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software-installation.md

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Software installation

Steps required to install software required for tutorial

1. KNIME and 3D-e-Chem KNIME nodes

Install KNIME 3.3.1 + all free extensions from https://www.knime.org/downloads/overview

In KNIME go to Help > Install New Software…

Add the following update site: https://3d-e-chem.github.io/knime-node-collection

Click the checkbox and install the 3D-e-Chem KNIME node collection, then restart KNIME

The GPCRdb, KLIFS, Molviewer and ss-TEA nodes are ready to be used.

2. SyGMA and KRIPOdb

To be able to use the SyGMa and KripoDB nodes, do the following:

Install Miniconda for Python 2.7 from https://conda.io/miniconda.html

Open the Anaconda Prompt and execute the following commands:

conda install -c 3d-e-Chem -c rdkit -c conda-forge pandas protobuf rdkit git scipy sygma

pip install git+https://github.com/3D-e-Chem/kripodb.git

In KNIME go to File > Preferences > KNIME > Python and select your new Python executable (e.g. C:\ProgramData\Miniconda2\python.exe)

3. PLANTS KNIME nodes

To be able to use the PLANTS nodes, do the following:

In KNIME go to Help > Install New Software…

Add the following update site: https://3d-e-chem.github.io/updates

Check the KNIME PLANTS checkbox and install, then restart KNIME

The PLANTS executable can be downloaded from http://www.mnf.uni-tuebingen.de/fachbereiche/pharmazie-und-biochemie/pharmazie/pharmazeutische-chemie/pd-dr-t-exner/research/plants.html