitoxin system)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000021 "A toxin-antitoxin system is a set of two or more closely linked genes that together encode both a protein 'poison' and a corresponding 'antidote'. When these systems are contained on plasmids – transferable genetic elements – they ensure that only the daughter cells that inherit the plasmid survive after cell division. If the plasmid is absent in a daughter cell, the unstable anti-toxin is degraded and the stable toxic protein kills the new cell; this is known as 'post-segregational killing' (PSK).")
AnnotationAssertion(rdfs:label obo:MOBIO_0000021 "Toxin-antitoxin system")
# Class: obo:MOBIO_0000022 (Type I TA System)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000022 "Type I toxin-antitoxin systems rely on the base-pairing of complementary antitoxin RNA with the toxin's mRNA. Translation of the mRNA is then inhibited either by degradation via RNase III or by occluding the Shine-Dalgarno sequence or ribosome binding site.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000022 "Type I TA System")
SubClassOf(obo:MOBIO_0000022 obo:MOBIO_0000021)
# Class: obo:MOBIO_0000023 (Type II TA System)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000023 "In this system a labile protein antitoxin tightly binds and inhibits the activity of a stable toxin. Type II systems are organised in operons with the antitoxin protein typically being located upstream of the toxin. The antitoxin inhibits the toxin by downregulating its expression.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000023 "Type II TA System")
SubClassOf(obo:MOBIO_0000023 obo:MOBIO_0000021)
# Class: obo:MOBIO_0000024 (Type III TA System)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000024 "Type III toxin-antitoxin systems rely on direct interaction between a toxic protein and an RNA antitoxin. The toxic effects of the protein are neutralised by the RNA gene.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000024 "Type III TA System")
SubClassOf(obo:MOBIO_0000024 obo:MOBIO_0000021)
# Class: obo:MOBIO_0000025 (conjugal transfer subunit or complex)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000025 "The process of conjugation requires several different types of subunits and complexes.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000025 "conjugal transfer subunit or complex")
SubClassOf(obo:MOBIO_0000025 obo:MOBIO_0000185)
# Class: obo:MOBIO_0000026 (pilX7)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18375554") Annotation(oboInOwl:hasDbXref "PMID:19717626") obo:IAO_0000115 obo:MOBIO_0000026 "Protein involved in the conjugal transfer of DNA. First identified in conjugative plasmid R6K of E. coli.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000026 "pilX7")
SubClassOf(obo:MOBIO_0000026 obo:MOBIO_0000025)
# Class: obo:MOBIO_0000027 (pilX8)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18375554") Annotation(oboInOwl:hasDbXref "PMID:19717626") obo:IAO_0000115 obo:MOBIO_0000027 "Protein involved in conjugal transfer of DNA. First identified in conjugative plasmid R6K of E. coli.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000027 "pilX8")
SubClassOf(obo:MOBIO_0000027 obo:MOBIO_0000025)
# Class: obo:MOBIO_0000028 (colicin immunity protein)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000028 "Colicin immunity proteins are plasmid encoded proteins necessary for protecting the cell against colicins. Colicins are toxins released by bacteria during times of stress")
AnnotationAssertion(rdfs:label obo:MOBIO_0000028 "colicin immunity protein")
SubClassOf(obo:MOBIO_0000028 obo:MOBIO_0000188)
SubClassOf(obo:MOBIO_0000028 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000006))
# Class: obo:MOBIO_0000029 (pilX9)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18375554") Annotation(oboInOwl:hasDbXref "PMID:19717626") obo:IAO_0000115 obo:MOBIO_0000029 "Protein involved in conjugal transfer of DNA. First identified in conjugative plasmid R6K of E. coli.
