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Inferred path with (extra?) "drug x - Same as - chemical x" hop #951

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khanspers opened this issue Sep 19, 2024 · 2 comments
Open

Inferred path with (extra?) "drug x - Same as - chemical x" hop #951

khanspers opened this issue Sep 19, 2024 · 2 comments
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Hammerhead (Sprint 6) - due Oct 4 in CI This ticket will be fixed in CI by the end of Hammerhead (Sprint 6) (Oct 4) reasoning reasoned answer issue

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@khanspers
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In the results from the query "What drugs may treat conditions related to Leukemia", one of the drugs returned is Anistreplase with several inferred paths. The first hop in one of the paths is "Anistreplase (drug) - Same as - Anistreplase (chemical)". I haven't seen this before, so I'm wondering if it's a bug that this is shown in the UI?

Drug: (https://go.drugbank.com/drugs/DB00029)
Chemical: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2108250/

Screen Shot 2024-09-19 at 9 39 22 AM

It's coming from ARAX/DrugBank.

https://ui.test.transltr.io/results?l=Leukemia&i=MONDO:0005059&t=0&r=0&q=012e64bb-8aa6-43b9-bc8c-a8f17d0ecbb3

Will update this ticket if I find other examples.

@khanspers khanspers added the UI - display confusion on or overlooking information label Sep 19, 2024
@khanspers khanspers changed the title Inferred path with "drug - Same as - chemical" hop Inferred path with (extra?) "drug x - Same as - chemical x" hop Sep 19, 2024
@sstemann
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looks like it's coming from ARAX, i'm not sure who to assign it to so asking @edeutsch to take a look

image

@sstemann sstemann added reasoning reasoned answer issue and removed UI - display confusion on or overlooking information labels Sep 25, 2024
@edeutsch
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The current RTX-KG2 has some Drug - same_as - Chemical edges. Is that specifically disallowed?

In any case, the next RTX-KG2 in dev and CI no longer has these, so this will disappear in coming releases to TEST and PROD.

@sstemann sstemann added the Hammerhead (Sprint 6) - due Oct 4 in CI This ticket will be fixed in CI by the end of Hammerhead (Sprint 6) (Oct 4) label Sep 26, 2024
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Hammerhead (Sprint 6) - due Oct 4 in CI This ticket will be fixed in CI by the end of Hammerhead (Sprint 6) (Oct 4) reasoning reasoned answer issue
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