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请教关于VQSR的一些问题 #9

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cocpu opened this issue Oct 27, 2024 · 0 comments
Open

请教关于VQSR的一些问题 #9

cocpu opened this issue Oct 27, 2024 · 0 comments

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@cocpu
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cocpu commented Oct 27, 2024

老师您好，我想请教一下，假如我的X染色体是根据PAR区域设置了倍性，那么在后续的VQSR时可以将X染色体和常染色体放在一起建模吗？我想，X染色体和常染色体在VQSR的建模参数中应该只有DP会受到一些影响（一半的样本为男性导致的，即使忽略了PAR区域的倍性把男性作为二倍体也是如此），不知道老师在Nature的论文中是如何操作的呢
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