")
AnnotationAssertion(rdfs:label obo:MOBIO_0000029 "pilX9")
SubClassOf(obo:MOBIO_0000029 obo:MOBIO_0000025)
# Class: obo:MOBIO_0000030 (pilX10)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18375554") Annotation(oboInOwl:hasDbXref "PMID:19717626") obo:IAO_0000115 obo:MOBIO_0000030 "Protein involved in conjugal transfer of DNA. First identified in conjugative plasmid R6K of E. coli. It is homologous to type IV secretory pathway VirB10 protein")
AnnotationAssertion(rdfs:label obo:MOBIO_0000030 "pilX10")
SubClassOf(obo:MOBIO_0000030 obo:MOBIO_0000025)
# Class: obo:MOBIO_0000031 (pilX11)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18375554") Annotation(oboInOwl:hasDbXref "PMID:19717626") obo:IAO_0000115 obo:MOBIO_0000031 "Protein involved in conjugal transfer of DNA. First identified in conjugative plasmid R6K of E. coli. It is homologous to P-type DNA transfer ATPase VirB11.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000031 "pilX11")
SubClassOf(obo:MOBIO_0000031 obo:MOBIO_0000025)
# Class: obo:MOBIO_0000032 (taxB)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18375554") obo:IAO_0000115 obo:MOBIO_0000032 "conjugal transfer protein - conjugal transfer protein TraG")
AnnotationAssertion(rdfs:label obo:MOBIO_0000032 "taxB")
SubClassOf(obo:MOBIO_0000032 obo:MOBIO_0000181)
# Class: obo:MOBIO_0000033 (RelE)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:12526800") Annotation(oboInOwl:hasDbXref "PMID:15576765") Annotation(oboInOwl:hasDbXref "PMID:18375554") Annotation(oboInOwl:hasDbXref "PMID:21324908") Annotation(oboInOwl:hasDbXref "PMID:22210768") Annotation(oboInOwl:hasDbXref "PMID:9767574") obo:IAO_0000115 obo:MOBIO_0000033 "Toxic component of a type II toxin-antitoxin (TA) module. A sequence-specific, ribosome-dependent mRNA endoribonuclease that inhibits translation during amino acid starvation (the stringent response). In vitro acts by cleaving mRNA with high codon specificity in the ribosomal A site between positions 2 and 3. The stop codon UAG is cleaved at a fast rate while UAA and UGA are cleaved with intermediate and slow rates. In vitro mRNA cleavage can also occur in the ribosomal E site after peptide release from peptidyl-tRNA in the P site as well as on free 30S subunits. In vivo cuts frequently in the first 100 codons, most frequently after the second and third base and rarely near the stop codon. Overexpression of RelE results in the inhibition of bacterial growth and a sharp decrease in colony-forming ability which is neutralized by the labile cognate antitoxin RelB. Overexpression also sharply increases persisters (cells that neither grow nor die in the presence of bactericidal agents and are largely responsible for high levels of biofilm tolerance to antimicrobials). Plays a role in dormancy when expressed in high-density cells in the absence of antitoxin RelB; amino acid starvation and an unidentified extracellular factor promote dormancy, while expression of antitoxin RelB restores cell culturability. Acts with RelB as a corepressor of relBE transcription, considerably increasing the repression of RelB alone. 2 RelB dimers bind to 2 operator sequences; DNA-binding and repression is stronger when complexed with toxin/corepressor RelE by conditional cooperativity.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000033 "RelE")
SubClassOf(obo:MOBIO_0000033 obo:MOBIO_0000051)
SubClassOf(obo:MOBIO_0000033 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000123))
# Class: obo:MOBIO_0000034 (DNA topoisomerase)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000034 "Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. They bind to double-stranded DNA and cut the phosphate backbone of either one or both the DNA strands. ")
AnnotationAssertion(rdfs:label obo:MOBIO_0000034 "DNA topoisomerase")
SubClassOf(obo:MOBIO_0000034 obo:MOBIO_0000187)
SubClassOf(obo:MOBIO_0000034 ObjectSomeValuesFrom(obo:RO_0000056 obo:MOBIO_0000013))
SubClassOf(obo:MOBIO_0000034 ObjectSomeValuesFrom(obo:RO_0000056 obo:MOBIO_0000014))
SubClassOf(obo:MOBIO_0000034 ObjectSomeValuesFrom(obo:RO_0000056 obo:MOBIO_0000015))
# Class: obo:MOBIO_0000035 (traE)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18375554") obo:IAO_0000115 obo:MOBIO_0000035 "The traE gene, first identified in plasmid RP4, is a homologue of E. coli DNA topoisomerase III.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000035 "traE")
SubClassOf(obo:MOBIO_0000035 obo:MOBIO_0000034)
# Class: obo:MOBIO_0000036 (Molecular Chaperone)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000036 "Molecular chaperones are proteins that assist the covalent folding or unfolding and the assembly or disassembly of other macromolecular structures. Chaperones are present when the macromolecules perform their normal biological functions and have correctly completed the processes of folding and/or assembly. The chaperones are concerned primarily with protein folding. One major function of chaperones is to prevent both newly synthesized polypeptide chains and assembled subunits from aggregating into nonfunctional structures. Many chaperones are heat shock proteins because the tendency to aggregate increases as proteins are denatured by stress.
Molecular chaperones have been shown to be involved in both the assembly and disassembly of DNA replication complexes.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000036 "Molecular Chaperone")
SubClassOf(obo:MOBIO_0000036 obo:MOBIO_0000187)
SubClassOf(obo:MOBIO_0000036 ObjectSomeValuesFrom(obo:RO_0000056 obo:MOBIO_0000015))
# Class: obo:MOBIO_0000037 (DnaJ)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18375554") obo:IAO_0000115 obo:MOBIO_0000037 "Chaperone DnaJ, also known as Hsp40 (heat shock protein 40 kD), is a molecular chaperone protein. The J domain of DnaJ interacts with Hsp70 heat shock proteins. DnaJ heat-shock proteins play a role in regulating the ATPase activity of Hsp70 heat-shock proteins.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000037 "Hsp40")
AnnotationAssertion(rdfs:label obo:MOBIO_0000037 "DnaJ")
SubClassOf(obo:MOBIO_0000037 obo:MOBIO_0000036)
# Class: obo:MOBIO_0000038 (transposase)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000038 "Class 2 transposons encode transposase, which is an enzyme that binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism.
")
AnnotationAssertion(rdfs:label obo:MOBIO_0000038 "transposase")
SubClassOf(obo:MOBIO_0000038 obo:MOBIO_0000190)
SubClassOf(obo:MOBIO_0000038 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000003))
# Class: obo:MOBIO_0000039 (replication initiation protein RepC)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000039 "This protein is a specific topoisomerase involved in initiating replication. This protein is specifically required and may be rate-limiting for replication of the plasmid in vivo.
