Multiple myeloma (MM) whole bone marrow (WBM) niche cell type classifiers. Generated using scRNA-seq data and scClassify.
Two relapsed MM patients. Approx ~30,000 cells from WBM niche. Immune cells and MM cells. MM cells of training dataset identified using gene expression data and inferCNV.
Tested on publically available MM scRNA-seq data (GSE188632) (https://www-ncbi-nlm-nih-gov.ezproxy.u-pec.fr/geo/query/acc.cgi?acc=GSM5687372). High agreement between MM cell assignment of classifier and user defined cell-assignments of clusters using gene expression data.