-
Notifications
You must be signed in to change notification settings - Fork 0
/
project_3.html
1 lines (1 loc) · 8.51 KB
/
project_3.html
1
<!DOCTYPE html><html lang="en"><head><title>Machine Learning</title><meta charset="utf-8"><!--[if IE]><meta http-equiv='X-UA-Compatible' content='IE=edge,chrome=1'><![endif]--><meta name="viewport" content="width=device-width,initial-scale=1,maximum-scale=1"><meta name="description" content=""><link href="https://fonts.googleapis.com/css?family=Karla:400,400i,700%7CLato:300,400,400i,700" rel="stylesheet"><link rel="stylesheet" href="css/bootstrap.min.css"><link rel="stylesheet" href="css/magnific-popup.css"><link rel="stylesheet" href="css/font-icons.css"><link rel="stylesheet" href="css/sliders.css"><link rel="stylesheet" href="css/style.css"><link rel="shortcut icon" href="img/favicon.ico"><link rel="apple-touch-icon" href="img/apple-touch-icon.png"><link rel="apple-touch-icon" sizes="72x72" href="img/apple-touch-icon-72x72.png"><link rel="apple-touch-icon" sizes="114x114" href="img/apple-touch-icon-114x114.png"></head><body><div class="loader-mask"><div class="loader">"Loading..."</div></div><main class="main-wrapper"><header class="nav nav--transparent"><div class="nav__holder" id="sticky-nav"><div class="container-fluid"><div class="flex-parent"><div class="nav__header flex-child clearfix"><div class="logo-wrap"><a class="logo__link"></a></div><button type="button" class="nav__icon-toggle" id="nav__icon-toggle" data-toggle="collapse" data-target="#navbar-collapse"><span class="sr-only">Toggle navigation</span> <span class="nav__icon-toggle-bar"></span> <span class="nav__icon-toggle-bar"></span> <span class="nav__icon-toggle-bar"></span></button></div><nav id="navbar-collapse" class="nav__wrap flex-child collapse navbar-collapse"><ul class="nav__menu"><li id="flex-child_first" class="flex-child active"><a href="index.html">Home</a> <i class="ui-arrow-down nav__dropdown-trigger"></i><ul class="nav__dropdown-menu"><li><a href="index.html">Home</a></li></ul></li><li class="flex-child"><a href="goal.html">Our<span class="newstitle_hide">/</span>Goal</a> <i class="ui-arrow-down nav__dropdown-trigger"></i><ul class="nav__dropdown-menu"><li><a href="goal.html">Goal</a></li></ul></li><li class="nav__dropdown flex-child"><a href="team.html">Team</a> <i class="ui-arrow-down nav__dropdown-trigger"></i><ul class="nav__dropdown-menu"><li class="team_nav">Principal Investigator</li><li><a href="team_Panchenko.html">Anna R. Panchenko</a></li><li class="team_nav">Research Associates</li><li><a href="team_Li.html">Shuxiang Li</a></li><li class="team_nav">Research Assistants</li><li><a href="team_Elizabeth_George.html">Elizabeth George</a></li><li class="team_nav">Postdoctoral Fellows</li><li><a href="team_Tanay_Debnath.html">Tanay Debnath</a></li><li class="team_nav">Graduate Students</li><li><a href="team_Espiritu.html">Daniel Espiritu</a></li><li><a href="team_Ostroverkhova.html">Daria Ostroverkhova</a></li><li><a href="team_Rahman.html">Anisur Rahman</a></li><li><a href="team_Sheng.html">Yiru Sheng</a></li><li class="team_nav">Undergraduate Students</li><li><a href="team_Daniel_Tian.html">Daniel Tian</a></li><li><a href="team_Samuel_Tian.html">Samuel Tian</a></li><li><a href="team_Nathan_Nambiar.html">Nathan Nambiar</a></li><a href="alumni.html"><li class="team_life">Alumni</li></a></ul></li><li class="nav__dropdown flex-child"><a href="project_3.html">Projects</a> <i class="ui-arrow-down nav__dropdown-trigger"></i><ul class="nav__dropdown-menu"><li><a href="project_3.html">Cancer Research</a></li><li><a href="project_1.html">Structural Bioinformatics</a></li><li><a href="project_2.html">Chromatin Dynamics</a></li></ul></li><li class="nav__dropdown flex-child"><a href="server.html">Servers/Databases</a> <i class="ui-arrow-down nav__dropdown-trigger"></i><ul class="nav__dropdown-menu"><li><a href="server_2.html">HistoneDB</a></li><li><a href="server_4.html">MutaBind</a></li><li><a href="server_6.html">Histone Interactome</a></li><li><a href="server_trj.html">Nucleosome simulations</a></li><li><a href="server_5.html">Cancer driver mutation benchmark</a></li><li><a href="server_1.html">MutaGene</a></li><li><a href="server_3.html">HYDROID</a></li></ul></li><li class="nav__dropdown flex-child"><a href="publications.html">Publications</a> <i class="ui-arrow-down nav__dropdown-trigger"></i><ul class="nav__dropdown-menu"><li><a