")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000039 "repC")
AnnotationAssertion(rdfs:label obo:MOBIO_0000039 "replication initiation protein RepC")
SubClassOf(obo:MOBIO_0000039 obo:MOBIO_0000046)
# Class: obo:MOBIO_0000040 (Chromate transport protein)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000040 "These proteins reduce chromate accumulation and are essential for chromate resistance. They are composed of one or two copies of this region. The short-chain CHR proteins form heterodimer transporters which efflux chromate ions from the cytoplasm, while the long chain CHR proteins appear to have arisen from a gene fusion event of two short chain transporters")
AnnotationAssertion(rdfs:label obo:MOBIO_0000040 "Chromate transport protein")
SubClassOf(obo:MOBIO_0000040 obo:MOBIO_0000188)
# Class: obo:MOBIO_0000041 (Dihydrofolate reductase)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000041 "Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000041 "DfrA")
AnnotationAssertion(rdfs:label obo:MOBIO_0000041 "Dihydrofolate reductase")
SubClassOf(obo:MOBIO_0000041 obo:MOBIO_0000187)
SubClassOf(obo:MOBIO_0000041 ObjectSomeValuesFrom(obo:RO_0000056 obo:MOBIO_0000013))
SubClassOf(obo:MOBIO_0000041 ObjectSomeValuesFrom(obo:RO_0000056 obo:MOBIO_0000014))
SubClassOf(obo:MOBIO_0000041 ObjectSomeValuesFrom(obo:RO_0000056 obo:MOBIO_0000015))
# Class: obo:MOBIO_0000042 (Class 1 Integrase)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18193080") Annotation(oboInOwl:hasDbXref "PMID:8574395") obo:IAO_0000115 obo:MOBIO_0000042 "Class 1 Integrase is a site-specific recombination enzyme that is part of the class 1 integron system. It recognizes the recombination site, attI1, which is where it will catalyze the insertion of gene casettes.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000042 "Intl1")
AnnotationAssertion(rdfs:label obo:MOBIO_0000042 "Class 1 Integrase")
SubClassOf(obo:MOBIO_0000042 obo:MOBIO_0000104)
SubClassOf(obo:MOBIO_0000042 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000043))
# Class: obo:MOBIO_0000043 (integron)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000043 "Integrons are genetic mechanisms that allow bacteria to adapt and evolve rapidly through the acquisition, stockpiling and differential expression of new genes. Additionally, an integron will usually contain one or more gene cassettes that have been incorporated into it.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000043 "integron")
SubClassOf(obo:MOBIO_0000043 obo:MOBIO_0000001)
SubClassOf(obo:MOBIO_0000043 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000002))
SubClassOf(obo:MOBIO_0000043 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000003))
# Class: obo:MOBIO_0000044 (PadR family transcriptional regulator)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000044 "DNA-binding transcriptional regulator. Protein that is involved in negative regulation of phenolic acid metabolism.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000044 "PadR family transcriptional regulator")
SubClassOf(obo:MOBIO_0000044 obo:MOBIO_0000045)
# Class: obo:MOBIO_0000045 (transcriptional regulator of operons found in MGEs)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000045 "transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000045 "transcriptional regulator of operons found in MGEs")
SubClassOf(obo:MOBIO_0000045 obo:MOBIO_0000190)
# Class: obo:MOBIO_0000046 (replication initiation protein)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000046 "protein required for initiation of replication")
AnnotationAssertion(rdfs:label obo:MOBIO_0000046 "replication initiation protein")
SubClassOf(obo:MOBIO_0000046 obo:MOBIO_0000187)
SubClassOf(obo:MOBIO_0000046 ObjectSomeValuesFrom(obo:RO_0000056 obo:MOBIO_0000013))
SubClassOf(obo:MOBIO_0000046 ObjectSomeValuesFrom(obo:RO_0000056 obo:MOBIO_0000014))
SubClassOf(obo:MOBIO_0000046 ObjectSomeValuesFrom(obo:RO_0000056 obo:MOBIO_0000015))
# Class: obo:MOBIO_0000047 (replication initiation protein RepA)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000047 "This protein is essential for plasmid replication; it is involved in copy control functions")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000047 "RepA")
AnnotationAssertion(rdfs:label obo:MOBIO_0000047 "replication initiation protein RepA")
SubClassOf(obo:MOBIO_0000047 obo:MOBIO_0000046)
# Class: obo:MOBIO_0000048 (Major pili subunit operon regulatory protein papB)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000048 "papB may act as both positive and negative regulator of the pyelonephritis-associated pili (pap) pilin gene transcription. It is found in the pap operon.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000048 "Major pili subunit operon regulatory protein papB")
SubClassOf(obo:MOBIO_0000048 obo:MOBIO_0000025)
SubClassOf(obo:MOBIO_0000048 ObjectSomeValuesFrom(obo:RO_0000056 obo:MOBIO_0000017))
# Class: obo:MOBIO_0000049 (Type II post-segregation antitoxin)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000049 "Type II systems are organised in operons with the antitoxin protein typically being located upstream of the toxin. The antitoxin inhibits the toxin by downregulating its expression. ")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000049 "antitoxin")
AnnotationAssertion(rdfs:label obo:MOBIO_0000049 "Type II post-segregation antitoxin")
SubClassOf(obo:MOBIO_0000049 obo:MOBIO_0000191)
SubClassOf(obo:MOBIO_0000049 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000023))
# Class: obo:MOBIO_0000050 (C protein)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000050 "transcriptional regulator")
AnnotationAssertion(rdfs:label obo:MOBIO_0000050 "C protein")
SubClassOf(obo:MOBIO_0000050 obo:MOBIO_0000045)
