diff --git a/pkg/dependency/parser/python/pip/parse.go b/pkg/dependency/parser/python/pip/parse.go
index a849eb0cbea2..0d9e040f952b 100644
--- a/pkg/dependency/parser/python/pip/parse.go
+++ b/pkg/dependency/parser/python/pip/parse.go
@@ -10,7 +10,9 @@ import (
 	"golang.org/x/text/transform"
 	"golang.org/x/xerrors"
 
+	version "github.com/aquasecurity/go-pep440-version"
 	ftypes "github.com/aquasecurity/trivy/pkg/fanal/types"
+	"github.com/aquasecurity/trivy/pkg/log"
 	xio "github.com/aquasecurity/trivy/pkg/x/io"
 )
 
@@ -22,10 +24,14 @@ const (
 	endExtras     string = "]"
 )
 
-type Parser struct{}
+type Parser struct {
+	logger *log.Logger
+}
 
 func NewParser() *Parser {
-	return &Parser{}
+	return &Parser{
+		logger: log.WithPrefix("pip"),
+	}
 }
 
 func (p *Parser) Parse(r xio.ReadSeekerAt) ([]ftypes.Package, []ftypes.Dependency, error) {
@@ -40,8 +46,8 @@ func (p *Parser) Parse(r xio.ReadSeekerAt) ([]ftypes.Package, []ftypes.Dependenc
 	var lineNumber int
 	for scanner.Scan() {
 		lineNumber++
-		line := scanner.Text()
-		line = strings.ReplaceAll(line, " ", "")
+		text := scanner.Text()
+		line := strings.ReplaceAll(text, " ", "")
 		line = strings.ReplaceAll(line, `\`, "")
 		line = removeExtras(line)
 		line = rStripByKey(line, commentMarker)
@@ -51,6 +57,12 @@ func (p *Parser) Parse(r xio.ReadSeekerAt) ([]ftypes.Package, []ftypes.Dependenc
 		if len(s) != 2 {
 			continue
 		}
+
+		if !isValidName(s[0]) || !isValidVersion(s[1]) {
+			p.logger.Debug("Invalid package name/version in requirements.txt.", log.String("line", text))
+			continue
+		}
+
 		pkgs = append(pkgs, ftypes.Package{
 			Name:    s[0],
 			Version: s[1],
@@ -83,3 +95,19 @@ func removeExtras(line string) string {
 	}
 	return line
 }
+
+func isValidName(name string) bool {
+	for _, r := range name {
+		// only characters [A-Z0-9._-] are allowed (case insensitive)
+		// cf. https://peps.python.org/pep-0508/#names
+		if !unicode.IsLetter(r) && !unicode.IsDigit(r) && r != '.' && r != '_' && r != '-' {
+			return false
+		}
+	}
+	return true
+}
+
+func isValidVersion(ver string) bool {
+	_, err := version.Parse(ver)
+	return err == nil
+}
diff --git a/pkg/dependency/parser/python/pip/parse_test.go b/pkg/dependency/parser/python/pip/parse_test.go
index d887205fb148..3a13c5272cc8 100644
--- a/pkg/dependency/parser/python/pip/parse_test.go
+++ b/pkg/dependency/parser/python/pip/parse_test.go
@@ -2,7 +2,6 @@ package pip
 
 import (
 	"os"
-	"path"
 	"testing"
 
 	"github.com/stretchr/testify/assert"
@@ -12,57 +11,72 @@ import (
 )
 
 func TestParse(t *testing.T) {
-	vectors := []struct {
-		file string
-		want []ftypes.Package
+	tests := []struct {
+		name     string
+		filePath string
+		want     []ftypes.Package
 	}{
 		{
-			file: "testdata/requirements_flask.txt",
-			want: requirementsFlask,
+			name:     "happy path",
+			filePath: "testdata/requirements_flask.txt",
+			want:     requirementsFlask,
 		},
 		{
-			file: "testdata/requirements_comments.txt",
-			want: requirementsComments,
+			name:     "happy path with comments",
+			filePath: "testdata/requirements_comments.txt",
+			want:     requirementsComments,
 		},
 		{
-			file: "testdata/requirements_spaces.txt",
-			want: requirementsSpaces,
+			name:     "happy path with spaces",
+			filePath: "testdata/requirements_spaces.txt",
+			want:     requirementsSpaces,
 		},
 		{
-			file: "testdata/requirements_no_version.txt",
-			want: requirementsNoVersion,
+			name:     "happy path with dependency without version",
+			filePath: "testdata/requirements_no_version.txt",
+			want:     requirementsNoVersion,
 		},
 		{
-			file: "testdata/requirements_operator.txt",
-			want: requirementsOperator,
+			name:     "happy path with operator",
+			filePath: "testdata/requirements_operator.txt",
+			want:     requirementsOperator,
 		},
 		{
-			file: "testdata/requirements_hash.txt",
-			want: requirementsHash,
+			name:     "happy path with hash",
+			filePath: "testdata/requirements_hash.txt",
+			want:     requirementsHash,
 		},
 		{
-			file: "testdata/requirements_hyphens.txt",
-			want: requirementsHyphens,
+			name:     "happy path with hyphens",
+			filePath: "testdata/requirements_hyphens.txt",
+			want:     requirementsHyphens,
 		},
 		{
-			file: "testdata/requirement_exstras.txt",
-			want: requirementsExtras,
+			name:     "happy path with exstras",
+			filePath: "testdata/requirement_exstras.txt",
+			want:     requirementsExtras,
 		},
 		{
-			file: "testdata/requirements_utf16le.txt",
-			want: requirementsUtf16le,
+			name:     "happy path. File uses utf16le",
+			filePath: "testdata/requirements_utf16le.txt",
+			want:     requirementsUtf16le,
+		},
+		{
+			name:     "happy path with templating engine",
+			filePath: "testdata/requirements_with_templating_engine.txt",
+			want:     nil,
 		},
 	}
 
-	for _, v := range vectors {
-		t.Run(path.Base(v.file), func(t *testing.T) {
-			f, err := os.Open(v.file)
+	for _, tt := range tests {
+		t.Run(tt.name, func(t *testing.T) {
+			f, err := os.Open(tt.filePath)
 			require.NoError(t, err)
 
 			got, _, err := NewParser().Parse(f)
 			require.NoError(t, err)
 
-			assert.Equal(t, v.want, got)
+			assert.Equal(t, tt.want, got)
 		})
 	}
 }
diff --git a/pkg/dependency/parser/python/pip/testdata/requirements_with_templating_engine.txt b/pkg/dependency/parser/python/pip/testdata/requirements_with_templating_engine.txt
new file mode 100644
index 000000000000..c121e2517d9f
--- /dev/null
+++ b/pkg/dependency/parser/python/pip/testdata/requirements_with_templating_engine.txt
@@ -0,0 +1,5 @@
+%ifcookiecutter.command_line_interface|lower=='click'-%}
+foo|bar=='1.2.4'
+foo{bar}==%%
+foo,bar&&foobar==1.2.3
+foo=='invalid-version'
\ No newline at end of file