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Pathfinder Support Graph Display #940

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sstemann opened this issue Sep 10, 2024 · 3 comments
Open

Pathfinder Support Graph Display #940

sstemann opened this issue Sep 10, 2024 · 3 comments
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@sstemann
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I ran Pathfinder for Cystic Fibrosis and Joubert Syndrome

https://ui.ci.transltr.io/pathfinder/results?lone=Cystic%20Fibrosis&ltwo=Joubert%20Syndrome&ione=MONDO:0009061&itwo=MONDO:0018772&t=p&r=0&q=114f0fad-0b21-4248-94f0-fa0daa8dbd37

If you expand the first result - direct path, it looks like the support graphs (with genes) are displayed (i was expecting only direct paths)

image

If you expand the second result - with gene intermediary, all of the paths EPC are "BTE" only
image

image

It seems like the actual EPC is in the direct path.

@dnsmith124
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After reviewing this with Gus the data that's coming back from BTE appears to be correct--they seem to be intending to return predicted edges as in the first result. So the first result is actually being displayed as BTE intended.

Both of the edges in each path in the second result are also marked as predictions in the data, but presently the UI does not support displaying more than 1 support graph per path, so they are appearing like direct edges. This will require a change to the UI backend to fix

@sstemann
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this is an example of a direct path with 8000+ paths

https://ui.ci.transltr.io/pathfinder/results?lone=GNRHR&ltwo=KISS1R&ione=NCBIGene:2798&itwo=NCBIGene:84634&t=p&r=0&q=da53c98c-569d-4827-82f7-618d5db16905

my chrome wont expand it

@Genomewide
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Another example:
https://ui.ci.transltr.io/pathfinder/results?lone=MAPK8IP3&ltwo=Amantadine&ione=NCBIGene:23162&itwo=CHEBI:2618&t=p&r=0&q=58abd604-0797-42ca-83b5-1b1ee6f8804b

image

ARAX graph:
image

In ARAX bottom edge
image

Left edge:
image

Right edge:
image

Inferred 'related' does not make sense to me for this?

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