# Class: obo:MOBIO_0000051 (Type II toxin)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000051 "Type II systems are organised in operons with the antitoxin protein typically being located upstream of the toxin. The antitoxin inhibits the toxin by downregulating its expression. ")
AnnotationAssertion(rdfs:label obo:MOBIO_0000051 "Type II toxin")
SubClassOf(obo:MOBIO_0000051 obo:MOBIO_0000191)
SubClassOf(obo:MOBIO_0000051 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000023))
# Class: obo:MOBIO_0000052 (CcdA)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:27357537") obo:IAO_0000115 obo:MOBIO_0000052 "Antitoxin component of a toxin-antitoxin (TA) module which inhibits the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Labile antitoxin with a half-life of about 1 hour in the presence of CcdB. Binds to and blocks the activity of CcdB; will also remove bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation. The N-terminal 36 residues are not required for rejuventation. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdB.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000052 "CcdA")
SubClassOf(obo:MOBIO_0000052 obo:MOBIO_0000049)
SubClassOf(obo:MOBIO_0000052 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000079))
# Class: obo:MOBIO_0000053 (CcdB)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000053 "Toxic component of a toxin-antitoxin (TA) module, functioning in plasmid maintainence. Responsible for the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Half-life of over 2 hours. Cell killing by CcdB is accompanied by filamentation, defects in chromosome and plasmid segregation, defects in cell division, formation of anucleate cells, decreased DNA synthesis and plasmid loss. Interferes with the activity of DNA gyrase, inducing it to form a covalent GyrA-DNA complex that cannot be resolved, thus promoting breakage of plasmid and chromosomal DNA. DNA breakage requires hydrolyzable ATP. Toxicity is inhibited by labile antitoxin CcdA, which blocks the activity of CcdB; CcdA also removes bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation. Also acts to inhibit partitioning of the chromosomal DNA. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdA.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000053 "CcdB")
SubClassOf(obo:MOBIO_0000053 obo:MOBIO_0000051)
SubClassOf(obo:MOBIO_0000053 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000079))
# Class: obo:MOBIO_0000054 (replication initiation protein RepE)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000054 "Replication initiator in the monomeric form, and autogenous repressor in the dimeric form.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000054 "RepE")
AnnotationAssertion(rdfs:label obo:MOBIO_0000054 "replication initiation protein RepE")
SubClassOf(obo:MOBIO_0000054 obo:MOBIO_0000046)
# Class: obo:MOBIO_0000055 (plasmid partition system)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000055 "A plasmid partition system is the mechanism that assures the stable transmission of plasmids during bacterial cell division. Each plasmid has its independent replication system which control the number of copy of a plasmid in a cell.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000055 "plasmid partition system")
SubClassOf(obo:MOBIO_0000055 obo:MOBIO_0000011)
# Class: obo:MOBIO_0000056 (Type I Partition System)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000056 "This system is also used by most bacteria for chromosome segregation. Type I partition system are composed of an ATPase which contains Walker motifs and a CBP which is structurally distinct in type Ia and Ib. ATPases and CBP from type Ia are longer than the one from type Ib, but both CBPs contain an arginine finger in their N-terminal part. ParA proteins from different plasmids and bacterial species show 25 to 30% of sequence identity to the protein ParA of the plasmid P1. The partition of type I system uses a \"diffusion-ratchet\" mechanism. ")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000056 "Type 1 Partition System")
AnnotationAssertion(rdfs:label obo:MOBIO_0000056 "Type I Partition System")
SubClassOf(obo:MOBIO_0000056 obo:MOBIO_0000055)
# Class: obo:MOBIO_0000057 (Type Ia Partition System)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000057 "def")
AnnotationAssertion(rdfs:label obo:MOBIO_0000057 "Type Ia Partition System")
SubClassOf(obo:MOBIO_0000057 obo:MOBIO_0000056)
# Class: obo:MOBIO_0000058 (Type Ib partition system)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000058 "partition system")
AnnotationAssertion(rdfs:label obo:MOBIO_0000058 "Type Ib partition system")
# Class: obo:MOBIO_0000059 (Type II Partition System)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000059 "This system is composed of an actin-like ATPase, ParM, and a CBP called ParR. The centromere-like site, parC contains two sets of five 11 base pair direct repeats separated by the parMR promoter. The amino-acid sequence identity can go down to 15% between ParM and other actin-like ATPase.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000059 "Type II Partition System")
SubClassOf(obo:MOBIO_0000059 obo:MOBIO_0000055)
# Class: obo:MOBIO_0000060 (Type III Partition System)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000060 "This mechanism is composed of tubulin-like GTPase termed TubZ, and the CBP is termed TubR. Amino-acid sequence identity can go down to 21% for TubZ proteins")
AnnotationAssertion(rdfs:label obo:MOBIO_0000060 "Type III Partition System")
SubClassOf(obo:MOBIO_0000060 obo:MOBIO_0000055)
# Class: obo:MOBIO_0000061 (R388 Partition System)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000061 "The partition system of the plasmid R388 has been found within the stb operon. This operon is composed of three genes, stbA, stbB and stbC")
AnnotationAssertion(rdfs:label obo:MOBIO_0000061 "R388 Partition System")