href="publications.html">2024</a></li><li><a href="publications.html#2023">2023</a></li><li><a href="publications.html#2022">2022</a></li><li><a href="publications.html#2021">2021</a></li><li><a href="publications.html#2020">2020</a></li><li><a href="publications.html#2019">2019</a></li><li><a href="publications.html#2018">2018</a></li><li><a href="publications.html#2017">2017</a></li><li><a href="publications.html#2016">2016</a></li><li><a href="publications.html#2015">2015 and before</a></li></ul></li><li class="flex-child"><a href="lablife.html">Photo<span class="newstitle_hide">/</span>Gallery</a> <i class="ui-arrow-down nav__dropdown-trigger"></i><ul class="nav__dropdown-menu"><li><a href="lablife.html">Gallery</a></li></ul></li><li class="flex-child"><a href="news.html">News</a> <i class="ui-arrow-down nav__dropdown-trigger"></i><ul class="nav__dropdown-menu"><li><a href="news.html">News</a></li></ul></li><li class="flex-child"><a href="contact.html">Contact</a> <i class="ui-arrow-down nav__dropdown-trigger"></i><ul class="nav__dropdown-menu"><li><a href="contact.html">Contact</a></li></ul></li></ul></nav></div></div></div></header><div class="content-wrapper oh"><section class="page-title bg-img text-center" style="background: linear-gradient(rgba(0, 0, 0, 0.6), rgba(0, 0, 0, 0.3) ), url('../img/team/banner.jpg')"></section><section class="section-wrap blog pb-10"><div class="container"><div class="row"><div class="col-md-10 col-md-offset-1 blog__content mb-10"><article class="entry text-center"><h2 class="entry__title"><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508748/" target="_blank">Developing mathematical models to explore mutational processes and predict drivers in cancer</a></h2><div class="entry__excerpt"><p>Much remains unknown about the progression and heterogeneity of mutational processes in different cancers and their diagnostic and clinical potential. We develop methods and mathematical models to explore DNA context-dependent mutational patterns and underlying somatic cancer mutagenesis. We construct and analyze mutational profiles of cancer samples, that are categorized based on cancer type and primary tumor sites and are normalized by removing the bias from mutational hotspots with recurring mutations.We identify the combinations of underlying mutagenic processes including those related to infidelity of DNA replication and repair machinery, and various other endogenous and exogenous mutagenic factors. In addition, we derive mutagen or cancer-specific mutational background models and apply them to calculate expected DNA and protein site mutability to decouple relative contributions of mutagenesis and selection in carcinogenesis.</p></div><div class="entry__video video-wrap col-md-6"><img src="img/project/dataanalysis2.png" alt="" class="promo-section__img"></div><div class="entry__video video-wrap col-md-6"><img src="img/project/dataanalysis1.png" alt="" class="promo-section__img"></div></article></div></div></div></section><footer class="footer bg-dark"><div class="container"><div class="footer__widgets"><div class="row"><div class="col-md-4 col-sm-6 col-xs-12"><div class="widget footer__get-in-touch text-sm-center"><div class="footer__logo"></div><p class="footer__get-in-touch__paragraph"></p></div></div><div class="col-md-6 col-md-offset-2 col-sm-6 col-xs-12"><div class="widget footer__nav-links text-right text-sm-center"><ul class="list-inline"><li><a href="index.html">Home</a></li><li><a href="goal.html">Our<span class="newstitle_hide">/</span>Goal</a></li><li><a href="project_2.html">Projects</a></li><li><a href="server_1.html">Servers/Databases</a></li><li><a href="publications.html">Publications</a></li><li><a href="contact.html">Contact</a></li></ul><div class="footer__socials mt-20"><div class="social-icons social-icons--nobase"><a href="https://twitter.com/AnnaPanchenko13" target="_blank"><i class="ui-twitter"></i></a> <a href="#"><i class="ui-facebook"></i></a> <a href="#"><i class="ui-linkedin"></i></a></div></div></div></div></div></div></div></footer><div id="back-to-top"><a href="#top"><i class="ui-arrow-up"></i></a></div></div></main><script type="text/javascript" src="js/jquery.min.js"></script><script type="text/javascript" src="js/bootstrap.min.js"></script><script type="text/javascript" src="js/plugins.js"></script><script type="text/javascript" src="js/scripts.js"></script></body></html>