diff --git a/Cargo.lock b/Cargo.lock
index 98c9e1b5..ae82e339 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -203,7 +203,7 @@ version = "0.10.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "43975e01fb4293021af4950366a6f80c45d7301d499622359c7533bd7af19592"
 dependencies = [
- "proc-macro-crate",
+ "proc-macro-crate 1.3.1",
  "proc-macro2",
  "quote",
  "syn 2.0.70",
@@ -264,7 +264,7 @@ version = "4.5.8"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "2bac35c6dafb060fd4d275d9a4ffae97917c13a6327903a8be2153cd964f7085"
 dependencies = [
- "heck 0.5.0",
+ "heck",
  "proc-macro2",
  "quote",
  "syn 2.0.70",
@@ -720,12 +720,6 @@ dependencies = [
  "allocator-api2",
 ]
 
-[[package]]
-name = "heck"
-version = "0.4.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "95505c38b4572b2d910cecb0281560f54b440a19336cbbcb27bf6ce6adc6f5a8"
-
 [[package]]
 name = "heck"
 version = "0.5.0"
@@ -881,16 +875,6 @@ dependencies = [
  "num-traits",
 ]
 
-[[package]]
-name = "lock_api"
-version = "0.4.12"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "07af8b9cdd281b7915f413fa73f29ebd5d55d0d3f0155584dade1ff18cea1b17"
-dependencies = [
- "autocfg",
- "scopeguard",
-]
-
 [[package]]
 name = "log"
 version = "0.4.22"
@@ -1031,29 +1015,6 @@ dependencies = [
  "sha2",
 ]
 
-[[package]]
-name = "parking_lot"
-version = "0.12.3"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f1bf18183cf54e8d6059647fc3063646a1801cf30896933ec2311622cc4b9a27"
-dependencies = [
- "lock_api",
- "parking_lot_core",
-]
-
-[[package]]
-name = "parking_lot_core"
-version = "0.9.10"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1e401f977ab385c9e4e3ab30627d6f26d00e2c73eef317493c4ec6d468726cf8"
-dependencies = [
- "cfg-if",
- "libc",
- "redox_syscall",
- "smallvec",
- "windows-targets",
-]
-
 [[package]]
 name = "pem-rfc7468"
 version = "0.7.0"
@@ -1147,7 +1108,16 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "7f4c021e1093a56626774e81216a4ce732a735e5bad4868a03f3ed65ca0c3919"
 dependencies = [
  "once_cell",
- "toml_edit",
+ "toml_edit 0.19.15",
+]
+
+[[package]]
+name = "proc-macro-crate"
+version = "3.1.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "6d37c51ca738a55da99dc0c4a34860fd675453b8b36209178c2249bb13651284"
+dependencies = [
+ "toml_edit 0.21.1",
 ]
 