SubClassOf(obo:MOBIO_0000061 obo:MOBIO_0000055)
# Class: obo:MOBIO_0000062 (pSK1 partition system)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000062 "pSK1 is plasmid from Staphylococcus aureus. This plasmid has a partition system determined by a single gene, par, previously known as orf245. This gene has effect neither on the plasmid copy number nor on the growth rate (excluding its implication in a post-segregational killing system). A centromere-like binding sequence is present upstream the par gene, and is composed of seven direct repeats and one inverted repeat.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000062 "pSK1 partition system")
SubClassOf(obo:MOBIO_0000062 obo:MOBIO_0000055)
# Class: obo:MOBIO_0000063 (ParA)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000063 "Partitioning protein - ATPase")
AnnotationAssertion(rdfs:label obo:MOBIO_0000063 "ParA")
SubClassOf(obo:MOBIO_0000063 obo:MOBIO_0000186)
SubClassOf(obo:MOBIO_0000063 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000058))
# Class: obo:MOBIO_0000064 (pifA)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:7883717") obo:IAO_0000115 obo:MOBIO_0000064 "PifA is encoded on plasmid F and is responsible for the exclusion of phage T7. E. coli cells that carry plasmid F inhibit the growth of bacteriophage T7. ")
AnnotationAssertion(rdfs:label obo:MOBIO_0000064 "pifA")
SubClassOf(obo:MOBIO_0000064 obo:MOBIO_0000193)
# Class: obo:MOBIO_0000065 (replication initiation protein RepB)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18375554") obo:IAO_0000115 obo:MOBIO_0000065 "Is essential for plasmid replication. Nicks the positive strand at the plus origin of replication.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000065 "Pi protein")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000065 "RepB")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000065 "pir")
AnnotationAssertion(rdfs:label obo:MOBIO_0000065 "replication initiation protein RepB")
SubClassOf(obo:MOBIO_0000065 obo:MOBIO_0000046)
# Class: obo:MOBIO_0000066 (replication regulatory protein)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000066 "regulates replication")
AnnotationAssertion(rdfs:label obo:MOBIO_0000066 "replication regulatory protein")
SubClassOf(obo:MOBIO_0000066 obo:MOBIO_0000187)
# Class: obo:MOBIO_0000067 (repA2)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000067 "This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein RepA.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000067 "repA2")
SubClassOf(obo:MOBIO_0000067 obo:MOBIO_0000066)
# Class: obo:MOBIO_0000068 (SopA)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") Annotation(oboInOwl:hasDbXref "PMID:2670941") obo:IAO_0000115 obo:MOBIO_0000068 "This protein is essential for plasmid partition. It ensures the proper distribution of newly replicated plasmids to daughter cells during cell division. SopA is trans-acting and binds to a sequence in the sopAB operon, thus regulating the expression of the operon. ")
AnnotationAssertion(rdfs:label obo:MOBIO_0000068 "SopA")
SubClassOf(obo:MOBIO_0000068 obo:MOBIO_0000186)
SubClassOf(obo:MOBIO_0000068 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000058))
# Class: obo:MOBIO_0000069 (SopB)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") Annotation(oboInOwl:hasDbXref "PMID:2670941") obo:IAO_0000115 obo:MOBIO_0000069 "SopB is involved in the control of plasmid partitioning. It is trans-acting and binds specifically with the DNA segment containing the sopC region. The presence of SopB in the SopAB complex enhances SopA binding to the target DNA sequence.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000069 "SopB")
SubClassOf(obo:MOBIO_0000069 obo:MOBIO_0000186)
SubClassOf(obo:MOBIO_0000069 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000058))
# Class: obo:MOBIO_0000070 (antirestriction protein KlcA)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20007596") obo:IAO_0000115 obo:MOBIO_0000070 "Bacterial cells often contain type I DNA and restriction modification (RM) systems that degrade foreign DNA during bacterial conjugation. KlcA could be involved in inhibiting the RM systems and enhancing the success of conjugation.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000070 "antirestriction protein KlcA")
SubClassOf(obo:MOBIO_0000070 obo:MOBIO_0000025)
# Class: obo:MOBIO_0000071 (group II intron reverse transcriptase/maturase)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000071 "Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain followed by an RNA-binding maturase domain. These proteins play a role in site-specific DNA insertion.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000071 "group II intron reverse transcriptase/maturase")
SubClassOf(obo:MOBIO_0000071 obo:MOBIO_0000190)
# Class: obo:MOBIO_0000072 (hydrolase)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000072 "An enzyme that catalyzes the hydrolysis of a particular substrate. Many hydrolases participate in the inactivation of antibiotics.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000072 "hydrolase")
SubClassOf(obo:MOBIO_0000072 obo:MOBIO_0000188)
# Class: obo:MOBIO_0000073 (single stranded DNA binding protein)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000073 "Single-strand DNA-binding protein (SSB) binds to single-stranded regions of deoxyribonucleic acid (DNA). Single-stranded DNA is produced during all aspects of DNA metabolism: replication, recombination, and repair.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000073 "single stranded DNA binding protein")
SubClassOf(obo:MOBIO_0000073 obo:MOBIO_0000187)
# Class: obo:MOBIO_0000074 (PsiB)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:19818715") Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000074 "The PsiB protein inhibits the functional activity of RecA by binding to it. By doing so, this prevents RecA by catalyzing the autocleavage of LexA, which triggers the SOS response. ")
AnnotationAssertion(rdfs:label obo:MOBIO_0000074 "PsiB")
