TAD_calculator makes incorrect TAD calls

[zjiang-lji]

TAD_calculator makes incorrect TAD calls. It only makes correct calls on simulation data. Can you help me with this problem? Thanks.

My data's TAD_calculator result:

Singularity> python3 /bin/TADsplimer.py TAD_calculator -c /home/zjiang/software/tadsplimer/input/IKDN7002/1.txt -u 1.7 -d 0.2 -o "/home/zjiang/software/tadsplimer/input/IKDN7002_chr1_TAD"

$ cat 1.6500.7500.subchr.TAD.merge.txt

0.000000000000000000e+00        0.000000000000000000e+00        0.000000000000000000e+00
0.000000000000000000e+00        5.000000000000000000e+02        5.000000000000000000e+02
0.000000000000000000e+00        1.000000000000000000e+03        1.000000000000000000e+03
0.000000000000000000e+00        1.500000000000000000e+03        1.500000000000000000e+03
0.000000000000000000e+00        2.000000000000000000e+03        2.000000000000000000e+03
0.000000000000000000e+00        2.500000000000000000e+03        2.500000000000000000e+03
0.000000000000000000e+00        3.000000000000000000e+03        3.000000000000000000e+03
0.000000000000000000e+00        3.500000000000000000e+03        3.500000000000000000e+03
0.000000000000000000e+00        4.000000000000000000e+03        4.000000000000000000e+03
0.000000000000000000e+00        4.500000000000000000e+03        4.500000000000000000e+03
0.000000000000000000e+00        5.000000000000000000e+03        5.000000000000000000e+03
0.000000000000000000e+00        5.500000000000000000e+03        5.500000000000000000e+03
0.000000000000000000e+00        6.000000000000000000e+03        6.000000000000000000e+03
0.000000000000000000e+00        6.500000000000000000e+03        6.500000000000000000e+03
0.000000000000000000e+00        7.000000000000000000e+03        7.000000000000000000e+03
0.000000000000000000e+00        7.500000000000000000e+03        7.500000000000000000e+03
0.000000000000000000e+00        8.000000000000000000e+03        8.000000000000000000e+03
0.000000000000000000e+00        8.500000000000000000e+03        8.500000000000000000e+03
0.000000000000000000e+00        9.000000000000000000e+03        9.000000000000000000e+03
0.000000000000000000e+00        9.500000000000000000e+03        9.500000000000000000e+03
0.000000000000000000e+00        1.000000000000000000e+04        1.000000000000000000e+04
0.000000000000000000e+00        1.050000000000000000e+04        1.050000000000000000e+04
0.000000000000000000e+00        1.100000000000000000e+04        1.100000000000000000e+04
0.000000000000000000e+00        1.150000000000000000e+04        1.150000000000000000e+04
0.000000000000000000e+00        1.200000000000000000e+04        1.200000000000000000e+04
0.000000000000000000e+00        1.250000000000000000e+04        1.250000000000000000e+04
0.000000000000000000e+00        1.300000000000000000e+04        1.300000000000000000e+04
0.000000000000000000e+00        1.350000000000000000e+04        1.350000000000000000e+04
0.000000000000000000e+00        1.400000000000000000e+04        1.400000000000000000e+04
0.000000000000000000e+00        1.450000000000000000e+04        1.450000000000000000e+04
0.000000000000000000e+00        1.500000000000000000e+04        1.500000000000000000e+04
0.000000000000000000e+00        1.550000000000000000e+04        1.550000000000000000e+04
0.000000000000000000e+00        1.600000000000000000e+04        1.600000000000000000e+04
0.000000000000000000e+00        1.650000000000000000e+04        1.650000000000000000e+04
0.000000000000000000e+00        1.700000000000000000e+04        1.700000000000000000e+04
0.000000000000000000e+00        1.750000000000000000e+04        1.750000000000000000e+04
0.000000000000000000e+00        1.800000000000000000e+04        1.800000000000000000e+04
0.000000000000000000e+00        1.850000000000000000e+04        1.850000000000000000e+04
0.000000000000000000e+00        1.900000000000000000e+04        1.900000000000000000e+04
0.000000000000000000e+00        1.950000000000000000e+04        1.950000000000000000e+04

simulation data's TAD_calculator result:

Singularity> python3 /bin/TADsplimer.py TAD_calculator -c simulation_merge.txt -u 1.7 -d 0.2 -o "/home/zjiang/software/tadsplimer/github/example"

$ cat simulation_merge.0.1000.subchr.TAD.merge.txt

8.338754493097589870e-01        1.000000000000000000e+02        2.910000000000000000e+02
8.576901150277900232e-01        2.870000000000000000e+02        3.820000000000000000e+02
8.533736117325949611e-01        3.880000000000000000e+02        4.740000000000000000e+02
9.271438708128589834e-01        4.840000000000000000e+02        6.220000000000000000e+02
9.808470451652480104e-01        6.270000000000000000e+02        9.020000000000000000e+02
8.585633319398340291e-01        9.010000000000000000e+02        9.830000000000000000e+02