 [[package]]
@@ -1161,15 +1131,15 @@ dependencies = [
 
 [[package]]
 name = "pyo3"
-version = "0.21.2"
+version = "0.22.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a5e00b96a521718e08e03b1a622f01c8a8deb50719335de3f60b3b3950f069d8"
+checksum = "4e99090d12f6182924499253aaa1e73bf15c69cea8d2774c3c781e35badc3548"
 dependencies = [
  "cfg-if",
  "indoc",
  "libc",
  "memoffset",
- "parking_lot",
+ "once_cell",
  "portable-atomic",
  "pyo3-build-config",
  "pyo3-ffi",
@@ -1179,9 +1149,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-build-config"
-version = "0.21.2"
+version = "0.22.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7883df5835fafdad87c0d888b266c8ec0f4c9ca48a5bed6bbb592e8dedee1b50"
+checksum = "7879eb018ac754bba32cb0eec7526391c02c14a093121857ed09fbf1d1057d41"
 dependencies = [
  "once_cell",
  "target-lexicon",
@@ -1189,9 +1159,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-ffi"
-version = "0.21.2"
+version = "0.22.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "01be5843dc60b916ab4dad1dca6d20b9b4e6ddc8e15f50c47fe6d85f1fb97403"
+checksum = "ce2baa5559a411fc1cf519295f24c34b53d5d725818bc96b5abf94762da09041"
 dependencies = [
  "libc",
  "pyo3-build-config",
@@ -1199,9 +1169,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros"
-version = "0.21.2"
+version = "0.22.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "77b34069fc0682e11b31dbd10321cbf94808394c56fd996796ce45217dfac53c"
+checksum = "049621c20a23f2def20f4fe67978d1da8d8a883d64b9c21362f3b776e254edc7"
 dependencies = [
  "proc-macro2",
  "pyo3-macros-backend",
@@ -1211,11 +1181,11 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.21.2"
+version = "0.22.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "08260721f32db5e1a5beae69a55553f56b99bd0e1c3e6e0a5e8851a9d0f5a85c"
+checksum = "0e969ee2e025435f1819d31a275ba4bb9cbbdf3ac535227fdbd85b9322ffe144"
 dependencies = [
- "heck 0.4.1",
+ "heck",
  "proc-macro2",
  "pyo3-build-config",
  "quote",
@@ -1281,15 +1251,6 @@ dependencies = [
  "crossbeam-utils",
 ]
 
-[[package]]
-name = "redox_syscall"
-version = "0.5.2"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "c82cf8cff14456045f55ec4241383baeff27af886adb72ffb2162f99911de0fd"
-dependencies = [
- "bitflags",
-]
-
 [[package]]
 name = "regex"
 version = "1.10.5"
@@ -1319,6 +1280,12 @@ version = "0.8.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "7a66a03ae7c801facd77a29370b4faec201768915ac14a721ba36f20bc9c209b"
 
+[[package]]
+name = "relative-path"
+version = "1.9.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "ba39f3699c378cd8970968dcbff9c43159ea4cfbd88d43c00b22f2ef10a435d2"
+
 [[package]]
 name = "rfc6979"
 version = "0.4.0"
@@ -1331,9 +1298,9 @@ dependencies = [
 
 [[package]]
 name = "rstest"
-version = "0.17.0"
+version = "0.21.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "de1bb486a691878cd320c2f0d319ba91eeaa2e894066d8b5f8f117c000e9d962"
+checksum = "9afd55a67069d6e434a95161415f5beeada95a01c7b815508a82dcb0e1593682"
 dependencies = [
  "futures",
  "futures-timer",
@@ -1343,15 +1310,19 @@ dependencies = [
 
 [[package]]
 name = "rstest_macros"
-version = "0.17.0"
+version = "0.21.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "290ca1a1c8ca7edb7c3283bd44dc35dd54fdec6253a3912e201ba1072018fca8"
+checksum = "4165dfae59a39dd41d8dec720d3cbfbc71f69744efb480a3920f5d4e0cc6798d"
 dependencies = [
  "cfg-if",
+ "glob",
+ "proc-macro-crate 3.1.0",
  "proc-macro2",
  "quote",
+ "regex",
+ "relative-path",
  "rustc_version",
- "syn 1.0.109",
+ "syn 2.0.70",
  "unicode-ident",
 ]
 
@@ -1385,12 +1356,6 @@ version = "1.0.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "e1cf6437eb19a8f4a6cc0f7dca544973b0b78843adbfeb3683d1a94a0024a294"
 
-[[package]]
-name = "scopeguard"
-version = "1.2.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "94143f37725109f92c262ed2cf5e59bce7498c01bcc1502d7b9afe439a4e9f49"
-
 [[package]]
 name = "sec1"
 version = "0.7.3"
@@ -1483,12 +1448,6 @@ dependencies = [
  "autocfg",
 ]
 
-[[package]]
-name = "smallvec"
-version = "1.13.2"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "3c5e1a9a646d36c3599cd173a41282daf47c44583ad367b8e6837255952e5c67"
-
 [[package]]
 name = "spki"
 version = "0.7.3"
@@ -1595,6 +1554,17 @@ dependencies = [
  "winnow",
 ]
 