SubClassOf(obo:MOBIO_0000074 obo:MOBIO_0000195)
# Class: obo:MOBIO_0000075 (PsiA)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:2201950") Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000075 "PsiA is a protein encoded in the Psi region, which also encodes the PsiB protein. PsiA and PsiB are most likely transcribed in a polycistronic manner. The role of PsiA has not been identified, however it does not seem to influence SOS inhibition mediated by PsiB.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000075 "PsiA")
SubClassOf(obo:MOBIO_0000075 obo:MOBIO_0000195)
# Class: obo:MOBIO_0000076 (Plasmid SOS inhibition)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000076 "The process of bacterial conjugation involves the transfer of a conjugative plasmid as a single strand. The potentially deleterious SOS response, which is normally triggered by the appearance of single-stranded DNA, is suppressed in the recipient cell by a complex involving the PsiB protein. This complex inhibits the activity of RecA, preventing RecA from catalyzing the auto-cleavage of LexA, which activates the SOS response. SOS inhibition allows for the successful transfer of plasmid genetic information between bacterial cells through conjugation.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000076 "Plasmid SOS inhibition")
SubClassOf(obo:MOBIO_0000076 obo:MOBIO_0000019)
SubClassOf(obo:MOBIO_0000076 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000017))
# Class: obo:MOBIO_0000077 (Type I Toxin)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000077 "toxin")
AnnotationAssertion(rdfs:label obo:MOBIO_0000077 "Type I Toxin")
SubClassOf(obo:MOBIO_0000077 obo:MOBIO_0000191)
SubClassOf(obo:MOBIO_0000077 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000022))
# Class: obo:MOBIO_0000078 (Type I Antitoxin)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000078 "Type I antitoxins are RNA molecules that are complementary to the toxin mRNA, thus binding to the toxin and inhibiting its translation.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000078 "Type I Antitoxin")
SubClassOf(obo:MOBIO_0000078 obo:MOBIO_0000191)
SubClassOf(obo:MOBIO_0000078 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000022))
# Class: obo:MOBIO_0000079 (CcdA/CcdB Type II Toxin-antitoxin system)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000079 "The CcdA/CCdB Type II Toxin-antitoxin system is one example of the bacterial toxin-antitoxin (TA) systems that encode two proteins, one a potent inhibitor of cell proliferation (toxin) and the other its specific antidote (antitoxin). These systems preferentially guarantee growth of plasmid-carrying daughter cells in a bacterial population by killing newborn bacteria that have not inherited a plasmid copy at cell division (post-segregational killing).")
AnnotationAssertion(rdfs:label obo:MOBIO_0000079 "CcdA/CcdB Type II Toxin-antitoxin system")
SubClassOf(obo:MOBIO_0000079 obo:MOBIO_0000023)
# Class: obo:MOBIO_0000080 (Hok/sok system)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000080 "The hok/sok system is a postsegregational killing mechanism employed by the R1 plasmid in Escherichia coli to maintain a low copy number.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000080 "Hok/sok system")
SubClassOf(obo:MOBIO_0000080 obo:MOBIO_0000022)
# Class: obo:MOBIO_0000081 (Hok)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000081 "host killing - a long lived (half-life 20 minutes) toxin")
AnnotationAssertion(rdfs:label obo:MOBIO_0000081 "Hok")
SubClassOf(obo:MOBIO_0000081 obo:MOBIO_0000077)
SubClassOf(obo:MOBIO_0000081 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000080))
# Class: obo:MOBIO_0000082 (Mok)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000082 "The mok reading frame in the hok/sok locus overlaps with the hok reading frame and is needed for the transcription of the hok gene.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000082 "Mok")
SubClassOf(obo:MOBIO_0000082 obo:MOBIO_0000191)
SubClassOf(obo:MOBIO_0000082 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000080))
# Class: obo:MOBIO_0000083 (TraM)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000083 "Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site. Cooperatively binds 3 regions in the F plasmid oriT locus; 2 are required for autoregulation while the other is required for plasmid transfer. Bends oriT DNA less than 50 degrees. Plasmid specificity is conferred by the TraD-TraM pair.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000083 "TraM")
SubClassOf(obo:MOBIO_0000083 obo:MOBIO_0000182)
# Class: obo:MOBIO_0000084 (TraJ)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000084 "TraJ is a conjugal transfer transcriptional regulator.It recruits the relaxasome complex to the oriT site")
AnnotationAssertion(rdfs:label obo:MOBIO_0000084 "TraJ")
SubClassOf(obo:MOBIO_0000084 obo:MOBIO_0000182)
# Class: obo:MOBIO_0000085 (TraY)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000085 "TraY is a subunit of the relaxosome. It facilitates the binding of the relaxase to the oriT, and enhances cleaving activity.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000085 "TraY")
SubClassOf(obo:MOBIO_0000085 obo:MOBIO_0000182)
# Class: obo:MOBIO_0000086 (TraA)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000086 "The traA gene codes for relaxase, which is an enzyme that initiates plasmid DNA transfer during bacterial conjugation. Relaxase forms a relaxosome complex with auxiliary proteins to initiate conjugation. Relaxosome binds to the origin of transfer (oriT) sequence and cleaves the DNA strand that will be transferred (the T strand).")
AnnotationAssertion(rdfs:label obo:MOBIO_0000086 "TraA")
SubClassOf(obo:MOBIO_0000086 obo:MOBIO_0000120)
# Class: obo:MOBIO_0000087 (TraL)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000087 "Membrane protein involved in F pilin formation")
AnnotationAssertion(rdfs:label obo:MOBIO_0000087 "TraL")
SubClassOf(obo:MOBIO_0000087 obo:MOBIO_0000183)
# Class: obo:MOBIO_0000088 (traK)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000088 "conjugal transfer protein")
AnnotationAssertion(rdfs:label obo:MOBIO_0000088 "traK")
SubClassOf(obo:MOBIO_0000088 obo:MOBIO_0000025)
# Class: obo:MOBIO_0000089 (TraB)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000089 "conjugal transfer protein")
AnnotationAssertion(rdfs:label obo:MOBIO_0000089 "TraB")
SubClassOf(obo:MOBIO_0000089 obo:MOBIO_0000025)
# Class: obo:MOBIO_0000090 (resolvase)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000090 "A family of nucleases involved in resolution during DNA recombination. Resolvase enzymes resolve DNA intermediates known as junctions. Some resolvases have also been identified as repressors of transposase enzymes.")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000090 "recombinase")
AnnotationAssertion(rdfs:label obo:MOBIO_0000090 "resolvase")
SubClassOf(obo:MOBIO_0000090 obo:MOBIO_0000190)
SubClassOf(obo:MOBIO_0000090 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000003))
# Class: obo:MOBIO_0000091 (ResD)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000091 "resolvase")
AnnotationAssertion(rdfs:label obo:MOBIO_0000091 "ResD")
SubClassOf(obo:MOBIO_0000091 obo:MOBIO_0000090)
# Class: obo:MOBIO_0000092 (helicase)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000092 "A helicase is an enzyme that participates in separating the strands of a nucleic acid duplex, which is required for processes such as DNA replication, transcription, recombination, and repair.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000092 "helicase")
SubClassOf(obo:MOBIO_0000092 obo:MOBIO_0000187)
# Class: obo:MOBIO_0000093 (UvrD)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:17190599") obo:IAO_0000115 obo:MOBIO_0000093 "UvrD is a helicase that participates in nucleotide excision repair and other DNA repair and replication processes.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000093 "UvrD")
SubClassOf(obo:MOBIO_0000093 obo:MOBIO_0000092)
# Class: obo:MOBIO_0000094 (IS1 InsA)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000094 "tranposase - Family IS1")
AnnotationAssertion(rdfs:label obo:MOBIO_0000094 "IS1 InsA")
SubClassOf(obo:MOBIO_0000094 obo:MOBIO_0000038)
# Class: obo:MOBIO_0000095 (IS1 InsB)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000095 "tranposase - family IS1
")
AnnotationAssertion(rdfs:label obo:MOBIO_0000095 "IS1 InsB")
SubClassOf(obo:MOBIO_0000095 obo:MOBIO_0000038)
# Class: obo:MOBIO_0000096 (DNA resolvase)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000096 "DNA resolvase")
AnnotationAssertion(rdfs:label obo:MOBIO_0000096 "DNA resolvase")
SubClassOf(obo:MOBIO_0000096 obo:MOBIO_0000090)
# Class: obo:MOBIO_0000097 (PemI)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:17416361") Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000097 "Antitoxin component of a type II toxin-antitoxin (TA) module. Labile antitoxin that binds to its cognate PemK endoribonuclease toxin and neutralizes its activity. Responsible for the stable maintenance of the plasmid during cell division. Both PemI and PemK proteins bind to the promoter region of the pem operon to autoregulate their synthesis.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000097 "PemI")
SubClassOf(obo:MOBIO_0000097 obo:MOBIO_0000049)
SubClassOf(obo:MOBIO_0000097 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000124))
# Class: obo:MOBIO_0000098 (PemK)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:17416361") Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000098 "Toxic component of a type II toxin-antitoxin (TA) module. Probably functions as an endoribonuclease. Responsible for the stable maintenance of the plasmid during cell division by postsegregational killing of plasmid-less daughter cells. Neutralized by coexpression with cognate antitoxin PemI. Both PemI and PemK proteins bind to the promoter region of the pem operon to autoregulate their synthesis.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000098 "PemK")
SubClassOf(obo:MOBIO_0000098 obo:MOBIO_0000051)
SubClassOf(obo:MOBIO_0000098 ObjectSomeValuesFrom(obo:BFO_0000050 obo:MOBIO_0000124))
# Class: obo:MOBIO_0000099 (RepA4)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000099 "Associated with replication initiation.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000099 "RepA4")
SubClassOf(obo:MOBIO_0000099 obo:MOBIO_0000046)