+[[package]]
+name = "toml_edit"
+version = "0.21.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "6a8534fd7f78b5405e860340ad6575217ce99f38d4d5c8f2442cb5ecb50090e1"
+dependencies = [
+ "indexmap",
+ "toml_datetime",
+ "winnow",
+]
+
 [[package]]
 name = "typenum"
 version = "1.17.0"
diff --git a/Cargo.toml b/Cargo.toml
index 427cd005..652cbc03 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -34,9 +34,9 @@ openssl = ["dep:openssl"]
 lto = "thin"
 
 [dependencies]
-lazy_static = "1.4.0"
-num-bigint = "0.4.4"
-num-traits = "0.2.15"
+lazy_static = "1.5.0"
+num-bigint = "0.4.6"
+num-traits = "0.2.19"
 num-integer = "0.1.46"
 chia-bls = "0.10.0"
 sha2 = "0.10.8"
@@ -47,7 +47,7 @@ k256 = { version = "0.13.3", features = ["ecdsa"] }
 p256 = { version = "0.13.2", features = ["ecdsa"] }
 
 [dev-dependencies]
-rstest = "0.17.0"
+rstest = "0.21.0"
 criterion = "0.5.1"
 hex = "0.4.3"
 
diff --git a/tools/Cargo.toml b/tools/Cargo.toml
index 932ffdc1..d545190c 100644
--- a/tools/Cargo.toml
+++ b/tools/Cargo.toml
@@ -12,15 +12,15 @@ readme = "README.md"
 [dependencies]
 hex-literal = "0.4.1"
 hex = "0.4.3"
-rand = "0.8.4"
+rand = "0.8.5"
 sha1 = "0.10.6"
 linreg = "0.2.0"
 clvmr = { path = ".." }
 chia-bls = "0.10.0"
-num-bigint = "0.4.4"
-serde = { version = "1.0.163", features = ["derive"] }
-serde_json = "1.0.96"
-clap = { version = "4.4.18", features = ["derive"] }
+num-bigint = "0.4.6"
+serde = { version = "1.0.204", features = ["derive"] }
+serde_json = "1.0.120"
+clap = { version = "4.5.9", features = ["derive"] }
 
 [[bin]]
 name = "generate-fuzz-corpus"
diff --git a/wasm/Cargo.toml b/wasm/Cargo.toml
index d62ec91b..7d97bbba 100644
--- a/wasm/Cargo.toml
+++ b/wasm/Cargo.toml
@@ -16,7 +16,7 @@ path = "src/lib.rs"
 
 [dependencies]
 clvmr = { path = ".." }
-wasm-bindgen = "0.2.87"
-wasm-bindgen-test = "0.3.37"
-js-sys = "0.3.61"
-getrandom = { version = "0.2.9", features = ["js"] }
+wasm-bindgen = "0.2.92"
+wasm-bindgen-test = "0.3.42"
+js-sys = "0.3.69"
+getrandom = { version = "0.2.15", features = ["js"] }
diff --git a/wheel/Cargo.toml b/wheel/Cargo.toml
index 013962ae..baf63a0e 100644
--- a/wheel/Cargo.toml
+++ b/wheel/Cargo.toml
@@ -16,7 +16,7 @@ path = "src/lib.rs"
 
 [dependencies]
 clvmr = { path = ".." }
-pyo3 = { version = "0.21.2", features = ["abi3-py38", "extension-module"] }
+pyo3 = { version = "0.22.1", features = ["abi3-py38", "extension-module"] }
 