# Class: obo:MOBIO_0000100 (ArgR family transcriptional regulator)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000100 "Arginine repressor")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:MOBIO_0000100 "ArgR")
AnnotationAssertion(rdfs:label obo:MOBIO_0000100 "ArgR family transcriptional regulator")
SubClassOf(obo:MOBIO_0000100 obo:MOBIO_0000045)
# Class: obo:MOBIO_0000101 (TraI)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:26899414") obo:IAO_0000115 obo:MOBIO_0000101 "TraI codes for a relaxase of F plasmids, which cleaves the DNA in the initiationof plasmid conjugation. It has also been identified as DNA helicase I. DNA helicase I is a potent, highly processive DNA-dependent ATPase, able to unwind about 1.1 kb dsDNA per second in a 5' to 3' manner. TraI forms a covalent 5'-phosphotyrosine intermediate linkage to the ssDNA. The transesterified T-strand moves from the donor cell to the recipient cell in a 5'to 3' direction, with the DNA helicase activity of TraI unwinding the DNA")
AnnotationAssertion(rdfs:label obo:MOBIO_0000101 "TraI")
SubClassOf(obo:MOBIO_0000101 obo:MOBIO_0000120)
# Class: obo:MOBIO_0000102 (TraX)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25753630") obo:IAO_0000115 obo:MOBIO_0000102 "conjugal transfer protein - pilus acetylase")
AnnotationAssertion(rdfs:label obo:MOBIO_0000102 "TraX")
SubClassOf(obo:MOBIO_0000102 obo:MOBIO_0000025)
# Class: obo:MOBIO_0000103 (MarR famiy transcriptional regulator)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000103 "Members of the Multiple Antibiotic Resistance Regulator (MarR) family. MarR regulates an operon that encodes a drug efflux pump, and mutations in proteins that partcipate in this system lead to a multiple antibiotic resistance phenotype. MarR proteins are members of the winged helix-turn-helix family of transcription factors. Some MarR homologs activate transcription, while most repress gene activity.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000103 "MarR famiy transcriptional regulator")
SubClassOf(obo:MOBIO_0000103 obo:MOBIO_0000045)
# Class: obo:MOBIO_0000104 (recombinase)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000104 "Recombinases are genetic recombination enzymes. DNA recombinases are widely used in multicellular organisms to manipulate the structure of genomes, and to control gene expression.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000104 "recombinase")
SubClassOf(obo:MOBIO_0000104 obo:MOBIO_0000190)
# Class: obo:MOBIO_0000105 (Sin)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:11994145") obo:IAO_0000115 obo:MOBIO_0000105 "Serine recombinases can rearrange DNA sequences with topological selectivity.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000105 "Sin")
SubClassOf(obo:MOBIO_0000105 obo:MOBIO_0000104)
# Class: obo:MOBIO_0000106 (bin)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000106 "resolvase/integrase
a nuclease which is involved in DNA recombination.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000106 "bin")
SubClassOf(obo:MOBIO_0000106 obo:MOBIO_0000090)
# Class: obo:MOBIO_0000108 (AbiK)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000108 "A reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000108 "AbiK")
SubClassOf(obo:MOBIO_0000108 obo:MOBIO_0000193)
# Class: obo:MOBIO_0000109 (ArsR family transcriptional regulator)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000109 "functions as a transcriptional repressor of an arsenic resistance operon")
AnnotationAssertion(rdfs:label obo:MOBIO_0000109 "ArsR family transcriptional regulator")
SubClassOf(obo:MOBIO_0000109 obo:MOBIO_0000045)
# Class: obo:MOBIO_0000110 (transposon DNA invertase)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000110 "Enzyme that repress transposases")
AnnotationAssertion(rdfs:label obo:MOBIO_0000110 "transposon DNA invertase")
SubClassOf(obo:MOBIO_0000110 obo:MOBIO_0000090)
# Class: obo:MOBIO_0000111 (IS6 family transposase)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000111 "The transposase produces nicks at the donor and the recipient sites. The 3' end of the transposon is ligated to the 5' end of the target sequence. The transposon is duplicated after DNA replication.")
AnnotationAssertion(rdfs:label obo:MOBIO_0000111 "IS6 family transposase")
SubClassOf(obo:MOBIO_0000111 obo:MOBIO_0000038)
# Class: obo:MOBIO_0000112 (transposon Tn552 resolvase)
AnnotationAssertion(obo:IAO_0000115 obo:MOBIO_0000112 "Resolvase catalyzes the resolution (a site-specific recombination) of the cointegrated replicon to yield the final transposition products")
AnnotationAssertion(rdfs:label obo:MOBIO_0000112 "transposon Tn552 resolvase")