 [features]
 openssl = ["clvmr/openssl"]
diff --git a/wheel/src/adapt_response.rs b/wheel/src/adapt_response.rs
index 6b30886a..3816034b 100644
--- a/wheel/src/adapt_response.rs
+++ b/wheel/src/adapt_response.rs
@@ -21,7 +21,7 @@ pub fn adapt_response(
         Err(eval_err) => {
             let sexp = LazyNode::new(Rc::new(allocator), eval_err.0).to_object(py);
             let msg = eval_err.1.to_object(py);
-            let tuple = PyTuple::new(py, [msg, sexp]);
+            let tuple = PyTuple::new_bound(py, [msg, sexp]);
             let value_error: PyErr = PyValueError::new_err(tuple.to_object(py));
             Err(value_error)
         }
diff --git a/wheel/src/api.rs b/wheel/src/api.rs
index e3eebc6f..07ef0a45 100644
--- a/wheel/src/api.rs
+++ b/wheel/src/api.rs
@@ -48,12 +48,12 @@ fn tuple_for_parsed_triple(py: Python<'_>, p: &ParsedTriple) -> PyObject {
             start,
             end,
             atom_offset,
-        } => PyTuple::new(py, [*start, *end, *atom_offset as u64]),
+        } => PyTuple::new_bound(py, [*start, *end, *atom_offset as u64]),
         ParsedTriple::Pair {
             start,
             end,
             right_index,
-        } => PyTuple::new(py, [*start, *end, *right_index as u64]),
+        } => PyTuple::new_bound(py, [*start, *end, *right_index as u64]),
     };
     tuple.into_py(py)
 }
@@ -67,12 +67,16 @@ fn deserialize_as_tree(
     let mut cursor = io::Cursor::new(blob);
     let (r, tree_hashes) = parse_triples(&mut cursor, calculate_tree_hashes)?;
     let r = r.iter().map(|pt| tuple_for_parsed_triple(py, pt)).collect();
-    let s = tree_hashes.map(|ths| ths.iter().map(|b| PyBytes::new(py, b).into()).collect());
+    let s = tree_hashes.map(|ths| {
+        ths.iter()
+            .map(|b| PyBytes::new_bound(py, b).into())
+            .collect()
+    });
     Ok((r, s))
 }
 
 #[pymodule]
-fn clvm_rs(_py: Python, m: &PyModule) -> PyResult<()> {
+fn clvm_rs(_py: Python, m: &Bound<'_, PyModule>) -> PyResult<()> {
     m.add_function(wrap_pyfunction!(run_serialized_chia_program, m)?)?;
     m.add_function(wrap_pyfunction!(serialized_length, m)?)?;
     m.add_function(wrap_pyfunction!(deserialize_as_tree, m)?)?;
diff --git a/wheel/src/lazy_node.rs b/wheel/src/lazy_node.rs
index 0243369b..71eae760 100644
--- a/wheel/src/lazy_node.rs
+++ b/wheel/src/lazy_node.rs
@@ -13,9 +13,8 @@ pub struct LazyNode {
 
 impl ToPyObject for LazyNode {
     fn to_object(&self, py: Python<'_>) -> PyObject {
-        let node: &PyCell<LazyNode> = PyCell::new(py, self.clone()).unwrap();
-        let pa: &PyAny = node;
-        pa.to_object(py)
+        let node: Bound<LazyNode> = Bound::new(py, self.clone()).unwrap();
+        node.to_object(py)
     }
 }
 
@@ -27,7 +26,7 @@ impl LazyNode {
             SExp::Pair(p1, p2) => {
                 let r1 = Self::new(self.allocator.clone(), *p1);
                 let r2 = Self::new(self.allocator.clone(), *p2);
-                let v: &PyTuple = PyTuple::new(py, &[r1, r2]);
+                let v = PyTuple::new_bound(py, &[r1, r2]);
                 Ok(Some(v.into()))
             }
             _ => Ok(None),
@@ -37,7 +36,9 @@ impl LazyNode {
     #[getter(atom)]
     pub fn atom(&self, py: Python) -> Option<PyObject> {
         match &self.allocator.sexp(self.node) {
-            SExp::Atom => Some(PyBytes::new(py, self.allocator.atom(self.node).as_ref()).into()),
+            SExp::Atom => {
+                Some(PyBytes::new_bound(py, self.allocator.atom(self.node).as_ref()).into())
+            }
             _ => None,
         }
     }